How mental activity sculpts neural structure; the benefits and pitfalls of integrating neuroscience and psychotherapy; the neural substrates of self-compassion; and how to activate the lateral networks of mindful awareness.
Paper Tiger Paranoia - Rick Hanson, PhDRick Hanson
How the brain’s “negativity bias” makes clients overestimate threats, underestimate opportunities, and underestimate inner and outer resources, leading to anxiety, anger, depression, and conflicts with others – and how to help clients overcome that bias, see the good facts about the others, the world, and themselves, and build resilience for happiness, healthy relationships, and occupational success.
More resources are freely offered at http://www.rickhanson.net.
Managing the Caveman Brain in the 21st CenturyRick Hanson
The human brain evolved in three stages: reptile, mammal, and primate. Each stage has a core motivation: avoid harm, approach reward, and attach to "us." Modern life challenges these ancient neural systems with bombardments of threat messages, the endless stimulation of desire, and social disconnections and tensions of industrial, multicultural societies. This talk will explore brain-savvy ways to cultivate mindfulness in young people, and then use that mindfulness to internalize a greater sense of strength and safety, contentment, and being loved.
Rick Hanson gave this keynote address for the Bridging the Hearts and Minds of Youth: Mindfulness in Clinical Practice, Education and Research Conference at the UCSD Center for Mindfulness in February, 2012.
Buddha's Brain: The Practical Neuroscience of Happiness, Love and Wisdom - Ri...Rick Hanson
How mental activity sculpts neural structure; the benefits and pitfalls of integrating neuroscience and psychotherapy; the neural substrates of self-compassion; and how to activate the lateral networks of mindful awareness.
More resources are freely offered at http://www.rickhanson.net.
Paper Tiger Paranoia - Rick Hanson, PhDRick Hanson
How the brain’s “negativity bias” makes clients overestimate threats, underestimate opportunities, and underestimate inner and outer resources, leading to anxiety, anger, depression, and conflicts with others – and how to help clients overcome that bias, see the good facts about the others, the world, and themselves, and build resilience for happiness, healthy relationships, and occupational success.
More resources are freely offered at http://www.rickhanson.net.
Managing the Caveman Brain in the 21st CenturyRick Hanson
The human brain evolved in three stages: reptile, mammal, and primate. Each stage has a core motivation: avoid harm, approach reward, and attach to "us." Modern life challenges these ancient neural systems with bombardments of threat messages, the endless stimulation of desire, and social disconnections and tensions of industrial, multicultural societies. This talk will explore brain-savvy ways to cultivate mindfulness in young people, and then use that mindfulness to internalize a greater sense of strength and safety, contentment, and being loved.
Rick Hanson gave this keynote address for the Bridging the Hearts and Minds of Youth: Mindfulness in Clinical Practice, Education and Research Conference at the UCSD Center for Mindfulness in February, 2012.
Buddha's Brain: The Practical Neuroscience of Happiness, Love and Wisdom - Ri...Rick Hanson
How mental activity sculpts neural structure; the benefits and pitfalls of integrating neuroscience and psychotherapy; the neural substrates of self-compassion; and how to activate the lateral networks of mindful awareness.
More resources are freely offered at http://www.rickhanson.net.
Captación de la información
Proceso Selectivo: Seleccionar en presencia de otros estímulos
Proceso Distribución: Entender a varias cosa a la vez
Proceso Mantenimiento o Sostenimiento: Mantener la atención durante un tiempo amplio
This powerpoint presentation was put together by Jordan Greenbaum, M.D., Children's Healthcare of Atlanta and presented on June 14th as part of our GA-CAN! Community Conversation on Timeout, Restraint and Spanking.
Psychotherapy the biological dimensionismail sadek
is it real word can affect your brain?
many people say not and don't believe that the psychotherapy change not only our behavior but also it can change the brain structure
Buddha's Brain: Lighting Up the Neural Circuits of Happiness, Love and WisdomRick Hanson
Combining the power of the latest brain science with the wisdom of contemplative practice, these are practical methods for centering your brain in its natural state of gladness, love, and peace.
Captación de la información
Proceso Selectivo: Seleccionar en presencia de otros estímulos
Proceso Distribución: Entender a varias cosa a la vez
Proceso Mantenimiento o Sostenimiento: Mantener la atención durante un tiempo amplio
This powerpoint presentation was put together by Jordan Greenbaum, M.D., Children's Healthcare of Atlanta and presented on June 14th as part of our GA-CAN! Community Conversation on Timeout, Restraint and Spanking.
