The diet of our precursors was represented by plants and animals. This is to satisfy (still) human needs in proteins and lipids of about 1g / kg body weight each and about 100 grams of carbohydrates per day….
Learning Outcomes and Outline Delivery
Appreciate the importance of cultural factors in international management;
Compare different cultures using appropriate contextual frameworks and understand the complexity of culture within organisations
Develop effective communication and management strategies for future working practices within the international management environment and demonstrate the ability to communicate effectively in a group context;
Identify good practice for motivating and leading workforce of different cultural background.
This presentation outlines the historical, influences that came to shape our modern idea of cuisine along with the science that is helping us to understand how our sense of taste works.
A brief outline of advances in hair transplantation by Dr. Souvik Adhikari, a hair transplant surgeon. He practices the modern methods of hair transplantation with predictable results.
All forms of hair transplantation including FUT, FUE and BHT are performed by him in his hair transplant clinic in Kolkata. Corrective hair transplant surgery using unique methods is also performed by him.
For more details look into:
http://www.thehairclinic.co.in
Learning Outcomes and Outline Delivery
Appreciate the importance of cultural factors in international management;
Compare different cultures using appropriate contextual frameworks and understand the complexity of culture within organisations
Develop effective communication and management strategies for future working practices within the international management environment and demonstrate the ability to communicate effectively in a group context;
Identify good practice for motivating and leading workforce of different cultural background.
This presentation outlines the historical, influences that came to shape our modern idea of cuisine along with the science that is helping us to understand how our sense of taste works.
A brief outline of advances in hair transplantation by Dr. Souvik Adhikari, a hair transplant surgeon. He practices the modern methods of hair transplantation with predictable results.
All forms of hair transplantation including FUT, FUE and BHT are performed by him in his hair transplant clinic in Kolkata. Corrective hair transplant surgery using unique methods is also performed by him.
For more details look into:
http://www.thehairclinic.co.in
To learn more about diabetic foot wounds visit my website
www.healmyfootwoundfast.com
Educational power point on foot wounds relating to:
1. Obesity in America
2. The Epidemic of Diabetes
3. Complications of Diabetes
4. Cost Realities of Diabetes
5. Chronic Foot Ulcers
Dr. Donald Pelto
299 Lincoln Street Suite 202
Worcester, MA 01605
A look at the gastronomic delicacies of the ancient worldPeter Theodorou
Food science, gastronomic appreciation, cookery shows, culinary experimentation, etc., all seem modern concepts, which make us wonder how things were in the past.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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1. The history of nutrition
Giorgio Pitzalis
www.giustopeso.it
First part
The diet of our precursors was represented by plants and animals. This is to satisfy (still)
human needs in proteins and lipids of about 1g / kg body weight each and about 100 grams of
carbohydrates per day. Few plant products were then suitable for human nutrition, as
cellulose and lignin, the main structural components of plants, are not processable from the
human digestion. Those plants were then available for human nutrition mainly fruit and
berries (to cover the needs in carbohydrates and water), and semi nocispeci to cover the
needs in lipids and proteins. The rest consisted occasionally in animal products readily
available without tools and weapons (arthropods and other small animals).
What they ate the ancient Egyptians? Essentially the diet was based on bread (also spelled
flour leavened). The mixture could be enriched with fat, milk, eggs and spices, and with the
addition of figs and dates, you could also prepare sweet buns. The beer (quite different from
the modern) was very popular and appreciated by the Egyptians. It was a dense and highly
nutritious drink. The initial procedure of processing was common to that of bread. They were
prepared using the loaves of barley flour and you would cook only superficially, so as to leave
the inner raw and facilitate the subsequent fermentation that was occurring within large tubs
in which the so-called loaves from beer were crumbled, wet and left to rest with the addition
of flavoring substances, such as juice, dates, figs and carob. A wide variety of vegetables
enriched the table of the ancient Egyptians. Among the most consumed vegetables were
onions and garlic, sweeter and smaller than modern ones. Legumes were an important source
2. of protein for those who could not normally afford meat: in addition to chickpeas, broad
beans, peas and lentils, the Egyptians ate a native legume called Lubia, similar to the bean.
