11.03.08(c): Histology of the Cardiovascular SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
Learning Objectives:
Compare and contrast the structure and function
of
Arteries
Veins
Capillaries
ulatory
system
Arteries
Arterioles
Capillaries
Venules
Veins
3 tunics
Lume
The Vessels
Functions:
Distribution of blood
Exchange of materials with tissues
Return of blood to the heart
Structure:
Most have the same basic structure:
– 3 layers surrounding a hollow lumen
11.03.08(c): Histology of the Cardiovascular SystemOpen.Michigan
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
Learning Objectives:
Compare and contrast the structure and function
of
Arteries
Veins
Capillaries
ulatory
system
Arteries
Arterioles
Capillaries
Venules
Veins
3 tunics
Lume
The Vessels
Functions:
Distribution of blood
Exchange of materials with tissues
Return of blood to the heart
Structure:
Most have the same basic structure:
– 3 layers surrounding a hollow lumen
IT WILL BE HELPFUL FOR IRREGULAR STUDENTS LIKE ME. YOU MAY COPY AND PASTE IT.
The circulatory system is an organ system that permits blood and lymph circulation to transport nutrients, oxygen, carbon dioxide, hormones, blood cells, etc. to and from cells in the body to nourish it and help to fight diseases, stabilize body temperature and pH, and to maintain homeostasis.
This system may be seen strictly as a blood distribution network, but some consider the circulatory system as composed of the cardiovascular system, which distributes blood, and the lymphatic system, which returns excess filtered blood plasma from the interstitial fluid (between cells) as lymph. While humans, as well as other vertebrates, have a closed cardiovascular system (meaning that the blood never leaves the network of arteries, veins and capillaries), some invertebrate groups have an open cardiovascular system. The more primitive, diploblastic animal phyla lack circulatory systems. The lymphatic system, on the other hand, is an open system providing an accessory route for excess interstitial fluid to get returned to the blood.
Powerpoint presentation about nutrient support. This has the process on how nutrients were taken, absorbed, utilized and how waste materials were eliminated in the body.
The Cardiovascular System Essay
The Circulatory System
The Circulatory System Essay
Circulatory System Essay
The Circulatory System Essays
Circulatory System
The Circulatory System
The Circulatory System
The Cardiovascular System Essay
HUMAN CIRCULATORY SYSTEM CHAPTER 8 - CBSE BIOLOGY CLASS-VIIBIOLOGY TEACHER
* Circulatory System: This system is concerned with the circulation of body fluids to distribute various substances to various body parts. The circulatory system is also known as the cardiovascular system.
Similar to The Cardiovascular System -- HEART -- Histology -- جهاز الدوران (20)
My report . (wbc count)
Report to practical physiology .
......
University of AL_Ameed .
College of Dentistry .
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Telegram : @Goldenalzaidy
Instagram : goldenalzaidy
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تقرير كامل ومفيد عن طريقة حساب عدد الكريات البيض تستطيع اعادة صياغته وتقديمه
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My report . (anemia disease)
Anemia Report to practical physiology .
......
University of AL_Ameed .
College of Dentistry .
________________________________
Telegram : @Goldenalzaidy
Instagram : goldenalzaidy
__________________________________
تقرير كامل ومفيد عن مرض الانيميا تستطيع اعادة صياغته وتقديمه
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haemophilus -- Bactriology
هذا العرض يتحدث عن احد اخطر انواع البكتريا وهي التي تتغذا على مكونات الدم بالتحديد
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https://t.me/GoldenAlzaidy
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youtube روابط لشرح الموضوع على ال
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https://www.youtube.com/watch?v=QCMj9d5QBpU&t=22s
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https://www.youtube.com/watch?v=fM_vLqzxLZg&t=4s
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https://www.youtube.com/watch?v=ymegUm0UB7c&t=206s
The skin : هذا العرض يتحدث عن الجلد الذي يعتبر اكبر عضو بالجسم وشرح الطبقاة المكونة للجلد :
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https://t.me/GoldenAlzaidy
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youtube::: https://www.youtube.com/watch?v=Orumw-PyNjw
Pdf - water bath - Laboratory Applications.Ameen ALzaidy
water bath..
هذا العرض التقديمي يتحدث عن الحمام المائي المستعمل بالمختبرات العلمية بشكل واسع بالتجارب الكيميائية .....
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https://t.me/GoldenAlzaidy
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youtubeروابط لمشاهدة هذا الجهاز على اليوتيوب....
1- https://www.youtube.com/watch?v=bDd74KsIUME
2- https://www.youtube.com/watch?v=JzvOQUifFRY
3- https://www.youtube.com/watch?v=hM6nAkFbW1U
Water bath ... اجهزة مختبرية- الحمام المائيAmeen ALzaidy
Water bath.
هذا العرض يتحدث عن الحمام المائي المستخدم بالمختبرات العلمية ...
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https://t.me/GoldenAlzaidy
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
عرض تقديمي عن مادة
الــEDTA
Ethylene diamine tetra acetic acid
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https://t.me/GoldenAlzaidy
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(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
The Cardiovascular System -- HEART -- Histology -- جهاز الدوران
1. The cardiovascular system, also called the circulatory system, is an organ
system that permits blood to circulate and transport gases and nutrients
through the body.
