Phytosomes are novel drug delivery systems containing hydrophilic plant constituents bound to phospholipids. This improves the absorption of the plant constituents, which are typically poorly absorbed due to their water-solubility and large molecule size. Phytosomes increase the bioavailability of plant extracts by forming complexes with phospholipids that are lipid-compatible and can be absorbed in the intestinal tract. They also show improved stability compared to plant extracts alone due to chemical bonds formed between the phospholipids and phytoconstituents. Phytosomes have applications for enhancing delivery of plant extracts, as well as for transdermal and dermal delivery in cosmetics and pharmaceuticals.

1. PHYTOSOMES
Presented By,
Yogita T. Rayate
M.Pharm First Year
Pharmaceutics
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2.  What is Phytosome ?:
Phytosomes are novel drug delivery system
containing hydrophilic bioactive
phytoconstituents of herbs surround and
bound by phospholipids .
 Phytomedicines are complex chemical
mixtures prepared from plants.
 Water soluble phytoconstituents
(flavonoids) are poorly absorbed.
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3. 1. Multiple-ring large size molecules - can not
be absorbed by simple diffusion.
2. Poor miscibility.
 Water-soluble phytoconstituents can be
converted into lipid-compatible molecular
complexes.
 Phytosomes are more bioavailable .
 Phytosomes are lipid-compatible
molecular complexes.
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4. Physical properties:
 It is lipophilic substance
 Freely soluble in nonpolar solvent .
 Moderately soluble in fats .
 Insoluble in water
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5. 1. There is a enhancement of the
bioavaibility of botanical extract due to their
complexation with phospholipid and
improved absorption in the intestinal tract.
2. The formulation of phytosomes is safe and
the components have all been approved for
pharmaceutical s and cosmetic use.
3. Phytosomes shows better stability profile
because chemical bond are formed between
phosphotidylcholine molecules and
phytoconstituents.
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6. 4.This technology offers cost effective delivery
of phytoconstituents.
5.They can be also used for enhanced
permeation of drug through skin for
transdermal and dermal delivery.
6. Phytosomes are also superior to liposomes in
the skin care products.
7.They can be widely used in the cosmetics
due to their improved skin penetration and
high lipid profile.
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10. Phospholipids
Solution of phospholipidsin organic solvent
with drug extract
Drying
Formation of thin film
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11. Hydration
Formation of phytosomal suspension
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12. 1.Entrapment efficiency
2.Vesicle size
3.Surface tension activity measurement
4.Spectroscopic evaluation
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13.  Enhancing bioavailability
 Antioxidant properties
 Hepato protective
 Transdermal application
 Cancer tretment
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14. 1.Chivte Prajkta ,A review on therapeutic
applications of phytosomes,Journal of drug
delivery &therapeutics, 2017;(5):17-21
2.Joseph Kareparamban ,pravin
Nikam,Phytosome-A novel revoluation in
herbal drugs,IJRPC 2012,2(2)
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15. THANK YOU
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