The document provides guidance on how to build an effective manifesto for a startup. It recommends beginning with the end in mind by envisioning the company's big goal and impact. It then suggests defining the business mission as solving a big problem in an audacious way. The next step is defining the desired company culture as a drastically different workplace. Lastly, it advises writing from the heart using well-chosen words to make a meaningful promise to employees, investors and customers. An effective manifesto communicates the company's mission, culture and goals in a thoughtful, heartfelt manner.
The rapid changes in the advertising industry may feel like the ad-pocalypse is upon us, but embracing the revolution and partnering with strategic thinkers can help connect brands to customers today and tomorrow.
The rapid changes in the advertising industry may feel like the ad-pocalypse is upon us, but embracing the revolution and partnering with strategic thinkers can help connect brands to customers today and tomorrow.
Humanizing Brands: How to build a business that connects from the heart.Romulo Castilho
Do we sound like a robot instead of a real human?
This workshop were designed to teach how you we can humanize your products, and build delightful experiences that connects from the heart and converts like magic!
Co-created together with The Orange Hide Community.
It is no longer acceptable to be good enough you need to be exceptional in the eyes of your customers. Giving your customers a HUG - Hear Understand Give back incredible value - is a powerful way to stand out so your customers choose you instead of your competitors.
BizSmart Lunch & Learn Webinar
Presenter - Philippe Ingels
Company - WAKSTER
Everyone’s competing for the attention of new and existing customer. Content marketing is now one of the most important tactics in a marketers’ mix but research shows that the biggest challenges content marketers consistently face are producing enough content, and producing the kind of content that engages their targets. The entertainment industry has been consistently creating and delivering engaging content for hundreds of years – what can we learn from them?
Brand Positioning and Elevator Pitch Slides Kaitlin Zhang Workshop LondonKaitlin Zhang
Kaitlin Zhang presents a workshop on "Brand Positioning and Elevator Pitch" at Kennington Park Business Centre, London. This event was hosted in conjunction with Club Workspace.
9 November 2016
Kaitlin Zhang is the CEO of Oval Branding, a cross-border branding agency between the UK, USA and China, specialising in tech, financial services, government based in London, UK.
www.ovalbranding.com
30 Tips To Build Your Personal Brand From 37 ExpertsReferralCandy
Having a strong personal brand is a tremendous asset to every entrepreneur. While brands and businesses might be built around ideas, like it or not, they’re still ultimately represented by people. Are you doing your brand justice?
To help you, here are 30 tips we’ve aggregated from a wonderful blogpost by Navid Moazzez, featuring 37 experts. We hope you find them useful!
6 Commandments for Launching a Startup Brand - a lecture for the ASU Venture ...Mike Jones ⚡
Lessons learned from branding and launching J Walkyn - an online marketplace for buyers and sellers of Nike Air Jordan shoes. There were lots of lessons, both good and bad, learned in this process and we've distilled them down into 6 fundamental keys to a successful startup launch.
This presentation was given to the ASU Venture Devils startup incubator course in April 2017.
Bootstrap Business Seminar 5: Creating an Awesome BrandCityStarters
The 5th Seminar in our Bootstrap Business Seminar series looks at how to create an awesome brand with Creative Director at Branding Agency One Ltd, Ben Mumby-Croft.
Humanizing Brands: How to build a business that connects from the heart.Romulo Castilho
Do we sound like a robot instead of a real human?
This workshop were designed to teach how you we can humanize your products, and build delightful experiences that connects from the heart and converts like magic!
Co-created together with The Orange Hide Community.
It is no longer acceptable to be good enough you need to be exceptional in the eyes of your customers. Giving your customers a HUG - Hear Understand Give back incredible value - is a powerful way to stand out so your customers choose you instead of your competitors.
BizSmart Lunch & Learn Webinar
Presenter - Philippe Ingels
Company - WAKSTER
Everyone’s competing for the attention of new and existing customer. Content marketing is now one of the most important tactics in a marketers’ mix but research shows that the biggest challenges content marketers consistently face are producing enough content, and producing the kind of content that engages their targets. The entertainment industry has been consistently creating and delivering engaging content for hundreds of years – what can we learn from them?
Brand Positioning and Elevator Pitch Slides Kaitlin Zhang Workshop LondonKaitlin Zhang
Kaitlin Zhang presents a workshop on "Brand Positioning and Elevator Pitch" at Kennington Park Business Centre, London. This event was hosted in conjunction with Club Workspace.
