coating ppt-1 Md Aman Raeen.pptx
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This document discusses different types of tablet coatings. It defines tablet coating as applying a coating material to the exterior of tablets using polymers, plasticizers, and solvents. The main types of coatings discussed are sugar coating, film coating, and enteric coating. Sugar coating is a multi-step process using sucrose to coat tablets. Film coating sprays a coating solution onto rotating tablets. Enteric coatings are polymers that dissolve in the small intestine but not the stomach. Tablet coatings serve functional purposes like protecting drugs, masking tastes, or controlling drug release location in the digestive system.
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Presentation for Tablet Coating
Tablet coating is done to improve properties like taste, appearance, and drug release. There are several types of coatings including sugar coating, film coating, and enteric coating. Film coating involves spraying a polymer solution onto tablets to form a thin protective film. Important considerations for film coating include the polymer, plasticizer, colorants, and solvent used. Tablet coating is done using specialized coating equipment and any issues during coating like roughness, cracking or color variation must be monitored and addressed.
Anju coatg
1. Tablet coating is applied to tablets to provide benefits like protection from light and moisture, improved mechanical strength and taste masking. The main types of tablet coating are film coating, sugar coating, and press coating.
2. Film coating uses a single-stage process to apply a thin polymer coating for purposes like functional coatings. Sugar coating is a multi-stage process used mainly for taste masking and bulking.
3. Important polymers used in film coatings include cellulose derivatives, acrylic polymers, and shellac which are chosen based on properties like solubility and permeability for desired drug release.
TABLET COATING
This document discusses tablet coating, which involves covering tablet surfaces with a polymeric film to provide benefits like masking taste, protecting drugs, and controlling drug release. It describes the main types of tablet coating - sugar coating, film coating, enteric coating, vacuum film coating, electrostatic coating, and dip coating. For each coating type, it outlines the basic process and materials used. The document also explains the need for tablet coating and lists the ideal characteristics of coating materials.
Tablet coating
Tablet coating engineering is one of the prominent topics in pharmaceutical field.
This slide will help pharmacy student to become familiar with coating technology
Tablet Coating technology ppt
The document discusses tablet coating technology and processes. It begins by outlining the objectives of tablet coating, such as masking taste or odor, providing physical protection, and controlling drug release. It then describes various coating equipment like standard coating pans, perforated coating pans, and fluidized bed systems. The coating processes of sugar coating, film coating, and enteric coating are explained. Finally, potential film defects in tablet coating like sticking, roughness, capping, and cracking are reviewed along with methods to prevent or correct them.
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This document summarizes tablet coating techniques. It discusses the concepts of tablet coating including sugar coating, film coating, and enteric coating. Recent trends in tablet coating that are discussed include solventless coating techniques like electrostatic dry coating, magnetically assisted impaction coating, and supercritical fluid coating. The document provides details on the history of tablet coating techniques and components involved in the tablet coating process.
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This document summarizes tablet coating techniques. It discusses the concepts of tablet coating including sugar coating, film coating, and enteric coating. Recent trends in tablet coating that are discussed include solventless coating techniques like electrostatic dry coating, magnetically assisted impaction coating, and supercritical fluid coating. The document provides details on the history of tablet coating techniques and components involved in the tablet coating process.
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The document discusses various coating techniques used in pharmaceutical manufacturing. It describes common coating processes like sugar coating, film coating, enteric coating, and organic film coating. Recent coating technologies like electrostatic coating, vacuum film coating, compression coating, and dip coating are also summarized. The key equipment used for tablet coating include standard coating pans, perforated coating pans, and fluidized bed coaters. Coating is done to mask taste/odor, provide protection, control drug release, and incorporate incompatible drugs among other objectives.
Recommended
Presentation for Tablet Coating
Tablet coating is done to improve properties like taste, appearance, and drug release. There are several types of coatings including sugar coating, film coating, and enteric coating. Film coating involves spraying a polymer solution onto tablets to form a thin protective film. Important considerations for film coating include the polymer, plasticizer, colorants, and solvent used. Tablet coating is done using specialized coating equipment and any issues during coating like roughness, cracking or color variation must be monitored and addressed.
