The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
Progress is being made in developing new tuberculosis (TB) vaccines. Currently, 15 vaccine candidates have entered clinical trials with 12 currently in clinical testing. The Oxford-Emergent Tuberculosis Consortium (OETC) is developing MVA85A, an attenuated viral vector vaccine that boosts BCG. MVA85A has undergone safety and immunogenicity testing in various populations and two Phase IIb efficacy trials in infants and HIV-infected adults are ongoing. While progress has been made, continued momentum and funding is needed to demonstrate efficacy in late-stage trials and build capacity to develop and deliver new TB vaccines globally.
This document discusses strategies for improving global cardiovascular health, including political and economic factors influencing non-communicable diseases, the WHO's "25 by 25" goals, and polypills. It outlines WHO's proposed targets to reduce premature mortality from non-communicable diseases by 25% by 2025. It also discusses research on polypills, including a study in India that found a polypill reduced cardiovascular risk factors but not to the extent originally predicted, and had 16% of patients permanently stop medications after 12 weeks. Overall the document analyzes political, economic and scientific factors impacting efforts to address non-communicable diseases globally.
Presentation from the Livestock Inter-Agency Donor Group (IADG) Meeting 2010. 4-5 May 2010 Italy, Rome IFAD Headquarters.
The event involved approximately 45 representatives from the international partner agencies to discuss critical needs for livestock development and research issues for the coming decade.
[ Originally posted on http://www.cop-ppld.net/cop_knowledge_base ]
The CDC is set to release revised estimates showing more new HIV infections each year than previously estimated. HIV prevention funding has declined since 2003 and has not kept pace with need. Additional funding of $608 million is requested to support core HIV prevention programs, expand testing targeted at communities of color, and increase HIV surveillance funding.
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
The Power of Vaccines: ‘getting to zero’ for HIV and TB was an event hosted by the TB/HIV and Prevention Working Groups of the UK Consortium on AIDS and International Development. The meeting was sponsored by Pamela Nash MP and held on Friday, 18th May 2012, in Portcullis House, Westminster. Read more at http://storify.com/PamojaUK/the-power-of-vaccines
http://www.pamoja.uk.com
Progress is being made in developing new tuberculosis (TB) vaccines. Currently, 15 vaccine candidates have entered clinical trials with 12 currently in clinical testing. The Oxford-Emergent Tuberculosis Consortium (OETC) is developing MVA85A, an attenuated viral vector vaccine that boosts BCG. MVA85A has undergone safety and immunogenicity testing in various populations and two Phase IIb efficacy trials in infants and HIV-infected adults are ongoing. While progress has been made, continued momentum and funding is needed to demonstrate efficacy in late-stage trials and build capacity to develop and deliver new TB vaccines globally.
This document discusses strategies for improving global cardiovascular health, including political and economic factors influencing non-communicable diseases, the WHO's "25 by 25" goals, and polypills. It outlines WHO's proposed targets to reduce premature mortality from non-communicable diseases by 25% by 2025. It also discusses research on polypills, including a study in India that found a polypill reduced cardiovascular risk factors but not to the extent originally predicted, and had 16% of patients permanently stop medications after 12 weeks. Overall the document analyzes political, economic and scientific factors impacting efforts to address non-communicable diseases globally.
Presentation from the Livestock Inter-Agency Donor Group (IADG) Meeting 2010. 4-5 May 2010 Italy, Rome IFAD Headquarters.
The event involved approximately 45 representatives from the international partner agencies to discuss critical needs for livestock development and research issues for the coming decade.
[ Originally posted on http://www.cop-ppld.net/cop_knowledge_base ]
The CDC is set to release revised estimates showing more new HIV infections each year than previously estimated. HIV prevention funding has declined since 2003 and has not kept pace with need. Additional funding of $608 million is requested to support core HIV prevention programs, expand testing targeted at communities of color, and increase HIV surveillance funding.
Johnson & Johnson is a large healthcare company founded in 1886 that generates revenue through consumer products, medical devices and diagnostics, and pharmaceuticals. In 2011, the consumer segment accounted for 40% of sales, medical devices and diagnostics accounted for 36% of sales, and pharmaceuticals accounted for 24% of sales. Johnson & Johnson aims to provide stability for investors through consistent dividend payments, high stock prices, and financial strength.
