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Pediatric anesthesia
The Basics and Beyond
  Ahmad Abou Leila MD
   Dr.Roland Kaddoum
Presentation facts and objectives

        125 slides(72+53)

REVIEW the Peds anesthesia basics

         Updated Basics

 Some of the SVI mission in Egypt
Infants are not small adults
Different Anatomy
  Different Physiology
Different Pharmacology
 Different psychology
Different Approach and preparation




Better understanding of peds
    anesthesia principles
The different Physiology
Limited blood volume
   80ml/kg(full term)
Limited stroke volume
CO=SV x HR
CO=SV x HR
High Heart Rate to maintain CO
The parasympathetic system is mature in newborns
Dominant




                      Vagotonic




50% of apparently healthy babies
24 hours EKG recording
Have shown rhythm changes resembles complete 2:1 Block
Anything causes bradycardia
Hypoxia,hypothermia,laryncoscopy
Affect the CO
Pediatric Fundamentals – Heart and Circulation
                         Normal heart rate

                     Age (days)          Rate
                      1-3               100-140
                      4-7                80-145
                      8-15              110-165

                      Age (months)        Rate
                       0-1               100-180
                       1-3               110-180
                       3-12              100-180

                       Age (years)         Rate
                        1-3               100-180
                        3-5                60-150
                        5-9                60-130
                        9-12               50-110
                       12-16               50-100
HIGH HR……..Risk of fatigue
      compensation

     LOW afterload
Lowest acceptable SBP=70 + (age x2)
CO can be assessed clinically by stethoscope

Heart sounds become softer and muffled in low CO states
Contractile element is 30%
         (60%in adults)

Starling law is at maximum
Cannot tolerate volume overload
Thin wall atria and ventricle
Risk of tamponade during central line
             insertion
Born T wave upright in all chest leads



  In few hours T wave isoelectric or
        inverted in left chest



In 7 days T wave inverted in the Right
         chest leads (V1-V4)


Failure of T wave inversion in V1-V4 is
 the earliest sign of RV hypertrophy
Respiratory System
Almost all cardiac arrest due to
    respiratory problem
Limited AP expansion
Limited Lateral expansion


Ventilation depend on the
        Diaphragm
Diaphragm in neonates and
           infants<2y
          easy fatigue
(lacks the Type I muscle fibers )
Any restriction of the Diaphragm movement
       Results in respiratory difficulties


stomach inflation due to forceful inflation
         will hinder ventilation
High Risk of barotrauma on MV -PCV
Small lung volume relative to their body size

 Small FRC

High RR to maintain the FRC

High RR on MV
Under general anesthesia, FRC declines by




  10-25% in healthy adults
  35-45% in 6 to 18 year-olds
General anesthesia, FRC and PEEP


PEEP
       important in children < 3 years
       essential in infants < 9 months




Mean PEEP to resore FRC to normal
      infants < 6 months 6 cm H2O
      children                    6-12 cm H2O
Higher O2 Consumption
      6ml-7ml/kg
    Adults (3-4ml/kg)
   rapid desaturation
Aspiration Risk




Children < 3 years at greater risk of aspiration
No muscle
   Higher
                              relaxants
incidence of
                            Inadequate
    GERD
                             anesthesia

                 Short
               esophagus


  Limited                   Excessive air
 stomach                     swallowing
compliance                  during crying


               Baby trust
4 hours




6 hours




8 hours
Encourage water intake within two hours
Less dehydration
  (better induction
hemodynamic profile)




Less agitation and crying




   Promotes motility
Decrease gastric volume
Neonatal period the HB is HBF



HBF has high affinity to O2 ……P50 is ………
HBF decline with age
HBA peaks at 9 month
O2 dissociation curve shifts to the right by acidosis(more delivery)
O2 dissociation curve shifts to the left by alkalosis (less delivery)
MV in neonates avoid the hyperventilation induced alkalosis
P50   Hgb for equivalent tissue oxygen delivery
Adult        27            8     10     12
> 3 months   30            6.5    8.2    9.8
< 2 months   24           11.7   14.7   17.6
Implications for blood transfusion
        older infants may tolerate somewhat lower Hgb levels at which
        neonates ought certainly be transfused
Maximal allowable blood loss MABL: EBV x (Hcti-Hctf)/averaage Hct
Neonates have immature WBCs function ..risk of infection is high
Vitamin k dependent factors(II,VII,IX,X)
             20-60% of adult values

