SIREN Overview

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University of Michigan Department of Emergency Medicine

The document summarizes an update from Barsan Research Day in April 2022. It discusses the evolution of Dr. Barsan's research since 2017 and outlines key design principles and organizational values such as focusing on early treatment, meaningful outcomes for patients, efficiency, collaboration, and transforming clinical trials. It then provides details on the SIREN Clinical Trials network including the process for developing and funding clinical trials, accomplishments, current and potential future projects covering a range of conditions, and plans to expand and renew the portfolio.

Health & Medicine

Design principles and organizational values
•Focus on early treatment.
•Focus on meaningful outcomes for patients.
•Focus on efficiency.
•Focus on collaboration.
•Focus on transforming the clinical trials enterprise.

Clinical Trial Summary
and Rough Budget
Trial Ideas
(from
anybody)
Scientifically and
Clinically Important
Questions and
Observations
Institute
Pre-approval
to submit
Grant
application(s)
Collaborative
Grant Application
and Protocol
Development
with input from
Sites, Patients,
and Others
NIH Study
Section
Revise
Grant Award
Grant Award to
Scientific PI’s
Institution with
major subaward
to CCC
DCC may be
paired grant or
subaward
depending on
Institute
Begin discussions with NIH
program officers early
NIH program officers will
evaluate the fit for the
Institute
Begin discussions with SIREN leadership early as
well.
SIREN leadership will evaluate fit for the network,
contribute to concept, and relay to site PI’s
SIREN will NOT be a layer of scientific peer review
Institute Council

SIREN Projects: Ongoing or Being Developed

SIREN Projects: Development Redirected or Deferred

SIREN Projects: Ancillary, Affiliated, Grants and Supplements

SIREN Projects: Distributions of Conditions Studied

Expand the portfolio
Continued outreach and inclusiveness
Innovate and share methods and practices
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