GRF One Health Summit 2012, Davos: Presentation by Adnan Ali Khan CHOUDHURY, Australian Centre for International and Tropical Health, School of Population Health, University of Queensland, Public Health Building , Herston Rd , Herston Qld 4006, Brisbane, Australia
GHIs operating in Mozambique include the Global Fund, PEPFAR, President's Malaria Initiative, and others focused on specific diseases. While GHIs have increased funding and scale-up of targeted health services, their vertical nature has stressed harmonization efforts and negatively impacted health workers. Overall, GHIs could have achieved better health outcomes by jointly strengthening the overall health system in a more coherent manner.
Dr. Michael S. Perry - Afternoon Keynote Presentationmarsinnovation
Michael Perry gave a presentation at the MaRS Innovation Summit in Toronto, Canada on October 28, 2010. He discussed trends in pharmaceutical R&D including rising costs of drug development and declining productivity. He noted significant unmet medical needs in areas like oncology, cardiovascular disease, and diabetes. Perry also talked about how venture capital like Bay City Capital is fueling innovation by translating academic research into potential drugs and funding their development through commercialization. However, industry faces challenges like large patent cliffs and risk aversion. Perry proposed strategies like the Pharma Innovation Fund to help bridge gaps in translating discoveries into treatments.
using innovation in tobacco - prakit vathesatogkitNCAS1
The document proposes establishing a Thai Health Promotion Fund to support health promotion activities outside of the Ministry of Health (MOH). The new approach would focus on lifestyle and environmental factors to promote population health, rather than only providing services to the sick. The fund would receive 2% of alcohol and tobacco tax revenues annually to support a more sustainable and predictable budget for health promotion programs led by various government agencies and non-profits. Key provisions and regulations would ensure transparency and accountability for use of the funds.
The document summarizes key issues related to AIDS in 2010. It discusses (1) important dates like 2010 targets for universal access and the MDG deadline in 2015, (2) recent leadership changes and calls to mainstream AIDS responses, and (3) major issues for 2010 like nuanced prevention strategies, expanding treatment access, and sustainability concerns given the economic crisis.
Medtronic is a global leader in medical technology, innovation and healthcare with over 38,000 employees in 120 countries. It has a long history of innovation dating back to 1949 and invests $1.36 billion annually in R&D. Opportunities exist in developing markets due to favorable demographics like aging populations and increasing wealth. However, patient access hurdles around awareness, reimbursement and training must be overcome. Medtronic is addressing this through programs tailored to local needs in markets like China and India. Technologies also offer savings through remote monitoring and management of chronic diseases.
International Technological and Industrial R&D Cooperation, Mina Goldiak, Mat...Business Finland
The document provides an overview of international technological and industrial R&D cooperation for Israel. It discusses Israel's government support programs that encourage R&D, including technlogical incubators, Magnet program for generic R&D, and competitive R&D funding. It also outlines Israel's international cooperation foundations and agreements, notably with the US, Europe, Asia, and other regions. Models of cooperation include multi-national frameworks like the European FP7 program and EUREKA, an inter-governmental network for industrial innovation projects.
MSF (Doctors without Borders)
Objective: to support the Public Civil Action (ACP) and
demonstrate the feasibility of compulsory licensing
Result: technical report showing that Brazil has the
capacity to produce Lopinavir/ritonavir at a lower cost
than the imported price
This report was presented to the Federal Attorney General
and the Ministry of Health
Jorge Beloqui, agosto
2010
The Ministry of Health issues a
compulsory license for Efavirenz -
May 2007
- Price reduction of more than 50%
- Annual savings of US$ 30 million
- Extension of access to 190,000 people
Ezose Sciences Inc. is a relatively new biotech company located in New Jersey that focuses on glycomics and biomarker discovery. It has completed multiple collaborations and utilizes its GlycanMap technology. The pharmaceutical industry is facing pressures to control expenses as major drugs lose patent protection, while biomarkers, personalized medicine, and outsourced research and development represent growth opportunities. Glycomics is an underdeveloped field that could provide insights into disease, drug response and cellular processes.
