Steroid hormones can be grouped into 2 classes, corticosteroids (typically made in the adrenal cortex, hence cortico-) and sex steroids (typically made in the gonads or placenta).
Steroid Hormones - Dr. P. Saranraj, Assistant Professor, Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Vellore District, Tamil Nadu, India.
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
Steroid Hormones - Dr. P. Saranraj, Assistant Professor, Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Vellore District, Tamil Nadu, India.
sex-hormones belong to the steroid class of compounds and are produced in the gonads, i.e., testes in the male and ovaries in the female. In fact, their activity seems to be controlled and monitored by the hormones that are produced in the interior.
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
The two main sex hormones — estrogen and testosterone — have wide-ranging effects in the body. Produced primarily by the ovaries (estrogen) and testes (testosterone), these hormones affect not just your sexual function but also your bones, brain, and blood vessels.
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
The two main sex hormones — estrogen and testosterone — have wide-ranging effects in the body. Produced primarily by the ovaries (estrogen) and testes (testosterone), these hormones affect not just your sexual function but also your bones, brain, and blood vessels.
steroids, definition, classification, sterol, bile acids, cardiac glycosides, steroid hormones, classes of steroid hormones, identity tests for sterols, identity tests for cholesterol, identity tests for bile acids, identity tests for cardiac glycosides
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SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
Classification and Synthesis of Sulpha drugs, Anti Viral Drugs, Anti Fungal Agents, Anti Tubercular Agents, Anti leprotic Agents, Antiamoebic Agents, Anthelmintics, Anti Malarial Drugs, Anti cancer Drugs
Anticancer Drug, also called Anti-Neoplastic drug, that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include Alkylating Agents, Anti-metabolites, Plant Alkaloids and Hormones.
Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Make a Field invisible in Odoo 17Celine George
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Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
2. STEROID HORMONES
Steroid hormones and related products represents one of the most widely
used classes of therapeutic agents.
Birth control
Hormone-replacement therapy(HRT)
Inflammatory conditions
Cancer treatment
Most of these agents are chemically based on a common structural
backbone, the steroid backbone.
Steroid hormones in mammals are biosynthesized from cholesterol, which
in turn is made in vivo from acetyl-coenzyme A(acetyl-CoA) via the
mevalonate pathway.
These drugs are primarily in:
Cholesterol synthesis occurs in smooth ER and enzymatic conversion
occur in mitochondria.
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3. Steroid hormone receptors
Steroid hormones are lipid soluble molecules(Hydrophobic) that bind
to hormone receptors in the cytoplasm of the target cell.
Greatest progress in steroid research in recent years has been in the area
of steroid receptors, Considering the many diverse actions at even a
single class of steroid hormones.
The receptor-hormone complex binds to the regulatory region of the
gene and changes the expression of that gene.
Cytosolic and nuclear receptors - in the cytoplasm or nucleus
(“genomic”)
Activated receptor binds to DNA and initiates/alters gene transcription
Hormone must enter cell first
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4. A general scheme for steroid hormone receptor interactions:
1. Steroid crosses cell
membrane into
cytoplasm
2. Steroid binds cytosolic
receptor which is kept
inactive by heat-shock
proteins (HSPs)
3. Binding alters receptor
confirmation, releasing
HSPs
4. Active receptors bind
directly to DNA and
initiate transcription
5. mRNA enters
cytoplasm and a new
protein is synthesized.
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5. Estrogen receptor(ER)
There are two distinct estrogen receptors(ERs).
estrogen receptor α(ERα)
estrogen receptor β(ERβ)
ERα can be found in high abundance in the uterus, vagina, and ovaries, as
well as in the breast, hypothalamus.
ERβ is found in the ovaries and prostate, and low amount in the lungs, brain,
and vasculature.
Which are encoded by different genes.
Estrogens exert their effects by interaction with receptors that are members
of the super family of nuclear receptors.
After entering the cell by passive diffusion through the plasma
membrane, the hormone binds to an ER in the nucleus
In the nucleus, the ER is present as an inactive monomer bound to heat-shock
proteins, and upon binding estrogen, a change in ER confirmation dissociates
the heat-shock proteins and causes receptor dimerization, which increases the
affinity and the rate of receptor binding to DNA
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6. Progesterone receptor(PR)
The PR can also be found in two forms, but these are derived from a
single gene.
Progesterone receptor A(PRA)
Progesterone receptor B(PRB)
Progesterone receptor B mainly mediates the stimulatory actions of
progesterone.
PRA acts as a transcriptional inhibitor of ER, AR, GR, MR, and PRB.
Androgen, Glucocorticoids, and Mineralocorticoid receptors
The AR, GR, and MR are present in only a single form . Only one
gene and one protein are known for each receptor.
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7. Steroid hormones are classified in to two types.
Adrenal cortical hormones.
Sex hormones.
The adrenal cortex secrets steroidal hormones which have
Mineralocorticoids -Aldosterone.
Glucocorticoids - Hydrocortisone
Sex hormones - Androgens & Estrogens
Uses:
Mineralocorticoid effects on Na+, K+ and fluid balance.
Glucocorticoids effects on carbohydrate, protein, and fat metabolism.
Androgens effects on muscle development and maturity and coordination.
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8. S. A. R OF ADRENAL CORTICAL HORMONES
Cortisone and hydrocortisone have too much salt-retaining activity in the
doses needed for some therapeutic purpose.
Substituents which significantly increase anti inflammatory and glucocorticoid
activity. E.g. 1-dehydro,6α-fluro.
Substituents which significantly decrease mineralocorticoid activity and
glucocorticoid activity. E.g. 16α-hydroxy, 16α and 16β-methyl.
