Pests include any organisms that damage crops economically, destroying about 33% of the world's potential food harvest. While pesticides kill pests, they can accumulate in the environment and harm other species. Alternatives include integrated pest management using biological controls first before chemicals as a last resort. Genetic engineering transfers pest-resistant genes from one organism to crops, benefiting yields but raising safety and ethical concerns if genes from animals enter plants eaten by humans or weeds. Sustainable agriculture minimizes chemical use to conserve resources indefinitely.