GRF One Health Summit 2012, Davos: Presentation by Adnan Ali Khan CHOUDHURY, Australian Centre for International and Tropical Health, School of Population Health, University of Queensland, Public Health Building , Herston Rd , Herston Qld 4006, Brisbane, Australia
This presentation covers the key findings of the "Household Balance Sheet" section of our report on the State of Lending in America and it's Impact on U.S. Households.
City Harvest is a non-profit organization that rescues excess food and distributes it to food programs across New York City. Their strategic plan outlines goals to (1) provide more nutritious food to more hungry people over the next three years, (2) teach people nutrition and cooking skills, and (3) help more people access food stamp benefits and summer meal programs. The plan details objectives, outcomes, and initiatives to achieve these goals through food rescue, distribution, education, and enabling access to public food resources.
The document summarizes a report on the state of lending in America and its impact on U.S. households. It finds that while total debt levels remain high, the types of debt have shifted to mortgages and student loans. Consumer spending is key to the U.S. economy, but many families have little financial breathing room after covering expenses and debt payments each month. Predatory lending contributed to depleted household assets during the recession, with a $7 trillion drop in home equity alone.
Bovine TB is a complex infectious zoonotic disease of animals and humans. In this presentation BVA explain more about this disease, how it is spread and BVA policy approaches to badger culling. This was a presentation given to UK Parliamentarians on the 27th October 2015.
Diagnostic tools to detect pathogens causing tuberculosis in cattle and prev...ExternalEvents
This document discusses diagnostic tools for detecting Mycobacterium bovis, the pathogen that causes bovine tuberculosis, in cattle. It describes several tests, including the intradermal tuberculin test, the interferon-gamma test, post-mortem inspection, and PCR tests applied to milk and tissue samples. Each method has advantages and limitations in sensitivity, specificity, costs, and other factors. Genome sequencing is also discussed as a way to trace the origin of new tuberculosis cases as eradication programs progress.
This document summarizes information about bovine tuberculosis, a zoonotic disease caused by the bacterium Mycobacterium bovis. It primarily affects cattle but can infect many other species. Humans can contract it through ingesting unpasteurized dairy or inhaling infected aerosols. Control relies on test and slaughter programs along with pasteurization. Outbreaks in wildlife pose challenges. While treatable in humans, it remains an occupational hazard for farmers and abattoir workers in areas where bovine tuberculosis is endemic.
The following presentation is only for quick reference. I would advise you to read the theoretical aspects of the respective topic and then use this presentation for your last minute revision. I hope it helps you..!!
Mayur D. Chauhan
This presentation covers the key findings of the "Household Balance Sheet" section of our report on the State of Lending in America and it's Impact on U.S. Households.
City Harvest is a non-profit organization that rescues excess food and distributes it to food programs across New York City. Their strategic plan outlines goals to (1) provide more nutritious food to more hungry people over the next three years, (2) teach people nutrition and cooking skills, and (3) help more people access food stamp benefits and summer meal programs. The plan details objectives, outcomes, and initiatives to achieve these goals through food rescue, distribution, education, and enabling access to public food resources.
The document summarizes a report on the state of lending in America and its impact on U.S. households. It finds that while total debt levels remain high, the types of debt have shifted to mortgages and student loans. Consumer spending is key to the U.S. economy, but many families have little financial breathing room after covering expenses and debt payments each month. Predatory lending contributed to depleted household assets during the recession, with a $7 trillion drop in home equity alone.
Bovine TB is a complex infectious zoonotic disease of animals and humans. In this presentation BVA explain more about this disease, how it is spread and BVA policy approaches to badger culling. This was a presentation given to UK Parliamentarians on the 27th October 2015.
