Lassa fever is caused by the Lassa virus and is endemic in parts of West Africa. It is primarily transmitted to humans via contact with the urine or feces of infected Mastomys rodents. Person-to-person transmission can also occur. Most cases are mild, but severe cases can involve bleeding, shock, and death in 15-30% of patients. Diagnosis involves virus detection via PCR or serologic testing for antibodies. Treatment consists of supportive care and the antiviral ribavirin.
This document summarizes a seminar presentation on Lassa fever given by Dr. D.C. Briggs. It begins with an introduction covering viral hemorrhagic fevers in general and key characteristics of Lassa fever. It then discusses the epidemiology of Lassa fever, including its reservoir, transmission, and recent outbreaks in Nigeria. The document outlines the pathogenesis, clinical features, case definition, differential diagnosis, complications and management of Lassa fever cases. It concludes with the standard operating procedures for managing suspected Lassa fever cases at UPTH.
Lassa fever is a viral hemorrhagic illness transmitted to humans through contact with the urine or feces of infected Mastomys rats. It is endemic in parts of West Africa, with 100,000-300,000 infections estimated annually. Symptoms can include bleeding, abdominal pain, and fever. Treatment involves supportive care and the antiviral ribavirin if given early. Prevention focuses on proper food storage, hygiene practices, and rodent control to avoid exposure to infected rats.
The document summarizes Nigeria's 2016 Lassa fever epidemic. It describes the epidemiology and transmission of Lassa virus, symptoms and treatment of Lassa fever, and the response efforts. Key points include: (1) Lassa fever is endemic in West Africa and causes annual outbreaks in Nigeria, with the multimammate mouse being the primary host; (2) person-to-person transmission can occur in hospitals lacking infection control; (3) the case fatality rate was 1% historically but rose to 34.31% in the 2016 Nigeria outbreak; (4) supportive care and ribavirin treatment improve survival rates.
Lassa fever is a viral hemorrhagic fever caused by the Lassa virus and transmitted by rodents. It is endemic in West Africa, with an estimated 100,000-300,000 cases and 5,000 deaths annually. There is currently an outbreak in Nigeria affecting 12 states and 397 cases, resulting in 40 deaths so far. Clinical signs include gradual fever, headache, bleeding, and neck swelling. Diagnosis involves ELISA and PCR tests, and treatment is supportive care and the antiviral drug ribavirin. Preventing transmission involves avoiding contact with infected rodents and person-to-person spread through medical settings.
Lassa fever is an acute viral hemorrhagic fever caused by the Lassa virus. It is endemic to West Africa, where it is spread through contact with the urine or feces of the multimammate mouse host. Common symptoms include fever, weakness, facial swelling, vomiting, and bleeding. Diagnosis involves virus isolation from blood or tissue samples. Treatment consists of ribavirin antiviral therapy. Prevention focuses on rodent control and avoiding contact with infected materials. The mortality rate can be over 50% without treatment but is reduced to 5-10% with early ribavirin administration.
Lassa fever aka Lassa hemorrhagic fever is caused by lassa virus and is a Zoonotic disease. It is epidemic in Nigeria, Sierra Leone and Liberia.
Limiting direct contact between humans and rodents can help prevent this disease.
LASSA FEVER, THE FOE TO AFRIEND SINCE 1969Moses Daodu
Lassa fever is a viral illness endemic to West Africa that is transmitted to humans from contact with the multimammate rat. The document outlines the virus, transmission, symptoms, diagnosis and treatment of Lassa fever. It is most commonly spread through contact with urine or droppings from infected rats, which can enter the body through inhalation or ingestion. Person-to-person transmission is also possible. Supportive care and the antiviral drug ribavirin are used to treat the illness. Prevention focuses on reducing contact with rats and proper isolation of infected individuals.
This document discusses viral hemorrhagic fever (VHF), specifically Lassa fever. It defines VHF and notes that Lassa fever, caused by the Lassa virus, is endemic in parts of West Africa. The virus is transmitted from rodents to humans and then through human contact. Symptoms can range from mild to severe. Diagnosis involves ELISA, PCR and immunohistochemistry. Treatment for Lassa fever involves supportive care and the antiviral drug ribavirin. Prevention focuses on avoiding contact with rodents, proper food storage, hygiene and use of PPE during potential human exposures.
This document summarizes a seminar presentation on Lassa fever given by Dr. D.C. Briggs. It begins with an introduction covering viral hemorrhagic fevers in general and key characteristics of Lassa fever. It then discusses the epidemiology of Lassa fever, including its reservoir, transmission, and recent outbreaks in Nigeria. The document outlines the pathogenesis, clinical features, case definition, differential diagnosis, complications and management of Lassa fever cases. It concludes with the standard operating procedures for managing suspected Lassa fever cases at UPTH.
Lassa fever is a viral hemorrhagic illness transmitted to humans through contact with the urine or feces of infected Mastomys rats. It is endemic in parts of West Africa, with 100,000-300,000 infections estimated annually. Symptoms can include bleeding, abdominal pain, and fever. Treatment involves supportive care and the antiviral ribavirin if given early. Prevention focuses on proper food storage, hygiene practices, and rodent control to avoid exposure to infected rats.
The document summarizes Nigeria's 2016 Lassa fever epidemic. It describes the epidemiology and transmission of Lassa virus, symptoms and treatment of Lassa fever, and the response efforts. Key points include: (1) Lassa fever is endemic in West Africa and causes annual outbreaks in Nigeria, with the multimammate mouse being the primary host; (2) person-to-person transmission can occur in hospitals lacking infection control; (3) the case fatality rate was 1% historically but rose to 34.31% in the 2016 Nigeria outbreak; (4) supportive care and ribavirin treatment improve survival rates.