The major functions of the circulatory system are
1. Transport oxygen and carbon dioxide to and from tissues.
2. Transport nutrients, waste products and hormones.
3.Regulates body temperature and pH, and maintain homeostasis.
The Cardiovascular System
2. 4. Play a role in the immune response.
5. Maintain appropriate environment in all the tissue fluids of
the body for optimal survival and function of the cells,
The major components of cardiovascular system are blood,
heart, and blood vessels
3. HEART
The heart is a muscular pump that maintains unidirectional flow of
blood. The heart contains four chambers, the right and left atria and
right and left ventricles, through which blood is pumped. valves guard
the exits of the chambers, preventing 3 backflow of blood.
4. Cardiac Cycle
The term cardiac cycle refers to the repetitive pumping process that
begins with the onset of cardiac muscle contraction and ends with the
beginning of the next contraction. Pressure changes produced within the
heart chambers as result of cardiac muscle contraction are responsible
for blood movement because blood moves from areas of higher pressure
to areas of lower pressure.
5. Atrial systole is contraction of the atria and ventricular systole is
contraction of the ventricles. Atrial diastole is relaxation of the atria
and ventricular diastole is relaxation of the ventricles. when the atria
are relaxed, blood flows from the superior and inferior vena cava to
the right atrium and through the pulmonary veins to the left atrium
6. The following factors affect cardiac output:
u he basic level of body metabolism
(2) whether the person is exercising
(3) the person's age, and
(4) size of the body.
7. Blood vessels
Blood vessels are an extensive tubular network that transports blood
throughout the human body, carry the blood from and to the heart,
There are five major types where of blood vessels
8. ✔️⭕⭕Arteries, are blood vessels that carry the blood away from the
heart to the e tissues under high pressure. For this reason, it have
strong vascular walls, and blood flows at a high velocity in the arteries
✔️⭕⭕Arterioles, are the last small branches of the arterial system: they
act as control conduits through which blood is released into the
capillaries, The arteriole has a wall that can close the arteriole
completely or can dilate it strong muscular several fold.
9. ✔️⭕⭕capillaries, are tine blood vessels, enable the actual
exchange of water and nutrients between the blood and the
tissues. The capillary walls are very thin and have numerous
minute capillary pores permeable to water and other small
molecular substances,
✔️⭕⭕Venules, collect blood from the capillaries, and they
gradually convene into progressively larger veins.
✔️⭕⭕Veins, are blood vessels that carry blood from the venules
back toward the heart, they serve as a controllable reservoir for
the extra blood. The pressure in the venous system is very low,
and the venous walls are thin.
10. The circulation is divide in to:
1. The systemic circulation: It is also called the greater circulation or
peripheral circulation. It supplies blood flow to all the tissues of the body
except the lungs, and the vessels called the snemic vessels, which transport
blood through all parts of the body from the left ventricle and back to the
right atrium. Blood flowing through Pulmonary croulation systemic vessels
supplies oxygen and nutrients to all tissues of the body and carries away
carbon Sugeror dioxide and waste. vena cava
11. 2. The pulmonary circulation: It is Heart-7% carries blood flow from
heart to the lungs, and their vessels called the pulmonary vessels,
which transport Antanes-131i blood through the lungs from the right
ventricle and back to the left capillanes-7Ni atrium. Blood flowing
through pulmonary vessels takes up oxygen through the lung and
releases carbon dioxide.
12. Two circuits distribute blood in the body
✔️⭕⭕1_. Pulmonary circulating conveys blood from the heart to the
lung and from the lung to the heart
Right Ventricle ➡️Pulmonary artery ➡️Lung ➡️Pulmonary Vein➡️Left
Atrium
✔️⭕⭕2._ Systemic circulating conveys blood from the heart to other
tissues of the body and from other tissues to the heart
Left Ventricle ➡️Aorta ➡️Larage and Small Arteries ➡️Arterioles
➡️Capillaries ➡️Venules ➡️Small and Large Veins ➡️Right Atrium
13. Basic Theory of Circulatory Function
the The function of the circulation is to service the needs of the body
tissues, where heart and circulation are controlled to provide the
necessary cardiac output and arterial pressure to cause the needed
blood flow to tissue, There are three basic principles that underlie the
controlled rate of blood flow through most tissues:
14. 1_The rate of blood flow to tissues of the body is always
controlled in relation to the tissue need.
2. The cardiac output is controlled mainly by the sum of all the
local tissue flows.
.3 The arterial pressure is controlled independently of either local
blood fow control or cardiac output control.
15. The Blood
Blood is a bodily fluid in humans that delivers necessary substances such as
nutrients and oxygen to the cells and transports metabolic waste products
away from those same cells. Blood is a type of connective tissue that
consists of blood cells suspended in liquid matrix (blood plasma); and
accounts for 7% of the human body weight. The average adult has a
blood volume of roughly s liters, which is composed of plasma (constitute
about 54% of whole blood) and several kinds of blood cells (red blood
cells (about 45%), white blood cells, and platelets dess l%), accounts for
the remaining volume