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The Schizophrenia Prodrome ,[object Object]
Aims & Objectives ,[object Object],[object Object],[object Object]
Schizophrenia & it’s societal burden ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Natural History of Schizophrenia ,[object Object]
The early psychosis movement ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention of a disease ,[object Object],[object Object],[object Object],[object Object],[object Object],Prevention Universal Selective Indicated Early
What is Prodrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Universal prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic risk in Schizophrenia?
SELECTIVE: Genetically at risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ I don’t do any hard drugs” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Can Marijuana cause Schizophrenia: The Daithesis Stress Model ,[object Object],[object Object],[object Object]
Cannabis as a causal factor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Resources for Teens ,[object Object],[object Object],[object Object]
Why the Prodromal approach ,[object Object],[object Object],[object Object],[object Object],[object Object]
Risks & benefits of prodromal approach ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Early intervention
Progression of Prodrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],2/3=BS 2/3=APS 4=BLIPS Psychosis 1=UN
Predictive Basic Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Closed-in Approach or the UHR ,[object Object],[object Object],[object Object],[object Object],[object Object]
Attenuated positive symptoms ,[object Object],[object Object]
Brief Limited Intermittent Psychotic symptoms (BLIPS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
State and Trait Risk factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rationale for Preventive Intervention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Duration of Untreated Psychosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Cochrane review ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Cochrane review, contd: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PACE @ EPPIC  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PRIME Study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PRIME Contd: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EDIE ,[object Object],[object Object],[object Object],[object Object],[object Object]
EDIE-2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Call for early CBT interventions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vienna  ω -3 PUFA Study ,[object Object],[object Object],[object Object],[object Object],[object Object]
Omega-3 Fatty Acids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The North American Prodromal Longitudinal Study (NAPLS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
European Prediction of Psychosis Study (EPOS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Case for diagnostic criteria in DSM-5 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Attenuated Psychosis Syndrome DSM-V ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Deterministic to Probabilistic approach(es) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recommendations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Concept of recovery then to now…. ,[object Object],[object Object],[object Object]
Elyn Saks ,[object Object],[object Object],[object Object],[object Object],[object Object]
Carol. S. North M.D. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fall seven times, stand up eight.   Japanese proverb   ,[object Object],[object Object],[object Object],[object Object]
Future directions & Challanges ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Early intervention Clinics in USA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dr. Ashok. R. Shah  Dr. David. R. Rosenberg Dr. Rajaprabhakaran Rajarethinam Acknowledgements
Questions ???? ,[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object]

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The Prodrome of Schizophrenia

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  • 9. Genetic risk in Schizophrenia?
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  • 48. Dr. Ashok. R. Shah Dr. David. R. Rosenberg Dr. Rajaprabhakaran Rajarethinam Acknowledgements
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Editor's Notes

  1. Even if the illness can not be prevented altogether, early intervention will help the patient. The idea is to prevent the first psychotic breakdown and so to keep the patient well.
  2. Last 15 years have seen a systematic, international collaborative movement of clinicians and researchers has sought to modify and apply the principles and practice of early diagnosis and staged treatment akin to other areas of medicine such as cancer and cardiovascular diseases.
  3. Schizophrenia is a debilitating and
  4. Pandys maturation : Abnormal timing and pattern of acquisitions of milestones and growth retardation among high risk group. The limitation of Gnentic HR study is its inability to generalize the findings to all those who develop the diease.
  5. C
  6. The damage starts long before the patient comes to medical attention. So we want to shift the point far back to the point even before first psychotic episode. We want to Model is similar to the Framingham heart The Framingham Heart Study identified risk factors for coronary heart disease and developed an algorithm based on demographic variables
  7. The Framingham Heart Study identified risk factors for coronary heart disease. Current criteria, based on demographic and clinical features, are not yet sensitive enough to reliably predict future psychosis, nor are we able to predict future schizophrenia versus other Axis I disorders
  8. Yes, people with these severe mental illnesses can recover