Psychotherapy the biological dimensionismail sadek
is it real word can affect your brain?
many people say not and don't believe that the psychotherapy change not only our behavior but also it can change the brain structure
Buddha's Brain: Lighting Up the Neural Circuits of Happiness, Love and WisdomRick Hanson
Combining the power of the latest brain science with the wisdom of contemplative practice, these are practical methods for centering your brain in its natural state of gladness, love, and peace.
Steadying the Mind - Healing and Treating Trauma, Addictions and Related Diso...Rick Hanson
To stay alive in the wild, our ancestors evolved highly distractible attentional systems – which pose real challenges to developing greater mindfulness today. This presentation covers how attention works in your brain, and the implications of normal neurological diversity for the “turtles” and “jackrabbits” at either end of the spectrum.
Buddha's Brain: The Practical Neuroscience of Inner Peace - Rick Hanson, PhDRick Hanson
Integrate the latest brain science research with the ancient wisdom of contemplative practice. Discover practical methods for improving mindfulness and concentration, calming the heart, weaving positive experiences into your brain and your self, and then bringing these new strengths into your relationships with both kindness and assertiveness.
More resources are freely offered at http://www.rickhanson.net.
Pairing Positive and Negative to Fill the Hole in the HeartRick Hanson
Implicit memory systems – including expectations, emotional residues and reactive patterns – are a primary target of therapy. Since they are vulnerable to change during consolidation, the skillful pairing of positive and negative material in awareness can gradually soothe and ultimately replace negative implicit memories. This workshop will explore neuro-savvy methods for doing this, including how to identify the positive material that will best "antidote" old pain or deficits in internalized resources.
Mindfulness and Taking in the Good: Using Neuroplasticity to Weave Resources ...Rick Hanson
How the brain evolved a “negativity bias” that continually looks for, reacts to, and stores negative experiences; how this shapes the interior landscape of the mind, leading to pessimism, depressed and anxious mood, and over-reactions; the neural machinery of memory; how to “trick” that machinery into weaving positive experiences into the brain and the self, leading to greater resilience, happiness, and interpersonal effectiveness; applications to particular situations, including healing trauma, cooperation with medical or psychological treatment, and raising or teaching children.
The Loving Brain - Healing and Treating Trauma, Addictions and Related Disord...Rick Hanson
Over millions of years, social abilities – such as bonding, empathy, compassion, language, and cooperative planning – really aided survival. Love, broadly defined, has profoundly shaped the evolution of the human brain.
Presented at Spirit Rock Meditation Center - December, 2011.
The biological evolution of awareness and the apparent self; what neuroscience tells us about the distributed and endlessly variable neural nature of the apparent self; the stress, suffering, and interpersonal difficulties that come from “excesses of self”; the importance of healthy self-compassion and self-advocacy; how to heal injuries to self-worth; methods for taking things less personally, relaxing possessiveness, and feeling more at one with all things.
Introduction to the neuroscience of mindfulness and meditation; brain-wise methods for steadying the mind, quieting it, bringing it to singleness, and concentrating it; an exploration of what could be happening in the brain during the non-ordinary states of consciousness
Taking in the Good: Helping Children Build Inner Strength and HappinessRick Hanson
Scientists believe the brain evolved a "negativity bias" that makes it like Velcro for negative experiences but Teflon for positive ones. This helped our ancestors survive, but it's bad for children (and parents) today - leading them to overreact, hold onto hurts and resentments, and have a harder time developing inner resources. To address this challenge, this presentation will use practical neuroscience to show how to weave positive experiences into the fabric of the brain and the self - including how to pair a positive experience with a negative one to heal old pain.
Rick Hanson gave this public lecture for the Bridging the Hearts and Minds of Youth: Mindfulness in Clinical Practice, Education and Research Conference at the UCSD Center for Mindfulness in February, 2012.
The Not-Craving Brain: From Greed, Hated and Heartache to Contentment, Peace ...Rick Hanson
An integrated contemplative neuroscience model that can be used in healthy ways, fulfilled and even transcended.
