The document discusses two scientific articles about discoveries related to cancer recurrence and stem cells. The first article describes a DNA-repairing protein that may help prevent cancer recurrence by allowing cancer cells to repair DNA damage from chemotherapy. The second article finds that a retrovirus present in the human genome is active in pluripotent stem cells and could help develop new gene therapy treatments.
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
This paper highlights mainly on gene therapy for oral cancer
Oral cancer is one of the deadly disease which need a different vision of treatment because of its pooor prognosis rate.
This paper highlights the basic idea of gene therapy , techniques , steps , its merits & limitations.
Pamphlet with the presentation of two news on Genetic Transcription:
- How 1,000 new genetic variants were discovered in blood groups
- New mechanisms of gene inactivation may prevent aging and cancer
Suicide gene therapy is based on the delivery of a gene encoding a cytotoxic protein into tumor cells.
For this, there are two possible strategies:
1. Indirect gene therapy using enzyme-activated pro-drug, which allows the conversion of a pro-drug into a lethal drug into cells.
2. Direct gene therapy using a toxin gene, whose expression can change the stability of the cell membrane and reduce the viability of tumor cells, or correct mutated pro-apoptotic genes, generally tumor suppressor genes that in normal condition induce cell suicide.
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
This paper highlights mainly on gene therapy for oral cancer
Oral cancer is one of the deadly disease which need a different vision of treatment because of its pooor prognosis rate.
This paper highlights the basic idea of gene therapy , techniques , steps , its merits & limitations.
Pamphlet with the presentation of two news on Genetic Transcription:
- How 1,000 new genetic variants were discovered in blood groups
- New mechanisms of gene inactivation may prevent aging and cancer
Suicide gene therapy is based on the delivery of a gene encoding a cytotoxic protein into tumor cells.
For this, there are two possible strategies:
1. Indirect gene therapy using enzyme-activated pro-drug, which allows the conversion of a pro-drug into a lethal drug into cells.
2. Direct gene therapy using a toxin gene, whose expression can change the stability of the cell membrane and reduce the viability of tumor cells, or correct mutated pro-apoptotic genes, generally tumor suppressor genes that in normal condition induce cell suicide.
Similar to DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER -AND- RETROVIRUS IN THE HUMAN GENOME IS ACTIVE IN PLURIPOTENT STEM CELL.
Similar to DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER -AND- RETROVIRUS IN THE HUMAN GENOME IS ACTIVE IN PLURIPOTENT STEM CELL. (20)
DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER -AND- RETROVIRUS IN THE HUMAN GENOME IS ACTIVE IN PLURIPOTENT STEM CELL.
1. DNA– REPAIRING PROTEIN MAY BE KEY TO
PREVENTING RECURRENCE OF SOME CANCER
-AND-
RETROVIRUS IN THE HUMAN GENOME IS ACTIVE
IN PLURIPOTENT STEM CELL.
Natalia Perilla Hernandez
Medical Student
Third semester
2.
3.
4. INTRDUCTION
In the two news they talk about the
importance to know more about the
genetic.
It is incredible to think that just
knowing a little bit of the composition
of the genetic code we can repair
some of the diseases, and probably
cure the human before birth.
5. DNA– repairing protein may be key to preventing
recurrence of some cancer . Science daily. January.
23, 2013.
6. DNA– repairing
protein may be key to
preventing recurrence
of some cancer
• The KLF8 is a protein that
protect the tumor cell from drugs.
• Jihe Zhao one of the scientific
that discoverd this protein said
that all cell have a DNA repair but
the KLF8 is overexpressed in a
specific cancer such as breast and
ovarian cancer.
7. DNA– repairing
protein may be key to
preventing recurrence
of some cancer
• In the States are between 2.5 million
and 2.7 million women who have
breast cancer. This study is going to
help a lot of people in the future, if
they can find the way to inactivate the
KLF8 protein
• The results showed that KLF8 can
repair the DNA of the carcinogenic cell
when they are attacked with drug that
are used for the treatment of cancer
such as doxorubicin that induce cell
death
8. Student Opinion:
Is important to keep the investigation, because this
let us know more about the tumoral cells and be
more close to finding the cure of cancer.
9. Retrovirus in the human genome is active in pluripotent
stem cell. Science daily . Jan. 28, 2013.
10. Retrovirus in the
human genome is
active in pluripotent
stem cell
• The HERV-H is a retrovirus that
are in human embryonic stem
cell, and is one of the most
abundantly expressed genes in
pluripotent stem cell.
• This retrovirus codify a RNA, and
also have the same sequence that
use to reprogram skin cells into
induced pluripotent stem cells.
11. Retrovirus in the
human genome is
active in pluripotent
stem cell
• The Ips (pluripotent stem cell)
became a new marker of pluripotency.
•The retrovirus infect a cell, when he
goes inside of the genome into the
chromosomal DNA. As a result, the cell
treats the virus as part of his own
genome and begins to make the
proteins that the viral genome needs
to be insert. In rare cases the viral
genome goes inside the germinales
cells and if the resulting embryo
survive the retrovirus can become a
part of a new genetic code.
12. Retrovirus in the
human genome is
active in pluripotent
stem cell
• This chromosomal DNA retrovirus
can potentiality the development of
drugs that protect against the
infections, also can make a better gene
therapy treatments, and use this one
like a marker to find specify anomaly
of the human genome.
13. Student Opinion
it would be nice to continue with the investigation,
because is a way to use the enemies of the human
body in a way to find a cure for a lot of diseases.
14.
15. MEDICAL UTILITY
DNA– repairing protein may be key to preventing
recurrence of some cancer
Discover the protein that allows cancer
cells to reactivate again, gives to the
science an advantage to the cancer
treatment, allowing to make new
techniques and maybe avoid the
treatment that can be worst for the
patient that the disease itself.
17. BIBLIOGRAPHY
· Martinez S, Lina Maria. Biología Molecular. 5 ed
Medellín: UPB. Facultad Medicina.
· Dna– repairing protein may be key to preventing
recurrence of some cancer . Science daily. January.
23, 2013.
· Retrovirus in the human genome is active in pluripotent
stem cell. Science daily . Jan. 28, 2013.