This document provides an overview of topics that will be covered in a clinical toxicology seminar, including definitions of terms like toxicity and toxicokinetics. It discusses factors that influence poisoning like dose, route of entry, and metabolism. It also covers classifications of toxicology like environmental, clinical, and forensic toxicology. Examples are given of quotes about toxicity from historical figures like Paracelcus and Pauling. Different types of toxic substances are defined like nephrotoxic, neurotoxic, and carcinogenic compounds. An overview of toxicokinetics is provided covering absorption, distribution, metabolism and excretion of toxins. References are listed at the end.

1. TOKSIKOLOGI
KLINIK
WHEN
Wednesday,
07.00-12.00, 13.00-17.00
WHERE
Student Auditorium
Prodi Analis Kesehatan Stikes Jenderal Achmad Yani Cimahi
FEATURING •
Ganthina Sugihartina, M.Si,
Perdina Nursdika, M.Si
ANALIS-AYANI.AC.ID
PERDINA
NURSIDIKA, M.SI
PENDAHULUAN
Definisi
Terminologi
Toksisitas
Toksikinetik
Toksodinamik
Pengaruh thd Organ
MANAJEMEN
KERACUNAN
TOKSIKOLOGI
BAHAN
MAKANAN
TOKSIKOLOGI
LOGAM BERAT
Toksikologi
Lingkungan
Toksikologi
pestisida
Toksikologi
Obat

2. PENDAHULUAN SENYAWA
TOKSIK
Zat yang
menyebabkan
sakit/kematian
TOKSISITAS
Efek yang mungkin
ditimbulkan oleh
racun
FAKTOR
KERACUNAN
• Dosis
• Cara masuk
(Intoksikasi)
• Toksokokinetik
• toksodinamik
KLASIFIKASI
• Toksikologi industry
• Toksikologi
lingkungan
• Toksikologi klinik
• Toksikologi hewan
• Toksikologi forensik
All substances are poisons; there is none
which is not a poison. The right dose
differentiates a poison and a remedy
(Paracelcus)
What astonished me was the very low
toxicity of a substance that has such
very great physiological power (Pauling)
The official toxicity limit for humans is
between one and one and half grams of
cocaine depending on body weight. I was
averaging five grams a day, maybe more. I
snorted ten grams in ten minutes once. I
guess I had a high tolerance (Blow, Movie)
Lack of scientific fundamentals causes
people to make foolish decisions about issues
such as the toxicity of chemicals, the
efficacy of medicines, the changes in the
global climate (Peter Agre)

3. ISTILAH

4. ISTILAH

5. ISTILAH NEFROTOKSIK
NEUROTOKSIK
KARSINOGENIK
Sitotoksik
hemotoksik
TERATOGENIK
OTOTOKSIK
Venom
Necrotoxic
Detoksikasi
Brothersoft.com

6. TOKSOKINETIK
Absorbsi
Distribusi
Metabolisme
eksresi
ADSORBSI
Penyerapan
DISTRIBUSI
Penyebaran
METABOLISME
Perubahan
EKSRESI
Pengeluaran
Tugas, jelaskan!
1. Tingkat bahaya penggunaan
ekstasi dibandingkan dengan
heroin, ditinjau dari segi
toksokinetik!
2. Senyawa karsinogenik bersifat
kronik!
3. Mengapa rokok disebut senyawa
teratogenik!
Dufus, JH, Worth HGJ. Fundamental Toxicology. 2006
Hodgson E, Textbiik of Modern Toxicology 3rd edition