Lassa fever is a viral hemorrhagic fever caused by the Lassa virus and transmitted by rodents. It is endemic in West Africa, with an estimated 100,000-300,000 cases and 5,000 deaths annually. There is currently an outbreak in Nigeria affecting 12 states and 397 cases, resulting in 40 deaths so far. Clinical signs include gradual fever, headache, bleeding, and neck swelling. Diagnosis involves ELISA and PCR tests, and treatment is supportive care and the antiviral drug ribavirin. Preventing transmission involves avoiding contact with infected rodents and person-to-person spread through medical settings.
Lassa fever is an acute viral hemorrhagic fever caused by the Lassa virus. It is endemic to West Africa, where it is spread through contact with the urine or feces of the multimammate mouse host. Common symptoms include fever, weakness, facial swelling, vomiting, and bleeding. Diagnosis involves virus isolation from blood or tissue samples. Treatment consists of ribavirin antiviral therapy. Prevention focuses on rodent control and avoiding contact with infected materials. The mortality rate can be over 50% without treatment but is reduced to 5-10% with early ribavirin administration.
Lassa fever aka Lassa hemorrhagic fever is caused by lassa virus and is a Zoonotic disease. It is epidemic in Nigeria, Sierra Leone and Liberia.
Limiting direct contact between humans and rodents can help prevent this disease.
LASSA FEVER, THE FOE TO AFRIEND SINCE 1969Moses Daodu
Lassa fever is a viral illness endemic to West Africa that is transmitted to humans from contact with the multimammate rat. The document outlines the virus, transmission, symptoms, diagnosis and treatment of Lassa fever. It is most commonly spread through contact with urine or droppings from infected rats, which can enter the body through inhalation or ingestion. Person-to-person transmission is also possible. Supportive care and the antiviral drug ribavirin are used to treat the illness. Prevention focuses on reducing contact with rats and proper isolation of infected individuals.
This document discusses viral hemorrhagic fever (VHF), specifically Lassa fever. It defines VHF and notes that Lassa fever, caused by the Lassa virus, is endemic in parts of West Africa. The virus is transmitted from rodents to humans and then through human contact. Symptoms can range from mild to severe. Diagnosis involves ELISA, PCR and immunohistochemistry. Treatment for Lassa fever involves supportive care and the antiviral drug ribavirin. Prevention focuses on avoiding contact with rodents, proper food storage, hygiene and use of PPE during potential human exposures.
Lassa fever is caused by the Lassa virus and is spread chiefly from rodents to humans. It was first discovered in Nigeria and is highly prevalent in West African countries, where an estimated 300-500,000 cases and 5,000 deaths occur annually. Symptoms include fever, headache, muscle pain and bleeding. Transmission occurs through contact with infected rodent excreta or bodily fluids or inhalation of aerosolized viruses. Prevention focuses on eliminating rodents and maintaining clean households and personal hygiene. While there is no cure, early diagnosis and treatment can reduce mortality.
A simple presentation on the Lassa fever endemic in Nigeria - from its first discovery in a town called Lassa in northeastern Nigeria, the mode of transmission, to the control and prevention measures that can be applied to curbing the spread of the virus. Suitable for rural sensitization.
Excerpt from CDC -- [Signs & symptoms]
Signs and symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. For the majority of Lassa fever virus infections (approximately 80%), symptoms are mild and are undiagnosed. Mild symptoms include slight fever, general malaise and weakness, and headache. In 20% of infected individuals, however, disease may progress to more serious symptoms including hemorrhaging (in gums, eyes, or nose, as examples), respiratory distress, repeated vomiting, facial swelling, pain in the chest, back, and abdomen, and shock. Neurological problems have also been described, including hearing loss, tremors, and encephalitis. Death may occur within two weeks after symptom onset due to multi-organ failure.
The most common complication of Lassa fever is deafness. Various degrees of deafness occur in approximately one-third of infections, and in many cases hearing loss is permanent. As far as is known, severity of the disease does not affect this complication: deafness may develop in mild as well as in severe cases.
Approximately 15%-20% of patients hospitalized for Lassa fever die from the illness. However, only 1% of all Lassa virus infections result in death. The death rates for women in the third trimester of pregnancy are particularly high. Spontaneous abortion is a serious complication of infection with an estimated 95% mortality in fetuses of infected pregnant mothers.
Because the symptoms of Lassa fever are so varied and nonspecific, clinical diagnosis is often difficult. Lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50% in hospitalized patients.
The document summarizes the 1969 outbreak of Lassa fever that originated in Nigeria. It describes how the American missionary nurse Laura Wine became the first known case and infected the nurse Charlotte Shaw who cared for her. Their deaths prompted an investigation that led to the discovery of the Lassa virus. The virus is endemic in West African countries and transmitted from rodents to humans. It can also spread between humans. The document provides details on the epidemiology, clinical presentation, diagnosis and treatment of Lassa fever.
Lassa fever is a viral hemorrhagic fever endemic to parts of West Africa that is transmitted to humans from multimammate rats and can also spread between humans; it causes a range of symptoms from mild to severe and death in around 1/5 of cases without treatment, and treatment involves supportive care and the antiviral drug ribavirin which is most effective when given early.
