This document outlines and provides examples of 8 specific types of quantitative research designs: 1) clinical trials, 2) evaluation research, 3) outcome research, 4) operational research, 5) methodological research, 6) secondary data research, 7) meta-analysis, and 8) ecological studies. Each type is defined and an example is given to illustrate how that particular design is used in research.
This slide contains B.Pharm 8th Sem Biostatistics and research methodology, Unit-3.
Topic covered: Designing the methodology, Sample size determination and Power of a study, Report writing
and presentation of data, Protocol, Cohorts studies, Observational studies, Experimental studies,
Designing clinical trial, various phases.
This slide contains B.Pharm 8th Sem Biostatistics and research methodology, Unit-3.
Topic covered: Designing the methodology, Sample size determination and Power of a study, Report writing
and presentation of data, Protocol, Cohorts studies, Observational studies, Experimental studies,
Designing clinical trial, various phases.
184 Deutsches Ärzteblatt International⏐⏐Dtsch Arztebl Int 2009.docxhyacinthshackley2629
184 Deutsches Ärzteblatt International⏐⏐Dtsch Arztebl Int 2009; 106(11): 184–9
M E D I C I N E
M edical research studies can be split into fivephases—planning, performance, documenta-
tion, analysis, and publication (1, 2). Aside from finan-
cial, organizational, logistical and personnel questions,
scientific study design is the most important aspect of
study planning. The significance of study design for
subsequent quality, the relability of the conclusions,
and the ability to publish a study are often underestimated
(1). Long before the volunteers are recruited, the study
design has set the points for fulfilling the study objec-
tives. In contrast to errors in the statistical evaluation,
errors in design cannot be corrected after the study has
been completed. This is why the study design must be
laid down carefully before starting and specified in the
study protocol.
The term "study design" is not used consistently in
the scientific literature. The term is often restricted to
the use of a suitable type of study. However, the term
can also mean the overall plan for all procedures in-
volved in the study. If a study is properly planned, the
factors which distort or bias the result of a test procedure
can be minimized (3, 4). We will use the term in a
comprehensive sense in the present article. This will
deal with the following six aspects of study design:
the question to be answered, the study population, the
type of study, the unit of analysis, the measuring tech-
nique, and the calculation of sample size—, on the
basis of selected articles from the international litera-
ture and our own expertise. This is intended to help
the reader to classify and evaluate the results in publi-
cations. Those who plan to perform their own studies
must occupy themselves intensively with the issue of
study design.
Question to be answered
The question to be answered by the research is of
decisive importance for study planning. The research
worker must be clear about the objectives. He must
think very carefully about the question(s) to be
answered by the study. This question must be opera-
tionalized, meaning that it must be converted into a
measurable and evaluable form. This demands an
adequate design and suitable measurement parameters.
A distinction must be made between the main questions
to be answered and secondary questions. The result of
the study should be that open questions are answered
R E V I E W A RT I C L E
Study Design in Medical Research
Part 2 of a Series on the Evaluation of Scientific Publications
Bernd Röhrig, Jean-Baptist du Prel, Maria Blettner
SUMMARY
Background: The scientific value and informativeness of
a medical study are determined to a major extent by the
study design. Errors in study design cannot be corrected
afterwards. Various aspects of study design are discussed
in this article.
Methods: Six essential considerations in the planning and
evaluation of medical research studies are presented and
discussed in the light.
184 Deutsches Ärzteblatt International⏐⏐Dtsch Arztebl Int 2009.docxhyacinthshackley2629
184 Deutsches Ärzteblatt International⏐⏐Dtsch Arztebl Int 2009; 106(11): 184–9
M E D I C I N E
M edical research studies can be split into fivephases—planning, performance, documenta-
tion, analysis, and publication (1, 2). Aside from finan-
cial, organizational, logistical and personnel questions,
scientific study design is the most important aspect of
study planning. The significance of study design for
subsequent quality, the relability of the conclusions,
and the ability to publish a study are often underestimated
(1). Long before the volunteers are recruited, the study
design has set the points for fulfilling the study objec-
tives. In contrast to errors in the statistical evaluation,
errors in design cannot be corrected after the study has
been completed. This is why the study design must be
laid down carefully before starting and specified in the
study protocol.
The term "study design" is not used consistently in
the scientific literature. The term is often restricted to
the use of a suitable type of study. However, the term
can also mean the overall plan for all procedures in-
volved in the study. If a study is properly planned, the
factors which distort or bias the result of a test procedure
can be minimized (3, 4). We will use the term in a
comprehensive sense in the present article. This will
deal with the following six aspects of study design:
the question to be answered, the study population, the
type of study, the unit of analysis, the measuring tech-
nique, and the calculation of sample size—, on the
basis of selected articles from the international litera-
ture and our own expertise. This is intended to help
the reader to classify and evaluate the results in publi-
cations. Those who plan to perform their own studies
must occupy themselves intensively with the issue of
study design.
Question to be answered
The question to be answered by the research is of
decisive importance for study planning. The research
worker must be clear about the objectives. He must
think very carefully about the question(s) to be
answered by the study. This question must be opera-
tionalized, meaning that it must be converted into a
measurable and evaluable form. This demands an
adequate design and suitable measurement parameters.
