The document discusses the importance of nutrient management and the 4R nutrient stewardship framework (applying the right fertilizer source at the right rate, right time, and right place) for crop production and water quality. It notes several knowledge gaps around measuring nutrient loss and the impacts of various 4R practices. It also describes ongoing research projects and a new multi-state project that aim to quantify the effects of 4R practices on crop yields, nutrient losses to air and water, and soil health. The document advocates for farmer and advisor partnerships to promote 4R approaches and provides an example of improving yields and reducing costs through advanced 4R practices over time.