More resources, freely offered at http://www.rickhanson.net
Taking in the Good: Building Resilience into the Brain through Positive Exper...Rick Hanson
How the brain evolved a “negativity bias” that continually looks for, reacts to, and stores negative experiences; how this shapes the interior landscape of the mind, leading to pessimism, depressed and anxious mood, and over-reactions; the neural machinery of memory; how to “trick” that machinery into weaving positive experiences into the brain and the self, leading to greater resilience, happiness, and interpersonal effectiveness; applications to particular situations, including healing trauma, cooperation with medical or psychological treatment, and raising or teaching children.
Natural Contentment And Brain Evolution - Rick Hanson, PhDRick Hanson
With the power of modern neuroscience, informed by ancient contemplative wisdom, you can use your mind alone to change your brain for the better. Self-directed neuroplasticity involves steadying the mind (key to both worldly success and spiritual practice), cooling the fires of stress reactivity, weaving positive experiences into the fabric of your brain and self, and taking life less personally.
More resources are freely offered at http://www.rickhanson.net.
New science is showing how mental activity sculpts neural structure. Using the power of self-directed neuroplasticity, you can target, stimulate, and thus gradually strengthen the neural substrates of well-being.
More resources are freely offered at http://www.rickhanson.net.
The Whole Holy Brain: Activating Integrative Processes in Your Nervous System...Rick Hanson
How you can use your mind to reshape your brain for the better, plus three specific ways to promote integrative processes in your brain.
More resources, freely offered at http://www.rickhanson.net
Using the Mind To Change the Brain: Talks @Google - Rick Hanson, PhDRick Hanson
Jesus, Moses, the Buddha, and other great teachers were all born with a brain built essentially like anyone else's. Then they used their minds to change their brains in ways that changed history. With the new breakthroughs in neuroscience, combined with insights from thousands of years of contemplative practice, you, too, can shape your own brain for greater happiness, love, and wisdom.
Written with neurologist Richard Mendius, M.D., and with a Foreword by Daniel Siegel, M.D. and a Preface by Jack Kornfield, Ph.D., Buddha's Brain: The Practical Neuroscience of Happiness, Love, and Wisdom joins modern science with ancient teachings to show you how to have greater emotional balance in turbulent times, as well as healthier relationships, more effective actions, and greater peace of mind.
http://amzn.to/oLTD3B
Use Your Mind to Change Your Brain: Tools for Cultivating Happiness, Love an...Rick Hanson
Tools for well-being, grounded in cutting-edge science and the wisdom of the world’s contemplative traditions.
More resources, freely offered at http://www.rickhanson.net
Buddha's Brain: The Practical Neuroscience of Happiness, Love and WisdomRick Hanson
How mental activity sculpts neural structure; the benefits and pitfalls of integrating neuroscience and psychotherapy; the neural substrates of self-compassion; and how to activate the lateral networks of mindful awareness.
More resources, freely offered at http://www.rickhanson.net
The Negativity Bias and Taking in the GoodRick Hanson
The brain's evolved bias is like Velcro for negative experiences, but Teflon for positive ones. The unfortunate results include stress and threat reactivity, anxiety, depression, and limited gains in psychotherapy. Happily, through tree steps of mindful attention, we can internalize positive experiences in implicit memory systems, weaving resources for well-being, coping, and kindness into the fabric of the barin and the self.
Buddha's Brain: Natural Enlightenment and Unshakable Peace - Rick Hanson, PhDRick Hanson
Combining the power of the latest brain science with the wisdom of contemplative practice, this workshop will present practical methods for centering your brain in its natural state of gladness, love, and peace. In particular, you'll learn brain-savvy ways to reduce anxiety and irritability, feel stronger and safer, and clear old pain.
More resources are freely offered at http://www.rickhanson.net.
Mindfulness in Clinical Practice - Rick Hanson, PhDRick Hanson
On mindfulness as a concept, experience, and clinical tool for clinical and personal practice.
More resources are freely offered at http://www.rickhanson.net.
Buddha's Brain: Lighting up Your Own Circuits of Happiness, Love, and Wisdom ...Rick Hanson
How mental activity sculpts neural structure; the benefits and pitfalls of integrating neuroscience and psychotherapy; the neural substrates of self-compassion; and how to activate the lateral networks of mindful awareness.
More resources, freely offered at http://www.rickhanson.net
Use Your Mind to Change Your Brain: Tools for Cultivating Happiness, Love and...Rick Hanson
Tools for well-being, grounded in cutting-edge science and the wisdom of the world’s contemplative traditions.