A distinction must be made between the main questions
to be answered and secondary questions. The result of
the study should be that open questions are answered
R E V I E W A RT I C L E
Study Design in Medical Research
Part 2 of a Series on the Evaluation of Scientific Publications
Bernd Röhrig, Jean-Baptist du Prel, Maria Blettner
SUMMARY
Background: The scientific value and informativeness of
a medical study are determined to a major extent by the
study design. Errors in study design cannot be corrected
afterwards. Various aspects of study design are discussed
in this article.
Methods: Six essential considerations in the planning and
evaluation of medical research studies are presented and
discussed in the light.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
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Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
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Specific quantitative.pptx
1. Specific types of
Quantitative Research Design
Prof.Dr.Chinna Chadayan.N
RN.RM., B.Sc (N)., M.Sc (N)., Ph.D (N).,
Professor,
Enam Nursing College – Savar,
Unit 13c
Specific Quantitative Research
Design
3. Specific types of Quantitative Research Design
1) Clinical trials
2) Evaluation Research
3) Out come Research
4) Operational Research
5) Methodological research
6) Secondary data Research
7) Meta-Analysis
8) Ecological Studies
4. 1.Clinical trials
A clinical trial is a type of patient-oriented clinical research study which
prospectively assigns a participant, also known as a human subject, to one or more
biomedical or behavioral interventions to evaluate health-related outcomes.
Types of clinical trials
• Pilot studies and feasibility studies.
• Prevention trials.
• Screening trials.
• Treatment trials.
• Multi-arm multi-stage (MAMS) trials.
• Cohort studies.
• Case control studies.
• Cross sectional studies.
•For example, investigators may give a drug or treatment to participants who have high blood
pressure to see whether their blood pressure decreases. Clinical trials used in drug development are
sometimes described by phase. These phases are defined by the Food and Drug Administration (FDA).
5. 2.Evaluation research
The evaluation of nursing research results consists of the examination and
determination of the scientificity, creativity, and scientific value of these
results and the assessment of the specific quality and benefits of these
results.
Methods of evaluation in nursing
The three main types of evaluation methods are
goal-based,
process-based
and outcomes-based.
Example :Evaluation research, also known as program evaluation, refers to
research purpose instead of a specific method. Evaluation research is the
systematic assessment of the worth or merit of time, money, effort and
resources spent in order to achieve a goal.
6. 3.Outcome research
Outcomes research seeks to understand the end results of particular health care
practices and interventions. End results include effects that people experience and
care about, such as change in the ability to function.
An outcome is defined as a measurable individual, family, or community state,
behavior or perception that is measured along a continuum in response to nursing
interventions. The outcomes are developed for use in all clinical settings and with all
patient populations.
Examples of some outcomes that can be measured are cure rates for certain
diseases, patient functional status and activities of daily living, respiratory function,
or the rate of hospital admission or outpatient visits.
7. 4.Operational Research
It involves research into the problem using principles of epidemiology. It tests more
than one possible solution and provides rational basis, in the absence of complete
information, for the best alternative to improve program efficiency. It requires close
interaction between program managers and researchers.
For Example: The researcher evaluates every possible option by weighing each
option's pros and cons. For example, in order for making Staff Rotation / Routine to
have a master Roster plan, Nursing Superintendent has to decide which nurse should
be sent where, when, and how much they should charge for their work time according
to their qualification and experience.
8. 5.Methodological Research
Methodological studies – studies that evaluate the design, analysis or reporting of
other research-related reports – play an important role in health research. They help to
highlight issues in the conduct of research with the aim of improving health research
methodology, and ultimately reducing research waste.
Approaches
There are two general research methodology approaches when collecting and
analyzing data; these approaches are quantitative and qualitative.
For Example: Interviews (which can be unstructured, semi-structured or
structured) Focus groups and group interviews. Surveys (online or physical
surveys) Observations to improve the methodology
9. 6.Secondary data Research
Secondary Research: This is when an author of the source you are using gathers
existing data, usually produced by someone else, and they then report, analyze or
interpret that other person's data.
Sources include administrative data, claims-based datasets, electronic health records
health surveys, patient or disease or both registries, quality improvement initiatives,
as well as data from existing trials.
Example: Secondary data is research data that has previously been gathered and can
be accessed by researchers. The term contrasts with primary data, which is data
collected directly from its source.
10. 7.Meta-Analysis
Meta-analysis is a statistical process that combines the data of multiple studies to find
common results and to identify overall trends.
Example: The subjects from all eight studies (total: 860 subjects) were pooled and
statistically analyzed to determine the effect of the relationship between wearing
sunscreen and melanoma. This meta-analysis showed a 50% reduction in melanoma
diagnosis among sunscreen-wearers.
11. 8.Ecological Studies
Ecological studies are used to understand the relationship between outcome and exposure at a
population level, where 'population' represents a group of individuals with a shared characteristic
such as geography, ethnicity, socio-economic status of employment
For example, The study by John Snow regarding a cholera outbreak in London is considered the
first ecological study to solve a health issue. He used a map of deaths from cholera to determine
that the source of the cholera was a pump on Broad Street. He had the pump handle removed in
1854 and people stopped dying there
Purposes: Ecologic studies assesses the overall frequency of disease in a series of populations
and looks for a correlation with the average exposure in the populations.
The advantages of the ecological studies include the large number of people that can be included
in the study and the large number of risk-modifying factors that can be examined.