Substituents which significantly increase both mineralocorticoid and
glucocorticoid activity. E.g. 9α-fluro, 21-hydroxy, 2α-methyl, 9α-chloro.
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11. SEX HORMONES
ANDROGENS (OR) MALE SEX HORMONES
Androgens are synthesized from cholesterol in the testes and adrenal
cortex. It also been isolated from adrenal cortex and ovaries.
There are 4 naturally occurring androgens in man
i. Testosterone
ii. Androsterone
iii. Epiandrosterone (or) androstenedione
iv. Dehydroepiandrosterone (or) DTH
Adrenal cortex produces small quantities of Dehydroepiandrosterone
and androstenedione, which are called WEAK ANDROGENS.
Progestins are precursors to all androgens.
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Sex hormones are usually classified as follows
i. Androgens (Male sex hormones)
ii. Oestrogens (Female or Follicular hormones)
iii. Gestogens (Corpus luteum hormones)
17. Testosterone exerts its physiological activity after its conversion to
Dihydrotestosterone.
A steroidal skeleton is minimum structural requirement to have
androgenic activity.
17β hydroxyl function to be essential for androgenic and anabolic activity.
1-Dehydro isomer of testosterone is a potent compound.
S .A.R OF ANDROGENS
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18. Reduction of the A ring e.g., DHT may increase potency.
Introduction of 17α methyl group confers oral activity on testosterone.
Testosterone not effective orally, because metabolic changes at 17-β
oxygen, which is used to attach the receptor site. 17-α alkyl groups
prevent these metabolic changes so that compounds are orally active.
E.g.17α methyl testosterone.
Increasing the length of alkyl side chain at 17α position results
reduced activity. 18
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19. Esterification of testosterone at C-17 with a number of acids have long
duration of action when used parenterally.
-OH group in 17α position decreases androgenic or anabolic activity.
Heterocyclic rings are also incorporated yield good anabolic agents.
E.g. Stanozolol
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20. 19-norandrogens were synthesized, some of which were found to be
effective anabolic agents. E.g. 19-nortestosterone.
The 3-deoxy analogs have been found to be potent androgen .
Several heterocyclic rings were then fused to ring A. the pyrazole and
isoxazole were much more active then 17α-methyl testosterone.
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21. In men, effects:
Bone
Spermatogenesis
Behavior
Estrogens and progestin's are hormones that produce many physiological
actions.
Female sex hormones
In women:
Developmental effects (estrogens are largely responsible for
pubertal changes in girls and secondary sexual characteristics).
Neuroendocrine actions involved in: Control of ovulation and the
preparation of the reproductive tract for fertilization and implantation.
Major Actions on: Minerals, Carbohydrates, Proteins, and Lipid
Metabolism
Estrogens and Progestin's
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22. Estrogens
A group of steroid hormones that readily diffuse across the cell membrane
Inside the cell, they interact with estrogen receptors
Synthesis of estrogen begins from the synthesis of androstenedione
from cholesterol.
Androstenedione crosses the basal membrane into surrounding
granulosa cells, where its converted to estrone or estradiol wither
immediately or through testosterone.
The conversion is catalyzed by aromatase.
Therapeutic uses:
Development of secondary sex characteristics.
Growth of uterus during puberty.
Initial growth of endometrium during menstrual cycle.
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25. The most potent naturally occurring estrogen in humans for both the
Estrogen Receptor alpha and beta mediated actions is 17beta-estradiol,
followed by estrone and estriol.
Each estrogen contains a phenolic A ring with a hydroxyl group at carbon
3 and a beta-OH or ketone in position 17 of ring D.
The phenolic A ring is the principal structural feature responsible for
selective, high-affinity binding to both receptors.
Ring A and 3-OH, 17β-OH groups is necessary for activity.
S .A.R OF ESTROGEN
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26. Activity depends on mode of action
Subcutaneous= Estradiol > Estrone > Estriol
Oral = Estriol > Estradiol > Estrone
Ethinyl estradiol having greatest activity, because of resistant to
metabolism in liver and degradation by enzymes in GIT.
Removal of 3-OH group, epimerization of 17β-OH group, introduction
of unsaturation in ’B’ ring, expansion of ‘D’ ring drastically decrease the
activity.
Compound without steroid nucleus also shows activity.
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27. Progesterone
Progesterone is secreted mainly by the corpus luteum of the ovary. It is
also Formed in the placenta, adrenal cortex& testis.
Progestin's include the naturally occurring hormone progesterone, 17-
acetoxyprogesterone derivatives in the pregnane series, 19-nortestosterone
derivatives (estranges), and norgestrel and related compounds in the gonane
series.
Progesterone
17-acetoxyprogesterone 19-nortestosterone
pregnenolone, which is a progestin and is the precursor to all other steroid
hormones.
Pregnenolone is a prohormone.
Progesterone is important in maintaining pregnancy.
27
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29. Steroidal nucleus is essential for activity.
Substitution at 17 α with ethynyl, methyl, ethyl reduce activity.
Ethindrone more active orally than progesterone.
Removal of CH3 at C19 is more active. E.g. (Norethindrone)
Unsaturation of B or C ring of 19-Androstane derivatives increase activity.
Acetyalation of the 17β –OH of norethindrone long duration of action.
S .A.R OF PROGESTERONE
29
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30. Hormonal Contraceptives
Ethinyl estradiol (a synthetic estrogen) and mestranol are the estrogens
most frequently used .
Levonorgestrel is the most common progestin used worldwide.
This type is the most frequently used in the United States, which
contain both an estrogen and a progestin.
Levonorgestrel
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