The document discusses the Big Bang theory, which proposes that the universe began approximately 13.7 billion years ago in an explosion from a single point of nearly infinite energy density and has been expanding ever since. Evidence for this theory includes Hubble's law of galaxy redshifts, the cosmic microwave background radiation, and abundances of light elements like hydrogen and helium. The early universe is described in different eras from the Planck era through nucleosynthesis and recombination. Inflation is proposed to have rapidly expanded the universe within the first fraction of a second. The Big Bang theory continues to be refined as new evidence is discovered.
This Lecture is based on Scientific Discoveries and Religious Scripture of Sikh religion " Sri Guru Granth Sahib". Surprisingly, Guru Nanak, founder of Sikh religion, was forerunner of Big Bang cosmology; his ideas on Creation of Space, Time and Universe find an echo in Big Bang Cosmological Models proposed 500 years after Guru Nanak's vision recorded in "Sri Guru Granth Sahib". Original quotes from Guru Nanak are recorded in Gurmukhi script/Fonts.
This Lecture is based on Scientific Discoveries and Religious Scripture of Sikh religion " Sri Guru Granth Sahib". Surprisingly, Guru Nanak, founder of Sikh religion, was forerunner of Big Bang cosmology; his ideas on Creation of Space, Time and Universe find an echo in Big Bang Cosmological Models proposed 500 years after Guru Nanak's vision recorded in "Sri Guru Granth Sahib". Original quotes from Guru Nanak are recorded in Gurmukhi script/Fonts.
There is a consensus that the universe has a beginning as well as an end, as the “Big Bang” theory indicates that the universe was dense, hot, and small, and then a big explosion occurred 13.8 billion years ago that expanded this small point in less than a billionth of a second to become It is billions of times larger than its original size in the so-called cosmic inflation phenomenon.
Studying the origins of the Universe and exploring it helps us build our civilization. Exploring how our civilization came into existence has evolved our ability of thinking and understanding our surrounding and also the universe in a better way. Our curiosity to get the answer to every query in relation to the origin and existence of universe has helped us to discover and build better technology that we so ungratefully enjoy in all walks of life. Humans have managed to advance in every field of technology, medicines, energy and telecommunication.
HOW RELATIONSHIPS MADE THE UNIVERE & HUMANSPaul H. Carr
-Einstein’s General Relativity (1916) frames modern cosmology.
-Big-Bang energetic beginning: interactive relationships of matter particles created our universe.
-Explains origin of 92 elements in the Periodic Table
- We are made of stardust.
- Symbiotic relations between cells led to the Cambrian explosion of complex and human life.
-BIG HISTORY: 13.8 BILLION YEARS
“Each of us is as old as the universe and experiences our greater self in the larger story of the universe.” Thomas Berry.
THE UNIVERSE
The high-quality-supported principle of our universe's foundation facilities on an occasion called the huge bang. This idea was born of the commentary that different galaxies are shifting far from our own at top notch speed in all directions, as though they had all been propelled with the aid of an historic explosive pressure.
A Belgian priest named Georges Lemaitre first counselled the massive bang theory in the Nineteen Twenties, while he theorized that the universe started from a unmarried primordial atom. The idea acquired fundamental boosts from Edwin Hubble's observations that galaxies are rushing far from us in all guidelines, as well as from the Nineteen Sixties discovery of cosmic microwave radiation—interpreted as echoes of the large bang—via Arno Penzias and Robert Wilson.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. What is the Big Bang?
The Big Bang Theory is a theory in astronomy that the universe originated
billions of years ago in an explosion from a single point of nearly infinite
energy density.
This is the leading hypothesis of how the Universe first started.
According to the standard theory, the Universe began its existence as
“singularity” around 13.7 billion years ago
3. Evidence for the Theory
There is evidence that galaxies appear to be moving away from us at a certain
speed proportional to their distance. This is known as “Hubble’s Law”, named
after Edwin Hubble who discovered this law in the 1900’s.