Orthopedic Patents Current Trends, Innovations and Future OpportunitiesJoseph Wyse
The document summarizes current trends in orthopedic patents, innovations, and future opportunities. It discusses how patents are used to create monopolies and extract licensing fees. The global orthopedic device market is projected to reach $41.2 billion by 2019, driven by aging populations and new technologies. The top 10 companies in orthopedics are profiled, with Johnson & Johnson projected to have the largest market share in 2020. Israeli companies and inventors are encouraged to target their innovations towards these large companies in order to monetize patents through licensing and reach patients.
This document discusses the concept of "megafunds" to help fund research and development for rare diseases. It notes that current sources of funding like venture capital and philanthropic venture capital are not enough to develop treatments for the over 7,000 known rare diseases. It proposes creating large pooled investment funds or "megafunds" that would attract funding from institutional investors by issuing bonds or debt backed by the intellectual property of a portfolio of drug development programs. This could open access to a larger pool of capital to fund more rare disease research more efficiently and at a reduced risk level through diversification. It provides examples of past proposals and discussions around this concept as a potential new model to help bridge the "valley of death"
The Medicines Patent Pool Presentation during the session "Market Interventions for Innovation and Access", UN High Level Meeting on HIV/AIDS
New York, 9 June 2011
The document provides an overview of Israel's Technological Incubators Program. It discusses how the program supports innovative startups through various incubators located around Israel. The program provides funding, facilities, expertise and other resources to help projects develop technologies and form startups. It highlights the government's significant involvement and discusses privatization efforts to strengthen the incubators. Statistics are given on the numbers of projects supported, fields of activity, and success metrics like private investments raised. Several high-profile Israeli tech companies that graduated from the incubator program are profiled as success stories.
Gino Martini, EIPG President
Presentation at Malta Qualified Persons Association-European Industrial Pharmacists Group-University of Malta joint seminar “The Successes And Challenges Of Today’s Pharmaceutical Industry”, Malta 2008.
The document discusses immune monitoring in vaccine trials. It provides context on regulatory requirements and the need for standardization. A variety of assays are used to assess cellular and antibody responses, including ELISPOT, flow cytometry, and neutralizing antibody assays [PRIMARY]. Challenges include the need for improved assays to measure antiviral function and mucosal responses. New technologies like single cell analysis and viral inhibition assays provide more detailed immune profiling but require significant bioinformatics support [SECONDARY]. The goal is to define immune correlates of protection to guide vaccine design, but this remains difficult without human challenge models [THIRDARY].
Johnson & Johnson is a large healthcare company founded in 1886 that generates revenue through consumer products, medical devices and diagnostics, and pharmaceuticals. In 2011, the consumer segment accounted for 40% of sales, medical devices and diagnostics accounted for 36% of sales, and pharmaceuticals accounted for 24% of sales. Johnson & Johnson aims to provide stability for investors through consistent dividend payments, high stock prices, and financial strength.
GRF One Health Summit 2012, Davos: Presentation by Adnan Ali Khan CHOUDHURY, Australian Centre for International and Tropical Health, School of Population Health, University of Queensland, Public Health Building , Herston Rd , Herston Qld 4006, Brisbane, Australia
GHIs operating in Mozambique include the Global Fund, PEPFAR, President's Malaria Initiative, and others focused on specific diseases. While GHIs have increased funding and scale-up of targeted health services, their vertical nature has stressed harmonization efforts and negatively impacted health workers. Overall, GHIs could have achieved better health outcomes by jointly strengthening the overall health system in a more coherent manner.