Anju coatg
1. Tablet coating is applied to tablets to provide benefits like protection from light and moisture, improved mechanical strength and taste masking. The main types of tablet coating are film coating, sugar coating, and press coating.
2. Film coating uses a single-stage process to apply a thin polymer coating for purposes like functional coatings. Sugar coating is a multi-stage process used mainly for taste masking and bulking.
3. Important polymers used in film coatings include cellulose derivatives, acrylic polymers, and shellac which are chosen based on properties like solubility and permeability for desired drug release.
TABLET COATING
This document discusses tablet coating, which involves covering tablet surfaces with a polymeric film to provide benefits like masking taste, protecting drugs, and controlling drug release. It describes the main types of tablet coating - sugar coating, film coating, enteric coating, vacuum film coating, electrostatic coating, and dip coating. For each coating type, it outlines the basic process and materials used. The document also explains the need for tablet coating and lists the ideal characteristics of coating materials.
Tablet coating
Tablet coating engineering is one of the prominent topics in pharmaceutical field.
This slide will help pharmacy student to become familiar with coating technology
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The document discusses tablet coating technology and processes. It begins by outlining the objectives of tablet coating, such as masking taste or odor, providing physical protection, and controlling drug release. It then describes various coating equipment like standard coating pans, perforated coating pans, and fluidized bed systems. The coating processes of sugar coating, film coating, and enteric coating are explained. Finally, potential film defects in tablet coating like sticking, roughness, capping, and cracking are reviewed along with methods to prevent or correct them.
Coating 3
This document summarizes tablet coating techniques. It discusses the concepts of tablet coating including sugar coating, film coating, and enteric coating. Recent trends in tablet coating that are discussed include solventless coating techniques like electrostatic dry coating, magnetically assisted impaction coating, and supercritical fluid coating. The document provides details on the history of tablet coating techniques and components involved in the tablet coating process.
Coating 3
This document summarizes tablet coating techniques. It discusses the concepts of tablet coating including sugar coating, film coating, and enteric coating. Recent trends in tablet coating that are discussed include solventless coating techniques like electrostatic dry coating, magnetically assisted impaction coating, and supercritical fluid coating. The document provides details on the history of tablet coating techniques and components involved in the tablet coating process.
Coating technology
The document discusses various coating techniques used in pharmaceutical manufacturing. It describes common coating processes like sugar coating, film coating, enteric coating, and organic film coating. Recent coating technologies like electrostatic coating, vacuum film coating, compression coating, and dip coating are also summarized. The key equipment used for tablet coating include standard coating pans, perforated coating pans, and fluidized bed coaters. Coating is done to mask taste/odor, provide protection, control drug release, and incorporate incompatible drugs among other objectives.
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This document discusses different types of tablet coatings used in pharmaceutical manufacturing. The three main types are film coating, sugar coating, and compression coating. Film coating involves spraying a thin polymer film onto tablets, while sugar coating builds up sucrose layers and compression coating compacts powder around tablets. Most new tablets are film coated rather than sugar coated. The document outlines ideal characteristics for film coaters and enteric coatings, which are resistant to stomach acid but dissolve in the intestine. It provides examples of polymers used for different coating purposes.
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This document discusses different coating methods and techniques used in the pharmaceutical industry. It describes:
1) Rotating coating pans and fluidized bed coaters are commonly used to coat tablets by spraying coating solutions and evaporating the liquid. Traditional techniques include sugar coating and film coating.
2) Key steps in sugar coating include sealing, sub coating, smoothing/syrup coating and finishing. Film coating uses similar equipment and parameters as sugar coating.
3) Common coating equipment includes standard coating pans, perforated coating pans, and fluidized bed coaters. Top spray, bottom spray, and tangential spray are fluidized bed coating methods that differ in how the coating solution is applied.
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The document discusses tablet coating processes and components, including the decision factors for coating tablets, the main components of coating (tablet properties, coating process, and coating compositions), common coating equipment and processes, film forming materials and other additives used in coatings, quality control of coated tablets, potential film defects, and the sugar coating process.
