The document discusses six key architectural design challenges in cloud computing:
1) Service availability and data lock-in due to proprietary APIs
2) Data privacy and security concerns due to increased attacks in public clouds
3) Unpredictable performance and bottlenecks due to I/O interference between VMs
4) Issues with distributed storage and widespread software bugs at large scale
5) Ensuring cloud scalability, interoperability, and standardization across providers
6) Addressing software licensing and reputation sharing in cloud environments