This document provides information on stress management and improving sleep. It discusses what stress is, common physical symptoms, and strategies to reduce stress such as exercise, assertiveness, nutrition, relaxation techniques, and seeking professional help. Supplements that may help with stress and sleep like Calm Day, Sleep Time, melatonin, 5-HTP, B vitamins, and taurine are described. Safety information is provided. The author is a chiropractor who provides nutritional consultations and recommends natural solutions over prescription drugs for stress and sleep issues.
Stress is what you feel when you have to handle more than you are used to. When you are stressed, your body responds as though you are in danger. It makes hormones that speed up your heart, make you breathe faster, and give you a burst of energy.
Diabetes Facts and Tips for a Healthy LifestyleSlideShop.com
In 2013, over 300 million people throughout the world have diabetes. How can we prevent ourselves from acquiring this disease? Check out this presentation.
More themed slides: https://slideshop.com/Themed-Slides
Stress is what you feel when you have to handle more than you are used to. When you are stressed, your body responds as though you are in danger. It makes hormones that speed up your heart, make you breathe faster, and give you a burst of energy.
Diabetes Facts and Tips for a Healthy LifestyleSlideShop.com
In 2013, over 300 million people throughout the world have diabetes. How can we prevent ourselves from acquiring this disease? Check out this presentation.
More themed slides: https://slideshop.com/Themed-Slides
The Footprint Forum in association with Partners In Purchasing tackled the role of food in staff performance and wellbeing. And while the idea of mood food is far from mainstream, more and more big businesses are looking at the concept
A happy gut does not only helps in improving your immune system but also has a positive effect on your mood swings and brain. C.A.R.E. of your gut is important - Cleanse, Activate, Restore and Enhance. So what is your gut telling you? Cause, in the end, your gut feeling is always right. True. Here is everything you need to know about a healthy gut...
Stress is the body’s physical and psychological response to a specific demand made of us or to an event in our life. In some cases it motivates and encourages us to complete a task we find difficult so that we can take pride in ourselves and what we achieve.
Detoxification of the major organ systems of the body is ever increasingly important. Environment, genetics, nutritional status and lifestyle all play interacting roles that can influence one's quality of life. Learn how to safely detoxify using real food and basic nutrients with the Detox 360 Program. This is an introduction for informational purposes only and is not intended to diagnose or replace medical care.
What is stress? Stress is a part of being alive. A total absence of stress can be achieved only in death. Stress is the "wear and tear" our minds and bodies experience.
Stress occurs when the pressure is greater than the resource. 80% of all modern diseases originate from 'stress'.
"Stress Management" is the art of taking care of oneself. So, become aware of your stressors and your physical and emotional reactions.
Our aim is not to eliminate stress but to learn how to manage and use it to help us.
Stress Management PowerPoint Presentation Content slides include topics such as: understanding the dynamics of stress, quickly and effectively managing stress, symptoms of stress, identifying sources of stress, negative and positive effects of stress, the five step system to tackle stress, 6 strategies to minimize burn-out, from distress to eustress, specific problems and associated treatments, 15 ways to make work less stressful, how to's and much more.
Wearables devices market and technologyKevin Huang
What is wearable technology?
Simply put, it’s technology that you incorporate into things you wear on a day-to-day basis, and it could be anything from a smart watch, augmented reality glasses, or even a personal health monitor in the form of a bracelet.
The idea is that technology will increasingly become more part of our daily lives, and it will become less intrusive, as it will be part of our clothing, and sometimes even part of our bodies!
Wearable tech presents a fascinating field to study. I have conducted some researches and hope you can also learn more about this high growth market.
The Footprint Forum in association with Partners In Purchasing tackled the role of food in staff performance and wellbeing. And while the idea of mood food is far from mainstream, more and more big businesses are looking at the concept
A happy gut does not only helps in improving your immune system but also has a positive effect on your mood swings and brain. C.A.R.E. of your gut is important - Cleanse, Activate, Restore and Enhance. So what is your gut telling you? Cause, in the end, your gut feeling is always right. True. Here is everything you need to know about a healthy gut...
Stress is the body’s physical and psychological response to a specific demand made of us or to an event in our life. In some cases it motivates and encourages us to complete a task we find difficult so that we can take pride in ourselves and what we achieve.
Detoxification of the major organ systems of the body is ever increasingly important. Environment, genetics, nutritional status and lifestyle all play interacting roles that can influence one's quality of life. Learn how to safely detoxify using real food and basic nutrients with the Detox 360 Program. This is an introduction for informational purposes only and is not intended to diagnose or replace medical care.
What is stress? Stress is a part of being alive. A total absence of stress can be achieved only in death. Stress is the "wear and tear" our minds and bodies experience.
Stress occurs when the pressure is greater than the resource. 80% of all modern diseases originate from 'stress'.
"Stress Management" is the art of taking care of oneself. So, become aware of your stressors and your physical and emotional reactions.
Our aim is not to eliminate stress but to learn how to manage and use it to help us.