Dr. Michael S. Perry - Afternoon Keynote Presentationmarsinnovation
Michael Perry gave a presentation at the MaRS Innovation Summit in Toronto, Canada on October 28, 2010. He discussed trends in pharmaceutical R&D including rising costs of drug development and declining productivity. He noted significant unmet medical needs in areas like oncology, cardiovascular disease, and diabetes. Perry also talked about how venture capital like Bay City Capital is fueling innovation by translating academic research into potential drugs and funding their development through commercialization. However, industry faces challenges like large patent cliffs and risk aversion. Perry proposed strategies like the Pharma Innovation Fund to help bridge gaps in translating discoveries into treatments.
using innovation in tobacco - prakit vathesatogkitNCAS1
The document proposes establishing a Thai Health Promotion Fund to support health promotion activities outside of the Ministry of Health (MOH). The new approach would focus on lifestyle and environmental factors to promote population health, rather than only providing services to the sick. The fund would receive 2% of alcohol and tobacco tax revenues annually to support a more sustainable and predictable budget for health promotion programs led by various government agencies and non-profits. Key provisions and regulations would ensure transparency and accountability for use of the funds.
The document summarizes key issues related to AIDS in 2010. It discusses (1) important dates like 2010 targets for universal access and the MDG deadline in 2015, (2) recent leadership changes and calls to mainstream AIDS responses, and (3) major issues for 2010 like nuanced prevention strategies, expanding treatment access, and sustainability concerns given the economic crisis.
Medtronic is a global leader in medical technology, innovation and healthcare with over 38,000 employees in 120 countries. It has a long history of innovation dating back to 1949 and invests $1.36 billion annually in R&D. Opportunities exist in developing markets due to favorable demographics like aging populations and increasing wealth. However, patient access hurdles around awareness, reimbursement and training must be overcome. Medtronic is addressing this through programs tailored to local needs in markets like China and India. Technologies also offer savings through remote monitoring and management of chronic diseases.
International Technological and Industrial R&D Cooperation, Mina Goldiak, Mat...Business Finland
The document provides an overview of international technological and industrial R&D cooperation for Israel. It discusses Israel's government support programs that encourage R&D, including technlogical incubators, Magnet program for generic R&D, and competitive R&D funding. It also outlines Israel's international cooperation foundations and agreements, notably with the US, Europe, Asia, and other regions. Models of cooperation include multi-national frameworks like the European FP7 program and EUREKA, an inter-governmental network for industrial innovation projects.
MSF (Doctors without Borders)
Objective: to support the Public Civil Action (ACP) and
demonstrate the feasibility of compulsory licensing
Result: technical report showing that Brazil has the
capacity to produce Lopinavir/ritonavir at a lower cost
than the imported price
This report was presented to the Federal Attorney General
and the Ministry of Health
Jorge Beloqui, agosto
2010
The Ministry of Health issues a
compulsory license for Efavirenz -
May 2007
- Price reduction of more than 50%
- Annual savings of US$ 30 million
- Extension of access to 190,000 people
Ezose Sciences Inc. is a relatively new biotech company located in New Jersey that focuses on glycomics and biomarker discovery. It has completed multiple collaborations and utilizes its GlycanMap technology. The pharmaceutical industry is facing pressures to control expenses as major drugs lose patent protection, while biomarkers, personalized medicine, and outsourced research and development represent growth opportunities. Glycomics is an underdeveloped field that could provide insights into disease, drug response and cellular processes.
Orthopedic Patents Current Trends, Innovations and Future OpportunitiesJoseph Wyse
The document summarizes current trends in orthopedic patents, innovations, and future opportunities. It discusses how patents are used to create monopolies and extract licensing fees. The global orthopedic device market is projected to reach $41.2 billion by 2019, driven by aging populations and new technologies. The top 10 companies in orthopedics are profiled, with Johnson & Johnson projected to have the largest market share in 2020. Israeli companies and inventors are encouraged to target their innovations towards these large companies in order to monetize patents through licensing and reach patients.
This document discusses the concept of "megafunds" to help fund research and development for rare diseases. It notes that current sources of funding like venture capital and philanthropic venture capital are not enough to develop treatments for the over 7,000 known rare diseases. It proposes creating large pooled investment funds or "megafunds" that would attract funding from institutional investors by issuing bonds or debt backed by the intellectual property of a portfolio of drug development programs. This could open access to a larger pool of capital to fund more rare disease research more efficiently and at a reduced risk level through diversification. It provides examples of past proposals and discussions around this concept as a potential new model to help bridge the "valley of death"
The Medicines Patent Pool Presentation during the session "Market Interventions for Innovation and Access", UN High Level Meeting on HIV/AIDS
New York, 9 June 2011
The document provides an overview of Israel's Technological Incubators Program. It discusses how the program supports innovative startups through various incubators located around Israel. The program provides funding, facilities, expertise and other resources to help projects develop technologies and form startups. It highlights the government's significant involvement and discusses privatization efforts to strengthen the incubators. Statistics are given on the numbers of projects supported, fields of activity, and success metrics like private investments raised. Several high-profile Israeli tech companies that graduated from the incubator program are profiled as success stories.