       Infants of mother who have received
 anticoagulation may develop severe bleeding like
                Vitamin K deficiency



Babies on MV showed significant thrombocytopenia
Large surface area relative to body weight(2-2.5x BW)
Thin skin and subcutaneous fat( less insulation)
Neonates no shivering
Immature thermoregulation center
Forced air warming systems always available
Fluid warmer
Room temperature
Infant kidneys
immature function at birth:

   GFR (‘til 2 years old)
   concentrating capacity
   Na reabsorption
   HCO3 /H exchange
   free H2O clearance
   urinary loss of K+, Cl-
What it means:

Newborn kidney has limited
capacity to compensate for
volume excess or
volume depletion
Maintenance Fluid Therapy

Term Newborn (ml/kg/day)
  Day 1     50-60            D10W
  Day 2     100              D10 1/2 NS
  >Day 7 100-150             D5-D10 1/4 NS
Older Child:    4-2-1 rule
Hourly Maintenance Fluids


                  4:2:1 Rule
4 ml/kg/hr 1st 10 kg +
2 ml/kg/hr 2nd 10 kg +
1 ml/kg/hr for each kg > 20
Rules 1

    Always Use volumetric Chambers or
                Microdrip
  (infusion pumps may continue to infuse
through dislodged catheters with out alarm)
Rule 2

       Warm up all infused fluid
      Crystalloids safe up to 54 C
Blood safe up to 42 C..risk of hemolysis)
Rule 3
Include dextrose in the maintenance hydration
     fluid (Dextrose 1% or Dextrose 2.5%)
        Risk of Hypoglycemia is higher in
                   Premature
        Sick babies(malnutrition,cardiac)
              Regional anesthesia
                Glucose infusion
hypoglycemia
      Apnea
    Cyanosis
Respiratory distress
    Limpness
    Sweating
     Seizures
Rule 4

Replace Deficits,losses, and bleeding by
 isotonic fluid (not glucose containing
                  fluid)
        Risks of Hyperglycemia
Rule 5
Monitor intravascular volume closely by
                   BP
                 UOP
                  SVV
             Heart sounds
           Warm extremities
             Capillary refill
Rule 6
  Montior electrolytes closely
Risk of Hyponatremia..Na losers
     Risk of hyperkalemia ..
        blood transfusion
         >1-2ml/kg/min
Different anatomy
Short distance between tongue and
             the glottis


 Tongue easily obstruct the airway




 Proximity of tongue to glottis
   visualization more difficult
more angulation between the oral
   axis and the laryngeal axis




  Straight blade preferred more
     effectively in tongue lift
Epiglottis axis acute angle with airway axis..more
                   difficult to lift
                         Stiff
 Omega shape ,touch the soft palate(easy airway
                    obstruction)
Large occiput (flexed head)
       Till one year
Shoulder Roll
(deflex the head + stabilize the head)
  Extreme extension will cause obstruction

    Head parallel to the ceiling
The narrowest area is…………………………….
MRI at level of cricoid cartilage (not
MRI of sub vocal cords area
                                              ring)
Bronchoscopy of glottis area
and sub glottis                Bronchoscopy of cricoid cartilage
Abide to the rules of ideal tube
           selection

         Tube Size
 Age(yrs)/4 +4(un cuffed)
         for cuffed tube
       Age(yrs)/4 +3.5
Subvocal cords area is the narrowest




               Don’t push the tube through tight glottis opening
                          Prepare smaller tube size
un-Cuffed

Cuffed
Radiologic evidence
            Airway is oval not circular




                  Clinical evidence
No difference in incidence of post intubation croup
         No complications in cuffed tube
Cuffed tubes can be used in kids< 8 years
Neonates have reduced incidence of
       subglottic stenosis
               Immature cartilage
         High water content in cartilage
      Less susceptible for ischemic injuries
Short Neck

