Here are some diagnostic tools that can be used: - Mini-Mental State Exam (MSE) - 30 point questionnaire; tests orientation, attention, calculation, recall, language, and motor skills. - Structural imaging tests like MRI and CT scans can show brain shrinkage in areas important for memory and thinking. - Functional imaging tests like PET and SPECT scans show how well the brain is functioning by detecting glucose metabolism and blood flow. Areas of the brain important for memory and thinking show decreased activity in people with Alzheimer's disease. - Spinal fluid tests - a sample of cerebrospinal fluid can be analyzed for beta-amyloid and tau protein levels. Elevated tau and beta-