Sixth Sense technology is a wearable gestural interface developed by Pranav Mistry at MIT that integrates digital information with the physical world, allowing users to interact using natural hand gestures. The system consists of a pendant-like device equipped with a camera, projector, mirror, and smartphone, enabling various applications such as making calls, mapping, and product recognition. Its advantages include real-time data access, portability, and the potential for creating a seamless user interface for accessing information.