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BROAD CONCEPT
COGNITIVE IMPAIRMENT
DISORDERS:
DELIRIUM AND DEMENTIA
PATHO/DELIRIUM
• Cognitive Impairment
• If treat early enough is reversible
• Characterized by clouding of the
consciousness, inability to focus &
maintain attention, & altered
perception
DELIRUM
• Occurs in 10-40% of hospitalized clients,
30-40% of hospitalized client with AIDS,
& up to 60% of nursing home residents
who are 75 years old & older.
• 80% of hospitalized clients near death
will develop delirium.
• Occurs suddenly.
SYSTEM SPECIFIC
ASSESSMENT
• CNS(central nervous system) affected by
many conditions e.g. anemia, ischemia,
hypoglycemia, lack of Vitamin B, endocrine
disorders, toxicity from alcohol or drugs,
trauma, infections, etc.
• Physical restraints may contribute
SYSTEM SPECIFIC
ASSESSMENT
• Behavior: poor impulse control, may be
withdrawn or agitated
• Speech: dull or rapid & pressured
• Picking at clothing and/or the air
• Bizarre behavior at night/Sundowner’s
SYSTEM SPECIFIC
ASSESSMENT
•
•
•
•

Affect:
Range from apathy to irritability
Labile emotions
Laughing or sad
SYSTEM SPECIFIC
ASSESSMENT
• Cognition: disorganized thinking
(rambling speech) & ↓ ability to maintain
& shift attention
• Visual hallucinations /altered perception
are common
• Thinking, memory, attention and
perception are disturbed
SYSTEM SPECIFIC
ASSESSMENT
• Interpersonal Relationships: Families
are anxious & frightened
• Physical: Sleep disturbance and
tremors.
• Safety: Keep the client safe!
INTERVENTIONS
• Eliminate cause of delirium
• Monitor LOC continually
• Reorient with each interaction – introduce self and
call client by their name
• Use short, simple, concrete phrases
• Keep the room well lit
• Provide clocks and calendars
• Have client use assistive devices (hearing
aids/glasses
• Clarify reality while justifying emotions/feelings
EVALUATE
PHARMOCOLGY
PHARMOCOLG
• Depends on cause of delirium
– Treat underlying cause first

• Haloperidol (Haldol) 1-2mg IV over
1-3 min may control symptoms.
May be given with lorazepam
(Ativan) IM
EVALUATE
PHARMACOLOGY
• If EPS develops, give diphenhydramine
(Benadryl) 25-50mg
DEMENTIA
• Alzheimer disease (AD) is behind 60-70%
of late-onset dementias. Affects 4.8
million Americans
• $200 billion in U.S. spent yearly
• Affect 50% of persons over age 85
• Women more than men
• 15-20% are inherited
• Course is 5-10 years
CULTURE
• Cultural Influences:
• In U.S ↑ risk for AD in Latin Americans & African
Americans
• Japanese, Italians, & those from Hong Kong have
a greater risk in Europe & Asia
• ↑ lower educational and socioeconomic levels
• ↑clients with previous head injuries
• ↑ clients with relatives that have AD
ETIOLOGIES
• Video: www.nia.nih.gov/alzheimers/ADvideo
• Genetics – cause is unknown, focusing
on beta-amyloid protein that
accumulates into plaques
• Early onset (30 to 60 y/o) is rare (5%)
and is related directly to the Alzheimer’s
gene
ETIOLOGIES
• 1-Neurofibrillary tangles (twisted fibrils
inside the neuron that disrupt cellular
processes and eventually kill the cell)
• 2-Plaques (it is the quantity of plaques
in relation to the person’s age that is
significant) (a) widened sulci and
narrowed gyri
AD
• AD affects:
– Communication, metabolism, and repair
process of neurons in the brain

• Which causes:
– Memory failure
– Personality changes
– Difficulty carrying out ADLs
• There is a progressive decline
AD
•
•
•
•

