This document discusses structural genomics and its goals of determining the 3D structures of large numbers of gene products to identify novel protein folds and sequences. It describes methods for structural determination including de novo and modeling based approaches. Specific proteome projects on Thermotoga maritima and Mycobacterium tuberculosis are mentioned. The objectives of structural genomics are outlined as providing structural information to aid research, experimental design, identification of new structure-based medicines, and development of better therapeutics.

1. BY
BHAVITHA PULAPARTHI
DEPT OF PHARMACOINFORMATICS
NIPER

2.  It is an effort aimed at determining the
3Dstructures of gene products in an efficient.
 Main aim is to identify novel protein folds and
sequences.

3.  Determining the structure of large number of
proteins.
 Developing and maintaining the Target
Registration Database
 Useful in manipulating genes and DNA
segments in particular species.
 Genes can be cloned on the knowing where
they are in genome.

4. 1) de novo method
2) Modeling Based :
 ab initio modeling
 Sequence based modeling
 Treading

5.  Thermotogo maritima proteome:
 as a goal of JCSG and PSI.
 Based on small genome consisting of 1,877
genes.
 Mycobacterium tuberculosis proteome:
 as a goal of TB SGC.
 Novel drugs against multi-therapy resistance.

6.  Began in 2000 to make the 3D atomic structures of
proteins of their corresponding DNA sequences.
 objectives:
 Structural description to help researchers.
 Experimental design and other biomedical
problems.
 Identification of new structure based medicines.
 Development of methodology for protein
production and crystallography.
 Better therapeutics for treating both genetic and
infectious diseases.