Validating microbiome claims – including the latest DNA techniques
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Abel Ureta-Vidal, Founder and CEO of Eagle Genomics, discusses how advanced DNA techniques help us to identify and characterise the microbiome, leading us to ways to prove cosmetic claims at the in-cosmetics formulation summit, 25th October 2017.
![About Eagle Genomics
Based in Cambridge, UK since 2008, on the Wellcome Genome Campus
AI augmented knowledge discovery platform for Life Sciences
• Human & animal health
• Personal care and cosmeceuticals
• Food and nutraceuticals
Delivering the innovation platform for the genomics era
e[automateddatascientist]
• to enable data driven decisions
• to increase the success rate of innovation](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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Validating microbiome claims – including the latest DNA techniques
- 1. Validating microbiome claims – including the latest DNA techniques Abel Ureta-Vidal Founder & CEO of Eagle Genomics abel.uretavidal@eaglegenomics.com In-cosmetics® formulation summit, 25th October 2017
- 2. About Eagle Genomics Based in Cambridge, UK since 2008, on the Wellcome Genome Campus AI augmented knowledge discovery platform for Life Sciences • Human & animal health • Personal care and cosmeceuticals • Food and nutraceuticals Delivering the innovation platform for the genomics era e[automateddatascientist] • to enable data driven decisions • to increase the success rate of innovation
- 5. $241M Metabolic Diseases Oncology $147B Infectious Diseases $46B $120B Association with • IBS • Certain cancers • Depression • Skin conditions Antibiotics resistance • Resistome • Finding more specific antibiotics
- 6. $5T Food Production Animal Health • Symbiotic relationship microbiome-plant • New natural biologically active compounds • Antibiotics resistance in animal spread in food chain
- 8. $200B Nutraceuticals & Supplements $1.9B Pre and pro biotics
- 10. Bad bacteria, good bacteria
- 11. Health claims – How things can go wrong?
- 12. Space – the final frontier Effects of space travel on the human microbiome http://journal.frontiersin.org/article/10.3389/fspas.2016.00023/full
- 13. Scaling up of microbiomics DNA analysis, the easy part! The metagenomics pipeline runs in less than 24h for about $30 The platform can sustain10x increase in input across 100s of studies Also can improve the precision of the analysis at the subspecies/strain level Numberofsequencingreads 16S 454 16S Illumina Metagenomics Illumina Human Genome 30x Human exome 50x 1m 470m 1.7b 720m 60m 2011 Today Cf. Human
- 14. Favouring a microbiome ecosystem for heathier mouth and gum Past: Stand alone Present: Server/Cluster Emerging: Secure Scalable Cloud Weeks / Months Days / Weeks Hours 100K Reads 5 Billion reads
- 15. Microbiome profiles without context are useless
- 16. Capturing context to accelerate insight discovery Genomics profile ‘omics profile Molecular results Genes & pathways Safety Toxicology Consumer Indication Microbiome profile Externally-exposed mucosa Skin/scalp
- 17. Today: Significant inertia in biologists doing data-rich tasks Data sources meta data summary documents protocols experiment al & clinical reports Concept entailment process concepts entities relations Jennifer Biologist
- 18. We have generalised for many applications… Genomics profile ‘omics profile Molecular resultsGenes & pathways Safety Toxicology Consumer Patient Animal Plant Product Indication Disease Health status Quality trait RWD Market access data Microbiome profile Externally-exposed mucosa Skin/scalp Gut (human, animal) Blood Soil Ocean/river/water Food
- 19. …in many different sectors Food & nutrition Skin biology Biomedical research Animal health & breeding … Soil engineering & plant yield Environment
- 20. The Automated Data Scientist AI augmented knowledge discovery to enable data-driven innovation
- 22. The bottleneck to data-driven innovation and data governance insight CURATE CATALOGUE DISCOVER EXPLOIT big data AI Machine Learning Modelling Focus of the industry for AI + ML applications necessary but not sufficient 50 40 30 20 10 0 Curate Catalog Discover Exploit effort value
- 23. Accelerating data driven innovation insight CURATE CATALOGUE DISCOVER EXPLOIT big data Conversational Learning Eagle Genomics focus – across the entire bridge 50 40 30 20 10 0 Curate Catalog Discover Exploit INTEGRATE STORE EXPLORE ANALYZE AI & Machine Learning Measurement Framework Effort distributed Value captured earlier