This document describes a study examining the implementation of a screening program for cancer-related distress. It found that screening increased clinicians' detection of distress, led to more patients' needs being met, and improved quality of care. Specifically, clinicians were more likely to offer help to patients who screened positive for distress or depression. The screening also clarified unmet needs and patients' desire for help. Based on these results, the study will move forward with an RCT of screening plus intervention for patients receiving radiotherapy.