Stress Management PowerPoint Presentation Content slides include topics such as: understanding the dynamics of stress, quickly and effectively managing stress, symptoms of stress, identifying sources of stress, negative and positive effects of stress, the five step system to tackle stress, 6 strategies to minimize burn-out, from distress to eustress, specific problems and associated treatments, 15 ways to make work less stressful, how to's and much more.
Wearables devices market and technologyKevin Huang
What is wearable technology?
Simply put, it’s technology that you incorporate into things you wear on a day-to-day basis, and it could be anything from a smart watch, augmented reality glasses, or even a personal health monitor in the form of a bracelet.
The idea is that technology will increasingly become more part of our daily lives, and it will become less intrusive, as it will be part of our clothing, and sometimes even part of our bodies!
Wearable tech presents a fascinating field to study. I have conducted some researches and hope you can also learn more about this high growth market.
Stress and its management in Indian soldiersRobin Victor
No human being is exempted from stress.
The army soldiers are no exception
This presentation highlights various risk factors leading to stress, depression and suicide, the clinical features of stress and various preventive strategies for prevention of stress for army soldiers.
Ownership of fitness tracker devices in the U.S. grew from about four million users at the beginning of 2013 to an estimated to an estimated 15 million in 2014, according to research from Parks Associates. The sales of fitness tracker devices will reach 15.6 million units in 2015, according to Consumer Technology Association, formerly Consumer Electronics Association (CEA).
As the connected fitness tracker market grows, expect competition to mount not only from within but especially outside the market from other devices including smartwatches and smartphones/apps. In this study, you can learn more about the technology and market trends.
this was one of our Marketing, MBA project. We had to Launch an Over the Counter Product, So we came up with this Nicotine Patch which could be used to drain off the urge for smoking cigarettes than using a nicotne gum.
This Product has not yet been Launched in Mumbai, or say India. If ever it is.. on a costlier basis.. So we came out with this product where the could fit ur wallet.
Thank you :)
if any queries, do contact me :) thank you
Best practices of mental health in AsiaMudasir Khan
The presentation cites the best examples of mental health programs from different countries in Asia. It also explains the lessons learnt from these programs for improving mental health services.
this ppt is made on Stress and stress management. this ppt tells us the reasons of stress in students life and how to overcome stress. this ppt is made for educational purpose only.
We all face stress in our lives and we all have different ways to cope with it. This presentation provides overview on stress and proven tips and tricks.
Lifestyle Changes to Deal with Stress Slidesbkling
Beth Taubes, RN, OCN, CBCN, is an oncology nurse with over 30 years of experience and certification as a health coach. Her talk addresses ways of coping with stress, getting motivated, changing habits, and overcoming barriers to change. Beth will help you find your own personal motivator to eat well, move well, and sleep well.
How should i handle my stress and anxietyfaiqa khurram
Stress is a very common thing in today's world. Almost everyone has experienced it. There
are millions of people around the world who are dealing with stress, and some of them even
suffer from it because of their job. If you're one of these people and your job is causing too
much stress for you, then it's time for you to search for an alternative way to deal with stress.
I hope you found the blog post useful and that you learned a thing or two about the causes
of stress and how to manage those things. One thing I'd like to point out is that it's never a
good idea to allow other things to distract you from your goals. Your biggest priority should
always be setting yourself up with the tools and skills necessary to reach your goals, both
long-term ones and even short-term ones
TATT, which stands for “tired all the time,” is an abbreviation created specifically for the phenomenon of feeling exhausted.
Everybody gets tired occasionally. The causes are typically clear and include:
staying up too late
working long hours
having a baby who keeps you awake at night
Yet, prolonged periods of fatigue or weariness are abnormal. Your capacity to go forward and enjoy life may be impacted.
One of the most frequent reasons for patients to visit their doctor is unexplained fatigue.
Why you might always feel fatigued
You might want to figure out how you got so exhausted in the first place before you go to the doctor.
Consider any aspects of your life that may be particularly taxing, such as work and family and any experiences that may have contributed to your fatigue, such as a bereavement or a breakup.
Anxiety is a natural human response to stress or danger, and it's a feeling of fear or unease about future events or situations. Anxiety is a common emotion experienced by almost everyone at some point in their life, but it becomes a problem when it is excessive or out of proportion to the actual threat posed by a situation.
Symptoms of anxiety can include physical sensations such as increased heart rate, sweating, and muscle tension, as well as cognitive and behavioral symptoms like worrying, avoidance, and difficulty concentrating. There are different types of anxiety disorders, such as generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobias, and each has its own unique features and diagnostic criteria.
Anxiety can be treated through various forms of therapy, including cognitive-behavioral therapy (CBT), exposure therapy, and medication, such as anti-anxiety medications and antidepressants. It's important to seek help from a mental health professional if you are experiencing excessive or prolonged anxiety that is interfering with your daily life.
mumtazqg75@gmail.com
what causes anxiety
Anxiety can be caused by a combination of factors, including genetic, environmental, and psychological factors. Some common causes of anxiety include:
Genetics: Anxiety can run in families, suggesting a genetic predisposition to the disorder.
Brain chemistry: Chemical imbalances in the brain, particularly involving neurotransmitters like serotonin and dopamine, can contribute to the development of anxiety.
