This document discusses Self-Emulsifying Drug Delivery Systems (SEDDS), which are isotropic mixtures of oils, surfactants, and co-solvents that can solubilize drugs and promote self-emulsification. SEDDS enhance oral drug bioavailability, protect drugs from the hostile gastrointestinal environment, and reduce variability. The document describes the components of SEDDS including oils, surfactants, co-surfactants and drugs. It also outlines the formulation process and methods to evaluate parameters like stability, dispersibility, droplet size and drug release. SEDDS are a promising approach for improving oral delivery of poorly soluble drugs.
drug execipent compatibilty studies is of prime importance for the better formulation of the new drug and also for reducing cost by verfication of the data at the earlier atage.
this presentation will give the brief explanation of the goal, importance, dteps involve to studi the drug execient compatibility studies with different examples suitable accordiingly.
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
drug execipent compatibilty studies is of prime importance for the better formulation of the new drug and also for reducing cost by verfication of the data at the earlier atage.
this presentation will give the brief explanation of the goal, importance, dteps involve to studi the drug execient compatibility studies with different examples suitable accordiingly.
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...PRAJAKTASAWANT33
Introduction, biopharmaceutic factors affecting drug bioavailability, rate–limiting steps in drug absorption, physicochemical nature of the drug formulation factors affecting drug product performance
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...PRAJAKTASAWANT33
Introduction, biopharmaceutic factors affecting drug bioavailability, rate–limiting steps in drug absorption, physicochemical nature of the drug formulation factors affecting drug product performance
This slide share includes the introduction about smedds, difference between emulsion and smedd and sedds and smedds, composition and its formulation aspects.
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxDipeshGamare
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) is a type of novel drug delivery system, in this presentation all aspect regarding SEDDS are covered with some novel points.
SEEDS- SELF EMULSIFYING DRUG DELIVERY SYSTEMSSiva Prasad U
A self-microemulsifying drug delivery system is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling.
** Disclaimer: All photos, logos, etc. used in this presentation are the property of their respective copyright owners and are used here for educational purposes only.
Formulation Development and Evaluation of Self Nano Emulsifying Drug Delivery...ijtsrd
The primary objective of the work was to develop a self nano emulsifying drug delivery system of dolutegravir HCL. Self nanoemulsifying drug delivery system is a lipid based formulation which consists of isotropic mixtures of oils, surfactants and co surfactants. It can conveniently develop the emulsion on gentle agitation and offers a considerable surface area for interaction between the SNEDDS formulation and the aqueous gastrointestinal fluid. This may lead to enhanced bioavailability of hydrophobic agents. The Liquid SNEDDS was prepared and after that solidified by aerosil 200. For 10 gm of liquid SNEDDS 5 gm of Aerosil 200 was used and after that product is dried by spray drying method. And 12 gm of product is remaining after the process. The drug excipients interaction studies were carried out using FTIR and DSC. The interaction studies were carried out to check physical and chemical stability of Dolutegravir with other excipients. FTIR spectra showed the characteristic peaks of drug i.e. for C H stretch, N C stretch appear in the spectra of physical mixtures at the same wave number indicating no modification or interaction between drug and the polymers. The liquid SNEDDS formulation C1 showed good thermodynamic stability without any precipitation and having globule size 536.6 nm and zeta potential 29.9. Based on thermodynamic stability, precipitation studies, self emulsification studies, globule size and zeta potential liquid SNEDDS of formulation batch C1 was selected as optimized formulation. Liquid SNEDDS and solid SNEDDS was prepared for Dolutegravir. SEM, IR, and DSC results confirmed that drug was present in an amorphous state in solid SNEDDS. In vitro drug release and drug content of optimized formulation was found to be 98.64 and 99.35 respectively. F3 batch of capsule formulation shows better drug release than marketed formulation. Suresh Mularam Choudhary | Prof S. A Waghmare | Hemant V. Kamble "Formulation Development and Evaluation of Self Nano Emulsifying Drug Delivery System of Dolutegravir" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50569.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50569/formulation-development-and-evaluation-of-self-nano-emulsifying-drug-delivery-system-of-dolutegravir/suresh-mularam-choudhary
Self emulsifing drug delivary systems (SEDDS)Mohamed Mohsen
A presentation about a new method for delivary of a drug to a target site within the body and to enhance its kinetics including absorption and bioavailability as a promising method using certain compounds
Self Micro Emulsifying Drug Delivery System (SMEDDS): A ReviewSagar Savale
Objective: Much attention has been given to lipid-based formulation with particular emphasis on self-micro emulsifying drug delivery system (SMEDDS) to improve the solubility and oral bioavailability of lipophilic as well as hydrophilic drugs.
Method: Various reports were taken from review or research articles published in journals, data from various books and other online available literature.
