This document summarizes a lecture on observational cosmology and the current state of the standard cosmological model. It discusses key aspects of the standard model like the Robertson-Walker metric, ingredients like dark matter and dark energy, and questionable aspects. It also covers alternatives to cold dark matter models, the possibility that dark matter is quantum mechanical, and anomalies in the cosmic microwave background data. The document emphasizes that cosmology involves massive data compression and cautions against overinterpreting potential anomalies in the data.
Astrophysics & Cosmology Masterclass November 2021Peter Coles
Slides used during a Science Week event at Maynooth University on 12th November 2021. These are the slides for the Cosmology part of the event which was run by Peter Coles and John Regan of the Department of Theoretical Physics at Maynooth University.
The Cosmic Web - Evening Lecture at Sussex University on 9th December 2013Peter Coles
The lecture focusses on the large-scale structure of the Universe and the ideas that physicists are weaving together to explain how it came to be the way it is. Over the last few decades, astronomers have revealed that our cosmos is not only vast in scale – at least 14 billion light years in radius – but also exceedingly complex, with galaxies and clusters of galaxies linked together in immense chains and sheets, surrounding giant voids of (apparently) empty space.
Cosmologists have developed theoretical explanations for its origin that involve such exotic concepts as ‘dark matter’ and ‘cosmic inflation’, producing a cosmic web of ideas that is, in some ways, as rich and fascinating as the Universe itself.
A general cosmology talk, covering two versions of the "Cosmic Web" : the physical network galaxies, clusters and filaments that makes up the large-scale structure of the Universe; and the web of interconnected theoretical ideas we use to understand how it came it being and is evolving.
How the concept was introduced by the astrophycists and examples that provide the base for the existence of dark matter. Basic introduction to types of dark matter according to standard cosmological theory.
Astrophysics & Cosmology Masterclass November 2021Peter Coles
Slides used during a Science Week event at Maynooth University on 12th November 2021. These are the slides for the Cosmology part of the event which was run by Peter Coles and John Regan of the Department of Theoretical Physics at Maynooth University.
The Cosmic Web - Evening Lecture at Sussex University on 9th December 2013Peter Coles
The lecture focusses on the large-scale structure of the Universe and the ideas that physicists are weaving together to explain how it came to be the way it is. Over the last few decades, astronomers have revealed that our cosmos is not only vast in scale – at least 14 billion light years in radius – but also exceedingly complex, with galaxies and clusters of galaxies linked together in immense chains and sheets, surrounding giant voids of (apparently) empty space.
Cosmologists have developed theoretical explanations for its origin that involve such exotic concepts as ‘dark matter’ and ‘cosmic inflation’, producing a cosmic web of ideas that is, in some ways, as rich and fascinating as the Universe itself.
A general cosmology talk, covering two versions of the "Cosmic Web" : the physical network galaxies, clusters and filaments that makes up the large-scale structure of the Universe; and the web of interconnected theoretical ideas we use to understand how it came it being and is evolving.
How the concept was introduced by the astrophycists and examples that provide the base for the existence of dark matter. Basic introduction to types of dark matter according to standard cosmological theory.
Lattice Energy LLC - HESS Collaboration reports evidence for PeV cosmic rays ...Lewis Larsen
HESS Collaboration has published important paper in Nature: detected gamma rays coming from Milky Way’s black hole indicating that PeV cosmic rays come from same source. Widom-Larsen-Srivastava theory provides many-body collective mechanism that can accelerate protons to PeV and higher energies in the immediate vicinity of such black holes. Cosmic ray particle energies depend upon field strength in magnetic structures, size of structure, and duration of charged particle accleration.
Lattice Energy LLC - HESS Collaboration reports evidence for PeV cosmic rays ...Lewis Larsen
HESS Collaboration has published important paper in Nature: detected gamma rays coming from Milky Way’s black hole indicating that PeV cosmic rays come from same source. Widom-Larsen-Srivastava theory provides many-body collective mechanism that can accelerate protons to PeV and higher energies in the immediate vicinity of such black holes. Cosmic ray particle energies depend upon field strength in magnetic structures, size of structure, and duration of charged particle accleration.
El Británico Roger Penrose por sus desarrollos teóricos sobre agujeros negros. La Estadounidense Andrea Ghez y el Alemán Reinhald Genzel por el hallazgo de un objeto súper masivo y compacto en el centro de nuestra galaxia.