Life experiences: Traumatic or stressful life events such as abuse, neglect, or the death of a loved one can trigger anxiety.
Personality traits: People with certain personality traits, such as perfectionism, low self-esteem, or a tendency to worry, may be more prone to developing anxiety.
Medical conditions: Certain medical conditions, such as thyroid disorders or heart disease, can cause anxiety symptoms.
Substance abuse: Alcohol and drug abuse can lead to or exacerbate anxiety.
Environmental factors: Certain environmental factors, such as high levels of stress at work or in the home environment, can contribute to anxiety.
It's important to note that while these factors can contribute to the development of anxiety, not everyone who experiences them will develop the disorder. Additionally, anxiety can sometimes occur for no clear reason. If you are experiencing excessive anxiety, it's important to seek help from a mental health professional to determine the underlying cause and develop an appropriate treatment plan.
mumtazqg75@gmail.com
can anxiety be cure
Anxiety can be effectively treated and managed, but it may not necessarily be "cured" in the traditional sense. Treatment can help reduce the severity and frequency of symptoms, increase coping skills, and improve overall quality of life.
Stress
• A person’s response to events that are threatening or
challenging.
• “ Stress can be defined as the sum of physical and mental
responses to an unacceptable disparity between real or
imagined personal experience and personal expectations”
Types of stress
•Acute stress. This is short-term stress that goes
away quickly
•Chronic stress. This is stress that lasts for a
longer period of time
Physical stress
•Physical stress is a demand that changes
the state of our body. We feel stressed when
we are overworked physically, lack of proper
diet, injury or lack of sleep.
• Environmental stressors are aspects of our
environment that are often unavoidable,
such as air pollution, crowding, noise, or fire,
earthquakes, floods.
Psychological stress
•These stressor are we generate ourselves in
our mind and individual experience them.
Some important sources of stress is
frustration, conflict, internal and social
pressure etc
Symptoms of stress
Physical symptoms
• Aches and pains.
• Chest pain or a feeling like your heart is racing.
• Exhaustion or trouble sleeping.
• Headaches, dizziness or shaking.
• High blood pressure.
• Muscle tension or jaw clenching.
• Stomach or digestive problems.
• Trouble having sex.
• Weak immune system.
Emotional symptoms
•Becoming easily agitated, frustrated, and moody
•Feeling defeated like you are loosing control
•Having difficulty in relaxing
•Low self esteem, lonely
•Avoiding others
Cognitive symptoms
•Forgetfulness and disorganization
•Poor judgment
•Constant worrying
•Racing thoughts
•Inability to focus
•Being pessimistic
Behavioral symptoms
•Change in appetite
•Increased use of drugs
•Procrastinating and avoiding responsibilities
•Exhibiting more nervous behaviors nail biting,
fidgeting, pacing etc
Coping
•Behavioral and cognitive responses used to deal with
stressors; involves efforts to change circumstances, or
our interpretation of them to make them more
favorable and less threatening.
• Problem-focused coping
•Emotion focused coping
Emotion focused coping
•People try to manage their emotions in the face
of stress, seeking to change the way they feel
about a problem such as accepting sympathy and
looking the bright side of a situation.
•Sympathy
•Empathy
Problem focused coping
•Attempts to modify the stressful problem or
source of stress. Problem focused strategies
lead to change in behavior or to the
development of a plan of action deal with
stress. Outing, group study, timeout etc
Stress management
•Relaxation therapy is a technique to reducing
tension by consciously relaxing muscles of the
body. What does meditation , hypnosis, yoga,
and prayer have in common
•They all draw on a relaxation response, a
condition of reduced muscle tension, cortical
activity, heart rate, breathing rate, and blood
pressure
•Meditation can lower blood pressure, heart rate,
and oxygen consumption.
•Possibly helps stress-related symptoms
•Practiced sitting quietly
Living Life Stress Free is recognised as a Centre of Excellence and is a Registered College of the Complementary Medical Association providing Stress Management courses and workshops to Corporates, Entrepreneurs and Professionals.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
Stress & sleep presentation
1. Sleep & Stress Management
Dr Jason Drivere
Doctor of Chiropractic
M.S. in Human Anatomy & Physiology Instruction
Contact Information:
driverechiropractic@yahoo.com
www.driverechirowellness.com
2. Legal Disclaimer
The following presentation is intended for
educational purposes only and is not a substitute
for medical advice. Please consult a physician or
a health professional if you have any questions
regarding treatment of medical conditions.
The statements in this presentation have not been
evaluated by the FDA. The products and
ingredients listed herein are not intended to
diagnose, treat, prevent, or cure any disease.
3. Got Stress?
Take a number. One thing that binds us together in
society is that most if not all of us have to deal with
stress on a daily basis.
4. What is stress?
Stress is defined as state of mental or emotional strain or
tension resulting from adverse or very demanding
circumstances..
5. What is stress?
Stress in general are things in your social environment
which are taxing on you mentally, physically, and spiritually.
6. What are the physical
symptoms of stress?
•Low energy & fatigue
•Headaches
•Upset stomach, including diarrhea, constipation and
nausea
•Aches, pains, and tense muscles
•Chest pain and rapid heartbeat
•Insomnia
•Frequent colds and infections
•Loss of sexual desire and/or ability.