World Malaria Day is observed annually on April 25th to raise awareness of malaria prevention and control efforts. The 2023 theme is "Time to deliver zero malaria: invest, innovate, implement". Malaria remains a significant global health issue, infecting over 200 million people annually. It is caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. P. falciparum is the most deadly malaria parasite. The complex lifecycle involves stages in both human and mosquito hosts. Historical milestones include the discovery of the malaria parasite in 1880 and determination of its mosquito transmission in 1897. Continued investment in prevention, treatment and vaccine development is needed to work towards eliminating malaria worldwide
The document summarizes information about influenza (flu) including:
1. Flu symptoms are usually more severe than a cold and include fever, muscle aches, and cough. Flu can make people feel quite ill for days or weeks.
2. High risk groups for flu include those over 50, young children, pregnant women, and those with chronic illnesses.
3. Flu spreads through droplets from coughs or sneezes and has an incubation period of 1-3 days. Proper hygiene and avoiding contact can help prevent spread.
This is a PowerPoint on the Marburg virus, which is a disease similar to Ebola. I very briefly talk about what the disease is, some of the key facts about the structure and death rate, some outbreak history, prevention and treatment and the social-economical impacts that have been caused.
Zoonotic diseases can be transmitted between animals and humans, with rabies being a notable example. Rabies is an acute viral infection of the central nervous system that is transmitted through the saliva of infected animals via bites or scratches. It is fatal in over 95% of cases in Asia and Africa. The rabies virus is a bullet-shaped rhabdovirus that infects both domestic and wild animals and spreads to humans through contact with infected saliva. There is no cure once symptoms appear, making vaccination important for those at risk of exposure.
Melioidosis is an infectious disease caused by the bacterium Burkholderia pseudomallei. It presents in various forms including skin abscesses, sepsis, pneumonia, and infection of internal organs. The bacterium is found in soil and water in tropical climates. It is transmitted through inhalation, ingestion or direct contact with contaminated materials. Risk factors include diabetes, chronic lung or kidney disease, and immunosuppression. Diagnosis involves culture of the bacterium from clinical samples. Treatment requires initial intensive antibiotic therapy followed by a longer eradication phase to prevent relapse. Prevention strategies focus on protective equipment for high risk workers and disinfection of water supplies. The first case in Nepal was reported in 2005 and a
infestation with or disease caused by Clonorchis sinensis
invades bile ducts of the liver after ingestion in uncooked fish and when present in large numbers causes severe systemic reactions
The document discusses scrub typhus, a common rickettsial disease seen in India. It is caused by the bacteria Orientia tsutsugamushi and transmitted by the bites of larval trombiculid mites. Symptoms include fever, rash, and often a characteristic eschar at the bite site. Complications can include pneumonia, meningitis, and multi-organ failure. Diagnosis is made through serology, PCR, or culture. Doxycycline is the treatment of choice, with azithromycin as an alternative, especially in pregnant women and children. Managing complications may require intravenous antibiotics in hospital. Scrub typhus has reemerged as an important cause of febrile
This document provides an overview of viral hemorrhagic fevers (VHFs). It discusses the etiology, epidemiology, pathogenesis, clinical features and treatment of various VHFs. The major viral families that cause VHF are Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. Common VHFs covered include Lassa fever, Ebola, yellow fever, dengue, Crimean-Congo hemorrhagic fever and hantavirus pulmonary syndrome. The document examines the mechanisms of pathogenesis for Ebola and Lassa virus, including increased vascular permeability, immunosuppression and cytokine storm.
Scrub typhus, also known as bush typhus, is a disease caused by a bacteria called ORIENTIA TSUTSUGAMUSHI.
Scrub typhus is spread to people through bites of infected chiggers (larval mites).
Most cases of scrub typhus occur in rural areas of Southeast Asia, Indonesia, China, Japan, India, and northern Australia. Anyone living in or travelling to areas where scrub typhus is found could get infected
Scrub typhus is not transmitted directly from person to person; it is only transmitted by the bites of vectors
Chiggers are abundant in locales with high relative humidity (60%–85%), low temperature (20°C–30°C), low incidence of sunlight, and a dense substrate-vegetative canopy.
Occupational risk is higher in farmers (aged 50–69 years), females.
Dengue (pronounced DENG-gay) can affect anyone but tends to be more severe in people with compromised immune systems. Because it is caused by one of four serotypes of virus, it is possible to get dengue fever multiple times. However, an attack of dengue produces immunity for a lifetime to that particular serotype to which the patient was exposed.
Cutaneous leishmaniasis is caused by protozoan parasites of the genus Leishmania which are transmitted by sand fly bites. It is endemic in 88 countries including Pakistan, where it is most common in Baluchistan, Khyber Pakhtunkhwa, Sindh and Punjab provinces. Clinical manifestations vary but typically appear as painless skin ulcers. Diagnosis involves microscopic examination of skin samples or PCR testing. Treatment options include pentavalent antimony drugs or alternatives like miltefosine. Prevention relies on early detection, vector control, reservoir control where relevant, and health education.