Scientists discovered the leftover radiation from the heat of the Earth, thus the
Big Bang suggests this is what caused it.
The abundance of “light elements” Hydrogen and Helium, found in the
observable universe are thought to support the Big Bang Theory.
If the universe were eternal, unchanging, and everywhere the same, the entire
night sky would be covered with stars.
The night sky is dark because we can see back to a time when there were no
stars.
4. History of the Universe
The history of the Universe started as the universe
cooled, and particle production stopped, thus leaving
matter instead of antimatter.
Fusion turned remaining neutrons into helium within
the first three minutes.
Radiation traveled freely after formation of the atoms
(no more electrons scattering); age = 380,000 years.
A Belgium priest named Georges Lemaitre was the
first to suggest the Big Bang Theory in the 1920s when
he made a theory that the Universe began from a
single primordial atom.
The early universe must have been extremely hot and
dense.
5. Different Eras Since the Big Bang
Planck Era: The immediate fractions of a second following the Big Bang,
known as the Planck Era, are not well understood. Cosmologists suspect that
the four fundamental forces at work in the universe today were combined into
a single unified force.
Grand Unification Era: This era followed the Planck Era, the era began with
gravity’s separation from the other three forces and ended with the separation
of the strong force from the electroweak force.
Electroweak Era: In the beginning, the strong force decoupled from the
electroweak force, releasing a tremendous amount of energy and triggering a
sudden rapid expansion known as inflation. The era ended with the separation
of electromagnetism from the weak force.
6. Different Eras Since the Big Bang
Elementary Particle Era: known as a “particle soup” filled the universe. Quarks
and antiquarks, electrons and positrons, and other particles and antiparticles
continually swapped mass for energy via matter-antimatter collisions. As the
temperature dropped, the cool temp enabled the strong nuclear force to draw
quarks together to form protons and neutrons.
Era of Nucleosynthesis: As fusion continued, the protons and neutrons
combined into the first atomic nuclei, hydrogen, and some of which fused
further into helium and lithium. The coolness in temp dipped too low for
fusion to continue, thus the plasma of positively charged nuclei and negatively
charged free electrons filled the universe, trapping photons in its midst.
7. Different Eras Since the Big Bang
Era of Atoms: Began as the universe finally
cooled and expanded enough for the
nuclei to capture free electrons, forming
fully-fledged, neutral atoms. Previously
trapped photons were finally free to move
through space ever since, forming the
cosmic microwave background. The
universe’s expansion has redshifted the
initially energetic photons to microwave
wavelengths. The CMB marks the furthest
point back in time that we can observe.
8. How did the Big Bang happen?
Scientists believe that the Universe underwent an
extremely brief and dramatic period of inflation,
expanding faster than the speed of light.
This doubled in size perhaps 100 times or more. This
occurred within the span of a few tiny fractions of a
second.
The cosmic microwave background was the radiation left
over from the Big Bang that was detected by Penzias and
Wilson in 1965.
9. Inflation Within the Big Bang
Inflation: Is a process that can make all the structure by
stretching tiny quantum ripples to enormous size.
Spacetime expands much faster than the speed of light, which
is okay because it is NOT matter. These ripples in density then
become the seeds for all structures.
Inflation of the universe flattens the overall geometry, like the
inflation of a balloon, causing overall density of matter plus
energy to be very close to critical density, that is the geometry
of spacetime is flat.
11. How Does the Big Bang Apply Now?
Since its conception, The Big Bang Theory has
been constantly challenged. These challenges
have led to those who believe in the theory to
search for more concrete evidence which then
would prove them correct.
Many people believe it violates the law of
thermodynamics.
NASA has recently made some discoveries which
lend themselves to the proof of The Big Bang.
The Hubble Telescope (named after the father of
Big Bang theory) has provided certain clues as to
what elements were present following creation.