More resources are freely offered at http://www.rickhanson.net.
How the brain’s “negativity bias” makes clients overestimate threats, underestimate opportunities, and underestimate inner and outer resources, leading to anxiety, anger, depression, and conflicts with others – and how to help clients overcome that bias, see the good facts about the others, the world, and themselves, and build resilience for happiness, healthy relationships, and occupational success.
More resources, freely offered at http://www.rickhanson.net
Whose Brain Is It, Anyway? Part II - Rick Hanson, PhDRick Hanson
Talk given at Hampton Boys School, London, England.
* How your brain works
* Why that matters
* What you can do about it
More resources, freely offered at http://www.rickhanson.net
Whose Brain Is It, Anyway? Part I - Rick Hanson, PhDRick Hanson
Talk given at Hampton Boys School, London, England.
* How your brain works
* Why that matters
* What you can do about it
More resources, freely offered at http://www.rickhanson.net
Being and Doing: Activating Neural Networks of Mindful Presence - Rick Hanson...Rick Hanson
In our turbocharged culture, "doing" routinely overpowers "being," so this talk and discussion covers effective ways to stimulate and strengthen "being networks: the neural substate of spacious contented awareness."
More resources, freely offered at http://www.rickhanson.net
Mindfulness and Twelve Step Recovery. The Wellspring Institute Winter Fund Drive and Your Best Brain workshop. Therapeutic mindfulness in dementia care. Skillful means: Do Nothing Meditation and Easy Rest.
Taking in the Good: Weaving Positive Emotions, Optimism and Resilience into t...Rick Hanson
How the brain evolved a “negativity bias” that continually looks for, reacts to, and stores negative experiences; how this shapes the interior landscape of the mind, leading to pessimism, depressed and anxious mood, and over-reactions; the neural machinery of memory; how to “trick” that machinery into weaving positive experiences into the brain and the self, leading to greater resilience, happiness, and interpersonal effectiveness; applications to particular situations, including healing trauma, cooperation with medical or psychological treatment, and raising or teaching children.
Just One Thing: Developing a Buddha Brain One Simple Practice at a Time - The...Rick Hanson
Just One Thing presents more than fifty simple practices readers can do each day to wire the brain for increased happiness, positive thinking, and wisdom. Written by Rick Hanson, author of "Buddha's Brain", this pocket-sized book helps readers reap the benefits of meditation through simple five to ten-minute practices they can access anytime, anywhere. Building on the success of "Buddha's Brain", each practice is grounded in neuroscience and positive psychology. The book offers information on why the practice is important and how it works, guidance for performing the practice, and additional resources readers can use to delve deeper into that particular type of practice. Some of the practices encourage readers to focus on gratitude for what they have, while others offer guidance for taking refuge and slowing down in stressful times. All of the practices are designed to gradually change the way readers process their emotions and create new neural pathways for greater happiness and fulfillment.
For more information and to order, visit http://bit.ly/qgZRiz.
Not-Self in the Brain - Rick Hanson, PhDRick Hanson
The biological evolution of awareness and the apparent self; what neuroscience tells us about the distributed and endlessly variable neural nature of the apparent self; the stress, suffering, and interpersonal difficulties that come from “excesses of self”; the importance of healthy self-compassion and self-advocacy; how to heal injuries to self-worth; methods for taking things less personally, relaxing possessiveness, and feeling more at one with all things.
More resources are freely offered at http://www.rickhanson.net.
The Neurology of Awakening - Rick Hanson, PhDRick Hanson
Using the New Brain Research to Steady Your Mind.
Introduction to the neuroscience of mindfulness and meditation; brain-wise methods for steadying the mind, quieting it, bringing it to singleness, and concentrating it; an exploration of what could be happening in the brain during the non-ordinary states of consciousness known as samadhis or jhanas.
More resources are freely offered at http://www.rickhanson.net.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Self -Directed Neuroplasticity: Using the New Brain Research to Deepen Clinical Practice
1. Self-Directed Neuroplasticity:
Using the New Brain Science
To Deepen Clinical Practice
Summit for Clinical Excellence
October 29, 2011
Rick Hanson, Ph.D.
The Wellspring Institute for Neuroscience and Contemplative Wisdom
www.WiseBrain.org www.RickHanson.net
drrh@comcast.net 1
2. Topics
Perspectives
Brain basics
Grounding the mind in nature
Self-directed neuroplasticity
The brain - so what?
