Target: UG medical students.

1. Sarcoidosis
Dr.CSBR.Prasad, M.D.,

2. Sarcoidosis
• Sarcoidosis is a multisystemic disease
• Unknown cause
• Characterized by noncaseating granulomas
• Lymphanodes, Lung, Skin, Eye
• Dx is made by exclusion
Other causes for non-caseating granulomas:
•Fungal infections
•Berylliosis
•some mycobacterial infections

3. Sarcoidosis
• More common in females
• More common in blacks
• Rare in Asians
• Thought to be immunologically mediated

4. Sarcoidosis
It is a disease of disordered immune
regulation in genetically predisposed
individuals exposed to certain
environmental agents

5. Sarcoidosis
1. Immunological factors
2. Genetic factors
3. Environmental factors

6. Sarcoidosis
1. Immunological factors:
• Intra-alveolar and interstitial accumulation of CD4+ T
cells
• Increased levels of T cell–derived TH1 cytokines such
as IL-2 and IFN-γ
• Increased levels of several cytokines in the local
environment - IL-8, TNF
• Polyclonal hypergammaglobulinemia

7. Sarcoidosis
2 - Genetic Factors :
• HLA-A1 &
• HLA-B8

8. Sarcoidosis
3 – Environmental Factors :
Several putative microbes have been proposed as
the inciting agent for sarcoidosis
1. Mycobacteria
2. Propionibacterium acnes, and
3. Rickettsia species

9. Sarcoidosis
Morphology: Virtually every organ in
the body may be involved in this
disease
well-formed non-caseating granulomas
Schaumann bodies
Asteroid bodies

10. Noncaseating granulomas

11. Noncaseating granulomas

12. Asteroid bodies

13. Asteroid body

14. Schaumann bodies

15. Sarcoidosis
• Lungs – Pleural involvement is rare
• Lymph nodes – Egg shell calcification
Mediastinal LNs
• Skin lesions – Discreet subcutaneous
nodules
• Eye – Iritis, iridocyclitis
• Parotids may be involved
• Muscle weakness and tenderness

16. Sarcoidosis
If you are encountered with a patient
with multisystemic manifestaions
have sarcoidosis in your diferential

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