Diagnostic tools to detect pathogens causing tuberculosis in cattle and prev...ExternalEvents
This document discusses diagnostic tools for detecting Mycobacterium bovis, the pathogen that causes bovine tuberculosis, in cattle. It describes several tests, including the intradermal tuberculin test, the interferon-gamma test, post-mortem inspection, and PCR tests applied to milk and tissue samples. Each method has advantages and limitations in sensitivity, specificity, costs, and other factors. Genome sequencing is also discussed as a way to trace the origin of new tuberculosis cases as eradication programs progress.
This document summarizes information about bovine tuberculosis, a zoonotic disease caused by the bacterium Mycobacterium bovis. It primarily affects cattle but can infect many other species. Humans can contract it through ingesting unpasteurized dairy or inhaling infected aerosols. Control relies on test and slaughter programs along with pasteurization. Outbreaks in wildlife pose challenges. While treatable in humans, it remains an occupational hazard for farmers and abattoir workers in areas where bovine tuberculosis is endemic.
The following presentation is only for quick reference. I would advise you to read the theoretical aspects of the respective topic and then use this presentation for your last minute revision. I hope it helps you..!!
Mayur D. Chauhan
A presentation built by Clay Marsh, MD. executive director of the OSU Center for Personalized Medicine, designed to explain some of the scientific and social angles that are a part of personalized health care.
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
Evaluating the cost effectiveness of Needle and Syringe exchange programs (NS...UNDP Eurasia
The document summarizes a study evaluating the cost-effectiveness of needle and syringe exchange programs (NSEPs) in Tajikistan from 2005-2010 and projecting their impact from 2011-2020. Some key findings:
1) From 2005-2010, NSEPs averted 4,004 new HIV infections and 6,124 new HCV infections in Tajikistan and over 505 DALYs related to HIV and 2,860 related to HCV.
2) NSEPs were found to be cost-effective, with a cumulative cost per DALY averted of $7,109 for HIV and $1,313 for HCV. They also saved $6.08 million in healthcare costs.
1) A study found that earlier antiretroviral therapy (ART) initiation significantly reduced HIV transmission between couples.
2) Modeling by the CDC showed that accelerating ART scale-up in Kenya to treat 900,000 people by 2015 could reduce new HIV infections by 31% and lower costs compared to the current approach.
3) For Kenya to achieve these benefits, guidelines and budgets need to be updated to accelerate treatment scale-up, including treating all serodiscordant couples and pregnant/nursing women, starting new and more effective drugs, and initiating ART earlier.
This document summarizes research on the costs, cost-effectiveness, and potential health impacts of scaling up an Integrated Prevention Campaign (IPC) globally. The research finds that IPC is very cost-effective in the top 10 countries with the highest disease burden, and even more so in subsequent campaigns as costs decline. Implementing IPC in the top 40 countries could avert 46 million Disability-Adjusted Life Years (DALYs) and save $1.4 billion. The conclusion is that scaling up IPC globally has strong potential for efficiently improving public health outcomes.
GHIs operating in Mozambique include the Global Fund, PEPFAR, President's Malaria Initiative, and others focused on specific diseases. While GHIs have increased funding and scale-up of targeted health services, their vertical nature has stressed harmonization efforts and negatively impacted health workers. Overall, GHIs could have achieved better health outcomes by jointly strengthening the overall health system in a more coherent manner.
using innovation in tobacco - prakit vathesatogkitNCAS1
The document proposes establishing a Thai Health Promotion Fund to support health promotion activities outside of the Ministry of Health (MOH). The new approach would focus on lifestyle and environmental factors to promote population health, rather than only providing services to the sick. The fund would receive 2% of alcohol and tobacco tax revenues annually to support a more sustainable and predictable budget for health promotion programs led by various government agencies and non-profits. Key provisions and regulations would ensure transparency and accountability for use of the funds.
Rashad's Analysis of China's Healthcare EconomicsRashad Salaam
China's healthcare spending has grown faster than GDP in recent decades. However, China still spends much less than other nations on healthcare per capita. China also lags in several health outcomes compared to other countries. The fee-for-service model in China may incentivize overspending. To improve its system, China could reform payments and invest more in public health prevention.