Short trachea



Risk of endobronchial Intubation
Airway management

  Depth of insertion
    Age/2 + 12
   Age (yrs) + 10
Depth of insertion
    One study used CXR to confirm the correct placement of
                            tube
    The foot length was accurate as weight based formulas




                Tube size X 3
Other uses of Tube size




   Tube size
   2 X Tube size=size of NG tube
   3 X Tube size =Depth of tube insertion
   4 X Tube size =size of chest tube
Intubation using Left molar approach
1. Left-molar Approach Improves the Laryngeal View in Patients with
         Difficult LaryngoscopyAnesthesiology. 2000 Jan;92(1):70-4 Full Text

  2. Comparative Study Of Molar Approaches Of Laryngoscopy Using
Macintosh Versus Flexitip BladeThe Internet Journal of Anesthesiology 2007 : Volume 12
                                      Number 1
 3. The use of the left-molar approach for direct laryngoscopy combined
  with a gum-elastic bougieEuropean Journal of Emergency Medicine December 2010
                                    ;17(6):355-356
Another anatomical difference


      Spinal cord ends at L3
     In adults it ends at……..


Be cautious in neuroaxial anesthesia
         Lumbar puncture
Epidural or caudal block LOR with saline
    LOR with air not recommended
Pharmacological difference
More free fraction of medication
              Greater effect                    Water soluble Drugs will distribute more
       Drugs high protein bound               Higher loading dose to achieve desired serum
         Altered protein binding
               Barbiturates                                      levels
                                                       High Volume of Distribution
               Bupivacaine                                  Muscle relaxants
                Alfentanil                                     Antibiotics
                Lidocaine




       Drugs that redistribute to fat
  Have larger initial peak levels (Opioids)
    Small proportion of fat and muscles           Immaturemetabolism and excretion
                                                   Delayed Kidney and liver functions
Less muscle mass (more sensitive to muscle
                 relaxants)
Inhalation agents
MAC



          HIGHER MAC
Highest MAC in infants 6 months and
              1 year
Fast induction
Greater Alveolar         High cardiac out
                                                 Reduced tissue
ventilation to FRC       put to vessel rich
                                                 blood solubility
       ratio               organs(brain)



                     Fast inhalation induction
SEVOFLURANE
HALOTHANE




ISOFLURANE
DESFLURANE




              97
When to intubate?
Pediatric psychology
Pediatric Perioperative
        anxiety
40%-60% of infants experience
    perioperative anxiety




Highest incidence 1-5 years
Consequences




Bad dreams, wake up crying or walking




         Disobeying parents




         New onset enuresis
Crying leads to aerophagia and then stomach inflation
  Higher risk of aspiration and inefficient ventilation
Parental presence induction
     anesthesia(PPIA)


           To date the experimental evidence doesn’t
                support the routine use of PPIA
Pharmacologic intervention superior to
         other intervention




       Parent are less anxious
Midazolam is most commonly used(85%)

0.5mg/kg PO is the best dose(less side effects , and rapid
                         onset)
Impulsive children shows paradoxical
response to Midazolam
Early infancy (neonate to about 7 months of age):
       Parents are the primary focus
       Comfortable separation in preop holding area usual
Later infancy to about 5 years:
           Separation anxiety major

          Selected parental presence

Midazolam 0.5 mg/kg orally 10 min before separation
>6 years: Child becomes primary focus.
        Explain exactly what will happen; what you will do
        Then do it that way. (Be trustworthy!)
Less insufflation pressure
6mmHg for infants
12mmHg for children
Abdomen insufflation causes vagal stimulation
Abdomen insufflation with Cold CO2
Increase the risk of hypothermia
Abdomen insufflation
Trend position
Higher risk of endobronchial intubation
Higher risk of Hypovolemia
Longer time for bleeding control
Indication for Cuffed ET tube
Higher risk of aspiration
Accurate CO2 sampling
Infants < 5 kg
Peri-umbilical area shouldn’t be used for port access
Risk of umbilical artery injury
This lecture is posted on
www.anesthesia-resident.blogspot.com
Thank you all
And have a nice day

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