Malaria is a life-threatening disease caused by Plasmodium parasites transmitted via mosquito bites. It is most prevalent in developing countries, especially sub-Saharan Africa. The most severe form is caused by P. falciparum. Symptoms include fever, chills, and flu-like illness. Diagnosis involves microscopy of blood smears or rapid diagnostic tests to detect parasites. Treatment depends on the Plasmodium species and disease severity, ranging from chloroquine for non-severe P. vivax to artemisinin-based combination therapy for P. falciparum. Prevention involves mosquito control and antimalarial drugs. Malaria poses a major global health challenge but can be controlled through
Buruli ulcer is a disease caused by the environmental pathogen Mycobacterium ulcerans that affects skin and soft tissue. It was first described in Australia in 1948 and has been reported in several sub-Saharan African countries since the late 19th century. The disease mainly affects children in rural areas and causes lesions and ulcers that can lead to disability if not treated. Recent research has identified a toxin produced by M. ulcerans that may be responsible for the disease's pathogenesis. Efforts are ongoing to understand transmission and develop effective control strategies, including through training of medical professionals and increased detection and treatment of cases.
The document summarizes information about Ebola virus hemorrhagic fever and Lassa virus hemorrhagic fever. It describes the etiology, epidemiology, signs and symptoms, diagnosis, treatment and prevention of the two viral hemorrhagic fevers. Ebola virus causes a severe multisystem disease in humans characterized by fever, headache and bleeding. Lassa fever is endemic in West Africa and transmitted from rodents to humans, causing fever, bleeding and organ dysfunction. Treatment involves supportive care and the antiviral drug ribavirin.
Lassa fever Presentation (Role of mos in D)thendondou11
Lassa fever is a viral hemorrhagic fever transmitted by rodents in West Africa. It is caused by the Lassa virus and can cause severe illness and death. The disease is endemic in parts of West Africa, where infection rates in the local population range from 4-52%. Transmission occurs through contact with infected rodent urine or feces or through person-to-person contact. While most cases are mild, Lassa fever can progress to bleeding, organ failure, and death if not treated early with the antiviral drug ribavirin. Prevention focuses on improving sanitation and limiting contact with rodents.
Lassa fever is caused by the Lassa virus and is spread chiefly from rodents to humans. It was first discovered in Nigeria and is highly prevalent in West African countries, where an estimated 300-500,000 cases and 5,000 deaths occur annually. Symptoms include fever, headache, muscle pain and bleeding. Transmission occurs through contact with infected rodent excreta or bodily fluids or inhalation of aerosolized viruses. Prevention focuses on eliminating rodents and maintaining clean households and personal hygiene. While there is no cure, early diagnosis and treatment can reduce mortality.
A simple presentation on the Lassa fever endemic in Nigeria - from its first discovery in a town called Lassa in northeastern Nigeria, the mode of transmission, to the control and prevention measures that can be applied to curbing the spread of the virus. Suitable for rural sensitization.
Excerpt from CDC -- [Signs & symptoms]
Signs and symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. For the majority of Lassa fever virus infections (approximately 80%), symptoms are mild and are undiagnosed. Mild symptoms include slight fever, general malaise and weakness, and headache. In 20% of infected individuals, however, disease may progress to more serious symptoms including hemorrhaging (in gums, eyes, or nose, as examples), respiratory distress, repeated vomiting, facial swelling, pain in the chest, back, and abdomen, and shock. Neurological problems have also been described, including hearing loss, tremors, and encephalitis. Death may occur within two weeks after symptom onset due to multi-organ failure.
The most common complication of Lassa fever is deafness. Various degrees of deafness occur in approximately one-third of infections, and in many cases hearing loss is permanent. As far as is known, severity of the disease does not affect this complication: deafness may develop in mild as well as in severe cases.
Approximately 15%-20% of patients hospitalized for Lassa fever die from the illness. However, only 1% of all Lassa virus infections result in death. The death rates for women in the third trimester of pregnancy are particularly high. Spontaneous abortion is a serious complication of infection with an estimated 95% mortality in fetuses of infected pregnant mothers.
Because the symptoms of Lassa fever are so varied and nonspecific, clinical diagnosis is often difficult. Lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50% in hospitalized patients.
The document summarizes the 1969 outbreak of Lassa fever that originated in Nigeria. It describes how the American missionary nurse Laura Wine became the first known case and infected the nurse Charlotte Shaw who cared for her. Their deaths prompted an investigation that led to the discovery of the Lassa virus. The virus is endemic in West African countries and transmitted from rodents to humans. It can also spread between humans. The document provides details on the epidemiology, clinical presentation, diagnosis and treatment of Lassa fever.
Lassa fever is a viral hemorrhagic fever endemic to parts of West Africa that is transmitted to humans from multimammate rats and can also spread between humans; it causes a range of symptoms from mild to severe and death in around 1/5 of cases without treatment, and treatment involves supportive care and the antiviral drug ribavirin which is most effective when given early.
World Malaria Day is observed annually on April 25th to raise awareness of malaria prevention and control efforts. The 2023 theme is "Time to deliver zero malaria: invest, innovate, implement". Malaria remains a significant global health issue, infecting over 200 million people annually. It is caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. P. falciparum is the most deadly malaria parasite. The complex lifecycle involves stages in both human and mosquito hosts. Historical milestones include the discovery of the malaria parasite in 1880 and determination of its mosquito transmission in 1897. Continued investment in prevention, treatment and vaccine development is needed to work towards eliminating malaria worldwide
The document summarizes information about influenza (flu) including:
1. Flu symptoms are usually more severe than a cold and include fever, muscle aches, and cough. Flu can make people feel quite ill for days or weeks.
2. High risk groups for flu include those over 50, young children, pregnant women, and those with chronic illnesses.
3. Flu spreads through droplets from coughs or sneezes and has an incubation period of 1-3 days. Proper hygiene and avoiding contact can help prevent spread.
This is a PowerPoint on the Marburg virus, which is a disease similar to Ebola. I very briefly talk about what the disease is, some of the key facts about the structure and death rate, some outbreak history, prevention and treatment and the social-economical impacts that have been caused.