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The document discusses tablet coating. It provides information on the types of coatings including film coating, sugar coating, press coating, and functional coatings. It describes the key components of coating formulations which include film formers like hydroxypropyl methylcellulose, solvents, plasticizers, and colorants. The principles and objectives of tablet coating are to protect drugs, mask tastes, control drug release and provide enteric properties. Equipment used includes pan coaters, printing machines for logos.
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This document discusses tablet coating and film coating processes. It provides details on common types of film formers/polymers used in coatings including hydroxypropyl methylcellulose (HPMC) and povidone. The document also discusses plasticizers, solvents, colorants, and other coating components. Finally, it describes the two main methods for film coating - pan-pour and pan-spray coating, and lists important process variables that must be controlled for successful film coating.
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This presentation is briefly explains about the steps involved in the coating process and problem arised during the process with their solutions.
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This document discusses tablet coating and enteric coating of tablets. It provides an overview of tablet coating, including the history and types of coating techniques. Sugar coating, film coating, and enteric coating are described in detail. The key steps and components involved in enteric coating of tablets are explained. Enteric coatings are described as necessary to protect active ingredients from stomach acid and ensure drug release in the small intestine. Evaluation methods for coated tablets are also mentioned.
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1) Enteric coating is used to protect drugs from gastric fluid and release them in the intestines. It uses polymers that are insoluble in acid but dissolve in basic pH.
2) Common enteric coating polymers include polymethacrylates, cellulose esters, and polyvinyl derivatives. They require plasticizers to make the coating flexible and prevent premature drug release in acid.
3) Factors like coating temperature, coating method, and storage conditions must be carefully controlled to ensure a uniform coating layer and stable drug release.
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This document discusses tablet coating, which involves applying a thin polymer film to tablets to improve appearance, mask unpleasant tastes, and provide protection from moisture and light. There are three main types of coatings: sugar coating for taste masking, film coating using polymers for a thin protective layer, and enteric coating to protect acids in the stomach. Ideal coating materials are non-toxic films that are resistant to heat, moisture and air while not affecting the drug. Tablet coatings can have defects like picking, sticking, cracking or roughness if the coating solution or process is not optimized.
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Polymers are commonly used to coat pharmaceutical tablets and dosage forms. There are various types of coatings including conventional and enteric coatings. Conventional coatings can improve aesthetics, mask tastes, and modify drug release. Enteric coatings only dissolve in the intestines above pH 5.5-7 to protect acid-sensitive drugs. Common polymers for coatings include cellulose derivatives, acrylates, and polyvinyl derivatives. New techniques like hot melt extrusion can be used to produce enteric coatings. Coatings can provide benefits like targeted drug release and protection of actives or gastric mucosa.
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Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug. Several troubleshooting problems such as twinning mottling, chipping, etc., may arise during or after or even during the shelf life of the film coated dosage forms. These troubleshooting problems may be due to tablet core faults, coating formulation faults and/or coating process faults. These problems must be overcome to avoid unnecessary product problems. Film coating as well as other parts of the pharmaceutical technology is subjecting to continuous innovation. The innovation may be at different levels including pharmaceutical excipients, processes, software, guidelines and equipment. In fact, of particular note is the growing interest in process analytical technology, quality by design, continuous coating processing and the inclusion of new ready for use coating formulations. In this review, we tried to explore and discuss the status of pharmaceutical film coating, the challenges that face this manufacturing process and the latest technological advances in this important manufacturing process.
TABLET COATING
The document discusses tablet coating, including its purposes, principles, history, types and processes. Tablet coating involves applying a thin outer layer or film to tablets to improve characteristics like taste, moisture protection and drug release. There are two main types: film coating, which uses a polymer film, and sugar coating, which builds up layers of sucrose. The coating process aims to evenly apply and dry coating solutions or suspensions in rotating equipment. Factors like coating thickness, temperature and ingredients affect the quality and performance of coated tablets.
