1. The study validated the Emotion Thermometers as a screening tool for mood disorders and distress in a diverse cancer population.
2. Results showed the Depression Thermometer had the best validity for detecting depression overall, while the Distress Thermometer was also good.
3. For detecting depression in ethnically diverse patients, the Distress Thermometer may have the best validity, achieving a sensitivity of 100%.
At the Advertising Research Foundation’s 2011 Annual re:think convention, Duncan Watts & David Reilly, Principal Research Scientists at Yahoo! Labs, gave a presentation on Randomized Experiments in Advertising, entitled Breaking Wanamaker’s Curse. The presentation shows how to use randomized experiments to measure advertising effectiveness.
At the Advertising Research Foundation’s 2011 Annual re:think convention, Duncan Watts & David Reilly, Principal Research Scientists at Yahoo! Labs, gave a presentation on Randomized Experiments in Advertising, entitled Breaking Wanamaker’s Curse. The presentation shows how to use randomized experiments to measure advertising effectiveness.
IPOS10 - T178 Implementation of a Screening Programme for Cancer Related Dist...Alex J Mitchell
Implementation of a Screening Programme for Cancer Related Distress: Part II - Does Screening Aid Clinicians' Communication, Judgement or Accuracy of Anxiety and Depression
Similar to IPOS10 T276 - Large Scale Validation of the Emotion Thermometers as a Screening Tool for Major Depression in an Ethnically Diverse Cancer Popn
IPOS10 - T178 Implementation of a Screening Programme for Cancer Related Dist...Alex J Mitchell
Implementation of a Screening Programme for Cancer Related Distress: Part II - Does Screening Aid Clinicians' Communication, Judgement or Accuracy of Anxiety and Depression
Similar to IPOS10 T276 - Large Scale Validation of the Emotion Thermometers as a Screening Tool for Major Depression in an Ethnically Diverse Cancer Popn (20)
Alex J Mitchell Alcohol Detection by Clinician (Aug2012)Alex J Mitchell
Powerpoint slides on detection and identification of alcohol problems (alcohol use disorder) by clinicians.
See related paper:
http://bjp.rcpsych.org/content/201/2/93.abstract
Royalty free for personal use, but please cite with credit to AJMitchell (Leicester)
Here are the most anticipated time-trial (triathlon) bikes of 2012. Carbon fibre masterpieces designed to go fast in a straight line. Image resolution 1600x1000 approx.
Illustration of Mental Health Clustering Calculator ajmitchellAlex J Mitchell
Our team has created a clustering calculator for mental health diagnoses. This is a preview of how it works. The idea is to allow clinicians to work out the correct cluster from the problem list inputs. The calculator is in MS excel and follows the suggested algorithms precisely
Weight diabetes and metabolic problems in patients taking atypical antipsycho...Alex J Mitchell
Free slide show on weight gain, diabetes and metabolic problems in those taking atypical antipsychotic medication in schizophrenia, bipolar disorder and related conditions. Image credits retained by original authors. Please give correct acknolwedgements if you present any material from here.
Photos from Tour of Britain London Stage (Sept11) taken by me (alex mitchell). Photos mostly used a sports panning technique to capture movement with some fill-in flash. Available to download.
POCOG - The Future of Psycho-Oncology (Aug 2011)Alex J Mitchell
This is an invited talk on the "The Future of Psycho-Oncology" given to the POCOG group of the University of Sydney (lead Phyllis Butow) in August 2011.
This is a combined one page one side screener consisting of the PHQ9 and GAD7. Both are in the public domain seperately, but here I have simply combined the two. The PHQ9 includes the standard question on function.
patient health questionnaire, generalized anxiety disorder
[ppt] RCpsych - Failing medical care of psychiatric patients (vMar11)Alex J Mitchell
This is a 30min talk given at the RCPsych liaison conference 2011 on the topic of the failing (suboptimal) medical care provided to psychiatric patients by physicians and psychiatrists. Available in free full text PPT for a limited period.
Rcpsych Workshop - Depression in medical settings (Mar11)Alex J Mitchell
Rcpsych liaison faculty workshop on; depression in medical settings: symptoms and screening. This is an update on the latest on screening for depression in medical settings.
COH Online- The future of screening for distress in cancer settings (February11)Alex J Mitchell
This is a presentation I did at the us city of hope comprehensive cancer center in february 2011. The topic was future of screening for distress (and depression) in cancer; including an overview of recent screening findings.
