This document discusses dissolvable films of silk fibroin for creating ultrathin conformal bio-integrated electronics. It covers the motivation and background of using transient electronics that dissolve at programmed rates. Examples are given of using thin silicon and silk membranes that safely dissolve over time for applications like biomedical sensors and drug delivery. The technology allows creating non-invasive electronic devices that conform to various biological surfaces. Future areas of research include further applications within and outside the human body using this novel approach of electronics that disappear without electronic waste.

1. Dissolvable films of silk fibroin for
ultrathin conformal bio-integrated
electronics
Dawn John Mullassery
Electrical and Computer Engineering
University of British Columbia
1

2. The Paper
John A Rogers 2

3. Overview
• Motivation and Background
• The technology
• Future
3

4. http://www.singularitysymposium.com/moores-law.html
MOORE’s LAW
“The observation made in 1965 by Gordon Moore, co-founder
of Intel, that the number of transistors per square inch on
integrated circuits had doubled every year since the
integrated circuit was invented. Moore predicted that this
trend would continue for the foreseeable future.”
- Webopedia
4

5. Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016), ieeemy.org,
http://www.computerhope.com/jargon/e/edsac.htm, 5

6. Bio-Integration
6

7. Existing Technology – Utah
http://www.sci.utah.edu/~gk/abstracts/bisti03/,
Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects - Eduardo et.al , doi: 10.3389/fneng.2014.00024
7

8. Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
N. Jeremy Hill et.al ; doi: 10.3791/3993 8

9. Two main areas!
• Bio-integrated or Biocompatible
electronics
• Transient electronics or Bioresorbable
electronics
9

10. Bio-Integrated Electronics
• Epidermal Electronics
• Non – uniform surfaces inside the body
10

11. Bio-Integrated Electronics - Brain
11

12. Bio-Integrated Electronics - Brain
12

13. http://rogers.matse.illinois.edu/multimedia.php
13

14. Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al;
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo: Jonathan Viventi, et.al;
14

15. Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; 15

16. http://rogers.matse.illinois.edu/multimedia.php
16

17. Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the
entire epicardium. Lizhi Xu et.al;
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17

18. Bio-Integrated Electronics - Advantages
• High resolution results
• Less complicated process
• Similar process can be used for epidermal
electronics
• Non – invasive method
18

19. Transient Electronics
Electronic systems that dissolve, resorb, or
otherwise physically disappear at
programmed rates or specific triggered times.
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
19

20. Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
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21. Water Soluble Silicon
Silicon for Transient
Electronics
• Silicon Thickness - 35
nm
• Dissolution Time – 10
days
• Water – 0.4 ml
Silicon for Regular
Electronics
• Silicon Thickness -
700 µm
• Dissolution Time –
600 to 1000 years
• Water - 8 L
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
21

22. Silk membranes dissolve
22

23. Transient Electronic Device
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
23

24. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
24

25. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
25

26. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
26

27. Why a novel approach?
• Biomedical Purposes
• Environmental Sensors
• Consumer Electronics
27

28. Biomedical Application – Transient Electronics
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
28

29. Biomedical Application – Surgical Site
Infections
A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE
29

30. Edible and Good!
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 µg vs ~ 10 mg
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31. Biomedical Applications
• Drug Delivery
• Electronic Aspirin
31

32. Environmental sensors & e- waste
32

33. http://rogers.matse.illinois.edu/multimedia.php
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34. Next Few Years & Future
• Human body
• Non – biomedical applications
• Further R & D required
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35. Why will this be a classic paper?
• New approach to existing techniques of
biomedical methods
• Any form of biological surface – with minimal
invasion
• Not limited to biomedical
35

36. 36