This document discusses health management as a serious business strategy for achieving zero healthcare costs. It presents research from the University of Michigan Health Management Research Center showing that a majority of employees have high health risks that result in high medical costs. The research finds that costs are significantly higher for employees with multiple health risks. It argues that the current healthcare approach of waiting for disease and then treating it is flawed and that engaging employees to improve their health risks can turn healthcare costs into a positive investment.
Cambodia’s Victim Zero: Global and National Response to Highly Pathogenic Avi...STEPS Centre
This document summarizes Cambodia's response to the global threat of avian influenza and pandemic preparedness. It provides a timeline of key events and discusses three main policy narratives around culling practices, public health priorities, and protecting livelihoods. Interviews and surveys with government, private, and NGO actors in Cambodia revealed differences in perceptions of how effectively the government and donors responded, with donors seen as intervening more effectively. The conclusion emphasizes that policies need to better protect livelihoods and compensation practices while building technical capacity within the agriculture ministry.
The document summarizes a presentation given by Steven Davis, the Executive Director of Academics for Higher Education and Development (AHED), about a project between AHED and Addis Ababa University's School of Nursing in Ethiopia. The project aims to establish a Master's program in maternal and reproductive health at the university by sending teams of nurses from the University of Toronto to help train local nursing faculty. Over three years, the program will be fully run by Ethiopian nurses, helping to improve health outcomes for women and children in the country. AHED is seeking to raise $12,832 in additional funding to fully cover the costs of the project.
The document discusses a holistic partnership called H2pe0ple between a mining company called Newmont and local community in Zocamoa. H2pe0ple is established as a low-profit limited liability company (L3C) to jointly address economic, social and environmental issues from mining through shared investments and responsibilities. It outlines various initiatives of H2pe0ple like building a water treatment plant, providing mobile/internet access, funding vocational schools and soccer facilities to benefit the community in a sustainable manner along with expected financial returns over time.
The document discusses the importance of health to business and the economy. It notes that a nation's health indicators provide a key measure of its wealth, and changes in the health and disease patterns of citizens will be reflected in the economy. The document then highlights Nigeria's poor health indices and infrastructure compared to global standards, and identifies factors contributing to poor health outcomes, such as poverty, corruption, and underfunding of the health sector. It argues that improving health is crucial for reducing poverty and driving economic growth.
The document discusses the importance of health to business and the economy. It notes that a nation's health indicators reflect the state of its wealth and economy. Poor health leads to a less productive workforce and economic drain. The document then provides an overview of Nigeria's poor health indices and underfunding of the health sector compared to global standards. It also discusses the social determinants of health issues in Nigeria like poverty, cultural beliefs, and brain drain of health professionals.
The document discusses drivers of rising healthcare costs in the US. It shows that US healthcare spending as a percentage of GDP and in absolute per capita terms far exceeds other developed nations. The high costs are driven by overutilization, high administrative expenses, and lack of coordination. Additionally, a small portion of the population accounts for a large percentage of total healthcare spending, indicating a concentration of costs among those with complex or chronic conditions. There is also a disparity between higher spending and lower quality of care outcomes in the US compared to other countries.
Mortality rates were higher in rural areas for major diseases while morbidity rates of cardiovascular disease and diabetes were higher in cities. Rural residents had higher hospital visit rates across all age groups and preferred local hospitals. Over 400 clinical trial sites are above county hospitals, so including rural patients may be challenging. Traditional Chinese medicine is commonly used alongside medications, requiring careful trial design. The Chinese Clinical Trial Registry and NIH database provide information on competing trials for patient recruitment planning. This data can help identify opportunities and threats to patient recruitment and retention in Chinese clinical trials.
The document provides an overview of the American College of Cardiology (ACC). It lists the current leadership of the ACC including the president, president-elect, vice president, and chair of the board of governors. It discusses the mission of the ACC to transform cardiovascular care and improve heart health. It also invites attendees to the upcoming ACC.13 conference in San Francisco and provides disclosure information for the presenter.
