This document discusses various tools used for target identification and validation in disease research, including microarrays, bioinformatics, and antisense oligonucleotides. Microarrays can be used to assess gene and protein expression changes to identify novel targets. Bioinformatics provides functional information on target candidates and their biological networks. Antisense oligonucleotides can block target mRNA and achieve gene knockdown, which was demonstrated to suppress cancer cell growth for the target COX17 in lung cancer research.