Conclusion: This method is suitable for all BCS class drugs where resulting emulsification gives faster dissolution and absorption rate.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
1. 1
Self-Emulsifying Drug Delivery System (SEDDS)
Presented by,
Mr.Panke Ashutosh Abhimanyu
M. Pharm-II Sem.
PUNE DISTRICT EDUCATION ASSOCIATION’S
Seth Govind Raghunath Sable College of Pharmacy, Saswad.
Department of Pharmaceutics
2014-15
3. Introduction
3
Self-emulsifying drug delivery systems
(SEDDS ) are defined as isotropic mixtures
of oils, surfactants and co-solvents.
4. Advantages
4
1. Enhanced oral bioavailability
2. Selective targeting of drug(s) toward
specific absorption window in GIT.
3. Protection of drug(s) from the hostile
environment in gut.
4. Reduced variability including food effects.
5. Protective of sensitive drug substances.
5. Drawback Of SEDDS
5
Lack of good predicative in vitro models for
assessment of the formulations.
The large quantity of surfactant in self-emulsifying
formulations (30-60%) irritates
Volatile co-solvents can migrate on capsule
shell.
6. Composition of SEDDSs
6
Composition of SEDDSs
Drug (API)
Oil
Surfactant
Co-Surfactants
7. Drug
7
The drugs with poor aqueous solubility and high permeability are classified as
class II drug by Biopharmaceutical classification system (BCS). These drugs are
use for formulate SEDDS.
Class II
Low Solubility
High Permeability
Class I
High Solubility
High Permeability
Class IV
Low Solubility
Low Permeability
Class III
High Solubility
Low Permeability
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Solubility
8. Oil
8
Oils are the most important excipient.
Help in solubilizing the lipophilic drug in a high amount.
Facilitate self-emulsification and increase the fraction of
lipophilic drug transported.
Increase absorption from the GI tract.
Both long-chain triglyceride and medium-chain triglyceride
oils with different degrees of saturation have been used for
the formulation of SEDDSs.
10. Surfactants
10
Non-ionic surfactants with high hydrophilic–lipophilic
balance (HLB) values are used in formulation of SEDDSs
Surfactant strength ranges between 30–60% w/w of the
formulation in order to form a stable SEDDS.
A large quantity of surfactant may irritate the GIT.
Non-ionic surfactants are less toxic as compared to ionic
surfactants.
12. Co-solvents/Co-Surfactants
12
Co-solvents help to dissolve large amounts of
hydrophilic surfactants or the hydrophobic drug in
the lipid base.
These solvents sometimes play the role as co-surfactant
in the micro-emulsion systems.
14. Mechanism of self emulsification
14
The free energy of the conventional emulsion is a
direct function of the energy required to create a
new surface between the oil and water phases
In emulsification process the free energy (ΔG)
associated is given by the equation:
15. Mechanism of self emulsification
15
where,
ΔG = free energy associated with the process
(ignoring the free energy of mixing)
N = number of droplets
r = Radius of droplets
б = interfacial energy
16. Mechanism of self emulsification
16
The two phases of emulsion tend to separate with
time to reduce the interfacial area, and subsequently,
the emulsion is stabilized by emulsifying agents.
17. General formulation Approach
Preliminary solubility profiling studies are performed for
selection of oil.
Drug excipient compatibility studies.
Preparation of a series of SEDDS system containing drug
in various oil and surfactant with different combinations.
Optimization of formulation on the basis of in vitro self-emulsification
17
properties, droplet size analysis, stability
studies, robustness to dilution upon addition to water
under mild agitation conditions.
18. Evaluation of SEDDS
18
1. Thermodynamic Stability Studies
2. Dispersibility test
3. Turbidimetric Evaluation
4. Viscosity Determination
5. Droplet Size Analysis and Particle Size Measurements
6. Refractive Index and Percent Transmittance
7. Electro Conductivity Study
8. In vitro Diffusion Study
9. Drug Content
10. In vivo permeability studies
19. Thermodynamic Stability Studies
19
Heating cooling cycle
Six cycles between refrigerator temperature 4⁰C
and 45⁰C with storage at each temperature of not
less than 48 h is studied.
Those formulations, which are stable at these
temperatures, are subjected to centrifugation test.
20. Thermodynamic Stability Studies
20
Centrifugation
Passed formulations are centrifuged at room
temperature at 3500 rpm for 30 min.
Those formulations that does not show any phase
separation are taken for the freeze thaw stress
test.
21. Thermodynamic Stability Studies
21
Freeze thaw cycle:-
Freeze was employed to evaluate the stability of
formulation.
Thermodynamic stability was evaluated at difference
temp. To chake the effect of temp. the formulation was
subjected to freeze thaw cycle(-20ºC) for 2-3 days.
22. Freeze thaw cycle:-
22
Formulation are exposed to at least three freeze
thaw cycles. Those formulations passed this test
showed good stability with no phase separation,
creaming, or cracking.
