A document tackling about the basis of Thunderstorms:
-What is Thunderstorm?
-How do the Thunderstorms form?
-What is the difference between thunder and lightning?
Between a water spout and a tornado?
-What are the types of Lightning? of a Thunderstorm?
-What are some signs of an approaching thunderstorm?
-What are some precautionary measures to do before and during a thunderstorm?
-Case of Thunderstorms in the Philippines and on Planes
A document tackling about the basis of Thunderstorms:
-What is Thunderstorm?
-How do the Thunderstorms form?
-What is the difference between thunder and lightning?
Between a water spout and a tornado?
-What are the types of Lightning? of a Thunderstorm?
-What are some signs of an approaching thunderstorm?
-What are some precautionary measures to do before and during a thunderstorm?
-Case of Thunderstorms in the Philippines and on Planes
Tornado Presentation , Formation of tornado , Causes , Types , Mitigation of ...Chandan Pradhan
Tornado is a violently rotating columns of air that extent form thunderstorm to the ground.
It is also called twister .
it can take various shape with the wind direction.
My first presentation on slideshare. A short research made by me about Tornado. I hope you all will like it and it will definitely help you. Thank you ! :)
Clouds
What are clouds?
A cloud is a large collection of very tiny droplets of water or ice crystals. The droplets are so small and light that they can float in the air.
Why do clouds float?
A cloud is made up of liquid water droplets. A cloud forms when air is heated by the sun. As it rises, it slowly cools it reaches the saturation point and water condenses, forming a cloud. As long as the cloud and the air that its made of is warmer than the outside air around it, it floats!
There are 3 main types of clouds:
Cirrus or thin feathery clouds
Stratus or layered clouds
Cumulus or fluffy clouds
Cirrus Clouds
Are the most common of the
high clouds. They are composed of ice and are thin, wispy clouds blown in high winds into long streamers. Cirrus clouds are usually white and predict fair to pleasant weather. By watching the movement of cirrus clouds you can tell from which direction weather is approaching. When you see cirrus clouds, it usually indicates that a change in the weather will occur within 24 hours.
Stratus Clouds
are uniform grayish clouds that often cover the entire sky. They resemble fog that doesn't reach the ground. Light mist or drizzle sometimes falls out of these clouds.
Cumulus Clouds
are white, puffy clouds that look like pieces of floating cotton. Cumulus clouds are often called "fair-weather clouds". The base of each cloud is flat and the top of each cloud has rounded towers. When the top of the cumulus clouds resemble the head of a cauliflower, it is called cumulus congestus or towering cumulus. These clouds grow upward and they can develop into giant cumulonimbus clouds, which are thunderstorm clouds.
The Importance of Clouds
Clouds help regulate Earth's energy balance by reflecting and scattering solar radiation and by absorbing Earth's infrared energy.
Clouds are required for precipitation to occur and, hence are an essential part of the hydrologic cycle.
Clouds indicate what type of atmospheric processes are occurring (e.g., cumulus clouds indicate surface heating and atmospheric turbulence).
Clouds help redistribute extra heat from the equator toward the poles.
References
https://www.google.com/search?q=clouds&biw=1366&bih=624&source=lnms&tbm=isch&sa=X&ved=0ahUKEwixqOqjlu3NAhVHNpQKHbtGCE0Q_AUIBigB#imgrc=_
https://www.google.com/search?biw=1366&bih=624&tbm=isch&q=clouds+clipart&sa=X&ved=0ahUKEwir8paml-3NAhXGkJQKHSrFAPUQhyYIHQ&dpr=1#imgrc=WZWIVB52x_MJRM%3A
https://en.wikipedia.org/wiki/List_of_cloud_types
http://www.weatherwizkids.com/weather-clouds.htm
Weather is the state of the atmosphere, to the degree that it is hot or cold, wet or dry, calm or stormy, clear or cloudy. Study the Types of weather in this amazing presentation!
Tornado Presentation , Formation of tornado , Causes , Types , Mitigation of ...Chandan Pradhan
Tornado is a violently rotating columns of air that extent form thunderstorm to the ground.
It is also called twister .
it can take various shape with the wind direction.
My first presentation on slideshare. A short research made by me about Tornado. I hope you all will like it and it will definitely help you. Thank you ! :)
Clouds
What are clouds?
A cloud is a large collection of very tiny droplets of water or ice crystals. The droplets are so small and light that they can float in the air.
Why do clouds float?
A cloud is made up of liquid water droplets. A cloud forms when air is heated by the sun. As it rises, it slowly cools it reaches the saturation point and water condenses, forming a cloud. As long as the cloud and the air that its made of is warmer than the outside air around it, it floats!
There are 3 main types of clouds:
Cirrus or thin feathery clouds
Stratus or layered clouds
Cumulus or fluffy clouds
Cirrus Clouds
Are the most common of the
high clouds. They are composed of ice and are thin, wispy clouds blown in high winds into long streamers. Cirrus clouds are usually white and predict fair to pleasant weather. By watching the movement of cirrus clouds you can tell from which direction weather is approaching. When you see cirrus clouds, it usually indicates that a change in the weather will occur within 24 hours.
Stratus Clouds
are uniform grayish clouds that often cover the entire sky. They resemble fog that doesn't reach the ground. Light mist or drizzle sometimes falls out of these clouds.
Cumulus Clouds
are white, puffy clouds that look like pieces of floating cotton. Cumulus clouds are often called "fair-weather clouds". The base of each cloud is flat and the top of each cloud has rounded towers. When the top of the cumulus clouds resemble the head of a cauliflower, it is called cumulus congestus or towering cumulus. These clouds grow upward and they can develop into giant cumulonimbus clouds, which are thunderstorm clouds.
The Importance of Clouds
Clouds help regulate Earth's energy balance by reflecting and scattering solar radiation and by absorbing Earth's infrared energy.
Clouds are required for precipitation to occur and, hence are an essential part of the hydrologic cycle.
Clouds indicate what type of atmospheric processes are occurring (e.g., cumulus clouds indicate surface heating and atmospheric turbulence).
Clouds help redistribute extra heat from the equator toward the poles.
References
https://www.google.com/search?q=clouds&biw=1366&bih=624&source=lnms&tbm=isch&sa=X&ved=0ahUKEwixqOqjlu3NAhVHNpQKHbtGCE0Q_AUIBigB#imgrc=_
https://www.google.com/search?biw=1366&bih=624&tbm=isch&q=clouds+clipart&sa=X&ved=0ahUKEwir8paml-3NAhXGkJQKHSrFAPUQhyYIHQ&dpr=1#imgrc=WZWIVB52x_MJRM%3A
https://en.wikipedia.org/wiki/List_of_cloud_types
http://www.weatherwizkids.com/weather-clouds.htm
Weather is the state of the atmosphere, to the degree that it is hot or cold, wet or dry, calm or stormy, clear or cloudy. Study the Types of weather in this amazing presentation!
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.