A complete presentation about all-aspects of the Alzheimer's disease, including Patho Physiology, Treatment, Nursing Management, Prevention, Disease Overview, Clinical Manifestation, etc.
Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, resulting in loss of memory, imagination and speaking skills, and behavioural changes. Alzheimer's disease is the most common cause of dementia, or loss of intellectual function, among people aged 65 and older.
Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, resulting in loss of memory, imagination and speaking skills, and behavioural changes. Alzheimer's disease is the most common cause of dementia, or loss of intellectual function, among people aged 65 and older.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Dementia:
• Is a syndrome characterized by
dysfunction or loss of
memory, attention, language,
judgement, and reasoning
• Personality and behavior change
such as delusions, and hallucinations
• Dementia is not a specific disease but
is rather a general term for
the impaired ability to remember,
think, & make decisions
• Alzheimer’s disease is the most
common cause of dementia.
3. Alzheimer’s disease
• AD is a chronic progressive,
degenerative, disease of the brain
• AD is a progressive neurologic
disorder that causes the brain to
shrink (atrophy) and brain cells to die
• It is the most common form of
dementia
• Characterized by a gradual decline
in
• Memory.
• Reasoning and handling of
complex tasks.
• Language.
• Understanding visual form and
space relationship.
• Behavior and personality.
Prevalence:
• Early-onset Alzheimer’s
disease occurs before 65.
• Late-onset Alzheimer’s disease
occurs after age 65
• Dementia is more common in men
• AD affects more women than men
• Death with AD in women is about
twice as compare to men
4.
5. Causes Diagnosis
Causes:
• unknown
• Aging/ is most common risk factor
• Genetic factors
• Environmental factors
Classification:
• Familial AD
• a strong family
connection/Genetic
• Sporadic AD
• No family connection
• Rapidly progress
• Diagnosis
• History
• Physical exam
• Psychological evaluation
• Mini-menta state Examination
• CT, MRI,PET scan
• Autopsy/ Brain tissue
examination confirms the
neurofibrillary tangles and
plaques
Blood CP, TFT,LFTs,CBC,creatinine,
BUN
6. Stages Of AD
Early (Mild):
• Forgetting
• Newly learned information,
recent events, places and names.
• Inability to find right words to express
thoughts.
• Loss of initiative and interest
• Decreased judgement
• Defective problem-solving.
• Geographic disorientation
Middle (Moderate):
• typically the longest stage and can last
many years.
• Impaired ability to recognized close
family members & friends
• Loss of remote/short-term memory.
• Wandering/getting lost
• suspicious about family, friends and
caregivers
• Agitation, behavior change,
insomnia
• Delusions, Illusions, hallucination
Late (Severe)
• Little memory ,inability to process
new information
• Cannot understand words
• Difficult eating, swallowing
• Repetitious words or sounds
• Immobility
• Urine/bowel incontinence
8. Pathophysiology of AD
• Pathophysiology involves following process
1. Beta-Amyloid Plaque:
• AD is characterized by buildup of protein called Beta-Amyloid which forms
sticky plaques in brain between neurons that disrupted cell functioning and
cause brain cells to die
• APP/amyloid precursor protein splits beta-amyloid proteins, releases in
circulation
• Plaque is first develop in hippochempus and cerebral cortex which deals
with language and reasoning
2. Neurofibrillary tangles:
• collection of twisted protein threads in side the nerve cells.
• Tau protein is the main component of these structures, that provide
support to microtubules
• Result in cholinergic insufficiency, mitochondria dysfunction, inflammation
and degeneration of neuron
10. APP splits
beta-amyloid
proteins
am
Beta- amyloid
Protein
production Beta-amyloid
fragments clamping
forms plaques Plaques attached
To neuron
Microglia reacts
the plaques
Inflammatory
response
Tau proteins
Provide structural
Support to neuronal
microtubules Chemical
changes in
neuron Misshapen Tau
protein
Twisting &
tangling of
microtubules
Amyloid precursor
protein in
cell membrane Release in
circulation
in Hippocampus
& Cerebral cortex
Neurofibrillary Tangles
Beta-Amyloid Plaque
Neurofibrillary
Tangles
formation
Reached in
brain through
circulation
12. Collaborative Care
Drug therapy:
• To improve memory and cognition
Cholinesterase inhibitors:
• Donepezil, Rivastigmine, Galantamine
• To manage behavior problems
Anti-psychotic drugs
• Loxapine, Haloperidol
• Risperdal, olanzapine
• To treat depression
Selective serotonin reuptake inhibitors
SSRIs
• Fluoxetine, sertraline, fluvoxamine,
• valproic acid (anti convulsant)
• To manage sleep disturbance
• Zolpidem
To manage Pain
• NSAIDs
• To promote nerves growth
Antioxidant therapy
• Vitamin C, E supplements
• Cal + Vit. D supplement
• Folic acids
• TO prevent Plaque formation
cholesterol-lowering drugs
• Statins
• Alternative therapies
Have preventive & therapeutic effect
• Herbs (Ginkgo biloba)
13.
14. Health promotion
• Prevention of disease
• focus on health education
• Insist on Healthy & balance diet
• Use antioxidants /vitamins
• Periodic health checkup
• Early diagnosis
• Detection of high risk population
• Prompt treatment
• To prevent complications
• To control disease process advancement
15. Nursing Management
• Establish an effective communication System b/w Patient & family ;
• Help them in adjusting to the patient with alter cognition
• Promote a emotional support with patient
• Administer order medication & monitor side effects
• Offer a step-by-step instructions
• Repeat instructions
• Allow more time for response
• Listen attentively, with out interruption
• Answer the question patiently
• Promote a effective coping mechanism
• Establish a family support system
16. • Provide Assistance
• In self-care, bathing, dressing,
grooming and toileting
• Be available for assistance in daily life
activities to
• Encourage independence
• Facilitate personal/ toilet hygiene
• Regulate toilet habits by
• insisting the patient to void /eliminate in
specified timing
• Provide a safe environment
• Use of assistive devices correctly
• Provide assistive devices to
• Steady gait
• Provide supportive ambulation
• Prevent Fall/injuries
• Plan protective measures before
exposure to a specified
environment
• Patient must wear shoes
• well fitted and tied
• Non-skids sole
• Prevents triggers such as
• Agitation ,restlessness, pain,
fatigue, restrains etc
• Insist use of vision correcting
device /glasses
• Use bed side railing