Brief discussion of some the problems of cold dark matter in cosmological structure formation, the idea of `fuzzy' dark matter and some applications of the Schrodinger-Poisson system for cosmic reconstruction.
Talk given at `Post-Planck Cosmology', Inter-University Centre for Astronomy and Astrophysics, Pune, India (12th October 2017).
What We (Don't) Know About the Beginning of the UniverseSean Carroll
A plenary talk at the January 2017 meeting of the American Astronomical Society, on whether the universe truly had a beginning, and what might have come before.
The First Annual Robert Grosseteste Lecture on Astrophysics/Cosmology, a public talk given at the University of Lincoln.
The lecture focusses on the large-scale structure of the Universe and the ideas that physicists are weaving together to explain how it came to be the way it is. Over the last few decades, astronomers have revealed that our cosmos is not only vast in scale – at least 14 billion light years in radius – but also exceedingly complex, with galaxies and clusters of galaxies linked together in immense chains and sheets, surrounding giant voids of (apparently) empty space. Cosmologists have developed theoretical explanations for its origin that involve such exotic concepts as ‘dark matter’, ‘dark energy’ and ‘cosmic inflation’, producing a cosmic web of ideas that is, in some ways, as rich and fascinating as the Universe itself.
Gifford Lecture One: Cosmos, Time, MemorySean Carroll
Based on my book The Big Picture, this is the first of five lectures exploring how different ways of talking about the world fit together. The other four lectures are on YouTube.
Quantum Field Theory and the Limits of KnowledgeSean Carroll
A seminar, given to philosophers, on how quantum field theory allows us to delineate known from unknown in fundamental physics, and why the laws of physics underlying everyday phenomena are known.
What We (Don't) Know About the Beginning of the UniverseSean Carroll
A plenary talk at the January 2017 meeting of the American Astronomical Society, on whether the universe truly had a beginning, and what might have come before.
The First Annual Robert Grosseteste Lecture on Astrophysics/Cosmology, a public talk given at the University of Lincoln.
The lecture focusses on the large-scale structure of the Universe and the ideas that physicists are weaving together to explain how it came to be the way it is. Over the last few decades, astronomers have revealed that our cosmos is not only vast in scale – at least 14 billion light years in radius – but also exceedingly complex, with galaxies and clusters of galaxies linked together in immense chains and sheets, surrounding giant voids of (apparently) empty space. Cosmologists have developed theoretical explanations for its origin that involve such exotic concepts as ‘dark matter’, ‘dark energy’ and ‘cosmic inflation’, producing a cosmic web of ideas that is, in some ways, as rich and fascinating as the Universe itself.
Gifford Lecture One: Cosmos, Time, MemorySean Carroll
Based on my book The Big Picture, this is the first of five lectures exploring how different ways of talking about the world fit together. The other four lectures are on YouTube.
Quantum Field Theory and the Limits of KnowledgeSean Carroll
A seminar, given to philosophers, on how quantum field theory allows us to delineate known from unknown in fundamental physics, and why the laws of physics underlying everyday phenomena are known.
Space is not fundamental (although time might be). Talk at the 2010 Philosophy of Science Association Meeting, Montreal. By Sean Carroll, http://preposterousuniverse.com/
We believe the quantum entanglement is caused by the very space itself, not by any particles, and thus not bounded by the speed of light, so is the gravity, we stand at fireworks side.
IOSR Journal of Applied Physics (IOSR-JAP) is an open access international journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Relativity is a magnificent equality principle of nature at creating the universe.
However, it has many counter-intuitive, mind-blogging concepts, and many of us may have a hard time at understanding it.
How could light propagate in vacuum without a media?
How could the speed of light remain constant for all observers?
Why there are time dilation, length contraction, and loss of simultaneity?
Why the laws of nature remain the same for all moving frames?
How could space and time be bent by mass and energy?
Are our brains wired in such a way so that it is always difficult to understand relativity in a natural way?
Or there may exist a new knowledge framework, and a new representation so that relativity become easier to be understood.
This video offers a mechanical approach for the first time to explain relativity.
It attempts to make relativity easier for the general public to understand.
Spiritual truths are being affirmed with rapid advancement in Scientific knowledge. Sharing my reading and thoughts, that goes to establish that at long last Science has mellowed over the years, the animosity is no longer there, and Spirituality and Science are slowly but surely converging in the quest of TRUTH.
