Novel Drug delivery System (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. This story board give details from ancient time to 21st century.

1. NOVEL DRUG DELIVERY SYSTEM
Ayurveda, the
traditional Indian
system of medicine,
introduced various drug
delivery techniques,
including herbal
formulations like
Kasthausadhi e.g.,
Asavarista, Avleha,
Grafa Churena, Taila
and Rasausadhi .
The ancient Greek
physician Hippocrates is
known for introducing
the idea of using enemas
as a method of drug
delivery
During the
Middle Ages,
Arabic
physicians like
Avicenna made
contributions to
the field of
pharmaceuticals
, including the
development of
sublimation and
distillation
techniques.
2000s: RNA interference (RNAi)
discovered by Andrew Fire and Craig C.
Mello,as a therapeutic approach emerged
for gene-specific drug delivery.
2010s: The development of targeted drug
delivery systems utilizing nanoparticles
and nanocarriers continued to evolve.
2013: The FDA approved the first 3D-
printed prescription pill by Aprecia
Pharmaceuticals, marking a significant
step in personalized medicine and
customized drug delivery.
2015: Development of CRISPR-Cas9 gene
editing technology by Doudna and
Charpentier,French microbiologists
opened up new possibilities for gene-
specific drug delivery.
2017: mRNA-based vaccines, such as the
Pfizer-BioNTech COVID-19 vaccine by
Dr.Albert Bourla and Dr. Ugur Sahin,
demonstrated the potential of mRNA
delivery systems for immunization.
2020: The FDA approved the first drug,
Patisiran, using small interfering RNA
(siRNA) technology, offering a new
approach to treat rare diseases.
2021: The mRNA COVID-19 vaccines, like
the Moderna vaccine discovered by Dr.
Tal Zakas, played a pivotal role in
responding to the global pandemic and
showcased the power of rapid mRNA drug
delivery.
2022: Continued advancements in
nanomedicine and the use of nanocarriers
for targeted drug delivery.
Novel Drug delivery System (NDDS) refers to the approaches,
formulations, technologies, and systems for transporting a
pharmaceutical compound in the body as needed to safely
achieve its desired therapeutic effects
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AYURVEDA (CIRCA 1500 BCE)
MIDDLE AGES
)
19TH CENTURY
21ST CENTURY
STORY BOARD
HIPPOCRATES
(CIRCA460-370 BCE)
The concept of
sustained-
release drug
delivery was
introduced by Dr.
Paul Janssen.
Troches
(lozenges) and
elixirs were used
for slow drug
release.
20TH CENTURY
1950s: Oral contraceptives were
developed by Dr. Gregory
Pincus,Dr.John Rock and their
team marking a significant
advance in controlled drug
delivery.
1960s: The transdermal patch,
pioneered by Dr. Alejandro
Zaffaroni, revolutionized drug
delivery for various conditions.
1970s: Development of
microencapsulation technology for
controlled drug release by Proff.
Raymond W.Cannon.
1980s: Liposomes, tiny lipid-based
vesicles, were explored for
targeted drug delivery by Dr.Alec
D.Bangham.
1990s: Nanoparticles and
nanotechnology started to play a
crucial role in drug delivery
systems by Richard Feynman.