This document describes a program called SBIRT in Schools that implements Screening, Brief Intervention, and Referral to Treatment (SBIRT) for adolescents at risk of substance abuse. It will partner with six communities to screen youth and link those at low-moderate risk to a brief mentoring intervention aimed at enhancing social supports. Youth identified at higher risk will be referred to treatment. The goals are to increase youth SBIRT capacity, connect sites to resources and best practices, and test approaches that can be more widely replicated to prevent substance abuse.