Cook County spends $304.4 million annually on healthcare benefits for employees and retirees. Moving to a healthcare exchange could reduce these costs by $21-82 million annually. Transferring retiree healthcare obligations from the pension fund to the county, along with reducing COLAs for current employees and retirees to 3% or half of CPI and increasing employee contributions by 1%, could improve the pension fund's funded status to 88.1% by 2050.
Caribbean HIV Conference. AIDS Spending PresentationAndy Fearon
The document discusses HIV expenditure tracking in the Caribbean region. It presents data on HIV spending trends in Trinidad and Tobago from 2002-2009, showing increases in total spending over time but uneven allocation to prevention versus treatment. Expenditure targeting key populations like MSM and sex workers was relatively low. Regional data on four countries is also presented, showing variations in HIV spending as a share of GDP and per capita across countries from 2008-2010.
6th International Disaster and Risk Conference IDRC 2016 Integrative Risk Management - Towards Resilient Cities. 28 August - 01 September 2016 in Davos, Switzerland
Disaster risk reduction and nursing - human science research the view of surv...Global Risk Forum GRFDavos
6th International Disaster and Risk Conference IDRC 2016 Integrative Risk Management - Towards Resilient Cities. 28 August - 01 September 2016 in Davos, Switzerland
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A presentation built by Clay Marsh, MD. executive director of the OSU Center for Personalized Medicine, designed to explain some of the scientific and social angles that are a part of personalized health care.
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
Evaluating the cost effectiveness of Needle and Syringe exchange programs (NS...UNDP Eurasia
The document summarizes a study evaluating the cost-effectiveness of needle and syringe exchange programs (NSEPs) in Tajikistan from 2005-2010 and projecting their impact from 2011-2020. Some key findings:
1) From 2005-2010, NSEPs averted 4,004 new HIV infections and 6,124 new HCV infections in Tajikistan and over 505 DALYs related to HIV and 2,860 related to HCV.
2) NSEPs were found to be cost-effective, with a cumulative cost per DALY averted of $7,109 for HIV and $1,313 for HCV. They also saved $6.08 million in healthcare costs.
1) A study found that earlier antiretroviral therapy (ART) initiation significantly reduced HIV transmission between couples.
2) Modeling by the CDC showed that accelerating ART scale-up in Kenya to treat 900,000 people by 2015 could reduce new HIV infections by 31% and lower costs compared to the current approach.
3) For Kenya to achieve these benefits, guidelines and budgets need to be updated to accelerate treatment scale-up, including treating all serodiscordant couples and pregnant/nursing women, starting new and more effective drugs, and initiating ART earlier.
This document summarizes research on the costs, cost-effectiveness, and potential health impacts of scaling up an Integrated Prevention Campaign (IPC) globally. The research finds that IPC is very cost-effective in the top 10 countries with the highest disease burden, and even more so in subsequent campaigns as costs decline. Implementing IPC in the top 40 countries could avert 46 million Disability-Adjusted Life Years (DALYs) and save $1.4 billion. The conclusion is that scaling up IPC globally has strong potential for efficiently improving public health outcomes.
GHIs operating in Mozambique include the Global Fund, PEPFAR, President's Malaria Initiative, and others focused on specific diseases. While GHIs have increased funding and scale-up of targeted health services, their vertical nature has stressed harmonization efforts and negatively impacted health workers. Overall, GHIs could have achieved better health outcomes by jointly strengthening the overall health system in a more coherent manner.
using innovation in tobacco - prakit vathesatogkitNCAS1
The document proposes establishing a Thai Health Promotion Fund to support health promotion activities outside of the Ministry of Health (MOH). The new approach would focus on lifestyle and environmental factors to promote population health, rather than only providing services to the sick. The fund would receive 2% of alcohol and tobacco tax revenues annually to support a more sustainable and predictable budget for health promotion programs led by various government agencies and non-profits. Key provisions and regulations would ensure transparency and accountability for use of the funds.