Self-compassion 2
4. The history of science is rich in the example
of the fruitfulness of bringing
two sets of techniques, two sets of ideas,
developed in separate contexts
for the pursuit of new truth,
into touch with one another.
4
J. Robert Oppenheimer
5. Common - and Fertile - Ground
Neuroscience Psychology
Contemplative Practice
5
6. When the facts change,
I change my mind, sir.
What do you do?
John Maynard Keynes
6
7. We ask, “What is a thought?”
We don't know,
yet we are thinking continually.
Venerable Tenzin Palmo
7
12. The Connectome - 2
12
Hagmann, et al., 2008, PLoS Biology, 6:1479-1493
13. Your Brain: The Technical Specs
Size:
3 pounds of tofu-like tissue
1.1 trillion brain cells
100 billion “gray matter" neurons
Activity:
Always on 24/7/365 - Instant access to information on demand
20-25% of blood flow, oxygen, and glucose
Speed:
Neurons firing around 5 to 50 times a second (or faster)
Signals crossing your brain in a tenth of a second
Connectivity:
Typical neuron makes ~ 5000 connections with other neurons:
~ 500 trillion synapses
13
15. Evolution is a tinkerer. In living organisms, new capabilities
are achieved by modifying existing molecules slightly and
adjusting their interaction with other existing molecules.
Science has found surprisingly few proteins that are truly
unique to the human brain and no signaling systems that
are unique to it.
All life, including the substrate of our thoughts and
memories, is composed of the same building blocks.
15
Eric R. Kandel
18. All cells have specialized functions. Brain cells have
particular ways of processing information and
communicating with each other. Nerve cells form complete
circuits that carry and transform information.
Electrical signaling represents the language of mind, the
means whereby nerve cells, the building blocks of the brain,
communicate with one another over great distances. Nerve
cells generate electricity as a means of producing messages.
All animals have some form of mental life that reflects the
architecture of their nervous system.
18
Eric R. Kandel
19. The Mind/Brain System
“Mind” = flow of information within the nervous system:
Information is represented by the nervous system.
Most mind is unconscious; awareness is an aspect of mind.
The headquarters of the nervous system is the brain.
In essence then, apart from hypothetical transcendental
factors, the mind is what the brain does.
Brain = necessary, proximally sufficient condition for mind:
The brain depends on the nervous system, other bodily
systems, nature, and culture.
As we’ll see, the brain also depends on the mind.
Therefore, the brain and mind are two aspects of one 19
system, interdependently arising.
21. Fact #1
As your brain changes, your mind changes.
21
22. Ways That Brain Can Change Mind
For better:
A little caffeine: more alertness
Thicker insula: more self-awareness, empathy
More left prefrontal activation: more happiness
For worse:
Intoxication; imbalances in neurotransmitters
Concussion, stroke, tumor, Alzheimer’s
Cortisol-based shrinkage of hippocampus: less
capacity for contextual memory
22
23. Fact #2
As your mind changes, your brain changes.
Immaterial mental activity maps to material neural
activity.
This produces temporary changes in your brain and
lasting ones.
Temporary changes include:
Alterations in brainwaves (= changes in the firing patterns of
synchronized neurons)
Increased or decreased use of oxygen and glucose 23
Ebbs and flows of neurochemicals
27. Christian Nuns, Recalling a
Profound Spiritual Experience
27
Beauregard, et al., Neuroscience Letters, 9/25/06
28. Mind Changes Brain in Lasting Ways
What flows through the mind sculpts your brain.
Immaterial experience leaves material traces behind.
Increased blood/nutrient flow to active regions
Altered epigenetics (gene expression)
“Neurons that fire together wire together.”
Increasing excitability of active neurons
Strengthening existing synapses
Building new synapses; thickening cortex
Neuronal “pruning” - “use it or lose it” 28
29. Lazar, et al. 2005.
Meditation
experience is
associated
with increased
cortical thickness.
Neuroreport, 16,
1893-1897.
29
30. Honoring Experience
One’s experience matters.
Both for how it feels in the moment and for the
lasting residues it leaves behind, woven into
the fabric of a person’s brain and being.
30
31. Fact #3
You can use your mind
to change your brain
to change your mind for the better.
This is self-directed neuroplasticity.
