A powerpoint explaining in detail about all the intravenous induction agents and their clinical uses, pharmacokinetics & pharmacodynamics, adverse effects and complications.
properties, classification and principle of action of intravenous induction agent.
pharmacokinetics
comparison between properties of various agent
summary of ketamine, propofol, thiopenton etomidate , bzd and opioids.
A powerpoint explaining in detail about all the intravenous induction agents and their clinical uses, pharmacokinetics & pharmacodynamics, adverse effects and complications.
properties, classification and principle of action of intravenous induction agent.
pharmacokinetics
comparison between properties of various agent
summary of ketamine, propofol, thiopenton etomidate , bzd and opioids.
antidotes and their MOA
An antidote is a substance which can counteract a form of poisoning. The term ultimately derives from the Greek αντιδιδοναι antididonai, "given against"
antidotes and their MOA
An antidote is a substance which can counteract a form of poisoning. The term ultimately derives from the Greek αντιδιδοναι antididonai, "given against"
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
Intravenous Anaesthetics are a group of fast-acting
compounds that are used to induce a state of impaired
awareness of complete sedation.
These are drugs that, when given intravenously in an
appropriate dose, cause a rapid loss of consciousness.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
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Uses
Wherever rapid and profound
neuromuscular blockade is required Eg.
To facilitate tracheal intubation
For modification of fits after
electroconvulsive therapy
3. Chemical
• The dicholine ester of succinic acid{
equivalent to 2 acetylcholine molecules
joined back to back}
• Presentation
As a clear aqueous solution containing
50mg/ml of Suxamethonium chloride
The preparation should be stored at 4 degree
C
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4. Main action & MOA
Neuromuscular blockade of brief duration
in skeletal muscle
Suxamethonium causes prolonged
depolarization of skeletal muscle fibers to
a membrane potential above which an
action potential can be triggered
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5. Route of administration and
doses
• The intravenous dose is 0.5- 2.0 mg/kg
• The onset of action occurs with in 30 sec
and duration of action is 3-5 min
• The intramuscular dose is up to 2.5mg/kg
• The drug may also administered
sublingually at a doses of 2mg/kg
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6. Cardiovascular effects
With repeated doses of sux, bradycardia
and slight increase in MAP may occur
Premedication with atropine
Caution using on the patient already taking
B-blockers
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7. Central nervous system effects
• The adm. Of sux may initially cause
fasciculation which are then followed by
phase I depolarizing block
• The characteristics of the block is
A well sustained tetanus during stimulation at
50 -100hz
The absence of post- tetanic fasciculation
A train of four ratio > 0.7 and
Potentiation by anticholinesterases
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8. • With repeated administration or a large
total dose, phase II block may develop
• The characteristics of this block is
A poorly sustained tetanus
A post tetanic fasciculation
A train of four ratio < 0.3
Reversal by anticholinesterases and
Tachyphylaxis
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9. Other effects
• ICP and IOP are both raised following
administration of sux
• The intragastric pressure increases by 7-
12cmH2O, the lower esophageal sphincter
tone simultaneously decreases with the
use of suxamethonium
• Serum potassium concentration is briefly
increased in normal individual by 0.2-
0.4mmol/l
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10. Toxicity & side effects
• Bradycardia & other dysarrythmia
• Hyperkalemia
• Postoperative myalgia – in women middle
age
• Increases IOP,ICP & IGP
• Triggering agent for malignant
hyperthermia
• Sux apnea
• Anaphylactic reaction1/27/2019 10
11. Metabolism
• The drug is hydrolyzed by plasma
cholinesterase to succinylmonocholine
{which is weakly active} and choline
• The former is further hydrolyzed by
plasma cholinesterase to succinic acid and
choline
• 80% of administered dose is hydrolyzed
before it reaches the NMJ
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12. Special points
• The incidence of muscle pain after
administration of suxamethonium may be
decreased by pre-treatment with
A low dose {0.2mg/kg} dose of sux
A small dose of a non-depolarizing relaxants
Diazepam
Aspirin or
Vitamin C
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