They were also spread many species of cucurbits, such as pumpkins and watermelons, and
cruciferous vegetables such as cabbage and radishes. Among the wild plants they were
appreciated parts of the papyrus and water lilies, in particular the water lily, the
hallucinogenic properties, and the lotus flower, whose seeds, ground into flour, could be used
to make a type of bread.
Were abundantly available dates and figs, eaten fresh or dried and used for the preparation of
sweets and as aromas during fermentation beverage. Even the carob was used as a sweetener
and could be cooked to prepare a kind of jam.
The oil was used both as a condiment, both for the preservation of food. The most common
were the oil extracted from the seeds of Moringa, very sweet and can keep a long time without
turning rancid, and sesame oil, with emollient and laxative. The olive tree instead hardly grew
in Egypt and olive oil was mainly imported. The aromas and spices were usually used to flavor
foods. Cumin and coriander were the most used, but were also found traces of celery and
parsley, myrtle, thyme and fenugreek, similar to curry; Instead pepper and cinnamon were
imported products. The meat then came to the table of the lower classes rarely, during special
holidays or during funeral celebrations, when the foods were distributed in honor of the dead.
The meat of cattle, roasted or stewed, was a delicious dish, which alternated the products of
hunting, wild animals of large size, such as the Oryx, buffalo, gazelle, ibex, chamois. The reeds
along the banks of the Nile were also the ideal environment for the practice of bird: ostriches,
pelicans, herons and cranes, geese, ducks and quails were not only used in the kitchen, but
they were also bred for the supply of eggs . The fish, readily available and cheap, was part of
the daily diet of most Egyptians and constituted a great alternative to meat. Instead of beer,
wine was a luxury drink that only the upper classes could afford. The vinification took place in
an almost similar to ours and, although the grape wine was the most popular, is also produced
one of dates, figs, very alcoholic, and pomegranate. The milk was difficult to maintain long-
term and this was consumed straight from the cow, still hot, or left to ferment naturally to
obtain a sort of butter or cheese. Honey was considered a valuable product, used in the
kitchen for the preparation of sweet or fermented drinks, in order to increase the alcohol
content. It was a product used in the medical field, thanks to its emollient and antibacterial.
They produced several quality, using flower nectar or honeydew; with honey diluted in water
and left to ferment was produced mead.
The food of the ancient Greeks. Iliad heroes ate roasted meat, especially kids, lambs and beef;
also they drank red wine, very dense and sour, which was diluted with water and honey.
Cheese Iliad and Odyssey speak little: it was mostly consumed goat's milk. Very important
element was the oil, while they were almost absent fruits, vegetables and fish, consumed only
in emergency situations. Odyssey power appears much more varied: the cultivation of wheat
and barley alongside horticulture and consumption of vegetables and salads and, in addition
to the fire, appear other ways to cook the food.
From the fifth century. B.C. the fish becomes the main dish nutrition Greek. In classical Greece
during banquets they were consumed olives, cheeses, wild onions (also known as wild onions
with a bow), various types of vegetables, cakes, fruits like figs and myrtle, all kinds of meat
and game. As desserts were appreciated starches, a kind of puddings and cakes or sweet buns,
all sweetened with honey. The Greeks loved the bread, in the form of cakes, soft rolls, often
flavored with rocket and thyme. They particularly appreciated the strong flavors and sour and
grew great use of spices, especially safflower, thistle, coriander and cumin; among the
condiments it was used marjoram, mint, myrrh, pepper, silphium (plant now extinct) and
thyme. The lower classes made extensive use of legumes, especially lentils, in the form of
3. soups, for their high protein content. Real delicacy was garon (garum Latin), a sauce that was
obtained by macerating together small saltwater fish whole, salted and dried in the sun. The
recipe was then somewhat restored in the Middle Ages by the monastic groups present on the
Amalfi Coast, which in August used to store salted anchovies in wooden barrels (mbuosti);
under the action of the salt, anchovies lost liquid seeping through the cracks of the barrels.