Suppose it shows thermodynamically unstable
formulation which had larger droplet size
distribution upon dilution.
23. Dispersibility test
23
The efficiency of self-emulsification of oral nano or micro
emulsion is evaluated by using a standard USP XXII
dissolution apparatus 2 for dispersibility test.
Solution Tested: 1ml
Medium: 500 ml water
Temperature: 37 ± 1 ⁰C.
Paddle speed : 50 rpm
24. Dispersibility test
24
Grade A: Rapidly forming (within 1 min) nano-emulsion, having
a clear or bluish appearance.
Grade B : Rapidly forming slightly less clear emulsion having a
bluish white appearance.
Grade C: Fine milky emulsion that formed within 2 min.
Grade D: Dull, grayish white emulsion having slightly oily appearance
that is slow to emulsify (longer than 2 min).
Grade E: Formulation, exhibiting either poor or minimal emulsification
with large oil globules present on the surface.
Grade A and Grade B formulation will remain as nanoemulsion when
dispersed in GIT. While formulation falling in Grade C could be
recommended for SEDDS formulation.
25. Turbidimetric Evaluation
25
Nepheloturbidimetric evaluation is done to monitor
the growth of emulsification. Fixed quantity of Self
emulsifying system is added to fixed quantity of
suitable medium (0.1N hydrochloric acid) under
continuous stirring (50 rpm) on magnetic hot plate at
appropriate temperature, and the increase in
turbidity is measured, by using a turbidimeter
However, since the time required for complete
emulsification is too short, it is not possible to
monitor the rate of change of turbidity (rate of
emulsification)
26. Viscosity Determination
26
The SEDDS system is generally administered in
soft gelatin or hard gelatin capsules. So, it should
be easily pourable into capsules and such
systems should not be too thick to create a
problem.The rheological properties of the micro
emulsion are evaluated by Brookfield viscometer.
27. Droplet Size Analysis
27
The droplet size of the emulsions is determined by
photon correlation spectroscopy (which analyses
the fluctuations in light scattering due to Brownian
motion of the particles) using a Zetasizer able to
measure sizes between 10 and 5000 nm.
28. Refractive Index and Percent Transmittance
28
Refractive index and percent transmittance prove the
transparency of formulation.
The refractive index of the system is measured by
refractometer by putting a drop of solution on slide
and comparing it with water (1.333).
The percent transmittance of the system is measured at
particular wavelength using UV spectrophotometer by
using distilled water as blank.
If refractive index of system is similar to the refractive
index of water (1.333) and formulation have percent
transmittance > 99 percent, then formulation have
transparent nature.
29. Electro Conductivity Study
29
The SEDD system contains ionic or non-ionic
surfactant, oil, and water.
This test is performed for measurement of the
electro conductive nature of system.
The electro conductivity of resultant system is
measured by electro conductometer.
In conventional SEDDSs, the charge on an oil
droplet is negative due to presence of free fatty
acids.
30. In vitro Diffusion Study
30
In vitro diffusion studies are carried out to study the
drug release behavior of formulation from liquid
crystalline phase around the droplet using dialysis
technique.
31. Drug Content
31
Drug from pre-weighed SEDDS is extracted by
dissolving in suitable solvent. Drug content in the
solvent extract was analyzed by suitable analytical
method against the standard solvent solution of
drug.
32. Conclusion
32
Self‐emulsifying drug delivery systems are a
promising approach for the formulation of drug
compounds with poor aqueous solubility. The
oral delivery of hydrophobic drugs can be made
possible by SEDDSs, which have been shown to
substantially improve oral bioavailability. With
future development of this technology, SEDDSs
will continue to enable novel applications in drug
delivery and solve problems associated with the
delivery of poorly soluble drugs.
34. References
P.A. Patel, et al Self Emulsifying Drug Delivery System: A Review, Research J.
34
Pharm. and Tech. 1(4): Oct.-Dec. 2008,313-323.
A.Kumar, et al Self Emulsifying Drug Delivery System (SEDDS): Future Aspect .
Int J Pharm Pharm Sci, Vol 2, Suppl 4, 713,7-13.
J.Tang, et al Preparation of Self-emulsifying Drug Delivery Systems of Ginkgo
biloba Extracts and In vitro Dissolution Studies. Asian Journal of Traditional
Medicines, 2006, 1,3-4 .
R. Sachan, et al Self-Emulsifying Drug Delivery System A Novel Approach for
enhancement of Bioavalibility. Pharm Tech Res.2010,2(3) 1738-1745 .
M. Chitneni et al Intestinal Permeability Studies of Sulpiride Incorporated in to self-microemulsifying
drug delivery system (smedds) Pak. J. Pharm. Sci., .24,2, April
2011,.113-121.