This document provides information on tablet coating. It discusses why coating is necessary, the main types of coatings including sugar coating, film coating and enteric coating. It outlines important coating parameters and compositions. It also describes some common coating defects and how to troubleshoot them. Finally, it introduces some coating equipment and Ideal Cures coating products, including their Instanute and Instamodel lines.
Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug. Several troubleshooting problems such as twinning mottling, chipping, etc., may arise during or after or even during the shelf life of the film coated dosage forms. These troubleshooting problems may be due to tablet core faults, coating formulation faults and/or coating process faults. These problems must be overcome to avoid unnecessary product problems. Film coating as well as other parts of the pharmaceutical technology is subjecting to continuous innovation. The innovation may be at different levels including pharmaceutical excipients, processes, software, guidelines and equipment. In fact, of particular note is the growing interest in process analytical technology, quality by design, continuous coating processing and the inclusion of new ready for use coating formulations. In this review, we tried to explore and discuss the status of pharmaceutical film coating, the challenges that face this manufacturing process and the latest technological advances in this important manufacturing process.
Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug. Several troubleshooting problems such as twinning mottling, chipping, etc., may arise during or after or even during the shelf life of the film coated dosage forms. These troubleshooting problems may be due to tablet core faults, coating formulation faults and/or coating process faults. These problems must be overcome to avoid unnecessary product problems. Film coating as well as other parts of the pharmaceutical technology is subjecting to continuous innovation. The innovation may be at different levels including pharmaceutical excipients, processes, software, guidelines and equipment. In fact, of particular note is the growing interest in process analytical technology, quality by design, continuous coating processing and the inclusion of new ready for use coating formulations. In this review, we tried to explore and discuss the status of pharmaceutical film coating, the challenges that face this manufacturing process and the latest technological advances in this important manufacturing process.
Tablet defects can come from any of the unit operations upstream and from the tablet press. The raw materials may be of poor quality or do not meet specifications, causing excessive fines that lead to a host of defects. The formulation may be the source of defects if the material does not compress well or the processing step specified within the formulation fail to produce a powder with a good flow, compressibility, and ejection properties. The processing and granulation of powder are often the sources of the defect.
Every product behaves differently on a tablet press, even if it‘s the same product run on a different day. The variation often
stems from changes in the properties of the raw materials—active ingredients and excipients- from batch to batch. Naturally,
the goal is to minimize these changes. Tablet press operators, however, don‘t have any control over formulation and
granulation. Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others. This article focuses on these variations. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems.
Tablet defects can come from any of the unit operations upstream and from the tablet press. The raw materials may be of poor quality or do not meet specifications, causing excessive fines that lead to a host of defects. The formulation may be the source of defects if the material does not compress well or the processing step specified within the formulation fail to produce a powder with a good flow, compressibility, and ejection properties. The processing and granulation of powder are often the sources of the defect.
Every product behaves differently on a tablet press, even if it‘s the same product run on a different day. The variation often
stems from changes in the properties of the raw materials—active ingredients and excipients- from batch to batch. Naturally,
the goal is to minimize these changes. Tablet press operators, however, don‘t have any control over formulation and
granulation. Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others. This article focuses on these variations. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems.
It is an interesting material for all drug enthusiasts around the world. a lot of effort was put into it and I hope that it will benefit everyone in the slide share family.
Tablet coating engineering is one of the prominent topics in pharmaceutical field.
This slide will help pharmacy student to become familiar with coating technology
This presentation includes basics of coating operation of pharmaceutical tablets.
The following are discussed in detail:
1. What is coating
2. Reason for Tablets coating
3. Types of coating
4. Differences between sugar coating and film coating.
5. Steps of sugar coating
6. Advantages of Sugar coating
7. Disadvantages of Sugar coating
8. Advantages of pigment over dye
9. Mechanism of film formation in film coating
10. Materials used in film-coating
11. Immediate release coating
12. Modified release coating
13. Polymer characterization
A Review on TABLET COATING & A DETAILED STUDY OF ENTERIC COATING OF TABLETVishal Shelke
A Review on TABLET COATING & A DETAILED STUDY OF ENTERIC COATING OF TABLET
by Mr. Vishal Shelke
Sub :- Final Year B.Pharm Project (50 Marks)
B.Pharm Sem VIII
College :- Rajarambapu College of Pharmacy, Kasegaon
Shivaji University Kolhapur.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
3. WHY NECESSARY ???
Coating is the process that involves application
of coating polymer film to the core tablet.