How to do this, in skillful ways? 31
33. Neuroplasticity in Context
Neuroplasticity is not breaking news. It’s been long
presumed that mental activity changed neural
structure: what else is learning?
The news is in how the mind changes the brain.
Most neuroplasticity is incremental, not dramatic.
Neuroplasticity is ethically neutral.
33
34. Grounding in the Brain - Benefits
Organizing framework
Evolutionary neuropsychology
Common ground across theories and methods
Motivating to clients, clinicians, policy-makers
Concrete, in the body, physical
Status of medicine, hard science
Highlighting key principles and practices
Implicit memory
Nonverbal processes
Innovating with truly new methods
Neurofeedback
Fear extinction
34
35. Grounding in the Brain - Pitfalls
Adding little new meaning
Replacing psych terms with neuro (“amygdala made me do it”)
Over-simplifying
Over-localizing function (e.g., empathy = mirror neurons)
Over-emphasizing one factor (e.g., attachment experiences)
Exaggerated terms (“God-gene,” “female brain”)
Materialistic reductionism, though brain and mind co-arise
Claiming authority
Using neuro data to argue a political or cultural case
Using the secular religion of science to elevate status
Underestimating the mind
Most big changes in psyche involve tiny changes in soma; mental
plasticity holds more promise than neural plasticity.
Overlooking the insights and effectiveness of psychology
35
Ducking existential choices in values
37. Self-Goodwill
All the great teachers have told us to be compassionate and
kind toward all beings. And that whatever we do to the world
affects us, and whatever we do to ourselves affects the world.
You are one of the “all beings!” And kindness to yourself
benefits the world, while hurting yourself harms the world.
It’s a general moral principle that the more power you have over
someone, the greater your duty is to use that power wisely.
Well, who is the one person in the world you have the greatest
power over? It’s your future self. You hold that life in your hands,
and what it will be depends on how you care for it.
Consider yourself as an innocent child, as deserving of care and
happiness as any other. 37
38. The good life, as I conceive it, is a happy life.
I do not mean that if you are good you will be happy;
I mean that if you are happy you will be good.
Bertrand Russell
38
39. If one going down into a river,
swollen and swiftly flowing,
is carried away by the current --
how can one help others across?
The Buddha
39
40. Feeling Cared About
As we evolved, we increasingly turned to and relied
on others to feel safer and less threatened.
Exile from the band was a death sentence in the Serengeti.
Attachment: relying on the secure base
The well-documented power of social support to buffer
stress and aid recovery from painful experiences
Methods:
Recognize it’s kind to others to feel cared about yourself.
Look for occasions to feel cared about and take them in.
Deliberately bring to mind the experience of being cared
about in challenging situations.
40
Be caring yourself.
41. Self-Compassion
Compassion is the wish that a being not suffer, combined with
sympathetic concern. Self-compassion simply applies that to
oneself. It is not self-pity, complaining, or wallowing in pain.
Studies show that self-compassion buffers stress and increases
resilience and self-worth.
But self-compassion is hard for many people, due to feelings of
unworthiness, self-criticism, or “internalized oppression.” To
encourage the neural substrates of self-compassion:
Get the sense of being cared about by someone else.
Bring to mind someone you naturally feel compassion for
Sink into the experience of compassion in your body
Then shift the compassion to yourself, perhaps with phrases like:
“May I not suffer. May the pain of this moment pass.” 41
42. “Anthem”
Ring the bells that still can ring
Forget your perfect offering
There is a crack in everything
That’s how the light gets in
That’s how the light gets in
Leonard Cohen
42
44. Great Books
See www.RickHanson.net for other great books.
Austin, J. 2009. Selfless Insight. MIT Press.
Begley. S. 2007. Train Your Mind, Change Your Brain. Ballantine.
Carter, C. 2010. Raising Happiness. Ballantine.
Hanson, R. (with R. Mendius). 2009. Buddha’s Brain: The Practical
Neuroscience of Happiness, Love, and Wisdom. New Harbinger.
Johnson, S. 2005. Mind Wide Open. Scribner.
Keltner, D. 2009. Born to Be Good. Norton.
Kornfield, J. 2009. The Wise Heart. Bantam.
LeDoux, J. 2003. Synaptic Self. Penguin.
Linden, D. 2008. The Accidental Mind. Belknap.
