This document summarizes key points from a presentation on agri-food innovation and pathways to impact. It discusses how the introduction of IR8 rice in 1967 dramatically increased yields from 1.5 to 10 tons per hectare. It notes that the global agri-food system is currently falling short on goals like food security and sustainability. The presentation argues that both incremental improvements as well as transformational changes are needed. It provides examples of both incremental changes like increases in herd sizes and transformational changes in the dairy system in an unnamed location. Finally, it stresses that technologies do not exist in isolation and discusses the need for alignment across innovation portfolios, funding, integration, talent management and impact monitoring to achieve goals.