.
7. What can you do about it?
Stress is a part of life and you have to develop strategies to
adapt to it and manage it…or typically it simply manages
you.
8. Strategies to help reduce
stress
•Exercise Regularly- exercise has been proven to have
a beneficial effect on a person's mental and physical
state. For many people exercise is an extremely
effective stress buster.
•Division of labor - try to delegate your responsibilities
at work, or share them. If you make yourself
indispensable the likelihood of your feeling highly
stressed is significantly greater.
9. Strategies to help reduce
stress
• Assertiveness - don't say yes to everything. If you can't
do something well, or if something is not your
responsibility, try to seek ways of not agreeing to do
them.
• Alcohol and drugs - alcohol and drugs should not be
the first choices to help you manage your stress better.
Consider stopping consuming them completely, or cut
down. ** If you are on medications for stress,
depression, or anxiety always consult with a physician
before altering medication dosage.**
• Caffeine - if your consumption of coffee and other
drinks which contain caffeine is excessive, cut down.
10. Strategies to help reduce
stress
• Nutrition - eat plenty of fruit and vegetables. Make
sure you have a healthy and balanced diet.
• Time - make sure you set aside some time each day
just for yourself. Use that time to organize your life,
relax, and pursue your own interests.
• Breathing - there are some effective breathing
techniques which will slow down your system and
help you relax.
11. Strategies to help reduce
stress
• Communication - talk to you family, friends, work
colleagues and your boss. Express your thoughts
and worries.
• Seek professional help - if the stress is affecting the
way you function; go and see your doctor.
Heightened stress for prolonged periods can be bad
for your physical and mental health.
• Relaxation techniques - meditation, yoga,
chiropractic, or massage have been known to greatly
help people with stress.
12. Vitamin & Supplement
Support for Stress & Sleep
When necessary one should consider science-
based nutritional support to help increase the
effectiveness of stress relief strategies.
Supplements also are an easy, cost-effective and
logical method for helping to manage symptoms of
stress or sleep problems.
Many times people are often confused about what
supplements to take. I typically help them to
develop a supplement plan based on their
symptoms.
13. Vitamin & Supplement
Support for Stress & Sleep
Don’t simply trust your health to a salesperson in a retail
store. Also, be cautious when considering products
because recent studies show that store bought
supplements/herbs may not contain the listed ingredients.
Seek out the advice of a trusted nutritional health
professional to develop a treatment plan using quality
ingredients based on your individual needs.
The following slides include information including the
ingredients of a few supplements we have found to be
helpful for people suffering from stress or sleep problems.
15. Stressed &Tired
Stressed & Wired
Stressed & Hot
Stressed & Cold
Stressed & Depleted
Disturbed Sleep & Mood
Stress
Has Many Faces
16. CALM DAY
• Formulated to support production of the
neurotransmitters serotonin, and
dopamine.*
• Designed to improve problems with stress,
sleep, anxiety, cognitive function, mental
focus, ADD & OCD
• Typical dosage is 1-2 capsules, once or
twice a day.
18. Focus on the Ingredients
4-amino- 3-phenylbutyric acid (also called
phenibut or fenibut)
◦ anxiety-reducing & cognition-enhancing
◦ similar to the brain chemical GABA (gamma-
aminobutyric acid) except it crossed the blood/brain
barrier (GABA does not) and can be absorbed more
efficiently.
◦ extensively researched in Russia
◦ studied for its ability to prevent the negative effects of
sleep deprivation, namely protecting the adrenal
glands and reducing cognitive and emotional disorders
caused by lack of sleep.
◦ researched for its ability to reduce anxiety. Phenibut is
commonly used in Russia to improve anxiety, sleep
disorders, depression, post-traumatic stress disorders,
and more.
19. Focus on the Ingredients
Glycine:
– a non-essential amino acid.
– has been used to protect brain cells after ischemic
stroke.
– used to promote a sense of well-being and reduce
anxiety.
– Research has shown that glycine can subjectively
and objectively improve sleep quality.
– In a study where people’s sleep was restricted,
glycine also reduced daytime sleepiness.
20. Focus on the Ingredients
L-taurine:
– An amino acid that’s a GABA-receptor agonist,
meaning it produces a GABA-like effect in the body.
• GABA is a sedating, inhibitory neurotransmitter.
– In animal studies, application of taurine with GABA,
or taurine with glycine produced stronger effects than
taking either glycine or GABA alone.
– Taurine is sometimes used to enhance sleep quality.
21. Focus on the Ingredients
B vitamins are involved in nerve transmission,
nerve regeneration, neurotransmitter synthesis.
Vitamin B5-a water-soluble B vitamin with
numerous biological roles.
Used by the body to manufacture, among other
things, coenzyme A which is an important
compound for energy metabolism and the
production of fatty acids, cholesterol, and the
neurotransmitter acetylcholine.
22. Focus on the Ingredients
B6 is another water-soluble B vitamin. Many
functions in the body, including as a co-factor
in several reactions of amino acid metabolism.
