Tissue repair occurs through two main processes: regeneration and scar formation. Regeneration involves the proliferation of residual cells to completely restore lost tissue, while scar formation deposits connective tissue when regeneration is not possible. Wound healing involves inflammation, proliferation, granulation tissue formation, wound contraction, and strength acquisition. Tissue repair is influenced by factors like nutrition, infection, and wound location. Complications can arise from deficient or excessive scar formation, exuberant granulation tissue, and contractures.
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis and dermis form a protective barrier against the external environment
this a basic presentation which I got inspired to do after seeing some presentations made on slideshare. It basically covers types of wounds,wound healing process,factors affecting wound healing and wound care.
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis and dermis form a protective barrier against the external environment
this a basic presentation which I got inspired to do after seeing some presentations made on slideshare. It basically covers types of wounds,wound healing process,factors affecting wound healing and wound care.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Tissue
Repair/Healing
• Repair, sometimes called healing refers to the
restoration of tissue architecture and function
after an injury.
• Repair of damaged tissues occurs by two
types of reactions:
1. Regeneration.
2. Connective tissue deposition (scar
formation).
3. Tissue
Repair/Healing
• Regeneration: is complete restitution of lost
tissue components identical to those
removed or killed by proliferation of residual
(uninjured) cells and maturation of tissue
stem cells.
• Connective tissue deposition (scar formation):
If the injured tissues are incapable of
regeneration, or if the the tissue is severely
damaged, repair occurs by the deposition of
connective tissue.
4. Tissue
Repair/Healing
• Regeneration occurs for example, in the
rapidly dividing epithelia of the skin and
intestines, and in some parenchymal
organs, notably the liver.
• Scar formation takes place in fibrosis of
the lungs, liver, kidney and in Myocardial
Infarction.
8. Tissue
Regeneration
• Both regeneration and scar formation
contribute in varying degrees to the
ultimate repair.
• Both processes involve the proliferation of
various cells, and close interactions
between cells and the extracellular matrix
(ECM).
• The cell proliferation in regeneration and
9. Tissue proliferative
activity
1.Continually dividing cells (labile
tissues): These cells proliferate
through-out life.
Epithelium of the skin, GIT and cells of bone
marrow. 2.Quiescent cells (Stable tissue):
Have a low level of replication. Cells from
these tissue can undergo rapid division in
response to stimuli. parenchymal cells of
liver and kidneys.
3.Non-dividing (permanent cells):
Cells that can not undergo mitotic division in
10. Granulation
tissue
• Granulation tissue is the hallmark of
healing. Granulation tissue progressively
invades the site of injury.
• The term granulation tissue derives from
its pink, soft, granular appearance seen in
area of ongoing wound healing.
11. Granulation
tissue
• Granulation tissue is:
i. the proliferation of fibroblasts
ii. new thin-walled, delicate
capillaries (angiogenesis), in a
loose extracellular matrix.
iii. admixed inflammatory cells,
mainly macrophages.
13. Healing of skin
wound
• Healing of skin wound is a process that
involves both epithelial regeneration and
the formation of connective tissue scar.
• Based on the nature and size of the
wound, the healing of skin wounds
occurs by first or second intention.
14. Healing of skin
wound
Healing by first intension
• When the injury involves only the epithelial
layer and the principal mechanism of
repair is epithelial regeneration it is called
primary union or healing by first intention.
• It is the process of healing of a clean,
uninfected surgical incisions
approximated by sutures.
15. Healing by second
intension
• Healing by second intention is also
known as healing by secondary union.
• When cell or tissue loss is more extensive
like in large wounds, abscesses,
ulceration, and ischemic necrosis
(infarction) in parenchymal organs.
• The repair process in second intension
involves a combination of regeneration
and scar formation.
16. Difference
between
Primary intension
1. Inflammatory
reaction is less
marked.
2. No wound
contraction.
3. Margins are
apposed
together.
4. Minimal tissue
damage
5. Minimal bleeding
6. Heals quickly
Secondary intension
1. Intense
inflammation.
2. Much granulation
tissue formation.
3. Gap persists
between margins.
4. Marked damage
of tissues.
5. More bleeding.
6. Takes time to heal.
7. Large scar
18. Angiogenesis
New blood vessel development from existing vessel
Steps:
- Vasodilation
- Separation of pericytes and disintegration of BM
- Migration of endothelial cells
- Proliferation of endothelial cells behind leading tip
- Recruitment of periendothelial cells
- Suppression of endothelial proliferation and deposition of
BM
19.
20. Growth factors – VEGF, FGF, PDGF, TGF beta
Notch signalling – crosstalk with VEGF
Regulates sprouting and branching of
vessel
21. Factors influencing wound
healing
Systemic factors:
1.Nutritional status: Protein deficiency and
vitamin C deficiency inhibit collagen synthesis
and delay wound healing.
2.Metabolic status: DM is associated delay in
wound healing.
3.Circulatory status, poor perfusion: Inadequate
blood supply impair wound healing.
4.Hormones: Glucocorticoids have anti-
inflammatory effects and inhibits collagen
synthesis causing delay.
22. Factors influencing wound
healing
Local factors:
1.Infection (one of the most important cause of
delay in healing).
2.Mechanical factors (increased local
pressure, high mobility delays healing).
3.Foreign bodies (splinter, steel, glass delays
healing).
4.Size and shape of wound (clear cut surgical
wound heals quickly).
5.Location of the wound (wound in the face
heals quickly)
23. Complications of wound healing
Complications of wound healing are
grouped into three categories:
i. Deficient scar formation.
ii. Excessive scar formation.
iii.Exuberant granulation tissue
formation
iv.Formation of contractures.
24. Complications of wound healing
Deficient scar formation can lead to two
types of complications:
1.Dehiscence or rupture of a wound.
2. Ulceration.
Wound dehiscence is common after
abdominal surgery and is due to
increased abdominal pressure.
Wounds ulceration is due to inadequate
vascularization. Example lower extremity
wounds in with atherosclerosis.
25. Complications of wound healing
Excessive scar formation can give rise to:
(1) hypertrophic scar
(2)keloids.
• The accumulation of excessive
amounts of collagen give rise to a
hypertrophic scar.
• If the scar tissue grows beyond the
boundaries of original wound and does
not regress, it is called keloid.
27. Exuberant granulation
tissue
• Exuberant granulation is the formation of
excessive amounts of granulation tissue,
which protrudes above the level of the
surrounding skin and blocks re-
epithelialization (proud flesh).
• Excessive granulation must be removed by
cautery or surgical excision to allow re-
epithelialization.
28. Wound
Contracture
• An exaggeration of contraction of wound
gives rise to contracture and results in
deformities of the wound and the
surrounding tissues.
• Common areas affected palms, the soles
and the anterior aspect of the thorax.
• Contractures are commonly seen after
serious burns which compromise
30. Remodeling of Connective
Tissue
• The connective tissue in the scar
continues to be modified and remodeled.
• To increase the strength
- cross linking of collagen
- Change of collagen from type III to type I