Zoonotic diseases can be transmitted between animals and humans, with rabies being a notable example. Rabies is an acute viral infection of the central nervous system that is transmitted through the saliva of infected animals via bites or scratches. It is fatal in over 95% of cases in Asia and Africa. The rabies virus is a bullet-shaped rhabdovirus that infects both domestic and wild animals and spreads to humans through contact with infected saliva. There is no cure once symptoms appear, making vaccination important for those at risk of exposure.
Melioidosis is an infectious disease caused by the bacterium Burkholderia pseudomallei. It presents in various forms including skin abscesses, sepsis, pneumonia, and infection of internal organs. The bacterium is found in soil and water in tropical climates. It is transmitted through inhalation, ingestion or direct contact with contaminated materials. Risk factors include diabetes, chronic lung or kidney disease, and immunosuppression. Diagnosis involves culture of the bacterium from clinical samples. Treatment requires initial intensive antibiotic therapy followed by a longer eradication phase to prevent relapse. Prevention strategies focus on protective equipment for high risk workers and disinfection of water supplies. The first case in Nepal was reported in 2005 and a
infestation with or disease caused by Clonorchis sinensis
invades bile ducts of the liver after ingestion in uncooked fish and when present in large numbers causes severe systemic reactions
The document discusses scrub typhus, a common rickettsial disease seen in India. It is caused by the bacteria Orientia tsutsugamushi and transmitted by the bites of larval trombiculid mites. Symptoms include fever, rash, and often a characteristic eschar at the bite site. Complications can include pneumonia, meningitis, and multi-organ failure. Diagnosis is made through serology, PCR, or culture. Doxycycline is the treatment of choice, with azithromycin as an alternative, especially in pregnant women and children. Managing complications may require intravenous antibiotics in hospital. Scrub typhus has reemerged as an important cause of febrile
This document provides an overview of viral hemorrhagic fevers (VHFs). It discusses the etiology, epidemiology, pathogenesis, clinical features and treatment of various VHFs. The major viral families that cause VHF are Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. Common VHFs covered include Lassa fever, Ebola, yellow fever, dengue, Crimean-Congo hemorrhagic fever and hantavirus pulmonary syndrome. The document examines the mechanisms of pathogenesis for Ebola and Lassa virus, including increased vascular permeability, immunosuppression and cytokine storm.
Scrub typhus, also known as bush typhus, is a disease caused by a bacteria called ORIENTIA TSUTSUGAMUSHI.
Scrub typhus is spread to people through bites of infected chiggers (larval mites).
Most cases of scrub typhus occur in rural areas of Southeast Asia, Indonesia, China, Japan, India, and northern Australia. Anyone living in or travelling to areas where scrub typhus is found could get infected
Scrub typhus is not transmitted directly from person to person; it is only transmitted by the bites of vectors
Chiggers are abundant in locales with high relative humidity (60%–85%), low temperature (20°C–30°C), low incidence of sunlight, and a dense substrate-vegetative canopy.
Occupational risk is higher in farmers (aged 50–69 years), females.
Dengue (pronounced DENG-gay) can affect anyone but tends to be more severe in people with compromised immune systems. Because it is caused by one of four serotypes of virus, it is possible to get dengue fever multiple times. However, an attack of dengue produces immunity for a lifetime to that particular serotype to which the patient was exposed.
Cutaneous leishmaniasis is caused by protozoan parasites of the genus Leishmania which are transmitted by sand fly bites. It is endemic in 88 countries including Pakistan, where it is most common in Baluchistan, Khyber Pakhtunkhwa, Sindh and Punjab provinces. Clinical manifestations vary but typically appear as painless skin ulcers. Diagnosis involves microscopic examination of skin samples or PCR testing. Treatment options include pentavalent antimony drugs or alternatives like miltefosine. Prevention relies on early detection, vector control, reservoir control where relevant, and health education.
Malaria is a life-threatening disease caused by Plasmodium parasites transmitted via mosquito bites. It is most prevalent in developing countries, especially sub-Saharan Africa. The most severe form is caused by P. falciparum. Symptoms include fever, chills, and flu-like illness. Diagnosis involves microscopy of blood smears or rapid diagnostic tests to detect parasites. Treatment depends on the Plasmodium species and disease severity, ranging from chloroquine for non-severe P. vivax to artemisinin-based combination therapy for P. falciparum. Prevention involves mosquito control and antimalarial drugs. Malaria poses a major global health challenge but can be controlled through
Buruli ulcer is a disease caused by the environmental pathogen Mycobacterium ulcerans that affects skin and soft tissue. It was first described in Australia in 1948 and has been reported in several sub-Saharan African countries since the late 19th century. The disease mainly affects children in rural areas and causes lesions and ulcers that can lead to disability if not treated. Recent research has identified a toxin produced by M. ulcerans that may be responsible for the disease's pathogenesis. Efforts are ongoing to understand transmission and develop effective control strategies, including through training of medical professionals and increased detection and treatment of cases.
The document summarizes information about Ebola virus hemorrhagic fever and Lassa virus hemorrhagic fever. It describes the etiology, epidemiology, signs and symptoms, diagnosis, treatment and prevention of the two viral hemorrhagic fevers. Ebola virus causes a severe multisystem disease in humans characterized by fever, headache and bleeding. Lassa fever is endemic in West Africa and transmitted from rodents to humans, causing fever, bleeding and organ dysfunction. Treatment involves supportive care and the antiviral drug ribavirin.