Gino Martini, EIPG President
Presentation at Malta Qualified Persons Association-European Industrial Pharmacists Group-University of Malta joint seminar “The Successes And Challenges Of Today’s Pharmaceutical Industry”, Malta 2008.
The document discusses immune monitoring in vaccine trials. It provides context on regulatory requirements and the need for standardization. A variety of assays are used to assess cellular and antibody responses, including ELISPOT, flow cytometry, and neutralizing antibody assays [PRIMARY]. Challenges include the need for improved assays to measure antiviral function and mucosal responses. New technologies like single cell analysis and viral inhibition assays provide more detailed immune profiling but require significant bioinformatics support [SECONDARY]. The goal is to define immune correlates of protection to guide vaccine design, but this remains difficult without human challenge models [THIRDARY].
Mucosal immunity provides an important first line of defense against pathogens that enter through mucosal surfaces. Local mucosal responses are often short-lived, and systemic immunization is generally poor at inducing local immunity. Effective mucosal vaccines need to stimulate sustained mucosal responses through appropriate delivery methods, adjuvants, boosting, and routes of administration. More research is needed to better understand human mucosal immunity and develop vaccines that can induce protective mucosal immune responses.
During the last 30 years, several new vaccine technologies have made previously impossible vaccines possible. These include conjugate vaccines, reverse vaccinology, adjuvants, structural vaccinology, self-amplifying RNA, and lipid nanoparticle delivery systems. These innovations have allowed the development of vaccines for diseases like meningitis B, pneumonia, HIV, Ebola, Zika, and influenza, which were previously difficult to target. New vaccines are still needed to address major health challenges of the 21st century like emerging infections, poverty, and aging populations.
The document summarizes efforts to develop an HIV vaccine by inducing broadly neutralizing antibodies (bnAbs) through structure-based immunogen design. It describes how bnAbs isolated from infected individuals can inform design of immunogens that expose conserved vulnerabilities on HIV. Challenges include guiding antibody maturation along pathways to bnAbs and understanding how bnAbs develop naturally. Ongoing work includes defining HIV vulnerabilities with additional bnAbs and structures, understanding natural bnAb responses, epitope-directed and trimer-based immunogen design, and evaluating immunogens in collaboration between multiple research institutions. The goal is to develop an HIV vaccine to help curb the global AIDS pandemic.
Presentation by adrian hill [university of oxford]Pamoja
Malaria is a major global health problem, killing over 700,000 people annually. Developing an effective vaccine is challenging due to the parasite's complex life cycle and ability to evade the immune system. Current vaccine approaches include protein-adjuvant vaccines targeting specific stages, viral vectored vaccines to induce cellular immunity, and whole parasite vaccines. Significant progress has been made, but partial efficacy has required unprecedented immunogenicity. A multi-component vaccine targeting multiple stages may be needed for high efficacy.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Pharmacology of 5-hydroxytryptamine and Antagonist
Understanding the R&D landscape
1. The Power of Vaccines:
‘getting to zero’ for HIV and TB
Understanding the R&D funding
landscape
Roni Liyanage
Senior Policy Analyst
rliyanage@policycures.org
2. Outline
• About Policy Cures
• About G-FINDER
• Neglected disease R&D funding
• Vaccine R&D funding
