Self-nano emulsifying drug delivery systems (SNEDDS) are anhydrous homogeneous liquid mixtures, composed of oil, surfactant, drug, and/or cosolvents, which spontaneously form transparent nanoemulsion (20–200 nm droplet size) upon aqueous dilution with gentle agitation SNEDDS can offer the advantages of improved physical and/or chemical stability of the formulation and ability to fill them into unit dosage forms, such as soft/hard capsules, which improves their commercial viability and patient compliance/tolerability and minimizes palatability-related concerns
Self Nano-emulsifying drug delivery system (SNEDDS)Sagar Savale
The Self Nano-emulsifying Drug Delivery System (SNEDDS) is a Novel Drug Delivery System for Enhancement of water solubility of poorly water soluble drugs. It is isotropic mixture of oil, surfactant, co-surfactant molecules and it also containing co-solvent molecule.
Self Nano-emulsifying drug delivery system (SNEDDS)Sagar Savale
The Self Nano-emulsifying Drug Delivery System (SNEDDS) is a Novel Drug Delivery System for Enhancement of water solubility of poorly water soluble drugs. It is isotropic mixture of oil, surfactant, co-surfactant molecules and it also containing co-solvent molecule.
it provide a brief note on the drug excipient interaction and various technique to find it which is a part of preformulation studies. it gives help to mpharm(pharmaceutics) students. i.
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
The system to deliver the drug to the body to produced desired therapeutic action and activity against diseases and disorders is known as Drug delivery system
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
it provide a brief note on the drug excipient interaction and various technique to find it which is a part of preformulation studies. it gives help to mpharm(pharmaceutics) students. i.
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
The system to deliver the drug to the body to produced desired therapeutic action and activity against diseases and disorders is known as Drug delivery system
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
Oral lipid drug delivery system for poor water soluble drugsTanvi Shetty
The presentation talks about recent advancement in the delivery mode for many poorly water soluble drugs. Introduces you to various available Lipid based systems and a easy guide to use a specific mode through detailed description of pros & cons they hold.
Its will serve as very essential for researchers working on BCS class II drug to increase its systemic availability.
SEEDS- SELF EMULSIFYING DRUG DELIVERY SYSTEMSSiva Prasad U
A self-microemulsifying drug delivery system is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling.
** Disclaimer: All photos, logos, etc. used in this presentation are the property of their respective copyright owners and are used here for educational purposes only.
SMEDDS- Self Micro Emulsifying Drug Delivery System.pptxTanmai25
smedds is a lipid based drug delivery system , which uses a lipid as a carrier to deliver poorly soluble drug. Thereby increasing its dissolution and bioavailability.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
2. Contents
• Drug of choice
• Physiochemical properties of Glibenclamide
• Introduction
• Need for SEDDS
• Advantage
• Disadvantage
• Classification of lipid carrier
• Formulation Consideration
• Excipient used in SEDDS
• Preparation and method for SNEDDS
• Evaluation of SNEDDS
• Application
• Conclusion
• Reference
3. Drug of Choice- Glibenclamide
• Also called Glyburide.
• Glyburide is an oral second-era sulfonylurea
drug employed in the treatment of type II diabetes.
• Being a biopharmaceutical classification system
(BCS) class II drugs, it's very low water solubility
leads to incomplete and variable bioavailability.
4. Physiochemical Properties of
Glibenclamide
• MW-494
• Hydrogen bond donor count-3
• Hydrogen bond acceptor count-5
• Rotatable bond count-8
• Solubility-2.06-3 g/l
Pharmacokinetic profile-
• Excretion-
50%- Urine
50%- feces
• Clearance- 2.47-4.11 L/h
• Half life- 4.0-13.4h
5. Needs for SEDDS
• 40% of new drug candidates show poor aqueous
solubility and so poor bioavailability.
• BCS class II drugs( dissolution is rate limiting step
for absorption).
• BCS class II and Class IV needs some
improvement in their solubility.
• Enhancement of bioavailability for oral
formulation.
6. Introduction
• SNEDDS is an emulsion based system.
• It consist of isotropic anhydrous homogenous
liquid mixtures.
• These mixtures contains oil, surfactants, co-
surfactants and API.
• It will produce O/W emulsion into aqueous media.
• A nanoparticles size ranges between less than or
equal to 200nm.
• SNEDDS contains high amounts of lipids increases
absorption and bioavailability of poorly water
soluble drugs.
7. Advantage
• Thermodynamically and kinetically stable
• SNEDDS improve the solubility of BCS class II
and Class IV drugs.
• Improving dissolution as well as absorption rate.
• Novel approach for enhancing gastrointestinal
absorption of poorly water soluble drugs.
• Transparent or translucent non ionized dispersion
of O/W and W/O Nano-emulsion.
• SNEDDS can dissolved large amount of lipophilic
drugs.
10. Formulation Consideration
• The nature of the oil/surfactant pair.
• The concentration of surfactant
• Oil/surfactant ratio
• the concentration and nature of co surfactant
• Surfactant and co-surfactant ratio
• Temperature at which self emulsification occurs
15. Screening of excipient
• The solubility of Glyburide was investigated in
oils, surfactants and co-surfactants.
• An excess amount drug was added in 2 g of
selected solvent in vials and mixed with the help of
shaker for 72 h at 37±1o
C.
• The resulting samples were centrifuged at 6000×g
for 15 min.
• The supernatant was diluted with methanol and
then quantified by a validated HPLC system.
• The size of oily droplets was determined
• immediately by dynamic light scattering (DLS).
16. Characterization
• Droplet size
• Zeta potential
• Polydispersity index
• Entrapment efficiency(%)
• Drug loading capacity
• FTIR
• Thermal characterization
DSC
TGA
• SEM and TEM
17. Evaluation of SNEDDS
• Some basic method are enlisted for evaluation of
SNEDDS-
1. Thermodynamic stability of emulsion
2. Centrifugation study( 5000rpm for 30 min)
3. Heating and cooling cycle
4. Freeze thaw cycle(4oc for 24h after that 40oc for
24h then centrifuged at 3000rpm for 5min then
monitored phase separation)
5. Droplet size(Photon correlation spectroscopy)
6. Viscosity(Brookfield Viscometer)
18. Application
• SNEDDS is formulated in a variety of formulation
such as-
1. Liquids
2. Sprays
3. Foams
4. Creams
5. Ointment
6. Gel
7. Nano-emulsion
19. Conclusion
• SNEDDS is a novel approach for the formulation of drug
molecule with poor water solubility.
• SNEDDS is an isotropic mixture of oils, surfctant.co
surfactant and co solvents.
• When introduced into aqueous phase it emulsifies
spontaneously to produce O/W Nano-emulsion under mild
agitation.
• SNEDDS provide a good alternate to those drugs which have
poor solubility.
• The oral delivery of lipophilic drug can be made possible by
SNEDDS.
• According to this approach it is possible to prolong the
release of drug via incorporation of polymer in composition.
• SNEDDS seems to be appear as unique and industrially
survival approach with futuristic development.