The document discusses the Suzuki coupling reaction, a type of palladium-catalyzed cross-coupling reaction for forming carbon-carbon bonds. It compares this reaction with other historical reactions in organic chemistry, detailing variations in catalyst types and reaction conditions. It also provides references to various studies and reviews on the topic.

1. SuzukiCouplingReaction
(PalladiumCatalysedCrossCouplingReactions)
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2. 2Department of chemistry, University of Agriculture, Faisalabad

3. carbon-carbon bond
3Department of chemistry, University of Agriculture, Faisalabad
R-X + M-R R-R + MX

4. 4Department of chemistry, University of Agriculture, Faisalabad

5. Richard F. Heck Ei-ichi Negishi Akira Suzuki
Akira SuzukiEi-ichi NegishiRichard F. Heck
Previously in this area: The Grignard reaction (1912), the Diels-Alder reaction (1950), the
Wittig reaction (1979), and olefin metathesis (2005).
5Department of chemistry, University of Agriculture, Faisalabad

6. Reactio
ns
Year Hybrid
ization
of
Reacta
nt 1
Hybridiza
tion of
Reactant
2
Couplin
g type
cataly
st
Remark
s
Heck 1972 Sp2 Sp2 Cross Pd, Ni Require
base
Neigishi 1977 Sp3,
sp2, sp
Sp3, sp2 Cross Pd, Ni, Require
base
Suzuki 1979 Sp2 Sp2, sp3 Cross Pd, Ni,
Fe, Cu,
Ru
Require
base
Yield can be variable.
Temperature and pressure conditions may vary.
Negishi
6Department of chemistry, University of Agriculture, Faisalabad
R

7. A
B
7Department of chemistry, University of Agriculture, Faisalabad
CD isostrychnine

8. F
G
H
I
8Department of chemistry, University of Agriculture, Faisalabad

9. J
K
L
M
95% yield
92.5% yield
9Department of chemistry, University of Agriculture, Faisalabad

10. Department of chemistry, University of Agriculture, Faisalabad 10

11. N
O
P
11Department of chemistry, University of Agriculture, Faisalabad

12. Q
12Department of chemistry, University of Agriculture, Faisalabad

13. 13Department of chemistry, University of Agriculture, Faisalabad

14. References
Bäckvall, J. (2010). "Palladium-CatalyzedCross Couplings inOrganic Synthesis: Scientific Background
on the Nobel Prize in Chemistry 2010."The Royal Swedish Academy of Sciences.
Das, P. andW. Linert (2016). "Schiff base-derived homogeneous and heterogeneous palladium
catalysts for the Suzuki–Miyaura reaction."CoordinationChemistry Reviews 311: 1-23.
Gujral, S. S., et al. (2012). "Suzuki Cross Coupling Reaction-A Review." Indo Global J. Pharm. Sci 2: 351-
367.
Maluenda, I. and O. Navarro (2015). "Recent Developments in the Suzuki-Miyaura Reaction: 2010–
2014." Molecules 20(5): 7528-7557.
Suzuki, A. (1999). "Recent advances in the cross-coupling reactions of organoboron derivatives with
organic electrophiles, 1995–1998." Journal of OrganometallicChemistry 576(1): 147-168.
Is there any question?Thank you!
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