• Mask Bitter taste.
• Mask unpleasant odour.
• To increase the Product Stability, that
is to protect from
Light
Moisture
Oxidation
• To modify the drug release profile.
• Reduce operator exposure to active substance.
• Reduce damage during packaging process.
• For Product identity.
5. SUGAR COATING
• As the name suggests, this process involves application of sugar
(sucrose) based coating solution to the tablets.
• This is a highly skilled, multistep process that is very labour
intensive.
• Sugar coated products are aesthetically pleasing and have wide
consumer acceptability.
Steps involve in sugar coating
Seal-coating
Sub-coating
Syruping(smoothing)
Finishing
Polishing
Printing
6. • Seal coating: To prevent
moisture penetration to the
tablet core.
• Sub coating: To round off
the Sharpe edge of core.
• Smoothing: To smooth the
rough core surface
7. • Coloring : To obtain uniform
color
• Polishing : To enhance gloss.
• Printing: Use edible ink and
print by inkjet or pad printing
process.
8. FILM COATING
• It involves the application of a thin film of polymer material to
tablet surface.
• Film thickness range 20-200 μm
• Substantial reduction in quantity of coating applied (2-4% for
film coating, compared with 50-100% for sugar coating)
• It is a single stage coating process in which coating solution
includes:
– Plasticiser
– Polymer
– Solvent
– Colorant
9. ENTERIC COATING
• This coating facilitates the acid labile drug from the
gastric pH, bypass the stomach and release of drug in
intestine.
• To prevent gastric stress due to drug irritation.
• To provide delay release of drug.
10. COATING PARAMETERS
1. Effect of pan load
Under load lead to over wetting of tablet and overloading pan
lead to turbulent air flow pattern to tablet bed.
2.Spray Gun position
– 6-18 inches from the tablet bed
– 450 angle to the tablet bed
– spray gun too far :
Overlapping spray band
– Spray gun too close:
Over wetting may occur.
11. 3. Air volume and temperature
Balance the inlet and exhaust air flow rates such that there
is slight negative pressure in the chamber.
It is important to monitor the following three temperatures.
1. Inlet Air temperature (45-500C)
2. Tablet Bed temperature (40-450C)
3. Exhaust air temperature (35-450C)
4. Spray distribution
Spray gun having airless spray don’t control flow rate of
suspension and droplet so not recommend for aqueous
coating.
Air automized gun control flow rate of suspension and
droplet size.
12. Coating Composition
Polymers/ Film Former: it is long chain organic molecule. The
vicosity, film strenght and elasticity increase with polymer
chain length. Eg: HPMC, PolyVinylAlcohol,
PolyEthyleneGlycol
Plasticizer : It decrease the elasticity and increase the plasticity
of the polymer. Eg: PEG, Propylene Glycol,
Solvent: It is the medium in which coating materials disperse.
Eg: water, IPA , methylene chloride.
Colorants : For ease of product identification. Eg: Quinolin lake
color, Tartrazine lake color
13. COATING TROBULE SHOOTING
COATED TABLET DEFECTS CAUSE REMEDY
Sticking and Picking Coating solution spray rate
too high.
Pan speed too low
Low tablet bed temp
Optimize the spray rate.
Increase pan speed
Increase tablet bed temp.
Orange Peel Effect Too rapid drying.
High viscosity solution.
Decrease in drying rate.
Use Instacoat high solids low
viscosity system.
Twinning Tablet shape too flat or
capsule shape
Insufficient inlet air volume
Change tablet shape.
Increase inlet air volume.
14. COATED TABLET DEFECTS CAUSE REMEDY
Roughness Tablet too hygroscopic
Poor tablet surface hardness
i.e friable core.
Minimize superdisintegrants
in formulation.
Modify the formulation
Bridging/Filling Poor logo design in core
tablet.
Low plasticizer in
formulation.
High gun to bed distance
Improve logo design.
Increase plasticizer.
Decrease the distance.
Color Variation Improper mixing of the
tablet in the coating pan.
Poor opacity in coating
formulation.
Increase pan rpm or modify
baffle design.
Use optimized instacoat
coating system.
