Investigators discovered that the DNA methyltransferase 1 (DNMT1) enzyme is more efficient in cancer cells compared to normal cells, contributing to increased methylation tags in cancer genomes. They studied two cell types and used a mathematical model to correlate methylation status with DNMT1 levels. Researchers are developing combination therapies using epigenetic and traditional drugs to make cancer cells more susceptible to treatment and potentially kill cancer stem cells and overcome drug resistance. A separate study identified an alternative DNA repair mechanism in neuroblastoma tumors that may be a new treatment target for high-risk childhood neuroblastoma.
Gene is the basic physical unit of inheritance that passed information from parents to offspring. Genes are arranged, one after another, on structure called chromosome.
A gene is region of DNA that encodes function and chromosome consist of long DNA strands containing many genes.
A human chromosome can have up to 500 million base pair of DNA with thousands of genes.
Technique responsible for correcting the defective genes responsible for disease development is called Gene Therapy
Future Strategies for Treatment of Brain TumoursAsad Qureshi
It includes a brief description of the methods that are currently employed and the methods that hold promise for the complete cure of brain cancer in the future
Gene is the basic physical unit of inheritance that passed information from parents to offspring. Genes are arranged, one after another, on structure called chromosome.
A gene is region of DNA that encodes function and chromosome consist of long DNA strands containing many genes.
A human chromosome can have up to 500 million base pair of DNA with thousands of genes.
Technique responsible for correcting the defective genes responsible for disease development is called Gene Therapy
Future Strategies for Treatment of Brain TumoursAsad Qureshi
It includes a brief description of the methods that are currently employed and the methods that hold promise for the complete cure of brain cancer in the future
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
Perjuangan Diplomatik Menghadapi Agresi Militer II Belanda, Perundingan Roem-Royen, Konferensi Antar - Indonesia, Konferensi Meja Bundar, Pembentukan NRIS, Kembali ke Negara Kesatuan Republik Indonesia
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
Perjuangan Diplomatik Menghadapi Agresi Militer II Belanda, Perundingan Roem-Royen, Konferensi Antar - Indonesia, Konferensi Meja Bundar, Pembentukan NRIS, Kembali ke Negara Kesatuan Republik Indonesia
This presentation focuses on the science of Gene Therapy, the techniques of germ-line and somatic gene therapy and the mechanism of curing diseases and disorders using gene therapy. The presentation starts by discussing some common basic terms from genetics and moves on to the historical development of gene therapy techniques in chronological order. The different types of gene therapy techniques and their mechanisms have been discussed in detail subsequently. In concluding slides, some commercially available gene therapy products are mentioned and challenges of gene-therapy techniques have been highlighted.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
4. DNA is the
structure that
contains the
genetic information.
Currently scientists
have been studying
and researching the
environment's
effects on DNA
this fact is known
as epigenetic
the repair of
DNA sequences
that have been
altered is an
indispensable
mechanism
control for cells
which have
suffered damage
6. EFFICIENT METHYLATING ENZYME IDENTIFIED
FOR CANCER DEVELOPEMEN
• Investigators discovered that many
methyl tags in cancer cells its because a
hightly efficient DNA methyl
transferase 1 enzymes fund in these
cells.
• They worked with two type of cells
(cancer and normal cells), for each one
they used a mathematical equation to
determinate the methylation status
correlated with the enzyme present in
the cells.
7. EFFICIENT METHYLATING ENZYME IDENTIFIED
FOR CANCER DEVELOPEMEN
They are creating a
combination therapy using
epigenetic drugs with
traditional drugs which are
effective and able to
reduce cancer relapse
because make cancer cells
susceptible and possibly
kill cancer progenitor cells
and drug resistance.
8. EFFICIENT METHYLATING ENZYME IDENTIFIED
FOR CANCER DEVELOPEMEN
• Genes are transcriptionally silenced because an insulated
area which regulated enhancer and transcription factor
interactions, This area can be regulated by methylation
mechanism helping to cancer development.
9. EFFICIENT METHYLATING ENZYME IDENTIFIED
FOR CANCER DEVELOPEMEN
I think is very important
to continue studing the
enzyme action in genoma,
its interaccion and
intervencion to discover
what is the relation with
many deseas which affect
many people in the world
11. Alternative DNA repair mechanism could provide better
treatment for neuroblastoma in kids
• The most important target
for investigators is to find
a new treatment which
help childrens who have
high-risk disease, because
most of them don´t
survive.
12. • The most common
cancer in kids is
neuroblastoma and also
the most common solid
tumor outside the brain.
• In this cancer, the cells
develops from tissues
that form the nervous
system or in the adrenal
glands.
Alternative DNA repair mechanism could provide better
treatment for neuroblastoma in kids
13. • Its very important discover the
mechanism which neuroblastoma
tumors overcome DNA demage
because its study gives them evidence
that an atlternative repair mechanism
is functional in this type of cancer.
Alternative DNA repair mechanism could provide better
treatment for neuroblastoma in kids
14. Alternative DNA repair mechanism could provide better
treatment for neuroblastoma in kids
Is very importan to work on
deseas which affect the kids
buecause they are the most
suceptible persons and the
future scientists who will
create new forms to help
the world.
15.
16. Medical Utility
• Is essential for physicians to be
updated and know the advances in
cancer research to use this knowledge
for the welfare of patients.
• Also known cellular processes is
critical to understand that what many
diseases related to damage the
genome
17. EFFICIENT METHYLATING ENZYME IDENTIFIED
FOR CANCER DEVELOPEMEN
Discover the molecular mechanism that allow
expression or silencing of genes associated with
the development of diseases, including cancer, its
important to develop methods of counteracting
these mechanisms and treating deseas.
18. Alternative DNA repair mechanism could provide better
treatment for neuroblastoma in kids
Identified that que cell can use a
erroneus DNA repair pathway
promising a new target for develop
therapies for kinds with
neuroblastoma
19. BIbliography
· E. A. Newman, F. Lu, D. Bashllari, L. Wang, A. W.
Opipari, V. Castle. Alternative NHEJ Pathway
Components are Therapeutic Targets in High-risk
Neuroblastoma. Molecular Cancer Research, 2015.
from:
http://www.sciencedaily.com/releases/2015/01/15012
1173539.htm
· Eric Samorodnitsky, Emily Ghosh, Sahana Mazumder
and Sibaji Sarkar.Methylation by DNMT1 is more
Efficient in Chronic Lymphocytic Lymphoma Cells than
in Normal Cells. Journal of Proteomics and
Bioinformatics, January 2015. from:
http://www.sciencedaily.com/releases/2015/01/15012
3102535.htm