Lassa fever Presentation (Role of mos in D)thendondou11
Lassa fever is a viral hemorrhagic fever transmitted by rodents in West Africa. It is caused by the Lassa virus and can cause severe illness and death. The disease is endemic in parts of West Africa, where infection rates in the local population range from 4-52%. Transmission occurs through contact with infected rodent urine or feces or through person-to-person contact. While most cases are mild, Lassa fever can progress to bleeding, organ failure, and death if not treated early with the antiviral drug ribavirin. Prevention focuses on improving sanitation and limiting contact with rodents.
This document provides an overview of viral hemorrhagic fever (VHF) and focuses on yellow fever. It classifies VHFs and describes their pathogenesis. Yellow fever is caused by a flavivirus transmitted by mosquitoes. It presents with fever, bleeding, liver and kidney damage. Diagnosis involves blood tests showing low platelets and clotting factors. Treatment focuses on supportive care; vaccines can prevent yellow fever.
Malaria PRESENATION AT NEW YOR MEDICAL COLLEGE AKSHAT JAIN akshatusa
The document provides information on malaria, including:
1) Malaria is caused by a parasite transmitted through mosquito bites and remains a serious problem in parts of Africa and Asia.
2) Symptoms can include fever, chills, vomiting, and in severe cases seizures or coma.
3) Diagnosis is made through examination of blood smears under a microscope to identify the malaria parasite, with treatment depending on the identified parasite species.
Malaria is a disease caused by Plasmodium parasites and transmitted via the bites of infected Anopheles mosquitoes. There are four human-infecting Plasmodium species, with P. falciparum being the most deadly. Malaria transmission is influenced by factors like mosquito distribution, temperature, and patient immunity. In Tanzania, over 93% of the population lives in malaria-risk areas, making children and pregnant women most vulnerable.
Malaria is a global parasitic disease caused by Plasmodium parasites transmitted via mosquito bites. It is most prevalent in Africa, where it is a leading cause of mortality and disease burden. The document discusses the global scope of malaria, its transmission and life cycle, clinical manifestations ranging from uncomplicated to severe malaria including cerebral malaria, diagnostic criteria, risk factors and prognostic indicators.
This document provides an overview of a lecture on parasitic infections, focusing on malaria. It defines malaria as a protozoan infection caused by Plasmodium parasites and transmitted via mosquito bites. The epidemiology, causes, pathogenesis, clinical features, diagnosis and management of malaria are discussed in detail. Malaria remains a major public health problem in Zambia, with P. falciparum causing over 95% of cases. Clinical features range from acute to chronic or severe manifestations. Diagnosis involves blood smear microscopy or rapid diagnostic tests. First line treatment of uncomplicated malaria in Zambia is artemether-lumefantrine given over three days.
Leptospirosis: Its Epidemiology, Diagnosis and Control Chandrani Goswami
Leptospirosis is a zoonotic disease caused by Leptospira bacteria transmitted through contact with infected animal urine. It is endemic in tropical and subtropical regions including parts of India. The disease affects both animals and humans. In animals, it can cause reproductive issues like abortions. In humans, symptoms range from flu-like illness to severe symptoms involving multiple organ failure. Diagnosis involves microscopic examination of samples, culture, serological tests and PCR. Control relies on rodent control, sanitation measures, vaccination of animals, and personal protective measures for humans.
This document provides information about malaria, including:
1. Malaria threatens over 2 billion people worldwide and kills over 1 million people annually, mostly young children in Africa. Ninety percent of malaria cases occur in Africa south of the Sahara.
2. Effective prevention and treatment strategies include insecticide-treated mosquito nets, changes in drug treatment regimens due to resistance, and increasing caregiver skills. Artemisinin combination therapies are now the most effective treatments.
3. Malaria symptoms vary from mild to severe and can include fever, chills, vomiting and more. Complications like coma, bleeding and organ failure can occur without prompt treatment of severe cases. Immunity develops in areas
Typhoid fever is a severe illness caused by the bacteria Salmonella typhi. It is characterized by prolonged fever and can invade the liver, spleen, and other organs if untreated. It occurs primarily in developing countries with poor sanitation. Persons are infected by consuming food or water contaminated by the feces or urine of infected individuals. Diagnosis involves isolating the bacteria from blood or bone marrow cultures. Antibiotics are the primary treatment and help reduce complications if started early. Vaccines can help prevent infection but hygiene practices are also important for those in endemic areas.
This document provides information on non-typhoidal salmonellosis (NTS) for 5th year medical students. It describes the salmonella nomenclature system, epidemiology of NTS including common sources of infection, pathophysiology involving intestinal inflammation, clinical manifestations such as diarrhea and potential complications, diagnosis through stool and blood cultures, and treatment focusing on rehydration and antibiotic use only for severe cases. Prevention emphasizes reducing bacterial contamination of foods, improving food safety, and hygienic measures.
The document provides information about malaria, including:
1. Malaria is caused by Plasmodium parasites transmitted via the bites of infected Anopheles mosquitoes and is characterized by chills, fever and sweats.
2. There are four main species of Plasmodium that cause malaria in humans. Microscopic examination of blood smears remains the gold standard for diagnosis.
3. Treatment involves the use of antimalarial drugs to kill the blood stages of the parasite and prevent relapse, while also blocking transmission. Malaria prevention focuses on case management, vector control and personal protection measures.