Sapolsky, R. 2004. Why Zebras Don’t Get Ulcers. Holt.
Siegel, D. 2007. The Mindful Brain. Norton.
Thompson, E. 2007. Mind in Life. Belknap. 44
45. Key Papers - 1
See www.RickHanson.net for other scientific papers.
Atmanspacher, H. & Graben, P. 2007. Contextual emergence of mental
states from neurodynamics. Chaos & Complexity Letters, 2:151-168.
Baumeister, R., Bratlavsky, E., Finkenauer, C. & Vohs, K. 2001. Bad is
stronger than good. Review of General Psychology, 5:323-370.
Braver, T. & Cohen, J. 2000. On the control of control: The role of
dopamine in regulating prefrontal function and working memory; in
Control of Cognitive Processes: Attention and Performance XVIII.
Monsel, S. & Driver, J. (eds.). MIT Press.
Carter, O.L., Callistemon, C., Ungerer, Y., Liu, G.B., & Pettigrew, J.D.
2005. Meditation skills of Buddhist monks yield clues to brain's
regulation of attention. Current Biology. 15:412-413. 45
46. Key Papers - 2
Davidson, R.J. 2004. Well-being and affective style: neural substrates and
biobehavioural correlates. Philosophical Transactions of the Royal Society.
359:1395-1411.
Farb, N.A.S., Segal, Z.V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., and
Anderson, A.K. 2007. Attending to the present: Mindfulness meditation reveals
distinct neural modes of self-reflection. SCAN, 2, 313-322.
Gillihan, S.J. & Farah, M.J. 2005. Is self special? A critical review of evidence
from experimental psychology and cognitive neuroscience. Psychological
Bulletin, 131:76-97.
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C.J., Wedeen, V.J.,
& Sporns, O. 2008. Mapping the structural core of human cerebral cortex. PLoS
Biology. 6:1479-1493.
Hanson, R. 2008. Seven facts about the brain that incline the mind to joy. In
Measuring the immeasurable: The scientific case for spirituality. Sounds True. 46
47. Key Papers - 3
Lazar, S., Kerr, C., Wasserman, R., Gray, J., Greve, D., Treadway, M.,
McGarvey, M., Quinn, B., Dusek, J., Benson, H., Rauch, S., Moore, C., & Fischl,
B. 2005. Meditation experience is associated with increased cortical thickness.
Neuroreport. 16:1893-1897.
Lewis, M.D. & Todd, R.M. 2007. The self-regulating brain: Cortical-subcortical
feedback and the development of intelligent action. Cognitive Development,
22:406-430.
Lieberman, M.D. & Eisenberger, N.I. 2009. Pains and pleasures of social life.
Science. 323:890-891.
Lutz, A., Greischar, L., Rawlings, N., Ricard, M. and Davidson, R. 2004. Long-
term meditators self-induce high-amplitude gamma synchrony during mental
practice. PNAS. 101:16369-16373.
Lutz, A., Slager, H.A., Dunne, J.D., & Davidson, R. J. 2008. Attention regulation
and monitoring in meditation. Trends in Cognitive Sciences. 12:163-169. 47
48. Key Papers - 4
Rozin, P. & Royzman, E.B. 2001. Negativity bias, negativity dominance, and
contagion. Personality and Social Psychology Review, 5:296-320.
Takahashi, H., Kato, M., Matsuura, M., Mobbs, D., Suhara, T., & Okubo, Y.
2009. When your gain is my pain and your pain is my gain: Neural correlates of
envy and schadenfreude. Science, 323:937-939.
Tang, Y.-Y., Ma, Y., Wang, J., Fan, Y., Feng, S., Lu, Q., Yu, Q., Sui, D.,
Rothbart, M.K., Fan, M., & Posner, M. 2007. Short-term meditation training
improves attention and self-regulation. PNAS, 104:17152-17156.
Thompson, E. & Varela F.J. 2001. Radical embodiment: Neural dynamics and
consciousness. Trends in Cognitive Sciences, 5:418-425.
Walsh, R. & Shapiro, S. L. 2006. The meeting of meditative disciplines and
Western psychology: A mutually enriching dialogue. American Psychologist,
61:227-239.
48
49. Where to Find Rick Hanson Online
http://www.youtube.com/BuddhasBrain
http://www.facebook.com/BuddhasBrain
w
www.RickHanson.net
www.WiseBrain.org 49