The month of Ramadan is also known as the month of reflection and retrospection, and I have spent a few hours in this month to put up a presentation.
When asked to do a research assignment, Rafael , 12M (EJR) went for two topics that have puzzled him. This is the ppt he created as the support for his presentation.
Abstract: Dr. David Joseph Bohm an American scientist who theorized quantum mechanics in the most ordinary and understandable way, which is somewhat referred to as the “Pilot Wave-model”. Also he prophesized in neuropsychology, and gave the Holonomic model of brain affecting our view of the quantum mechanics. His theories suggest that the phenomenon of “NON LOCALITY” or quantum entanglement is due to the famous “frame dragging” phenomenon predicted by Sir. Albert Einstein’s theory of relativity.
Bohm’s theory also suggests that time doesn’t exist in the way we think it does as stated by “THE BIG CRUNCH” theory. According to it time exists due to the interacting frequencies of the waves due to particle vibrations in space and that the universe never began.
In this paper existence of quantum entanglement is used to question the degree of correctness of the Space-time fabric theory.
Talk given at ITP 2022 at the Dublin Institute for Advanced Study on May 26th 2022. In this talk I discuss some applications of the Schrodinger-Poisson wave-mechanical approach to
cosmological structure formation. The most obvious use of this formalism is to "fuzzy" dark matter,
i.e. dark matter consisting of extremely light particles whose eective de Broglie wavelength is
suciently large to be astrophysically relevant, but it can be used to model more general scenarios
and has a number of advantages over standard methods based on Eulerian perturbation theory. I
illustrate the formalism with some calculations for cosmic voids and discuss its application to the
cosmological reconstruction problem(s).
Space is not fundamental (although time might be). Talk at the 2010 Philosophy of Science Association Meeting, Montreal. By Sean Carroll, http://preposterousuniverse.com/
We believe the quantum entanglement is caused by the very space itself, not by any particles, and thus not bounded by the speed of light, so is the gravity, we stand at fireworks side.
IOSR Journal of Applied Physics (IOSR-JAP) is an open access international journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Relativity is a magnificent equality principle of nature at creating the universe.
However, it has many counter-intuitive, mind-blogging concepts, and many of us may have a hard time at understanding it.
How could light propagate in vacuum without a media?
How could the speed of light remain constant for all observers?
Why there are time dilation, length contraction, and loss of simultaneity?
Why the laws of nature remain the same for all moving frames?
How could space and time be bent by mass and energy?
Are our brains wired in such a way so that it is always difficult to understand relativity in a natural way?
Or there may exist a new knowledge framework, and a new representation so that relativity become easier to be understood.
This video offers a mechanical approach for the first time to explain relativity.
It attempts to make relativity easier for the general public to understand.
Spiritual truths are being affirmed with rapid advancement in Scientific knowledge. Sharing my reading and thoughts, that goes to establish that at long last Science has mellowed over the years, the animosity is no longer there, and Spirituality and Science are slowly but surely converging in the quest of TRUTH.
The month of Ramadan is also known as the month of reflection and retrospection, and I have spent a few hours in this month to put up a presentation.
When asked to do a research assignment, Rafael , 12M (EJR) went for two topics that have puzzled him. This is the ppt he created as the support for his presentation.
Abstract: Dr. David Joseph Bohm an American scientist who theorized quantum mechanics in the most ordinary and understandable way, which is somewhat referred to as the “Pilot Wave-model”. Also he prophesized in neuropsychology, and gave the Holonomic model of brain affecting our view of the quantum mechanics. His theories suggest that the phenomenon of “NON LOCALITY” or quantum entanglement is due to the famous “frame dragging” phenomenon predicted by Sir. Albert Einstein’s theory of relativity.
Bohm’s theory also suggests that time doesn’t exist in the way we think it does as stated by “THE BIG CRUNCH” theory. According to it time exists due to the interacting frequencies of the waves due to particle vibrations in space and that the universe never began.
In this paper existence of quantum entanglement is used to question the degree of correctness of the Space-time fabric theory.