9 November 2016
Kaitlin Zhang is the CEO of Oval Branding, a cross-border branding agency between the UK, USA and China, specialising in tech, financial services, government based in London, UK.
www.ovalbranding.com
30 Tips To Build Your Personal Brand From 37 ExpertsReferralCandy
Having a strong personal brand is a tremendous asset to every entrepreneur. While brands and businesses might be built around ideas, like it or not, they’re still ultimately represented by people. Are you doing your brand justice?
To help you, here are 30 tips we’ve aggregated from a wonderful blogpost by Navid Moazzez, featuring 37 experts. We hope you find them useful!
6 Commandments for Launching a Startup Brand - a lecture for the ASU Venture ...Mike Jones ⚡
Lessons learned from branding and launching J Walkyn - an online marketplace for buyers and sellers of Nike Air Jordan shoes. There were lots of lessons, both good and bad, learned in this process and we've distilled them down into 6 fundamental keys to a successful startup launch.
This presentation was given to the ASU Venture Devils startup incubator course in April 2017.
Bootstrap Business Seminar 5: Creating an Awesome BrandCityStarters
The 5th Seminar in our Bootstrap Business Seminar series looks at how to create an awesome brand with Creative Director at Branding Agency One Ltd, Ben Mumby-Croft.
Slides of my presentation on the visual revolution and visual content marketing at Social Media Week Rotterdam 2015. If you'd like to know more, have questions, or want to receive a Very Short Introduction to Visual Content Marketing please send an e-mail to VCM [at] elsekramer.com.
Why Startups Need Storytelling and Inbound Marketing, and #WTF is Growth HackingPaula Marttila
Why Storytelling and Inbound Marketing are crucial for startups, specifically regarding fundraising, recruiting and building company culture, and why culture and recruiting play a central role in growth hacking. Keynote at StartSmart! Marketing & Metrics day, in Tallinn March 2013 http://www.start-smart.me/en/events/startsmart-events/149/startsmart-marketingmetrics.
Startup Camp Berlin March 2014 http://startupcamp.co/2014/
How Word of Mouth Marketing is Transforming Brand Storytellingfoundationcap
Gone are the days of waiting six months for your company's brand tracker. Today, CMOs can instantly tap into the consumer zeitgeist to understand opportunities for and threats to their brands. At the heart of this shift is the power of Word of Mouth.
In our new SlideShare, learn about the 9 reasons why Word of Mouth Marketing matters most today. Plus get a closer look at the opportunities for startups to build game-changing solutions for marketers in this powerful space.
For more about Word of Mouth Marketing and the 10x opportunity for MarTech startups - check out Foundation Capital General Partner, Ashu Garg's latest whitepaper, MarTech and the Decade of the CMO. www.foundationcapital.com/decadeofthecmo
Sharability, Conversation, Interactivity...these are just a few of the characteristics of good YouTube creative. Read through all 10, and look up the examples referenced in support of each, to understand what works on the world's largest video platform.
For startups, storytelling is crucial because it lets them clearly articulate what they do and why potential customers should be interested. It also differentiates them from rivals.
To help you understand the underlying mechanisms that go into the creation of a compelling visual ad, check out this presentation to have a great visual imagery that is attractive, interesting, important for the audiences and most important – converts.
Visual Social Media Marketing -- Harnessing Images, Instagram, Infographics a...Krista Neher
Krista Neher (www.KristaNeher.com) author of Visual Social Media Marketing (www.VisualSocialMediaMarketing.com) shares this presentation how how visuals can enhance marketing for businesses.
Discover how Pinterest, Instagram, Infographics and Images can transform your business online.
How to Use Twitter for Marketing & ConnectionJulia Campbell
With 302 million monthly active users (34% of which log in multiple times per day), Twitter is a marketing powerhouse for businesses large and small.
If the words “retweet,” “trending topic,” “hashtag,” “@mention” sound like a foreign language, then this presentation for you. In it, I walk you through how to get started on Twitter from setting up an account, to getting more followers, to building up a community and establishing thought leadership in your industry.
I answer the following questions: What is a hashtag and how do I use it? Who should I follow and how do I find them? What should I tweet and how often? Social media time-saving and management tools are also covered.
The Creative Rule of Writing Ad Copy That ConvertsBannersnack
Writing ad copy has always been a hard task, so there are a few things you should consider before starting this process.
Here you can find the infographic version of this Slideshare Presentation: http://bit.ly/lbs_icc
Social media accounts for twenty-seven percent of all time spent online, so to say that they are an effective marketing resource would be an understatement. Furthermore, pictures obtain far more interaction than posts with simple text. The combination of these two resources make Pinterest and Instagram valuable assets to real estate professionals to connect with consumers. Erica Campbell, real estate social media extraordinaire, explains the best practices of using these social sites for growing your business in this NAR 2013 Presentation.
