Scleroderma is a chronic connective tissue disorder characterized by fibrosis of the skin and internal organs. There are two main types - diffuse, which is more severe and affects 20% of patients, and limited, which affects 80% of patients. The pathophysiology involves autoimmunity, excessive collagen deposition by fibroblasts in response to cytokines, and vasculopathy. Clinical features include Raynaud's phenomenon, skin thickening and tightening, gastrointestinal issues like reflux, pulmonary fibrosis or hypertension, and renal crisis. Diagnosis involves tests for autoantibodies and imaging/pulmonary function tests. Treatment focuses on symptoms like reflux, Raynaud's, and organ involvement using medications, though there is no