– Used in conversion of tryptophan to serotonin
– Biosynthesis of neurotransmitters GABA, dopamine,
serotonin, epinephrine, and norepinephrine.
– Pyridoxal 5-phosphate is the preferred, metabolically
active form of B-6 used in higher quality nutritional
supplements.
23. Calm Day
• Start with 1 cap in the morning and 1 cap
in the evening on empty stomach.
• Patient should “feel it “ within a few days
(usually 1 or 2 days); if they don’t within a
week double the dosage.
• It comes in 60 or 120 cap size
24. • Difficulty falling asleep
• Difficulty waking up
• Daytime drowsiness
• Waking up frequently
during the night with difficulty
returning to sleep
• “Zoning out” in the middle
of a conversation or task
• Difficulty concentrating
• Clumsy and/or slower
reactions times
• Feeling emotional
• Altered memory &
judgment
Some of the expressions of sleep
disturbances are the following:
http://www.cdc.gov/niosh/stresswk.html
25. Today, the practice of “burning the candle at both ends”
has created so much sleep deprivation that what is really
abnormal sleep is now almost the norm
http://www.stress.org/problem.htm
http://www.ninds.nih.gov
Disturbed Sleep & Mood
26. • Benzodiazpines (Valium)
• Flurazepam (Dalmane)
• Zolpidem tartrate (Ambien)
• Temazepam (Restoril)
• Triazolam (Halcion)
FDA Warning:
Commonly used Rx for sleep disorders can disrupt
performance and be addictive. Some recent studies show
that they could significantly increase the risk of dementia
and Alzheimer’s disease.
27. Deep Refreshing Sleep and Relaxation
Can Be Achieved Naturally and Safely By:
• Supporting a natural sleep cycle through
balancing neurotransmitter (serotonin,
dopamine and GABA) levels in the brain without
producing side effects or grogginess
• Stimulating alpha brain waves, which are
associated with an awake, yet relaxed, state
• Promoting healthy serotonin levels to
encourage falling asleep and deep sleep
http://www.ninds.nih.gov
28. What Are
Neurotransmitters?
• Neurotransmitters serve as
messengers, transmitting
information from one nerve
cell to another
• Deficits in specific neurotransmitters disrupt
the sleep cycle
• It is important to support healthy
neurotransmitter function when addressing
sleep disturbance
http://www.ninds.nih.gov
29. Neurotransmitters,
Brain Wave, Sleep
Connection
• Serotonin – influences mood,
appetite and sleep
• Dopamine – influences mood – possible depletion
during REM cycle
• GABA (gamma-aminobutyric acid) – mood,
cognition and sleep disorders – possible depletion
during REM cycle
http://www.brainsync.com/about/4states.asp
Beta
Theta
Alpha & Theta
Delta & Theta{
Beta
31. Sleep Time
• Same exact ingredients, as Calm Day except we added 5HTP
(trytophan) and melatonin for sleep issues to further enhance
any sleep issues
• Start with 2 caps 30-60 minutes before bed and increase
dosage by 1 cap until desired effect!
• Do not use if on anti-depressants (Prozac)!!
• Youtube “60 minutes the placebo effect” and you also may
have an increased risk of Alzheimer’s disease and dementia
with regular consumption of antidepressants.
http://www.medscape.com/viewarticle/838788
32. Tryptophan
• Effective Serotonin Precursor for Balancing
Mood, Appetite, Sleep, Sexual Behavior and
Pain Sensation
• Excellent safety profile: Readily crosses the
blood-brain barrier
• Well-tolerated
33. Tryptophan
Helps Regulate Sleep
• improves sleep quality
during stages 1, 4 and REM
sleep
• increases in REM sleep
• When using for sleep, 200
mg per day may be
preferable to higher dosages
Soulairac A, et al. Ann Med Psychol 1977;1:792-98. (French)
Guilleminault C, et al. Electroenceophalogr Clin Neurophysiol 1973;34:177-84.
Wyatt RJ, et al. Electroenceophalogr Clin Neurophysiol 1971;30:505-09.
34. Calm Day & Sleep Time
• Do not use if you are taking any
Benzo’s! (Valium/diazepam,
Clonazepin, Xanax) medications!
• Calm Day could be a natural
alternative to these medications.
• ***As always consult your
physician if you are considering
altering medication dosage.***
35. Other Key Natural Ingredients To
Safely Balance Neurotransmitters
Super B Complete:
• 5-methyl tetrahydrofolate (5-MTHF)
• Methylcobalamin (active B12)
• Pyridoxal 5-Phosphate (active Vitamin B6)
36. 5-MTHF ● Methylcobalamin ● Vitamin B6
Supports Neurotransmitter Synthesis ● Promotes Rest
• 5-methyl tetrahydrofolate (5-MTHF) and methylcobalamin,
neuroactive forms for folic acid and vitamin B12, are helpful
with depression and restless leg syndrome.
• 5-MTHF at levels as low as 200 mcg per day may exhibit
anti-depressive effects
• Methylcobalamin influences melatonin levels – a sleep
enhancing neurotransmitter, and may improve alertness
• Vitamin B6 is required for the creation of neurotransmitters -
serotonin, melatonin, epinephrine, norepinephrine, and
GABA
Am J Physiol 1975;229(3):777-82.
