The history of aquatic toxicology began with early classifications of poisons by Dioscorides and theories of toxicologist Paracelsus that the dose determines whether a substance is toxic. Through the Middle Ages and later, understanding of bioavailability and effects of chemicals like metals, industrial byproducts like methanol and lead, and environmental issues like acid rain, eutrophication, and uncleaned industrial waste developed toxicology as a field. Major events included Minamata disease from mercury in industrial wastewater in Japan and destruction of fish stocks from acid rain in Europe and North America. Remedies involved reducing sulfur in fuels and removing it from emissions to curb acid rain.