Management of uncomplicated and severe Malaria.pptxDesmond452126
Malaria is caused by five species of Plasmodium parasites transmitted via mosquito bites. P. falciparum is the most deadly species and a major cause of illness and death in Africa. Diagnosis involves microscopic examination of blood smears or rapid diagnostic tests to detect parasitic antigens. Treatment depends on severity, but uncomplicated malaria is typically treated with artemisinin-based combination therapies over 3 days. Severe malaria requires hospitalization and intravenous artesunate or quinine along with management of complications. Prevention focuses on vector control measures and antimalarial drugs.
This document discusses acute rheumatic fever, which is an inflammatory disease that can occur after a streptococcal throat infection. Some key points:
1. It is caused by an autoimmune reaction to a streptococcal infection and can damage the heart valves, joints, and brain. Untreated, it can lead to rheumatic heart disease.
2. It was first described in the 1500s and the link between strep throat and heart damage was established in the 1800s. Diagnostic criteria were developed in 1944.
3. It remains a major health problem in developing countries where the incidence is higher, though it has declined in developed nations with improved hygiene and access to antibiotics.
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
2. INTRODUCTION
Lassa fever is a hemorrhagic illness caused
by Lassa virus.
Lassa fever was first recognized in Lassa,
Nigeria, in 1969 and is endemic to West
Africa; there are approximately 300,000
cases and 5000 deaths annually.
Lassa virus is a single-stranded RNA virus
belonging to the Arenaviridae family and
has been classified as a category A
bioterrorism agent
3. EPIDEMIOLOGY
Lassa fever is endemic in parts of West
Africa including Guinea, Liberia, Sierra
Leone, Nigeria, Benin, Ghana, and Mali
The prevalence of Lassa virus infections
varies within endemic areas; the incidence
is highest in the forested regions of West
Africa where Guinea, Liberia, and Sierra
Leone share a border.
Cases of Lassa fever occur at all times of
year; the peak incidence occurs in March,
during the transition from dry to wet
season. In addition, there is a smaller
increase in incidence in December, during
the middle of the dry season.
Imported cases of Lassa fever have been
described among returned travelers, with
a relatively high case fatality rate (>30
percent)
4. TRANSMISSION
The primary mode of transmission to humans is via exposure
to infected Mastomys rodents via direct contact with rodent
urine and feces, inhalation of aerosolized rodent excretions,
or consumption of infected rodents as a food source
Mastomys rodent infestation is associated with households
built of poor-quality materials, such as crumbling mud, which
facilitates rodent burrows.
Person-to-person transmission may occur after exposure to
Lassa virus in the blood, urine, feces, or other bodily
secretions of an infected individual.
Risk for person-to-person transmission of Lassa virus persists
after recovery; the virus is shed in the urine for three to nine
weeks and in the semen for up to three months .
RODENT CONTACT
PERSON-TO-PERSON CONTACT
5. TRANSMISSION
Reservoir Mastomys
rats
Primary human
infections
Secondary human
infections
The virus maintains
itself in Mastomys rat
population
Virus is present in urine
and feces of infected
rats
80 to 90 % of humans are
infected through:
Food or household
items contaminated
by infected rat urine
and feces.
Direct contact while
handling Mastomys
rats (food source)
Secondary human-to-
human transmission
occurs through direct
contact with the blood
secretions, organs or
other body fluids of
infected persons
6. PATHOGENESIS
Transmission occurs via the nasopharyngeal mucosa, where it infects dendritic cells,
monocytes, and macrophages. Subsequently, the virus spreads to regional lymph
nodes before disseminating to virtually all tissues.
Inflammatory cell infiltrate of infected organs tends to be minimal; necrosis can occur,
particularly in the liver and spleen. Hepatic necrosis can be significant, involving up to
40 percent of hepatocytes. Splenic necrosis, adrenocortical and pituitary necrosis,
interstitial myocarditis, alveolar edema, and renal tubular injury are also
common.Severe disease appears to result from vascular instability and impaired
hemostasis.
Lassa virus stimulates macrophages and dendritic cells to release soluble mediators
resulting in the endothelial dysfunction, insufficient effective circulating intravascular
volume, and multiorgan failure. This results in pleural effusions and pulmonary
edema, ascites, and hemorrhagic manifestations of the gastrointestinal mucosa.
Hemorrhage has also been associated with a circulating inhibitor of platelet
aggregation and thrombocytopenia.
Among survivors, Lassa virus levels peak between days 4 and 9 of illness, and serum
viral RNA can be detected for up to three weeks after recovery. Cell-mediated
7. CLINICAL MANIFESTATIONS
The incubation period is 1 to 3 weeks.
Most infected individuals (approx. 80%) have mild symptoms (low-grade fever,
malaise, and headache) and may not seek medical attention.
Disease progresses to more serious signs and symptoms in approx. 20% of
patients; these include pharyngitis, cough, nausea, vomiting, diarrhea,
myalgias, retrosternal chest pain, back pain, and abdominal pain.
In severe cases, facial swelling, pulmonary edema, bleeding (from the mouth,
nose, vagina, or GI tract), and hypotension may develop. Proteinuria may be
noted.
Shock, seizures, tremor, disorientation, and coma may be seen in the later
stages.
8. The most common complication of Lassa fever is deafness, which occurs in
up to one-third of patients and may develop in the setting of mild or severe
illness. Hearing may improve after 1 to 3 months in approximately half of
cases.
Patients who recover generally begin to improve after 8 to 10 days of
symptom onset. Poor prognostic factors include the presence of vomiting,
sore throat, tachypnea, bleeding, and diarrhea.