Rashad's Analysis of China's Healthcare EconomicsRashad Salaam
China's healthcare spending has grown faster than GDP in recent decades. However, China still spends much less than other nations on healthcare per capita. China also lags in several health outcomes compared to other countries. The fee-for-service model in China may incentivize overspending. To improve its system, China could reform payments and invest more in public health prevention.
This document discusses health management as a serious business strategy for achieving zero healthcare costs. It presents research from the University of Michigan Health Management Research Center showing that a majority of employees have high health risks that result in high medical costs. The research finds that costs are significantly higher for employees with multiple health risks. It argues that the current healthcare approach of waiting for disease and then treating it is flawed and that engaging employees to improve their health risks can turn healthcare costs into a positive investment.
Cambodia’s Victim Zero: Global and National Response to Highly Pathogenic Avi...STEPS Centre
This document summarizes Cambodia's response to the global threat of avian influenza and pandemic preparedness. It provides a timeline of key events and discusses three main policy narratives around culling practices, public health priorities, and protecting livelihoods. Interviews and surveys with government, private, and NGO actors in Cambodia revealed differences in perceptions of how effectively the government and donors responded, with donors seen as intervening more effectively. The conclusion emphasizes that policies need to better protect livelihoods and compensation practices while building technical capacity within the agriculture ministry.
The document summarizes a presentation given by Steven Davis, the Executive Director of Academics for Higher Education and Development (AHED), about a project between AHED and Addis Ababa University's School of Nursing in Ethiopia. The project aims to establish a Master's program in maternal and reproductive health at the university by sending teams of nurses from the University of Toronto to help train local nursing faculty. Over three years, the program will be fully run by Ethiopian nurses, helping to improve health outcomes for women and children in the country. AHED is seeking to raise $12,832 in additional funding to fully cover the costs of the project.
The document discusses a holistic partnership called H2pe0ple between a mining company called Newmont and local community in Zocamoa. H2pe0ple is established as a low-profit limited liability company (L3C) to jointly address economic, social and environmental issues from mining through shared investments and responsibilities. It outlines various initiatives of H2pe0ple like building a water treatment plant, providing mobile/internet access, funding vocational schools and soccer facilities to benefit the community in a sustainable manner along with expected financial returns over time.
The document discusses the importance of health to business and the economy. It notes that a nation's health indicators provide a key measure of its wealth, and changes in the health and disease patterns of citizens will be reflected in the economy. The document then highlights Nigeria's poor health indices and infrastructure compared to global standards, and identifies factors contributing to poor health outcomes, such as poverty, corruption, and underfunding of the health sector. It argues that improving health is crucial for reducing poverty and driving economic growth.
The document discusses the importance of health to business and the economy. It notes that a nation's health indicators reflect the state of its wealth and economy. Poor health leads to a less productive workforce and economic drain. The document then provides an overview of Nigeria's poor health indices and underfunding of the health sector compared to global standards. It also discusses the social determinants of health issues in Nigeria like poverty, cultural beliefs, and brain drain of health professionals.
The document discusses drivers of rising healthcare costs in the US. It shows that US healthcare spending as a percentage of GDP and in absolute per capita terms far exceeds other developed nations. The high costs are driven by overutilization, high administrative expenses, and lack of coordination. Additionally, a small portion of the population accounts for a large percentage of total healthcare spending, indicating a concentration of costs among those with complex or chronic conditions. There is also a disparity between higher spending and lower quality of care outcomes in the US compared to other countries.
Mortality rates were higher in rural areas for major diseases while morbidity rates of cardiovascular disease and diabetes were higher in cities. Rural residents had higher hospital visit rates across all age groups and preferred local hospitals. Over 400 clinical trial sites are above county hospitals, so including rural patients may be challenging. Traditional Chinese medicine is commonly used alongside medications, requiring careful trial design. The Chinese Clinical Trial Registry and NIH database provide information on competing trials for patient recruitment planning. This data can help identify opportunities and threats to patient recruitment and retention in Chinese clinical trials.
