Philip Thornton discusses principles for effective agricultural research for development at CGIAR, emphasizing the importance of delivering impactful outcomes, utilizing strategic leverage points, and innovating in partnerships, communication, and learning. Key examples highlight successful initiatives such as climate-informed advisories for farmers and the creation of new insurance indices. The document outlines the need for a plausible theory of change and collaborative efforts to address challenges facing smallholders, including gender disparity and youth unemployment.