Death usually occurs within 2 weeks after onset of symptoms in fatal cases.
Approximately 1 percent of Lassa virus infections result in death; among
hospitalized patients, case-fatality rates range from 15 to 30 percent.
Mortality rates can be high (≥50 percent) in the setting of nosocomial
outbreaks.
9. SYMPTOMS
CNS – Sensorineural deafness occurs in up to 1/3 of patients, and it becomes
permanent in approximately 18%. In severe cases of Lassa virus infection,
disorientation, ataxia, and seizures can occur in as many as one-third of
patients
Head and neck – Cervical lymphadenopathy is a common symptom of Lassa
virus infection. Pharyngitis and bilateral conjunctivitis occur in 70 and 40% of
cases, respectively. Edema of the head and neck is a distinctive feature of
Lassa fever and is seen in approx. 30% of hospitalized cases.
Pulmonary – A dry cough may occur. Pulmonary edema and pleural
effusions may develop late in the course of disease
Cardiovascular – Retrosternal chest pain occurs in approximately 70% of
patients. Myocarditis has been observed in some cases of Lassa fever
10. GI – Diarrhea and vomiting are common. In severe cases, abdominal pain is
common, likely due to fluid accumulation
Renal – Acute renal failure occurs in 28% of cases
Rash – A maculopapular rash may appear on the thorax, face, and upper
extremities in less than 5% of cases.
Hemorrhage –Manifestations generally consist of blood oozing from the
mouth, nose, vagina, GI tract, and cannulation and injection sites due to
endovascular leakage as well as inhibition of platelet aggregation
11.
12. DIAGNOSIS
The diagnosis of Lassa fever should be suspected in individuals with
suggestive signs and symptoms in the setting of relevant epidemiologic
exposure.
Administration of empiric treatment with ribavirin is reasonable for patients in
endemic areas with symptoms strongly suggestive of Lassa fever, prior to
diagnostic confirmation.
The preferred test for diagnosis of Lassa fever is serum reverse-transcription
polymerase chain reaction; however, this is rarely used in regions where Lassa
fever is endemic because it requires expensive equipment and technical
expertise .
In addition, the genetic heterogeneity within and between the lineages makes
the molecular diagnosis of Lassa virus difficult.
13. The diagnosis of Lassa fever in some endemic regions may be established via serum
enzyme-linked immunosorbent serologic assay, which can detect immunoglobulin (Ig)M and
IgG antibodies and Lassa antigen. Antigen is typically detectable at the time of symptom
onset. However, if initial testing is negative, but a high index of suspicion for Lassa fever
remains, the test should be repeated in 24 to 48 hours.
Serum IgM is detectable 10 to 21 days after symptom onset; serum IgG is detectable
approximately 21 days after symptom onset .
Enzyme-linked immunosorbent serologic and antigen assays take 4 to 18 hours to perform
depending on the individual platform used.
Lassa virus may be cultured from blood, urine, or throat washings, but these are not routine
clinical diagnostic tools. A postmortem diagnosis may be established via
immunohistochemistry performed on formalin-fixed tissue specimens.
Diagnostic evaluation of patients with suspected Lassa fever infection should also include
diagnostic testing for malaria, blood cultures, and evaluation for other infections
14. LAB FINDINGS
Leukopenia –Patients generally have a mild leukopenia in the early stages. Subsequently,
patients may develop a leukocytosis with neutrophilia.
Thrombocytopenia – Mild thrombocytopenia has been observed. Patients with severe Lassa
fever have significantly decreased platelet aggregation
Elevated transaminases and amylase – Both alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) are elevated; AST is usually significantly greater than ALT. Amylase is
frequently elevated as well.
Renal abnormalities – Renal insufficiency has been associated with increased risk of
mortality due to Lassa fever. Proteinuria is common
Spinal fluid findings – Lassa virus has been isolated from the spinal fluid in a small number
of cases. Spinal fluid analysis in patients with Lassa fever has demonstrated mild to
moderate pleocytosis.
15. TREATMENT
It consists primarily of supportive care, including maintenance of oxygenation and blood
pressure. Fluid replacement is important although care must be taken to avoid volume
overload due to the risk of capillary leak and renal dysfunction. Aspirin and NSAIDs should
be avoided because these agents can adversely affect clotting.
In addition to supportive care, it is suggested to administer ribavirin for all symptomatic
patients with a confirmed diagnosis of Lassa fever.
Ribavirin has been reported to be most effective when given within the first six days after
onset of symptoms
Intravenous (IV) administration is preferred because higher serum concentrations can be
achieved than with oral formulations
Loading dose 30 mg/kg (maximum 2 g), followed by 15 mg/kg (maximum 1 g) every six
hours for four days, followed by 7.5 mg/kg (maximum 500 mg) every eight hours for six
days
16. PREVENTION
There is no vaccine for prevention of Lassa virus infection. Preventive measures include
avoiding Mastomys rodents and minimizing risk of person-to-person transmission
Patients with known or suspected Lassa fever should be managed in healthcare facilities
whenever possible; community-based care should be avoided to minimize the risk of person-
to-person transmission. Patients with signs and symptoms of infection should be considered
contagious, even if the clinical manifestations are mild
Blood and body fluid specimens from patients with suspected Lassa fever infection should be
considered highly infectious and handled with extreme caution.
The body of a deceased patient should not be returned to family members; it should be
placed in a sealed body bag and trained personnel in PPE should handle and bury the body.
Individuals should wait at least three months following resolution of Lassa fever infection
before unprotected sex.