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This document provides a review of recent advances in enteric coating technology. It begins with an introduction to tablet coating processes and equipment. The main focus is on enteric coatings, which are designed to resist stomach acid and release the drug in the small intestine. The ideal properties, materials used, and mechanisms of enteric coatings are described. These include polymers like cellulose acetate phthalate that are insoluble at low pH but dissolve at higher pH. The document discusses criteria for selecting drugs for enteric coatings and methods for manufacturing enteric coated tablets using spray coating techniques. In summary, the document reviews enteric coatings for oral drug delivery and controlling drug release locations in the gastrointestinal tract.
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This document provides a review of recent advances in enteric coating technology. It begins with an introduction to tablet coating processes and equipment. The main topics covered include:
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- Criteria for selecting drugs suitable for enteric coated drug delivery systems. These include drugs that degrade in the stomach or undergo extensive first-pass metabolism.
- The mechanism of enteric coated timed-release tablets, which use a layered design to prevent drug release in the stomach and provide controlled release in the intestines.
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This document discusses different types of tablet coatings used in pharmaceutical manufacturing. The three main types are film coating, sugar coating, and compression coating. Film coating involves spraying a thin polymer film onto tablets, while sugar coating builds up sucrose layers and compression coating compacts powder around tablets. Most new tablets are film coated rather than sugar coated. The document outlines ideal characteristics for film coaters and enteric coatings, which are resistant to stomach acid but dissolve in the intestine. It provides examples of polymers used for different coating purposes.
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This document discusses different coating methods and techniques used in the pharmaceutical industry. It describes:
1) Rotating coating pans and fluidized bed coaters are commonly used to coat tablets by spraying coating solutions and evaporating the liquid. Traditional techniques include sugar coating and film coating.
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This document discusses tablet coating, which involves applying a thin polymer film to tablets to improve appearance, mask unpleasant tastes, and provide protection from moisture and light. There are three main types of coatings: sugar coating for taste masking, film coating using polymers for a thin protective layer, and enteric coating to protect acids in the stomach. Ideal coating materials are non-toxic films that are resistant to heat, moisture and air while not affecting the drug. Tablet coatings can have defects like picking, sticking, cracking or roughness if the coating solution or process is not optimized.
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Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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coating ppt-1 Md Aman Raeen.pptx
- 1. TOPIC :-Tablet Coating Submitted by MD AMAN RAEEN B PHARMA (Final year) MUR 1800681
- 3. DEFINATION A Coating is a covering layer of a particular material that is applied to the surface of an object (the substrsate) Tablet coating involves application of a coating materials to the exterior of a tablet,and is done using different polymers. The coating solution is a blend of polymer,plasticizer, colorant and solvent. SOME POLYMERS,PLASTICIZER AND COLOURANT polyethylene glycol(PEG)400
- 4. Propylene glycol(PG) Esters as citrate,benzoates etc. Polyvinyl chloride(PVC) Plasticizer are added to the polymer used as film coating agents in order to make the polymer pliable and soft.
- 5. TYPES OF COATING Sugar coating Film coating Enteric coating Compression coating Others type coating
- 6. SUGAR COATING Sugar coating is the most conventional multi step coating Process. As the name suggests this process involves application of sugar (sucrose) based on coating solution to the tablets. It is carried out in coating pan having variable capacities and mounted at an angle of 40
- 7. FILM COATING Single stage process, which involves spraying a coating solution. The solution is sprayed onto a rotating tablet bed followed by drying, which facilitates the removal of the solvent leaving behind the deposition of thin film of coating materials around each tablet. In film coating ,coating materials is applied to tablet about 2-3% of wt. of uncoated tablets.
- 8. ENTERIC COATING An enteric coating is a barrier that controls the location of oral medication in the digestive system where it is absorbed. The word “enteric” indicates the small intestine. These are polymer coatings which are insoluble at low pH, but soluble at high pH. Enteric coatings are prepared from gastric resistant polymers.
- 9. SOME PARAMETERS Technical parameter of coating machine Capacity Motor power Rotation speed Hot air fan power Exhaust fan power Mixing barrel power
- 10. WHY COATING IS DONE A coating is done for the purpose of may be functional or decorative or both. It is done for the protection of the subtrate materials or to improve its mechanical,tribiological or other physical properties. Thickness of coating is great parameter which affects the properties. Functional purpose,to mask unpleasant odours and tastes or to protect drugs from environmental factors. THANKYOU