This document summarizes the proceedings from the Science Forum 2016 conference over three days. Day 1 focused on rethinking pathways for agricultural research to achieve rural prosperity. It discussed topics like timelines, direct and indirect impacts, off-farm contributions, diversification, and more. Day 2 centered on partnerships beyond agriculture including with NARS, CGIAR, smallholders, markets, value chains, and more. Day 3 identified three system-level outcomes: reducing poverty, improving food/nutrition security and health, and improving natural resources and ecosystem services. The document discusses how the forum priorities will inform the development of the next strategic research framework and strategic studies to identify gaps.