Por:
Herman J. Mosquera Cuesta
Ingeniero Mecánico UdeA.
PhD en Astrofísica.
Tres investigadores han sido galardonados con el premio Nobel de Física de este año por sus descubrimientos sobre estos fenómenos supermasivos. Roger Penrose por demostrar su existencia según la teoría de la relatividad general y Reinhard Genzel y Andrea Ghez por demostrar que los agujeros negros son capaces de interferir en las órbitas de estrellas cercanas.
Los astrónomos Roger Penrose, Reinhard Genzel y Andrea Ghez se han hecho con el premio Nobel de Física de 2020. El primero de los científicos ha obtenido la mitad del galardón por la demostración fáctica de la existencia de los agujeros negros, siguiendo los preceptos de la teoría de la relatividad de Einstein. Los otros dos investigadores han sido distinguidos por el descubrimiento de un objeto supermasivo en el centro de la Vía Láctea, a unos 26.000 años luz de nuestro planeta.
Reinhard Genzel y Andrea Ghez descubrieron un agujero negro en el centro de la Vía Láctea comprobando la velocidad de las órbitas de sus estrellas circundantes.
“Los descubrimientos de los galardonados de este año han abierto nuevos caminos en el estudio de objetos compactos y supermasivos. Pero estos objetos exóticos todavía plantean muchas preguntas que piden respuestas y plantean nuevos retos de investigación en el futuro, no solo sobre la estructura interna de estos objetos masivos, sino también sobre cómo usar la teoría de la relatividad general en condiciones extremas”, ha declarado David Haviland, presidente del Comité Nobel de Física.
One of the challenging open questions of theoretical physics is how to unify general relativity and quantum theory to find a microscopic description of gravity. There are many approaches to find a solution to this fundamental question. It is however difficult to constrain all these possibilities because the relevant scales are far smaller than those accessible by current experiments. With the recent technological breakthroughs of the detection of gravitational waves and the direct imaging of a black hole, we are at the dawn of an era of strong gravity astronomy. It is therefore more important than ever to concentrate on finding observable features of quantum gravity that could in principle leave an imprint in future experiments. After a brief introduction of the fundamental aspects of quantum gravity, I will give an example of such a feature which seems to be a universal property of theories of quantum gravity. In many theories of quantum gravity, space-time has fractal properties near the Planck scale. A consequence which in principle could be observed, is that the effective dimension of space-time is a function of the scale that one is probing.
Brief discussion of some the problems of cold dark matter in cosmological structure formation, the idea of `fuzzy' dark matter and some applications of the Schrodinger-Poisson system for cosmic reconstruction.
Talk given at `Post-Planck Cosmology', Inter-University Centre for Astronomy and Astrophysics, Pune, India (12th October 2017).
Based on recent work on quantum gravity and the holographic principle I argue that, instead of thinking of the universe as a 'bubble out of nothing', we should think of space, time, and gravity as emerging 'out of information'.
Talk given at ITP 2022 at the Dublin Institute for Advanced Study on May 26th 2022. In this talk I discuss some applications of the Schrodinger-Poisson wave-mechanical approach to
cosmological structure formation. The most obvious use of this formalism is to "fuzzy" dark matter,
i.e. dark matter consisting of extremely light particles whose eective de Broglie wavelength is
suciently large to be astrophysically relevant, but it can be used to model more general scenarios
and has a number of advantages over standard methods based on Eulerian perturbation theory. I
illustrate the formalism with some calculations for cosmic voids and discuss its application to the
cosmological reconstruction problem(s).
General relativity vs. quantum mechanics issues of foundations uv 1_oct2018SOCIEDAD JULIO GARAVITO
En este seminario, nos enfocaremos en los asuntos fundamentales relacionados con los pilares actuales de la física, y discutiremos los problemas para la creación de una teoría cuántica de la gravitación, es decir Teoría de Cuerdas, Super-Simetría o SUSY, o una Teoría del Todo.
Open Access Publishing in Astrophysics and the Open Journal of AstrophysicsPeter Coles
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Open Access Publishing in Astrophysics and the Open Journal of AstrophysicsPeter Coles
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Open Access Publishing and the Open Journal of AstrophysicsPeter Coles
A short talk given at the 'Astronomy Tea' at the University of Sydney, Australia, on February 19th 2024.
Abstract:
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Talk given at the Institut de Physique Théorique, Paris-Saclay, 28th November 2023.