Ikeda M, et al. Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin
synthesis in the rat pineal gland. Brain Research 1998;795(1-2):98-104.
OkawaM, et al. Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study.
Psychiatry Clin Neurosci. 1997;51(5):275-79.
37. Other Key Natural Ingredients To
Safely Balance Neurotransmitters
Melatonin
• Melatonin 1mg ( for children under 12 years)
• Melatonin 3mg sublingual (adults)
• Melatonin SR3 ( staying asleep)
38. Safety
Potential side-effects associated with 5-HTP are
– Occasional GI disturbance, heartburn, stomach pain, belching,
flatulence, nausea, vomiting, diarrhea
– Anecdotal reports regarding sleep: 400-600 mg doses taken one
hour prior to bedtime may be linked to vivid dreams and/or
nightmares
– Taking 100 mg 5-HTP between meals or one hour before sleep,
reduces chance of any digestive upset; titrate upward as needed
Potential herb interactions
– Do not use with botanicals known to significantly influence
serotonin balance, such as St. John’s Wort, unless under
supervision of the prescribing physician
Potential drug interactions
– Carbidopa (Lodosyn) (Parkinson’s)
– Serotonin agonists (Prozac, Zoloft), antagonists (Sansert), MAO
inhibitors, tricyclic and atypical antidepressants (Elavil)
39. Legal Disclaimer
U.S. law states that any substance which is claimed to
treat, cure, or prevent any disease is under the control of
the FDA and is “legally characterized as a drug” as a result
all non-drug products(vitamins, herbs, minerals, foods)
have to say the following:
The statements in this presentation have not been
evaluated by the FDA. The products and ingredients listed
herein are not intended to diagnose, treat, prevent, or cure
any disease.
40. References
* This statement has not been evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any disease.
Tiurenkov IN. Bagmetova W. Borodkina LE. et al. [Fenibut and its citrate
prevent psychoneurological disorders caused by chronic stress (paradoxical
sleep deprivation)]. Eksp Klin Farmakol. 2012;75(6):8-13.
Ziablintseva EA. Pavlova IV. [Influence of GABA agonist phenibut on the
neuronal activity and interaction in hippocampus and neocortex in
emotionally negative situations]. Ross Fiziol Zh Im I M Sechenova. 2009
Sep;95(9):907-18.
Zyablitseva EA. Pavlova IV. Effects of the GABA receptor agonist phenibut
on behavior and respiration in rabbits in emotionally negative situations.
Neurosci Behav Physiol. 2008 Jul;38(6):555-62.
Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.
CNS Drug Rev. 2001 Winter;7(4):471-81.
Song NY. Shi HB. Li CY. et al. Interaction between taurine and
GABA(A)/glycine receptors in neurons of the rat anteroventral cochlear
nucleus. Brain Res. 2012 Sep 7;1472:1-10.
Lin FJ. Pierce MM. Sehgal A. et al. Effect of caffeine and taurine on sleep-
wake activity in Drosophila melanogaster. Nat Sci Sleep. 2010 Sep
24;2:221-31.
41. References
Bannai M. Kawai N. New therapeutic strategy for amino
acid medicine: glycine improves quality of sleep. J
Pharmacol Sci. 2012;118(2):145-8.
Bannai M. Kawai N. Ono K. et al. The effects of glycine
on subjective daytime performance in partially sleep-
restricted healthy volunteers. Front Neurol. 2012;3:61.
doi: 10.3389/fneur.2012.00061.
Nordqvist, C. (2014, September 5). "What is stress? How
to deal with stress." Medical News Today. Retrieved from
Editor's Notes
Paying bills, relationships, driving, finances, taking children here and there, death in the family/close friend you name it.
Paying bills, relationships, driving, finances, taking children here and there, death in the family/close friend you name it.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
Many people use coffee as an “upper” when they have tiredness and fatigue during the workday. What causes this fatigue is stress and/or poor diet(sugar crash) in most cases. Using for energy when not getting to the source of the problem simply adds to your fatigue and stress “from the caffeine” when it wears off. This is a big problem with people because they don’t have the knowledge to understand that they are increasing their stress hormones(cortisol) as a side-effect for short term energy. Eventually people essentially get addicted to caffeine and if they don’t continue to get it from coffee or other sources they will get caffeine induced headaches.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
Think about how you feel when you first get up in the morning(your attitude, your mood, etc.). Now think about how you feel around lunchtime in a Monday or in the evening at the end of your workday. If you tend to wake up feeling OK and by the end of the day you are an emotional wreck it is likely that you suffer from mental stress.
The following products and ingredients are from a company I trust for nutritional management of health conditions. You don’t have to purchase products from me or from them to get favorable results, but you do need to purchase products that work if you want to see results. It is always best to seek out a science-based nutritional health professional when putting together a gameplan for improving a health condition. Otherwise you may be buying products that don’t work or have the wrong ingredients.
Do you just take vitamins or do you have a custom wellness nutritional program for your condition? It is all about the quality ingredients and the desired clinical result.