Top 100 Most Cited People in Psychiatry (Mental Health) (Jan 2011) [aka Top 1...Alex J Mitchell
This is an uptodate list of the top 100 most highly cited people in psychiatry (mental health). List includes neuroscientists and psychologists publishing in this field. Note that to qualify an author must be listed on a peer reviewed paper on web of science; not necessarily the lead author. Current as of 31-Jan-2011. Presentation also known as list of Top 100 Psychiatrists
Top 100 Papers & People in Psychiatry (Jan2011)Alex J Mitchell
Short slideshow of the top100 people and papers in psychiatry as of january 2011 based on Web of science. British emphasis, worlwide list in preparation.
Organizational chart of NHS staffing ratios 1999-2009Alex J Mitchell
This is an illustrative chart of NHS staffing, normalized per hospital consultant. In other words...for every 1 hospital consultant in the NHS there are X nurses; X managers X ambulance drivers etc.
Prepared by Alex J Mitchell (ajm80@le.ac.uk) from public data.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
IPOS10 T276 - Large Scale Validation of the Emotion Thermometers as a Screening Tool for Major Depression in an Ethnically Diverse Cancer Popn
1. T276 - -A Large Scale Validation of the Emotion Thermometers as
T276 A Large Scale Validation of the Emotion Thermometers as
aaScreening Tool for MDD & Distress in an Ethnically Diverse
Screening Tool for MDD & Distress in an Ethnically Diverse
Cancer Population
Cancer Population
Alex Mitchell www.psycho-oncology.info
Paul Symonds
Lorraine Grainger
Elena Baker-Glenn
Department of Cancer & Molecular Medicine, Leicester Royal Infirmary
IPOS 2010
2. Audit / Research Protocol
Phase I – DT across LNR network (incl training)
Phase II – Enhancements to DT
Phase III - Screening plus Intervention
4. Qualitative Limitations of DT
DT not always interpreted by patients
Distress not always understood by patients
There is no anchor
Patients who are angry or depressed may not say
“distressed”
But some patients may not interpret “depression”
5. Quantitative Limitations of DT
Of 401 chemotherapy attendees
59% have an emotional complication (3v4)
37% (62% of 59%) it included distress
23% it excluded distress
Validity of DT vs depression (DSMIV)
SE 80% SP 60% PPV 32% NPV 93%
7. ET - Table of Cut-Points
Distress Anxiety Depression Anger Help
Thermomete thermomet Thermomete Thermomete Thermomete
r er r r r Cut-point
Insignifica
nt 39.0 25.6 50.1 55.7 54.3 0,1
Minimal 20.1 22.5 18.3 13.6 15.4 2,3
Mild 16.9 16.5 12.2 10.5 12.2 4,5
Moderate 12.0 14.5 9.8 6.6 6.6 6,7
Severe 11.9 20.8 9.5 13.6 11.2 8,9,10
p130
8. 1.00
0.90
0.80
Ten
0.70 Nine
Eight
0.60 Seven
Six
0.50
Five
Four
0.40
Three
Two
0.30
One
0.20
Zero
0.10
0.00
Distress Anxiety Depression Anger
Thermometer Thermometer Thermometer Thermometer
12. Concerns linked with distress
t = 7.705129 P < 0.0001 Anxiety
t = 4.859186 P < 0.0001 depression/hopeless
t = 4.448083 P < 0.0001 Family concerns/issues
t = 4.10916 P < 0.0001 Anger/Irritability
t = 2.699969 P = 0.0073 Self-Esteem
t = 2.69652 P = 0.0073 Cancer worries
t = 2.497361 P = 0.013 Coping concerns
t = 2.371534 P = 0.0183 Sleep
15. Graphical – Screening principles
#
of Cut-Off
Individuals
Low High
Non-Depressed
<<<< low Specificity
Severity of Depression
High Sensitivity >>>> Depressed
#
of
Individuals
16. Validity Against HADS-T (distress)
We analysed data collected from Leicester Cancer Centre
from 2007-2009
The researcher applied the HADS and used a HADS-T >14
to signify distress.
We collated full data on 660 patient assessments
17. HADS-T
In the parent sample of 660:
SE SP AUC CUT
DT – 71.9% 78.4% 0.814 cut point =4
18. HADS-T
In the parent sample of 660:
SE SP AUC CUT
DT – 71.9% 78.4% 0.814 cut point =4
AnxT – 75.7% 73.4% 0.821 cut point =5
DepT – 77.6% 82.2% 0.855 cut point =3
AngT – 77.5% 77.6% 0.823 cut point =2
HelpT - 69.1% 80.8% 0.809 cut point =3
19. Against MDD
The researcher applied criteria for MDD. We collated full data on
660 patient assessments
MDD was defined by DSMIV criteria (5 of 9 symptoms)
12.9% had MDD and 14.8% were from ethnic minorities (largely
British South Asian of India descent).
25. Summary
Against Distress
All thermometers were “good” but DepT was best
Against Depression (all)
DepT > DT were “good”
Against Depression in BSA
DT may be best?