Tell your brand story (visually) using Social MediaIdeas Collide Inc
"Brands will need to experiment with just about any form of digital, VISUAL storytelling as the competition for attention time only gets fiercer." Ideas Collide's Matthew Clyde explains how to stand out to the crowd at Phoenix Startup Week.
Create A Vision For Your Service Desk. David Wright, Director of Professional...Service Desk Institute
Part of IT Service Week 2014 'Week of Webinars'.
David explores why it's important to have clearly defined mission and vision statements and gives advice on creating a powerful, meaningful and inspiring vision for your service desk.
Ever wonder what it’s like to work at the fastest growing tech startup in Europe? The Lesara Culture Code will give you a brief insight into our team, our values, our culture and how we are changing the fashion industry.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
13. SOME STARTUPS
ARE ALL ABOUT THE
MISSION.
IN BUSINESS TERMS:
MAKE CUSTOMERS HAPPY
=
MAKE INVESTORS HAPPY
14.
15. "This is Day 1 for the Internet and, if we
execute well, for Amazon.com.
Today, online commerce saves customers
money and precious time.
Tomorrow, through personalization, online
commerce will accelerate the very process of
discovery.
Amazon.com uses the Internet to create real
value for its customers and, by doing so,
hopes to create an enduring franchise, even
in established and large markets."
16.
17. "If you can bring real efficiency, real
convenience and real comfort to how you
move around a city, you can change the
way people live in that city."
"The "Uber" way of life is a reflection of
our mission to turn around transportation
into a seamless service and to enable a
transportation alternative in cities that
makes car ownership a thing of the past."
20. SOME STARTUPS
ARE ALL ABOUT THE
CULTURE.
IN BUSINESS TERMS:
MAKE EMPLOYEES HAPPY
=
MAKE CUSTOMERS HAPPY
21.
22. Our Philosophy
A commitment to culture and customers has helped
Buffer grow from humble beginnings to now serving
more than two million people every day. Our passion for
support, happiness and quality flow through everything
that we do.
The Buffer Vision
Our vision at Buffer is to build the simplest and most
powerful social media tool, and to set the bar for great
customer support. In addition to these product and
service goals, we have a focus on building one of the
most unique and fulfilling workplaces that exist, by
rethinking a lot of traditional practices.
23.
24. Introducing: Core Values Frog!
The best thing about the Zappos Family is our
unique culture. As we grew as a company, we didn’t
want to lose that culture, and we wanted a way to share
it with all employees and anyone else who touches
Zappos.com.
When searching for potential employees, we’re looking
for people who both understand the need for these
core values and are willing to embrace and embody
them. To help us along, every day, in every situation we
ask ourselves: What would Core Values Frog do . . . ?
27. "CUSTOMER SERVICE ISN'T JUST A
DEPARTMENT!
We've been asked by a lot of people how we've grown
so quickly, and the answer is actually pretty simple…
We've aligned the entire organization around one
mission: to provide the best customer service
possible. Internally, we call this our WOW philosophy."
28.
29. "OBSESS OVER CUSTOMERS
From the beginning, our focus has been on offering
our customers compelling value. We realized that
the Web was, and still is, the World Wide Wait.
Therefore, we set out to offer customers something
they simply could not get any other way. We brought
them much more selection than was possible in a
physical store, and presented it in a useful, easy-to-
search, and easy-to-browse format in a store open 365
days a year, 24 hours a day. We maintained a dogged
focus on improving the shopping experience. Word of
mouth remains the most powerful customer
acquisition tool we have."
32. Value #3 - DESIGN IS NOT A LUXURY
Good design means coalescing hundreds of details into a package
that is simple and beautiful. Squarespace strives for excellence in
design within everything we do, and iterates relentlessly in order to
achieve that ideal.
Value #4 - CREATE BEAUTIFUL TOOLS
We believe that we can create products that are not only simple
and powerful, but elegant. Using beautiful tools fundamentally
enhances both work and life.
OUR MISSION
Squarespace's mission is to provide creative tools that help anyone
give a voice to their ideas. From the designers and engineers who
are creating the next generation of web and mobile experiences,
to anyone putting a website together for the first time,
Squarespace provides elegant solutions that set new standards
for online publishing.
33.
34. Freedom of data expression
Query at the speed of thought to perform complex analysis simply
and quickly. Beauty by default, customization by design. We know
that the beauty of BIME lies in what you can produce with it. With
smart defaults, your visualizations and dashboards will not only be
efficient but they will also look gorgeous.
37. We are making it easy for folks to eat and live
better.
We're changing the way America eats and
reconnecting people with their food, one plate at
a time.
We believe the world is a better place when
it's easy for people to eat well.
