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Transfusion Medicine Ticu

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Dang Thanh Tuan
Dang Thanh Tuan

The document discusses various alternatives to blood transfusion, including hemoglobin-based oxygen carriers, perfluorocarbon oxygen carriers, antigen camouflage techniques, recombinant plasma proteins from transgenic animals, and potential platelet substitutes such as synthocytes and infusible platelet membranes. While these alternatives aim to address issues with blood supply and safety, each method still faces challenges with side effects, availability, and clinical efficacy that have prevented widespread use.

Health & Medicine
1 of 26
Tranfusion Medicine Amanda J. Wheeler, MD Trauma/Critical Care Stanford University Medical Center May 7, 2007
Tranfusion Medicine ,[object Object]
Transfusion Triggers/Indications: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hemoglobin Concentration ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Blood Transfusion Protocol at Stanford Surgery ICU ,[object Object],[object Object],[object Object],[object Object]
Blood Transfusion Protocol at Stanford Surgery ICU ,[object Object]
Massive Transfusion Guidelines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Alternatives: Blood Substitute Slides by Mary-Ann Purtill, MD ,[object Object],[object Object],[object Object],[object Object]
Three primary reasons driving the quest for a substitute for Blood: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Replacement Products ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oxygen Carrying Solutions ,[object Object],[object Object],[object Object],[object Object]
Oxygen Carrying Solutions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hemoglobin Based Oxygen Carrying Solutions (HBOCs) ,[object Object],[object Object],[object Object],[object Object],Historical Perspective
Problems with HBOCS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Comparison of HBOCs Hemolink PolyHeme Hemopure & Oxyglobin Product Name: 14 hours 24 hours 18-22 hours Half-life: Refrigerated/ RoomTemp Refrigerated Room Temp Storage: 1 year 1 year 3 years Shelf-life: Expired Human RBCs Expired Human RBCs Bovine Hgb Source: Hemosol Northfield Biopure  
Perflourocarbon Oxygen Carriers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Perflourocarbon Oxygen Carriers (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Problems with Perflourocarbons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antigen Camouflage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antigen Camouflage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recombinant Plasma Proteins ,[object Object],[object Object],[object Object],[object Object]
Transgenic Therapeutic Proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Platelet Substitutes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Platelet Substitutes (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Transfusion Medicine Ticu

  • 1. Tranfusion Medicine Amanda J. Wheeler, MD Trauma/Critical Care Stanford University Medical Center May 7, 2007
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  • 17. Comparison of HBOCs Hemolink PolyHeme Hemopure & Oxyglobin Product Name: 14 hours 24 hours 18-22 hours Half-life: Refrigerated/ RoomTemp Refrigerated Room Temp Storage: 1 year 1 year 3 years Shelf-life: Expired Human RBCs Expired Human RBCs Bovine Hgb Source: Hemosol Northfield Biopure  
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