Talk given at ITP 2022 at the Dublin Institute for Advanced Study on May 26th 2022. In this talk I discuss some applications of the Schrodinger-Poisson wave-mechanical approach to
cosmological structure formation. The most obvious use of this formalism is to "fuzzy" dark matter,
i.e. dark matter consisting of extremely light particles whose eective de Broglie wavelength is
suciently large to be astrophysically relevant, but it can be used to model more general scenarios
and has a number of advantages over standard methods based on Eulerian perturbation theory. I
illustrate the formalism with some calculations for cosmic voids and discuss its application to the
cosmological reconstruction problem(s).
Wave Mechanics and Large-scale StructurePeter Coles
Short talk given at the Osservatorio Astronomico di Bologna on Thursday 18th May 2017 on the use of wave mechanics in cosmology to study the formation and evolution of large-scale structure in the Universe.
Astrophysics seminar given at Imperial College, London, on 14th June 2017.
Recently there has been a resurgence of interest in the idea, originally raised in a seminal paper by Widrow & Kaiser (1993) that the equations describing the evolution of a self-gravitating fluid can be rewritten in the form of a Schrodinger equation coupled to a Poisson equation determining the gravitational potential. In this talk I’ll discuss some of the merits of this idea and explain why they are of topical interest.
General Relativity is inconsistent with quantum theory which
leaves our understanding of nature incomplete and unsatisfactory. The now 80 years old quest for a consistent theory of quantum gravity has so far almost entirely focused on mathematical consistency. But as of recently the possibility to look for observational evidence has received an increased amount of attention, as a tool to provide guidance for the construction of of the theory.
Here, I summarize recent developments in the search for
experimental signatures for quantum gravitational effects and how these help to put constraints on the theory-construction. Some of the topics that I will cover are the prospects of finding Planck scale effects in gamma ray bursts, in neutral Kaon oscillations, or with massive quantum oscillators. If time allows, I will also comment on the search for holographic noise and how to find evidence for space-time discreteness.
Erik Verlinde has recently published a proposal for Emergent Gravity that builds on his earlier work of 2009-2011 and extends it to a much more realistic de Sitter model. He is able to reproduce the empirical MOND (Modified Newtonian Dynamics) behavior and the Tully-Fisher relationship and even estimate the cosmological apparent dark matter percentage. But there is no dark matter in this view, gravity is a statistical phenomenon reflecting the entropy content of the dark energy medium. For large accelerations it follows a surface description and GR is correct, but for small accelerations there is an additional volume term which can dominate, providing additional gravity and 'spoofing' the existence of dark matter.
Open Access Publishing in Astrophysics and the Open Journal of AstrophysicsPeter Coles
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Open Access Publishing in Astrophysics and the Open Journal of AstrophysicsPeter Coles
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Open Access Publishing and the Open Journal of AstrophysicsPeter Coles
A short talk given at the 'Astronomy Tea' at the University of Sydney, Australia, on February 19th 2024.
Abstract:
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I shall discuss the ennvironment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I will also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Talk given at the Institut de Physique Théorique, Paris-Saclay, 28th November 2023.
Over the past decade, the landscape of academic publishing has changed dramatically, with publishers moving from subscription-based models to "open access" in which papers are available to read free of charge. Many journals have made the decision to maintain revenue by charging authors for this, via so-called "Article Processing Charges" (APCs) which can run to $1000s, thereby closing the door on those without funds to pay. More recently, there have been moves to encourage researchers to publish using "Diamond" Open Access wherein papers are published without charge to the authors and without cost to the reader. In this talk I discuss the environment for Open Access Publishing in Astrophysics with reference to the Open Journal of Astrophysics (OJAp), which offers a not-for-profit service of this kind using an arXiv-overlay model. I also offer a possible vision of the future of truly "Open Access" publishing based on a global network of institutional and/or subject-based repositories.
Slides for seminar given at Cardiff University on 1st November 2023, covering Open Access publishing in astrophysics with reference to the Open Journal of Astrophysics.
Public evening talk given on 6th September 2023 at an event called "Weird Matter at Maynooth University". Euclid is the name of a new scientific mission from the European Space Agency, launched on July 1st, designed to explore the composition and evolution of the Universe. The Euclid mission takes its name from the ancient Greek mathematician regarded by many as the Father of geometry. Until the last century, Euclid’s theorems were assumed not just to be mathematical notions, but to describe the geometrical structure of the physical Universe. Einstein’s general theory of relativity swept that idea aside and gave us new ways of describing space, by unifying it with time, and by allowing it to be affected by matter in a manner very different from that formulated by Euclid. Over the past century, this theory has proved to be very effective at describing the properties of the Universe as observed by modern astronomical telescopes, while also suggesting the existence of dark matter and dark energy.