• 4 stages
Mild – lasts 2-4 years
Moderate – longest stage, day care may
be necessary
Moderate to Severe AD – lasts 1-2 years,
24/7 care needed
Late/End stage
Stage 1 (Mild AD)
• Mild – lasts 2-4 years:
• characterized by
– Short-term memory loss
– Uses memory aids such as lists and
routine
– Aware of the problem
– Depression is common
– NOT diagnosable at this stage
Stage 2 (Moderate AD)
• Stage 2 Moderate AD is characterized by:
– Progressive memory loss
– Withdrawn from social activities
– Decline in instrumental ADLs (money
management, cooking, driving)
– DENIAL – fears “losing” his/her mind
– Depression
– Confabulation
– Symptoms worsen with physical/emotional stress
Stage 3 (Moderate/Severe AD)
• Stage 3 Moderate to Severe AD

is

characterized by:
– ADL losses: willingness to bathe, grooming,
choosing clothing, toileting, communication,
reading/writing
– Loss of reasoning ability
– Depression resolves as they become unaware of
loss
– Difficulty communicating
– Usually institutionalized or need care 24/7
Stage 4 (Late / End stage)
• Stage 4, late / end stage AD

is

characterized by:
– Family recognition/self recognition disappears
– Non-ambulatory
– Forgets how to eat, swallow, chew, wt loss
– Incontinent
– 24/7 care required
– Return to infantile reflexes and ultimately Death
• Death usually secondary to infection or choking
7 WARNING SIGNS of AD
• Asking the same questions over & over
• Repeating the same story, word for
word, again & again
• Forgetting how to cook, or how to make
repairs, or how to play cards – activities
that were previously done with ease
• Losing one’s ability to pay bills or
balance one’s checkbook
7 WARNING SIGNS of AD
• Getting lost in familiar surroundings
• Neglect to bathe, or wearing the same
clothes over & over while insisting
they are clean & are wearing dirty
clothes
• Relying on someone else close to
them to make decisions or answer
questions that they used to handle
OTHER DISORDERS
•
•
•
•
•
•
•

Pseudodementias - mimic dementia
Causes:
Drug toxicity
Infections
Metabolic disorders
Nutritional deficiencies
Depression- most common cause
EVALUATE
PHARMOCOLOGY
• DONAZEPIL (Aricept) 5mg P.O. daily @
bedtime. After 4-6 weeks↑ to 10mg
• Classification: cholinesterase inhibitor
• Action: improves cholinergic function by
inhibiting acetylcholinesterase
• Improves cognitive function
• *Missed doses should be skipped and
regular schedule returned to the following
day.
EVALUATE
PHARMACOLOGY
• Rivastigmine (Exelon) 1.5 mg. twice a
day with food, may ↑ by 1.5 mg. twice a
day every 2 weeks if tolerated. Target
dose 3 – 6 mg. twice a day. Max. dose
12 mg twice a day
• Classification: Cholinesterase Inhibitor
• Action: Treats mild to moderate AD
EVALUATE
PHARMACOLOGY
• Galntamine (Reminyl) 4 mg. twice a day
for at least 4 weeks, if tolerated may ↑
by 4 mg. twice a day every 4 weeks.
Target dose 12 mg twice a day.
• Classification: Cholinesterase inhibitor
• Action: treat mild to moderate dementia
EVALUATE
PHARMACOLOGY
SE: HA, diarrhea, nausea, sweating,
bradycardia, & insomnia
NSG: Taking after breakfast may
lessen side effects, teach how family
how to monitor pulse
*Do not cure – only slows down the
disease
EVALUATE
PHARMACOLOGY
• memantine HCL (NAMENDA)
• Used in moderate to severe Alzheimer’s
or with an acetylcholinesterase – less GI
disturbance
• Side effects: dizziness, HA, confusion
and constipation
MULTIDISCIPLINARY
INTERVENTIONS
•
•
•
•
•
•

Speech therapy
Physical therapy
Occupational therapy
Social workers
Pastoral counselors
New hope is gene therapy – new nerve
growth
ALTERNATIVE THERAPIES
• Antioxidants – found in green tea, grape seed
extract, deepest color fruits & veggies
• Omega-3 Fish Oil – found in salmon,
mackerel, sardines
• Phosphatidyl Serine – keeps nerve cells
flexible
• Melatonin – for sleep
• Estrogen – may be preventative in women
(not useful in existing dementia)
ALTERNATIVE THERAPIES
• Dehydroepiandrosterone (DHEA) –
regulates mood
• S_adenosylmethionine (SAMe) –
improves cell membrane flexibility,
caution in people with cardiac history
• Lecithin – found in soybeans & eggs
• Ginkgo Biloba –increase risk for
bleeding
ALTERNATIVE THERAPIES
• Music
– What type of music would be appropriate?