During the fall, winter, and spring months it would also be a good idea to get your Vitamin D levels checked since during the less sunny months optimal levels tend to be lower. Vitamin D can be attributed to improving mood, improving immunity, and reducing inflammation in the body. Bottom line it is very good for you!
Benzodiazpines (Valium)
use cautiously
short term management of insomnia; reduce sleep-onset latency, the number and duration of nighttime awakenings, total sleep time
Flurazepam (Dalmane)
decreases daytime alertness and sedation
accumulation; washout slow after termination; rapid absorption with 1/2 life 48-120 hours
effective in inducing and maintaining sleep for up to one month of consecutive use
Zolpidem tartrate (Ambien)
no next day residual effects or rebound insomnia
therapeutic gains maintained five weeks
Temazepam (Restoril)
3 months of use (minimal tolerance)
intermediate absorption (1/2 life 8-20 hours) moderate accumulation
sleep maintenance problems generally in later life
Triazolam (Halcion)
fast absorption, short 1/2 life 2-6 hours; minimal accumulation after multiple dosing
reduces sleep-onset latency and increases total sleep time; allows for maximal daytime alertness; may be associated with early morning awakening and daytime anxiety
Target Mechanisms
Stimulation of alpha brain waves, which are associated with an awake, yet relaxed, state in humans
Promotion of healthy serotonin levels
Promotion of relaxation, without inducing drowsiness
Previous sleep research has shown that neurons using certain neurotransmitters, such as serotonin and norepinephrine, have levels of activity that wax and wane in clear correlation with waking and sleeping alert animals have more of these neurons firing than do sleeping animals
Serotonin has been reported to play a role in the onset of sleep as well as having an effect on the amount of deep sleep. People who have a shortage of deep sleep also known as stage 4 delta sleep have problems with grogginess and alertness during their waking hours.
Dopamine - The results were exciting and yet not altogether surprising. "We found a very tight correlation [between the severity of REM sleep behavior disorder and the level of decrease in dopamine], so this suggests that there's a causal effect," Gilman says. "We can't prove that. It's a correlation only, but it certainly suggests that the amount of dopamine loss in the brain is related to this disorder."
GABA - Popularly referred to as the body's natural tranquilizer, GABA (gamma-aminobutyric acid) is an amino acid produced in the brain. It acts as a neurotransmitter--a chemical that fosters communication between nerve cells--and helps to keep stress-related nerve impulses at bay. Normally, the brain pumps out all the GABA we need. Unfortunately, due to a poor diet, exposure to environmental toxins, or other factors, levels of GABA may become depleted. Too little of this important compound may result in anxiety, irritability, and insomnia. A deficiency of GABA has also been linked to depression.
Neurotransmitters serve as data messengers, transmitting information from one nerve cell to another. Nerve cells release neurotransmitters into a small gap (synapse) between a data-sending nerve cell and a data-receiving nerve cell. In the gap, a neurotransmitter is attracted to and binds with a receptor on the receiving nerve cell and alters the activity of the receiving nerve cell. Once communication is complete, the neurotransmitter is released back into the synapse. The neurotransmitter remains there until it's taken back within the sending cell, a process called reuptake. Once back in the sending cell, the neurotransmitter is repackaged for future use or broken down by enzymes.
The levels of these neurotransmitters influence how you feel as well as how you react to daily life events. Normally, your brain properly matches your emotions with the situations you face. You feel happy, for instance, when you see a loved one or feel sad when you watch a sad movie.
Serotonin (ser-oh-TOE-nin) and norepinephrine (nor-ep-i-NEF-rin) are two chemicals called neurotransmitters that exist naturally in your brain and play a role in mood regulation.
Serotonin plays a role in the onset of sleep as well as having an effect on the amount of deep sleep. People who have a shortage of deep sleep also known as stage 4 delta sleep have problems with grogginess and alertness during their waking hours.
Dopamine (DOE-puh-mene) might also play a role in depression. Very tight correlation between the severity of REM sleep behavior disorder and the level of decrease in dopamine. Maybe there's a causal effect. Amount of dopamine loss in the brain correlates with REM disorder."
Many antidepressants work by increasing the levels of these neurotransmitters in the brain synapses.
GABA -Popularly referred to as the body's natural tranquilizer, GABA (gamma-aminobutyric acid) is an amino acid produced in the brain. It acts as a neurotransmitter--a chemical that fosters communication between nerve cells--and helps to keep stress-related nerve impulses at bay. Normally, the brain pumps out all the GABA we need. Unfortunately, due to a poor diet, exposure to environmental toxins, or other factors, levels of GABA may become depleted. Too little of this important compound may result in anxiety, irritability, and insomnia. A deficiency of GABA has also been linked to depression.
What is sleep?
You likely spend about one-third of your life in the state of unconsciousness known as sleep. But what exactly is going on while you're catching some ZZZs? Probably more than you'd expect.
Serotonin – mood, appetite and sleep
GABA - Too little of this important compound may result in anxiety, irritability, and insomnia. A deficiency of GABA has also been linked to depression.
While sleeping, you move through six phases:
Awake. It's normal to be awake for short periods during the night. Expect three to 10 brief arousals, though you probably won't remember each one. It's likely part of your body's defense mechanisms to keep you aware of what's going on around you.