The Euclid telescope will create an enormous map of the large-scale structure of the Universe across space and time by observing billions of galaxies out to 10 billion light-years, across more than a third of the sky. Euclid will explore how the Universe has expanded and how galaxies and clusters of galaxies have formed over cosmic history, and how space itself is distorted by these structures.
This talk discusses our modern ideas of space and time, how the Euclid mission will try to test whether or not they are correct and shed light on the nature of dark matter and dark energy.
Talk given at the Irish National Astronomy Meeting: a discussion of recent developments in Open Access Publishing, with particular reference to Astrophysics and the Open Journal of Astrophysics
A short talk for Space Week given at Maynooth University on October 6th 2022 about cosmology, the large-scale structure of the Universe and the European Space Agency's Euclid Mission.
Astrophysics & Cosmology Masterclass November 2021Peter Coles
Slides used during a Science Week event at Maynooth University on 12th November 2021. These are the slides for the Cosmology part of the event which was run by Peter Coles and John Regan of the Department of Theoretical Physics at Maynooth University.
The O-level Latin examinations I took in 1979. There are three papers altogether, Paper 1 which was a language examination, and Paper 2 (in two Sections A and B) which were about set books: we did Book II of Virgil's Aeneid and Book V of Caesar's De Bello Gallico.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
14. Problems with Cold Dark Matter
Astrophysics:
• Cuspy Halo Problem
• Missing Satellite Problem
• Planar Structures
• Galaxy Morphology
• …
Particle Physics
• No Evidence for Supersymmetry
• No evidence from Direct Searches
• …
15.
16.
17. RA Ibata et al. Nature 493, 62-65 (2013) doi:10.1038/nature11717
Satellite galaxy positions as viewed from Andromeda.
23. • Simple idea): DM is a (very) light particle (m~ 10-22 eV) then
the Compton wavelength can be a galactic scale.
• In this case the `quantum pressure’ is a real physical effect.
• Something like `warm’ dark matter arises (actually `fuzzy’ dark
matter), but with quantum pressure.
• Sometimes called Fuzzy Dark Matter
Might dark matter be quantum-
mechanical?
32. Structure formation basics
• Small primordial density perturbations grow via the
mechanism of gravitational instability.
• Large density fluctuations observable today thought to be
dominated by non-baryonic matter.
• Observations of clustering support some form of collisionless
CDM.
• Approximate model of structure formation:
Large-scale structure is the result of the gravitational
amplification of small inhomogeneities in the primordial
CDM distribution.
33. The fluid approach
• Treat collisionless CDM as a fluid.
• Linear perturbation theory gives an equation for the density
contrast
• In a spatially flat CDM-dominated universe
where:
• Comoving velocity associated with the growing
mode is irrotational:
1/ b
2/3
)(
)(
aaD
aaD Growing mode
Decaying mode
)X()(),X( iaDa
dad /XU
UXU
34. • Linear theory only valid at early times when fluctuations in
physical fluid quantities are small.
• Perturbations grow and the system becomes non-linear in
nature.
• Linear theory predicts the existence of spatial regions with
negative density , which is unphysical.
Problems with the fluid approach
1
35. The Zel’dovich approximation
• Follows perturbations in particle trajectories:
• Mass conservation leads to:
• Zel’dovich approximation remains valid in the quasi-linear
regime, after the breakdown of the linearised fluid approach.
)Q(UQ),Q(X aa
1
)1(
1
),X( 3
1
i
ia
a
36. Problems with the Zel’dovich
approximation
• The Zel’dovich approximation fails
when particle trajectories cross –
shell crossing.
• A region where shell-crossing
occurs is called a caustic.
• At caustics the mapping
is no longer unique and the density
becomes infinite.
• Particles pass through caustics
without responding to the large
gravitational force non-linear
regime described very poorly.
XQ
37. From Zel’dovich to Burgers
Define
Then
b
x
0
b
Modify RHS
2
b
Burgers’ Equation
“viscosity”
38. The wave-mechanical approach
• Apply the Madelung transformation
to the fluid equations.