• Touch
– How should a client with dementia
touched? What approach should the nurse
take?

• Animal-Assisted
– Assess for fears first, if possible
SYSTEM SPECIFIC
ASSESSMENT
• Behavior: Wandering, unable to do complex
tasks, frightened by their confusion, attempt
to cover up symptoms, need assistance
dressing
• ↑ appetite & food intake – no ↑ in weight
• Repetitive behaviors – lip smacking, pacing
• Sundown Syndrome – disoriented at days’
end. Orientated in day.
SYSTEM SPECIFIC
ASSESSMENT
• Affect:
• Mild stage: anxiety & depression occur
• Moderate stage: ↑ lability of emotions
(rage, irritability)
• Severe stage: person becomes
unresponsive to environment
SYSTEM SPECIFIC
ASSESSMENT
• Cognition: ↓ in concentration, ↑ distractibility,
absent-mindedness, unable to make
judgments
• Language skills begin to deteriorate
• Difficulty word-finding
• In mod AD – memory loss (recent & remote)
• Confabulation: filling in gaps with imaginary
information
SYSTEM SPECIFIC
ASSESSMENT - COGNITION
• Misidentification syndrome – familiar people
are unfamiliar
• Aphasia – unable to understand language
• Agraphia – unable to read or write
• Agnosia – unable to recognize familiar
people or situations
• Alexia – unable to tell what to do with a
frying pan, toothbrush, telephone
SYSTEM SPECIFIC
ASSESSMENT
• Perception: visual hallucinations most
common
– What would our intervention be?
HIGHER NEEDS
• Can you think of some problems with
clients & AD as they try to fulfill their
higher needs? Which ones would be
affected?
– What would some interventions be to help
address these higher needs?
NURSING CARE
• Safety is first priority for delirium &
dementia
– What are some interventions we can do
address the safety issues for clients with
delirium and dementia?

• Find local resources such as _________
NURSING CARE
• What are some interventions that you
can think of for someone suffering from
AD?
• How would you assist families?
Diagnostic Tools
•
•
•
•
•

No definitive test
PET
MRI
SCT and PET
MSE

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V. Wright Adult i dementia delirium 14 with narative