• HIV & TB vaccine funding
• Key messages
3. About Policy Cures
Innovative ideas and
accurate analysis to
accelerate development
and uptake of new drugs,
vaccines, diagnostics and
other products for
neglected diseases of the
developing world
4. About G-FINDER
• An annual funding survey (2007, 2008, 2009,
2010)
– 31 neglected diseases
– 134 product areas
– All R&D stages
• Over 8,000 entries per year
– Data from 54 countries <INSERT PICTURE>
– Data from 240 organisations
• Funded by the Bill & Melinda Gates
Foundation
WHO/MALI
6. Total Neglected Disease R&D funding
$3,500
Millions
$3,000
$2,500
$3,063
$2,000
million
$1,500 invested in neglected
disease R&D in 2010
$1,000
$500
↓$109m (-3.5%)
$0
2007 2008 2009 2010
7. HIV & TB R&D funding
$1,200
Millions
HIV/AIDS TB
$1,000
$800
$600 HIV
$1.07 TB $575.4
BILLION $400
MILLION
Total spend on Total spend on TB R&D
HIV/AIDS R&D in 2010 in 2010
$200
35% 18.8%
of Global ND R&D $- of Global ND R&D
funding 2007 2008 2009 2010 funding
11. Top funders of neglected disease vaccine R&D, 2010
1 NIH $509m
2 Pharmaceutical Industry $223m
3 Bill & Melinda Gates Foundation $176m
4 US Department of Defense (DOD) $43m
5 US Agency for International Development (USAID) $33m
6 UK Department for International Development (DFID) $30m
7 European Commission: Research Directorate-General $27m
13. HIV & TB Vaccine R&D funding 2007-2010
$700
Millions
HIV/AIDS TB
$600
$500
$400
HIV
$589.9 $300 TB $81.9
million $200 MILLION
Total spend on HIV Total spend on TB
Vaccine R&D in 2010 $100 Vaccine R&D in 2010
$-
2007 2008 2009 2010
14. HIV Vaccine R&D funding – by funder type 2010
Industry
Philanthropic funding
funding 2% Top funders HIV Vaccine R&D, 2010
12% 1 US NIH $414m
2 Bill & Melinda Gates $65m
Foundation
3 USAID $27m
4 US DoD $25m
5 Industry $21m
6 UK DFID $14m
Public 7 European Commission $10m
funding
86% 8 The Wellcome Trust $4m
15. TB Vaccine R&D funding – by funder type, 2010
Other
Industry
2% Top funders TB Vaccine R&D, 2010
funding 1 Bill & Melinda Gates Foundation $30m
9% Public funding
49% 2 Industry $17m
3 US NIH $15m
4 UK DFID $10m
5 Health Protection Agency $4m
6 European Commission $4m
Philanthropic
funding
40%
16. Science & Technology Vs Aid funding
90% of public funding for HIV vaccine R&D came from
Science and Technology funding agencies in 2010
66% of public funding for TB vaccine R&D came from
Science and Technology funding agencies in 2010
17. European public funding of HIV Vaccine R&D
$70
Millions
$60 ↓$15.8m (-29%) in 2010
Norway
$50 Switzerland
France
$40
Sweden
Denmark $16.7m (-22%) in 2010
$30 From UK
Ireland
Netherlands
$20
European Commission
UK
$10
$10.8m (-36%) in 2010
$-
From EC
2007 2008 2009 2010
18. European public funding of TB Vaccine R&D
$35
Millions
$30 ↓$5.9m (-20%) in 2010
$25 Spain
Sweden
$20
Denmark
Switzerland $14.3m (up 21%) in 2010
$15 From UK
Netherlands
European Commission
$10
UK
$5
$4.0m (-45%) in 2010
From EC
$-
2007 2008 2009 2010
19. The HIV and TB vaccine portfolios
30
25
20
Preclinical Several products moving
15 Phase I into expensive late-stage
Phase II clinical trials
10
Phase III
5
0
HIV Vaccines TB Vaccine
21. Vaccine R&D funding for neglected diseases
• Funding is highly concentrated
• Mostly comes from:
• US funders
• Public sector
• Science and technology budgets
• Funding cuts at a time when several
promising products are entering late
stage development
22. Vaccine R&D funding for neglected diseases
- R&D pipelines need reliable long-term funding
- Financial pressures mean smarter funding will be needed:
- Outcome driven and flexible
- Aligned with product and portfolio developments
- Coordinated
- Targeted to deliver the highest health impact
23. It took a long time and a lot of effort to restart
neglected disease vaccine R&D but it is under
threat –
The time to act is NOW