The document provides an overview of the American College of Cardiology (ACC). It lists the current leadership of the ACC including the president, president-elect, vice president, and chair of the board of governors. It discusses the mission of the ACC to transform cardiovascular care and improve heart health. It also invites attendees to the upcoming ACC.13 conference in San Francisco and provides disclosure information for the presenter.
Cook County spends $304.4 million annually on healthcare benefits for employees and retirees. Moving to a healthcare exchange could reduce these costs by $21-82 million annually. Transferring retiree healthcare obligations from the pension fund to the county, along with reducing COLAs for current employees and retirees to 3% or half of CPI and increasing employee contributions by 1%, could improve the pension fund's funded status to 88.1% by 2050.
Caribbean HIV Conference. AIDS Spending PresentationAndy Fearon
The document discusses HIV expenditure tracking in the Caribbean region. It presents data on HIV spending trends in Trinidad and Tobago from 2002-2009, showing increases in total spending over time but uneven allocation to prevention versus treatment. Expenditure targeting key populations like MSM and sex workers was relatively low. Regional data on four countries is also presented, showing variations in HIV spending as a share of GDP and per capita across countries from 2008-2010.
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6th International Disaster and Risk Conference IDRC 2016 Integrative Risk Management - Towards Resilient Cities. 28 August - 01 September 2016 in Davos, Switzerland
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- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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The societal impact of bovine tuberculosis in select Asian countries
1. The economic Impact of bovine Tuberculosis in
Ethiopia and China: A comparative study to assess
the importance of the disease in Asia
Author & Presenter:
Adnan Choudhury
Co-Authors:
Jakob Zinsstag, Vanessa Racloz, Maxine Whittaker
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
2. Aims
o To demonstrate the importance of Bovine Tuberculosis
in developing nations – such as Ethiopia and China
• Particularly in Asia
o To demonstrate the importance of both economic
evaluations and the One Health Approach
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
3. Bovine Tuberculosis
o Mycobacterium bovis, is a zoonotic disease that is
prevalent across a wide range of nations
o Aerosol transmission between hosts (man, cattle,
wildlife)
o Causes TB Symptoms in humans
o In Animal emaciation, fever, obstructed
airways/vessels
o Countries such as the United Kingdom spend £100
million a year in control efforts against the spread of
bTB.
o Less developed nations are usually unable to afford
the steep costs of bTB control
o As such the disease spreads and becomes prevalent
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
4. Bovine Tuberculosis in Africa
o A study in Tanzania returned a rate of 1.3% for bTB positive
cases in individual animals while (Shirima et al. 2003)
o Nigeria reported 1.08% (Ibrahim et al. 2010).
o Herd prevalence up to 48%
o The incidence of TB in Ethiopia was 353/100000 in 2004
o Estimated 430,000 fatal cases in Africa due to TB (WHO
2011b).
• 3.1% attributable to bTB (Worldwide)
o High prevalence of consumption of unboiled milk
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
5. Bovine Tuberculosis in Asia
o 62% of global cases of BTB are reported in the Asia
region (Cosivi et al. 1998).
o Annual mortality due to all strains of tuberculosis in
South-East Asia is estimated by the WHO to be
480,000
o China, the fifth largest producer of milk
o Intensive production setups to cope with the
overwhelming demand
o Risk factor for aerosol transmission
o Evidence suggests that human results disease-
associated costs of TB equate to 91% of annual
household income, (Jackson et al. 2006).
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
6. Methods
o Animal Sector: LDPS2
o Adapted from the FAO by Zinnstag et al
o Adds economic layer on top of the livestock demographic
system
o Allows the simulation of changes to the NPV of livestock
industry due to the prevalence of Bovine Tuberculosis
o Human Sector: Decision-Tree
o Markov-Chain decision tree
o Probabilistic model that simulates the disease cycle,
interventions, treatment seeking etc
o Life tables used to simulate the life cycle of 1000
individuals
o Uncertainty analysis: Monte Carlo Simulation
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
8. Assumptions
Seeking rate
China - 2% too poor to start treatment
Treatment seeking assumed 100% for both countries due to lack of data,
tempered by adherence and too poor to start.