  • 2. PATHO/DELIRIUM • Cognitive Impairment • If treat early enough is reversible • Characterized by clouding of the consciousness, inability to focus & maintain attention, & altered perception
  • 3. DELIRUM • Occurs in 10-40% of hospitalized clients, 30-40% of hospitalized client with AIDS, & up to 60% of nursing home residents who are 75 years old & older. • 80% of hospitalized clients near death will develop delirium. • Occurs suddenly.
  • 4. SYSTEM SPECIFIC ASSESSMENT • CNS(central nervous system) affected by many conditions e.g. anemia, ischemia, hypoglycemia, lack of Vitamin B, endocrine disorders, toxicity from alcohol or drugs, trauma, infections, etc. • Physical restraints may contribute
  • 5. SYSTEM SPECIFIC ASSESSMENT • Behavior: poor impulse control, may be withdrawn or agitated • Speech: dull or rapid & pressured • Picking at clothing and/or the air • Bizarre behavior at night/Sundowner’s
  • 6.
  • 7. SYSTEM SPECIFIC ASSESSMENT • • • • Affect: Range from apathy to irritability Labile emotions Laughing or sad
  • 8. SYSTEM SPECIFIC ASSESSMENT • Cognition: disorganized thinking (rambling speech) & ↓ ability to maintain & shift attention • Visual hallucinations /altered perception are common • Thinking, memory, attention and perception are disturbed
  • 9. SYSTEM SPECIFIC ASSESSMENT • Interpersonal Relationships: Families are anxious & frightened • Physical: Sleep disturbance and tremors. • Safety: Keep the client safe!
  • 10. INTERVENTIONS • Eliminate cause of delirium • Monitor LOC continually • Reorient with each interaction – introduce self and call client by their name • Use short, simple, concrete phrases • Keep the room well lit • Provide clocks and calendars • Have client use assistive devices (hearing aids/glasses • Clarify reality while justifying emotions/feelings
  • 11. EVALUATE PHARMOCOLGY PHARMOCOLG • Depends on cause of delirium – Treat underlying cause first • Haloperidol (Haldol) 1-2mg IV over 1-3 min may control symptoms. May be given with lorazepam (Ativan) IM
  • 12. EVALUATE PHARMACOLOGY • If EPS develops, give diphenhydramine (Benadryl) 25-50mg
  • 13. DEMENTIA • Alzheimer disease (AD) is behind 60-70% of late-onset dementias. Affects 4.8 million Americans • $200 billion in U.S. spent yearly • Affect 50% of persons over age 85 • Women more than men • 15-20% are inherited • Course is 5-10 years
  • 14. CULTURE • Cultural Influences: • In U.S ↑ risk for AD in Latin Americans & African Americans • Japanese, Italians, & those from Hong Kong have a greater risk in Europe & Asia • ↑ lower educational and socioeconomic levels • ↑clients with previous head injuries • ↑ clients with relatives that have AD
  • 15. ETIOLOGIES • Video: www.nia.nih.gov/alzheimers/ADvideo • Genetics – cause is unknown, focusing on beta-amyloid protein that accumulates into plaques • Early onset (30 to 60 y/o) is rare (5%) and is related directly to the Alzheimer’s gene
  • 16. ETIOLOGIES • 1-Neurofibrillary tangles (twisted fibrils inside the neuron that disrupt cellular processes and eventually kill the cell) • 2-Plaques (it is the quantity of plaques in relation to the person’s age that is significant) (a) widened sulci and narrowed gyri
  • 17.
  • 18.
  • 19. AD • AD affects: – Communication, metabolism, and repair process of neurons in the brain • Which causes: – Memory failure – Personality changes – Difficulty carrying out ADLs • There is a progressive decline
  • 20. AD • • • • • 4 stages Mild – lasts 2-4 years Moderate – longest stage, day care may be necessary Moderate to Severe AD – lasts 1-2 years, 24/7 care needed Late/End stage
  • 21. Stage 1 (Mild AD) • Mild – lasts 2-4 years: • characterized by – Short-term memory loss – Uses memory aids such as lists and routine – Aware of the problem – Depression is common – NOT diagnosable at this stage
  • 22. Stage 2 (Moderate AD) • Stage 2 Moderate AD is characterized by: – Progressive memory loss – Withdrawn from social activities – Decline in instrumental ADLs (money management, cooking, driving) – DENIAL – fears “losing” his/her mind – Depression – Confabulation – Symptoms worsen with physical/emotional stress
  • 23. Stage 3 (Moderate/Severe AD) • Stage 3 Moderate to Severe AD is characterized by: – ADL losses: willingness to bathe, grooming, choosing clothing, toileting, communication, reading/writing – Loss of reasoning ability – Depression resolves as they become unaware of loss – Difficulty communicating – Usually institutionalized or need care 24/7
  • 24. Stage 4 (Late / End stage) • Stage 4, late / end stage AD is characterized by: – Family recognition/self recognition disappears – Non-ambulatory – Forgets how to eat, swallow, chew, wt loss – Incontinent – 24/7 care required – Return to infantile reflexes and ultimately Death • Death usually secondary to infection or choking