• Obtain the Schrodinger equation:
• is the quantum pressure term.
• DeBroglie wavelength
)/exp( Ui
PV
a
i 2
X
2
2
2
X
2
2
P
dB
40. The wave-mechanical approach
• Assume the comoving velocity is irrotational:
• The equations of motion for a fluid of gravitating CDM
particles in an expanding universe are then:
where and
UXU
0)(
0)(
2
1
Xx
2
X
U
U
U
a
V
a
Bernoulli
Continuity
b /
U
p
a
a
aaa
V
222
2
‘Modified potential’
41. The Trouble with
• The classical limit has 0…
• BUT the “weight” oscillates wildly as this
limit is approached.
• For a finite computation, need a finite value of
• Also, system misbehaves
• Note is dimensionally a viscosity; c.f. Burgers
equation
)/exp( iS
2
d
Rs
42. • Assume a sinusoidal initial density profile in 1D:
where is the comoving period of the perturbation.
• Free parameters are:
1. The amplitude of the initial density fluctuation.
2. The dimensionless number
• Quantum pressure
• DeBroglie wavelength
Gravitational collapse in one
dimension
D
X
Xi
2
cos)( 0
D
0
ie aDR /2
2
/1 eRP
edB R/1
43. Gravitational collapse in one
dimension
Evolution of a periodic 1D self-gravitating system with )/2cos()( 0 DXXi
3
0
100.1
001.0
eR
44. Gravitational collapse in one
dimension
Evolution of a periodic 1D self-gravitating system with )/2cos()( 0 DXXi
7
0
102.1
001.0
eR
45. Cosmological Reconstruction
Problems
• We observe redshifts and (sometimes)
estimated distances in the evolved local
Universe for some galaxies
• Problem I. What is the real space
distribution of dark matter
• Problem II. What were the initial data that
evolved into the observed data?
46.
47. Problems with the Zel’dovich
approximation
• The Zel’dovich approximation fails
when particle trajectories cross –
shell crossing.
• Regions where shell-crossing
occurs are associated with
caustics.
• At caustics the mapping
is no longer unique and the density
becomes infinite.
• Particles pass through caustics
non-linear regime described
very poorly.
XQ
48. The ‘free-particle’ Schrodinger
equation
• In a spatially flat CDM-dominated universe, the ‘potential’
in the linear regime.
• Neglecting quantum pressure, the Schrodinger equation to be
solved is then the ‘free-particle’ equation:
• Can be solved exactly!
0V
2
X
2
2
a
i
49. The wave-mechanical approach
• For a collisionless
medium, shell-crossing
leads to the generation
of vorticity velocity
flow no longer
irrotational
• Possible to construct
more sophisticated
representations of the
wavefunction that allow
for multi-streaming
(Widrow & Kaiser 1993).
Phase-space evolution of a 1D self-gravitating
system with ,
0)( Xvi
)/exp()( 22
0 LXXi
51. • In Eulerian space the Zel’dovich approximation becomes:
• Reconstruction process:
1. Determine present comoving velocity potential
2. Smooth to remove non-linearities.
3. Integrate ZB equation backwards from to
4. Use linear theory to calculate initial density field
The Zel’dovich-Bernoulli method
)2(
0)(
2
1
22
2
X
aaaa
a
p
U
U
U
Zel’dovich-Bernoulli
0,U
10 a 001.0~ia
i
52. • The Zel’dovich-Bernoulli equation can be replaced by the
‘free-particle’ Schrodinger equation!
• Currently testing the `free-particle’ reconstruction method on a
2D N-body simulation.
• If successful, possible extensions are:
1. Model errors in galaxy position and velocity measurements by
exploiting the nature of quantum mechanics.
2. Work in redshift space coordinates
3. Generalise to 3D.
Wave-mechanics and the
Zel’dovich-Bernoulli method
)SˆU(SˆXS a
59. Summary
• The wave-mechanical approach can overcome some of the
main difficulties associated with the fluid approach and the
Zel’dovich approximation.
• More sophisticated representations of the wavefunction can
be used to allow for multi-streaming; the quantum pressure
term is crucial in determining how well the wave-mechanical
approach performs.
• The `free-particle’ Schrodinger equation can be applied to the
problem of reconstruction.
• Dark Matter may even be quantum-mechanical!