Adherence rate
China – 65% (literature)
Ethiopia – no data available, assumed to be 75% with a pert distribution
(low 0.5, high 0.9)
Prices
China – derived from literature review for human TB medication. After
weighted average of studies as well as conversion to USD, treatment
costs were assumed to be $US148.80 per person for a full
treatment.
Ethiopia – Very low treatment cost assumed – due to poor data available
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
9. Results – Animal Industry (Ethiopia)
$10,700,000,000
Average Annual NPV of Livestock Industry
$10,650,000,000
$10,600,000,000
$10,550,000,000
$10,500,000,000
$10,450,000,000
$10,400,000,000
0% 1% 2% 4% 8% 10% 15%
Prevalence
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
10. Results – Animal Industry (China)
$12,550,000,000
Average Annual NPV of Livestock Industry
$12,500,000,000
$12,450,000,000
$12,400,000,000
$12,350,000,000
$12,300,000,000
$12,250,000,000
0% 1% 2% 4% 8% 10% 15%
Prevalence
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
11. Results – Public Health (Ethiopia)
Per-Person Costs
Per-Person Cost of Disease to Society ($US) $0.14
$0.12
$0.10
$0.08
Mean
$0.06 LCI 95%
HCI 95%
$0.04
$0.02
$0.00
1% 2% 3% 8% 10%
% of bTB attributable to TB Cases
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
12. Results – Public Health (Ethiopia)
„Minimum‟ Cost to Society
$1,800,000.00
$1,600,000.00
'Minimum Cost of Disease to Society ($US)
$1,400,000.00
$1,200,000.00
$1,000,000.00
Mean
$800,000.00
LCI 95%
HCI 95%
$600,000.00
$400,000.00
$200,000.00
$0.00
1% 2% 3% 8% 10%
% of bTB attributable to TB Cases
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
13. Results – Public Health (China)
Per-Person Costs
$2.50
$2.00
Cost to Society Per-Person ($US)
$1.50
Mean
LCI 95%
$1.00
HCI 95%
$0.50
$0.00
1% 2% 4.20% 8% 10%
% of bTB attributable to TB Cases
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
14. Results – Public Health (China)
„Minimum‟ Cost to Society
$25,000,000.00
$20,000,000.00
"Minimum" Cost to Society ($US)
$15,000,000.00
LCI 95%
Mean
$10,000,000.00
HCI 95%
$5,000,000.00
$0.00
10% 8% 4.20% 2% 1%
% of bTB attributable to TB Cases
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
15. Key Variables
o China
o Medical Costs***
o Adherence Rate
o Daily Wage Rate
o Ethiopia
o Daily Wage Rate
o Adherence Rate
o LDPS2 – Differences in influential variables reflect industry
demand
o China: Milk
o Ethiopia: Traction
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
16. Implications
o The pasteurization barrier
o In nations with systematic pasteurization of milk, there is
little to no human bTB
o In most developing nations, there is little or no
systematic pasteurization of milk
• Therefore, bTB remains a disease of significance to
human health
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
17. The One Health Difference
o Thus far, we have covered economics of zoonotic
diseases
• This has not been “One Health”
o One Health in the next step
o One health is when we evaluate the true societal costs
and benefits of pasteurization
• The reduction of animal and human costs
• The added value to dairy products and benefits to
farmers
• The social benefits of purchasing milk safely from
your local store
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
18. Thank you!
The Economic Impact of Bovine Tuberculosis in Ethiopia and China 2012
Editor's Notes
Multi-sectoral valuations
Humans: fever, chills, chest pain, emaciation
although the extent of BTB in this expenditure has not been fully investigated