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s, thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I discuss the environment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Slides for seminar given at Cardiff University on 1st November 2023, covering Open Access publishing in astrophysics with reference to the Open Journal of Astrophysics.
Public evening talk given on 6th September 2023 at an event called "Weird Matter at Maynooth University". Euclid is the name of a new scientific mission from the European Space Agency, launched on July 1st, designed to explore the composition and evolution of the Universe. The Euclid mission takes its name from the ancient Greek mathematician regarded by many as the Father of geometry. Until the last century, Euclid’s theorems were assumed not just to be mathematical notions, but to describe the geometrical structure of the physical Universe. Einstein’s general theory of relativity swept that idea aside and gave us new ways of describing space, by unifying it with time, and by allowing it to be affected by matter in a manner very different from that formulated by Euclid. Over the past century, this theory has proved to be very effective at describing the properties of the Universe as observed by modern astronomical telescopes, while also suggesting the existence of dark matter and dark energy.
The Euclid telescope will create an enormous map of the large-scale structure of the Universe across space and time by observing billions of galaxies out to 10 billion light-years, across more than a third of the sky. Euclid will explore how the Universe has expanded and how galaxies and clusters of galaxies have formed over cosmic history, and how space itself is distorted by these structures.
This talk discusses our modern ideas of space and time, how the Euclid mission will try to test whether or not they are correct and shed light on the nature of dark matter and dark energy.
Talk given at the Irish National Astronomy Meeting: a discussion of recent developments in Open Access Publishing, with particular reference to Astrophysics and the Open Journal of Astrophysics
A short talk for Space Week given at Maynooth University on October 6th 2022 about cosmology, the large-scale structure of the Universe and the European Space Agency's Euclid Mission.
The O-level Latin examinations I took in 1979. There are three papers altogether, Paper 1 which was a language examination, and Paper 2 (in two Sections A and B) which were about set books: we did Book II of Virgil's Aeneid and Book V of Caesar's De Bello Gallico.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
16. The Robertson-Walker metric
In cosmology it is most useful to use spherical polar coordinates
rather than a Cartesian system. In this system the only metric
that describes space-times compatible with the cosmological
principle is the Robertson-Walker metric:
28. Whatever it is, Dark
Energy is a terrible name
for it…
• What is important is not so much the
energy, but the pressure…
• Dark Energy has to act like something
with negative pressure (or tension)
• It also has to be smoothly distributed
throughout space
39. Problems with Cold Dark Matter
Astrophysics:
•Cuspy Halo Problem
•Missing Satellite Problem
•Planar Structures
•Galaxy Morphology
•…
Particle Physics
•No Evidence for Supersymmetry
•No evidence from Direct Searches
•…
40.
41. RA Ibata et al. Nature 493, 62-65 (2013) doi:10.1038/nature11717
Satellite galaxy positions as viewed from Andromeda.
45. • Simple idea): DM is a (very) light particle (m~ 10-22 eV) then
the de Broglie wavelength can be a galactic scale.
• Something like `warm’ dark matter arises (actually `fuzzy’ dark
matter), but with quantum pressure.
• Sometimes called Fuzzy Dark Matter
Might dark matter be quantum-
mechanical?
46. From Schive et al., arXiv: 1406.6586 (also published in Nature)
48. Cosmology is an exercise in data compression
Cosmology is a massive
exercise in data
compression...
….but it is worth looking at
the information that has
been thrown away to check
that it makes sense!
49. Beyond the Power
Spectrum
• So far what we have discovered is
largely based on second-order
statistics…
• This is fine as long as we don’t throw
away important clues…
• ..ie if the fluctuations are statistically
homogeneous and istropic, and
Gaussian..
57. CMB Anomalies
•Type I – obvious problems with data
(e.g. foregrounds)
•Type II – anisotropies and alignments
(North-South, Axis of Evil..)
•Type III – localized features, e.g. “The
Cold Spot”
•Type IV – Something else (even/odd
multipoles, magnetic fields, ?)
66. A. There’s no problem at all
with CDM…
B. There are interesting
indications…
C. There’s definitely
evidence of new physics
67. • There are many unanswered theoretical
questions!
• So far the questions we’ve asked have
been the “easy” ones
• Now that this “boring” stuff is out of the
way, cosmology will start to get
interesting!
• Because we now have a better idea what
to ask!