15. COATING EQUIPMENT
• Conventional coating pan
Circular metal pan(mounted
angularly on a stand)
8-60 inches in diameter
Rotated on its horizontal axis by a
motor
heated air is supplied by inlet air
supply
Exhaust by means of ducts
use of atomizing system to
produce even distribution of
coating soln or suspension
17. Perforated coating pan
• Accela cota system
• Pan is fully perforated.
• Contains mixing blades.
• Inlet air is by a plenum in contact
with the top of the pan.
• Air is exhausted by a plenum
located below the pan.
20. Spray guns on basis of port
Port Two Port Gun Three Port Gun Four Port Gun
Port 1 Coating
Suspension
Coating
Suspension
Coating
Suspension
Port 2 Operating Air Operating Air Operating Air
Port 3 Atomizing Air Atomizing Air
Port 4 Pattern Air
ABC gun is used widely nowadays!!!
21. ABC spray gun
• Breading blocks liquid and air orifices, distorted spray
distribution and require frequent cleaning of gun.
• Thus Anti Breading Cap gun is used for smooth spraying.
Some Examples : Standard gun with horns, schlick ABC series
spray gun.
23. INSTANUTE IMMEDIATE RELEASE FILM COATING
Brand name polymer reconstitution
INSTACOAT 4G PVA 35% (AQUEOUS)
INSTACOAT EHP PVA 25% (AQUEOUS)
INSTA COAT AQUA II Graft PVA 20% (AQUEOUS)
INSTA COAT AQUA III HPMC 15% (AQUEOUS)
INSTACOAT UNIVERSAL HPMC 11% (AQUEOUS)
INSTACOAT P4 Sodium alginate 20% (AQUEOUS)
24. INSTANUTE MOISTURE BARRIER COATING
Brand Name Polymer Reconstitution
INSTACOAT EMB PVA 20% (AQUEOUS)
INSTACOATSHIELD AQUA II PVA 25% (AQUEOUS)
INSTACOATSHIELD HPMC AND EC 5% (ORGANIC)
INSTANUTE DELAYED RELEASE
Brand Name Polymer Reconstitution
INSTACOAT EN SUPER-II METHACRYLIC ACID
COPOLYMER
20% (AQUEOUS)
INSTACOAT EN SUPER-IV METHACRYLIC ACID
COPOLYMER
25% (AQUEOUS) /
9%(ORGANIC)
INSTACOAT EN HPMC-P HPMC PTHALATE 5% (ORGANIC)
25. Why INSTANUTE Series???
• Rapid reconstitution in water that contribute to speed
up process and save time.
• Aqueous processing promotes safe working
environment
• Aqueous processing prevents atmosphere pollution.
• Easy scale up and transfer to different equipment sites
• Enhance stability, longer shelf life.
26. Speciality Products
• INSTAGLOW : It is a dry ready to mix polishing system that can
be reconstitute in water or organic solvents. It enhance coated
tablet appearance at lower weight gain (0.5%).
• INSTASPRAY: It is a customized pigmented dispersion for tablet
film coating. It provide fast batch to batch color uniformity.
• INSTAMASK: It is a tailor made Potassium polyacrylates system
for taste masking. It is use in bitter drug like ceterizine,
azithromycin, ofloxacin.
• INSTA FLAVOUR: It is used to improve palatability.
27. Ideal Cures Approach : Instamodel blend
• Instamodel blend:
• It consists of hydrophilic polymers, pH sensitive polymers and
other GRAS excipients providing matrix system producing
predefine release pattern
• It fulfill the formulation of Extended release dosage form.
• Meets the dissolution requirement of various pharmacopoeial
monographs.
• Cost effective and ready to use.
28. Ideal Cures: Existing custom formulation
• INSTAMODEL for Gliclazide 30mg.
• INSTAMODEL for Metformin 500mg and 1000mg USP
• INSTAMODEL for Diclofenac sodium 100mg USP
• INSTAMODEL for Aceclofenace 200mg
• INSTAMODEL for Acetaminophen 650 mg USP
29. IDEAL CURES : Regulatory Compliance
• Product developed using Instamodel reportedly compatible
with drug substance and having pharmacopoeial monograph or
GRAS status.
• Dissolution criteria shown to be in compliance with
pharmacopoeial monograph and benchmarked to the
international inventor brand.
• Stability studies limited to the physical test, assay and release
behavior having been conducted as per ICH guidelines.