Stage one. During stage one, you sleep lightly and drift in and out of sleep. During this stage you're easily wakened. Your muscles begin to slow down and your eyes move very slowly. SEROTONIN
Stage two. In stage two, your muscles relax. Your brain waves slow down, though occasionally you have bursts of brain activity. You spend about half of your sleep in this stage.
Stages three and four. Deep sleep sets in. Your brain waves become large and slow. Your breathing becomes rhythmic, and your muscles remain relaxed. At this point your body begins releasing reparative hormones. Stages one through four are referred to as non-rapid eye movement (NREM). SEROTONIN
Rapid eye movement (REM). During REM sleep your muscles stop moving completely. Your breathing and heart rate become rapid and irregular, your blood pressure is more variable, and your eyes move rapidly in bursts of activity. Your brain waves show a pattern similar to wakefulness. Scientists believe this indicates that your brain is using this time to sort and organize your memories. Dreaming takes place during this stage. If you're awakened during REM sleep, you may recall vivid dreams. DEPRESSED DOPAMINE and GABA.
Throughout the night, you continuously move from one stage or type of sleep to another in cycles that can last from 70 to 90 minutes each. Early REM periods are very short, however, usually 5 to 10 minutes long. You may experience several longer REM periods as the night progresses.
Soulairac et al., 1977 (French);
Guilleminault et al., 1973 (one patient); Wyatt et al., 1971
5-HTP bypasses conversion of L.tryptophan by enzyme tryptophan hydrolase (P5P form of B6) which is a rate limiting step in the conversion of serotonin. This may account for inconsistancies in studies using L. tryptophan
Soulairac et al., 1977 (French);
Guilleminault et al., 1973 (one patient); Wyatt et al., 1971
The role of vitamin B6 in our nervous system is very broad, and involves many aspects of neurological activity. One aspect focuses on the creation of an important group of messaging molecules called amines. The nervous system relies on formation of these molecules for transmission of messages from one nerve to the next. (The molecules can be classified as "neurotransmitters" for this reason.)
Amines are one type of neurotransmitter in the nervous system. They are often made from parts of protein called amino acids, and the key nutrient for making this process happen is vitamin B6.
Some of the amine-derived neurotransmitters that require vitamin B6 for their production include serotonin, melatonin, epinephrine, norepinephrine, and GABA.
B6 -Support of nervous system activity
The role of vitamin B6 in our nervous system is very broad, and involves many aspects of neurological activity.
One aspect focuses on the creation of an important group of messaging molecules called amines. The nervous system relies on formation of these molecules for transmission of messages from one nerve to the next. (The molecules can be classified as "neurotransmitters" for this reason.) Amines are one type of neurotransmitter in the nervous system. They are often made from parts of protein called amino acids, and the key nutrient for making this process happen is vitamin B6. Some of the amine-derived neurotransmitters that require vitamin B6 for their production include serotonin, melatonin, epinephrine, norepinephrine, and GABA.
B12 and Folate Mechanism of action:
Norepinephrine, dopamine, and serotonin synthesis.
Coenzymes in the synthesis of S-adenosylmethionine (SAM), shown to have antidepressant properties
B12 & Folic Acid Regulate Homocysteinecardiovascular disease and impaired immune function can contribute to sleep disturbance and restless leg
Cardiovascular Effects of Homocysteine:
Damages the endothelial lining - atherogenesis.
Smooth muscle cell hyperplasia
Fibrosis
LDL converted to aggregates
At arterial intima forms Foam Cells
Lipids and Cholesterol released
Fibrolipid plaques
Am J Physiol. 1975 Sep;229(3): 777-82
“5-MTHF of folic acid was infused intravenously at a constant rate into conscious or methotrexate-pretreated rabbits. After 150 min, at equivalent plasma concentrations, folic acid or 5-MTHF readily entered the choroid plexus, but only 5-MTHF entered cerebrospinal fluid and probably brain by a saturable transport system. In contrast, after intraventricular injections, folic acid but not 5-MTHF was cleared from cerebrospinal fluid to blood by a saturable system… These results suggest that the transport system for 5-MTHF…helps maintain the cerebrospinal fluid and probably brain 5-MTHF concentrations within relatively narrow limits…”
The role of vitamin B6 in our nervous system is very broad, and involves many aspects of neurological activity. One aspect focuses on the creation of an important group of messaging molecules called amines. The nervous system relies on formation of these molecules for transmission of messages from one nerve to the next. (The molecules can be classified as "neurotransmitters" for this reason.)
Amines are one type of neurotransmitter in the nervous system. They are often made from parts of protein called amino acids, and the key nutrient for making this process happen is vitamin B6.
Some of the amine-derived neurotransmitters that require vitamin B6 for their production include serotonin, melatonin, epinephrine, norepinephrine, and GABA.
Soulairac et al., 1977 (French);
Guilleminault et al., 1973 (one patient); Wyatt et al., 1971
5-HTP bypasses conversion of L.tryptophan by enzyme tryptophan hydrolase (P5P form of B6) which is a rate limiting step in the conversion of serotonin. This may account for inconsistancies in studies using L. tryptophan