Power in Ancient Rome
The diet of the first inhabitants of Rome was represented mainly of vegetables and grain. The
production of the bread was of three qualities: one candidus, made of fine white flour,
secundarius always white but mixed with flour and finally the plebeius or rusticus a kind of
bread. Later, by the Etruscans he came to Rome in the habit of eating a food more varied and
rich in protein made up of both that game from farm animals. And when Rome came into
contact with the Greeks in the Hellenistic period of Ancient Greece from them he learned to
appreciate the fruits of olives and vines that had used until then, especially for religious rites.
From the age of Augustus, with the conquest of the East and the intense commercial relations
with Asia he arrived in Rome "everything that the earth produces beautiful and good 'and the
Roman power is refined: the food is understood as pure livelihood began in imperial times to
replace, even with the use of spices and aromas, taste and food culture, passing by the pure
power to the flavors.
The Romans divided their normal diet in three meals a day that at the beginning were called
ientaculum, dinner, vesperna and when it disappeared, was replaced by prandium. Rarely the
Romans devoted much attention to the first two meals that were never very nutritious and
most of the time abolished one of the first two. Martial describes his ientaculum consists of
bread and cheese, while the prandium consisted of cold meat, vegetables, fruit and a glass of
wine mixed with water. For the majority of the Romans before rushing to work the breakfast
was simple: a glass of water or something left over from dinner the night before and how to
prandium the poor and the common people certainly did not come back home for dinner but
most of the time They ate in tabernae where you could eat with bread commoner simple
dishes consisting of boiled eggs, cheese, vegetables and drinking wine mixed with hot water in
winter or cool in summer. He used to flavor foods with garum. The solid part was left by
maceration of small fish was the 'allec made to look like for our taste anchovy paste, but more
aromatic. For the main meal it was then dinner, which was for most of the first two equally
frugal meals. In essence, the vast majority of the Romans ate normally sitting on benches
(rarely on chairs) and around a table, as we do. In fact, Rome and the whole of society at the
time, consisted of a very broad popular layer made from poor or very poor, living in narrow
little rooms mostly for rent, with no kitchen, in the uncomfortable and dangerous islets, tall
houses up to eight floors. As the only crowded culina (kitchen) placed in the atrium of the
building common, a sort of courtyard, many were reduced to cooking the best with a warmer
in the middle of the room to prevent fire, and others were buying even in boiling water
thermopolium below (the bar at the time). These people could never afford couches (who
want a domus, a large house with spacious rooms and servants) and fine dining, if not - during
the Empire and putting aside savings - for the wedding dinner in triclinia rental put available
from tabernae (taverns). The time at which began the dinner was for the majority of the
Romans the same, the one that followed the bathroom: around 13-14 in winter and 15-16
after the summer. With the recognition of Christianity in 313 times Trimalcione are now
finished and the admonition of St. Ambrose, "who indulge in food and drink, does not believe
in the afterlife" is now the sign of a policy aimed at moralizing religious authorities remove
any excess, also as regards the power.
To be continued ....
Apicius, De Re Culinaria (Leiden: Sebastianus Gryphium), 1541
4. Jacques André. The alimentation et la cousine à Rome. Les Belles Lettres. Paris 1981
Antonella doses, Fançois Schnell. Eating with the ancient Romans. Rome 1984
Nico Valerio. The board of the ancients. Oscar Mondadori. Milano 1989
Case C. The kitchen in the ancient world. Archeology and history of food from prehistory to
the Middle Ages. Laurum 2009
Flandrin, J.-L. - Montanari, M. (ed) History of Food. Laterza 2011