The document outlines a strategy to improve translational research and clinical trials through more tailored and personalized approaches. It proposes combining basic research on topics like DNA repair mechanisms with biology-driven therapies and immunotherapies guided by a patient's specific biomarkers. The goal is to move beyond one-size-fits-all approaches to cancer treatment and instead target therapies based on a patient's individual cancer biology and vulnerabilities to achieve better outcomes.

1. To boost translational research
Streamlining interactions
Massive translational research
Initiating ad hoc clinical trials
Basic research
Translational research
Clinical Research

2. Our strategy
« one-size fits-all » Tailored Better therapy
approach therapy
Combining these approaches
to eradicate cancer
DNA damaging agents Biology-driven radiotherapy
(ie cisplatin and XRT Chemotherapy delivered to patients DNA repair mechanisms
in lung cancer) with DNA repair vulnerability context DNA damaging agents
Olaussen et al NEJM 2006
Non-specific Immunotherapy guided by SNP
immunotherapy DC-T cell-based immuno- modulation Patient adjusted immunotherapy
(ie interferon in RCC) Selection of chemotherapeutic drugs
according to their immune effects
Robert et al NEJM 2011
Identify target and resistance Cancer-cell based
Targeting oncogenes mechanisms at the patient’s level targeted agents
in large populations ->
(i.e. imatinib in GIST) optimal individualized
targeted agent
Delhommeau et al NEJM 2009

3. M CASTEDO S CHOUAIB W VAINCHENKER
BASIC Inserm 848 Inserm 753 Inserm 1009
RESEARCH F ROSSELLI L ZITVOGEL O BERNARD
CNRS 8200 Inserm 1025 Inserm 985
E DEUTSCH G KROEMER E SOLARY
Inserm 1030 Inserm 848 Inserm 1009
JC SORIA C ROBERT F ANDRE
TRANSLATIONAL Inserm 981 Inserm 981 Inserm 981
F DE VATHAIRE P AMIEL
RESEARCH Inserm 1018 Human Sciences &
Epidemiology Public health
CLINICAL EARLY DRUG DEVELOPMENT (SITEP)
RESEARCH CLINICAL RESEARCH DIVISION
TUMOR MOLECULAR
DNA REPAIR
IMMUNOLOGY CANCER MEDECINE
DIFFUSION OF KNOWLEDGE, PRACTICES
COLLABORATION, PARTNERSHIP AND VALORIZATION

4. Frequent tumors Rare tumors
Thyroid
DNA
REPAIR
Hematology
Melanoma
Sarcomas
Breast
TUMOR
Lung
IMMUNOLOGY
Pediatric
MOLECULAR
CANCER
MEDICINE