  • 25. 7 WARNING SIGNS of AD • Asking the same questions over & over • Repeating the same story, word for word, again & again • Forgetting how to cook, or how to make repairs, or how to play cards – activities that were previously done with ease • Losing one’s ability to pay bills or balance one’s checkbook
  • 26. 7 WARNING SIGNS of AD • Getting lost in familiar surroundings • Neglect to bathe, or wearing the same clothes over & over while insisting they are clean & are wearing dirty clothes • Relying on someone else close to them to make decisions or answer questions that they used to handle
  • 27. OTHER DISORDERS • • • • • • • Pseudodementias - mimic dementia Causes: Drug toxicity Infections Metabolic disorders Nutritional deficiencies Depression- most common cause
  • 28. EVALUATE PHARMOCOLOGY • DONAZEPIL (Aricept) 5mg P.O. daily @ bedtime. After 4-6 weeks↑ to 10mg • Classification: cholinesterase inhibitor • Action: improves cholinergic function by inhibiting acetylcholinesterase • Improves cognitive function • *Missed doses should be skipped and regular schedule returned to the following day.
  • 29. EVALUATE PHARMACOLOGY • Rivastigmine (Exelon) 1.5 mg. twice a day with food, may ↑ by 1.5 mg. twice a day every 2 weeks if tolerated. Target dose 3 – 6 mg. twice a day. Max. dose 12 mg twice a day • Classification: Cholinesterase Inhibitor • Action: Treats mild to moderate AD
  • 30. EVALUATE PHARMACOLOGY • Galntamine (Reminyl) 4 mg. twice a day for at least 4 weeks, if tolerated may ↑ by 4 mg. twice a day every 4 weeks. Target dose 12 mg twice a day. • Classification: Cholinesterase inhibitor • Action: treat mild to moderate dementia
  • 31. EVALUATE PHARMACOLOGY SE: HA, diarrhea, nausea, sweating, bradycardia, & insomnia NSG: Taking after breakfast may lessen side effects, teach how family how to monitor pulse *Do not cure – only slows down the disease
  • 32. EVALUATE PHARMACOLOGY • memantine HCL (NAMENDA) • Used in moderate to severe Alzheimer’s or with an acetylcholinesterase – less GI disturbance • Side effects: dizziness, HA, confusion and constipation
  • 33. MULTIDISCIPLINARY INTERVENTIONS • • • • • • Speech therapy Physical therapy Occupational therapy Social workers Pastoral counselors New hope is gene therapy – new nerve growth
  • 34. ALTERNATIVE THERAPIES • Antioxidants – found in green tea, grape seed extract, deepest color fruits & veggies • Omega-3 Fish Oil – found in salmon, mackerel, sardines • Phosphatidyl Serine – keeps nerve cells flexible • Melatonin – for sleep • Estrogen – may be preventative in women (not useful in existing dementia)
  • 35. ALTERNATIVE THERAPIES • Dehydroepiandrosterone (DHEA) – regulates mood • S_adenosylmethionine (SAMe) – improves cell membrane flexibility, caution in people with cardiac history • Lecithin – found in soybeans & eggs • Ginkgo Biloba –increase risk for bleeding
  • 36. ALTERNATIVE THERAPIES • Music – What type of music would be appropriate? • Touch – How should a client with dementia touched? What approach should the nurse take? • Animal-Assisted – Assess for fears first, if possible
  • 37. SYSTEM SPECIFIC ASSESSMENT • Behavior: Wandering, unable to do complex tasks, frightened by their confusion, attempt to cover up symptoms, need assistance dressing • ↑ appetite & food intake – no ↑ in weight • Repetitive behaviors – lip smacking, pacing • Sundown Syndrome – disoriented at days’ end. Orientated in day.
  • 38.
  • 39. SYSTEM SPECIFIC ASSESSMENT • Affect: • Mild stage: anxiety & depression occur • Moderate stage: ↑ lability of emotions (rage, irritability) • Severe stage: person becomes unresponsive to environment
  • 40. SYSTEM SPECIFIC ASSESSMENT • Cognition: ↓ in concentration, ↑ distractibility, absent-mindedness, unable to make judgments • Language skills begin to deteriorate • Difficulty word-finding • In mod AD – memory loss (recent & remote) • Confabulation: filling in gaps with imaginary information
  • 41. SYSTEM SPECIFIC ASSESSMENT - COGNITION • Misidentification syndrome – familiar people are unfamiliar • Aphasia – unable to understand language • Agraphia – unable to read or write • Agnosia – unable to recognize familiar people or situations • Alexia – unable to tell what to do with a frying pan, toothbrush, telephone
  • 42. SYSTEM SPECIFIC ASSESSMENT • Perception: visual hallucinations most common – What would our intervention be?
  • 43. HIGHER NEEDS • Can you think of some problems with clients & AD as they try to fulfill their higher needs? Which ones would be affected? – What would some interventions be to help address these higher needs?
  • 44. NURSING CARE • Safety is first priority for delirium & dementia – What are some interventions we can do address the safety issues for clients with delirium and dementia? • Find local resources such as _________
  • 45. NURSING CARE • What are some interventions that you can think of for someone suffering from AD? • How would you assist families?